{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:03:24Z","timestamp":1753884204849,"version":"3.41.2"},"reference-count":79,"publisher":"The Company of Biologists","issue":"12","license":[{"start":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T00:00:00Z","timestamp":1623715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"name":"Manipal Academy of Higher Education"},{"DOI":"10.13039\/501100001793","name":"Queensland University of Technology","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001793","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Manipal School of Life Sciences"},{"name":"Technology Information, Forecasting and Assessment Council-Centre of Relevance and Excellence"},{"name":"Institute of Health and Biomedical Innovation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,6,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>UVBR-induced photolesions in genomic DNA of keratinocytes impair cellular functions and potentially determine the cell fate post-irradiation. The ability of insulin-like growth factor-I (IGF-I) to rescue epidermal keratinocytes after photodamage via apoptosis prevention and photolesion removal was recently demonstrated using in vitro two-dimensional and three-dimensional skin models. Given the limited knowledge of specific signalling cascades contributing to post-UVBR IGF-I effects, we used inhibitors to investigate the impact of blockade of various signalling mediators on IGF-I photoprotection. IGF-I treatment, in the presence of signalling inhibitors, particularly TDRL-505, which targets replication protein A (RPA), impaired activation of IGF-1R downstream signalling, diminished cyclobutane pyrimidine dimer removal, arrested growth, reduced cell survival and increased apoptosis. Further, the transient partial knockdown of RPA was found to abrogate IGF-I-mediated responses in keratinocytes, ultimately affecting photoprotection and, thereby, establishing that RPA is required for IGF-I function. Our findings thus elucidate the importance of RPA in linking the damage response activation, cell cycle regulation, repair and survival pathways, separately initiated by IGF-I upon UVBR-induced damage. This information is potentially imperative for the development of effective sunburn and photodamage repair strategies.<\/jats:p>\n               <jats:p>This article has an associated First Person interview with the first author of the paper.<\/jats:p>","DOI":"10.1242\/jcs.255786","type":"journal-article","created":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T08:14:25Z","timestamp":1621498465000},"source":"Crossref","is-referenced-by-count":2,"title":["RPA facilitates rescue of keratinocytes from UVB radiation damage through insulin-like growth factor-I signalling"],"prefix":"10.1242","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4743-1735","authenticated-orcid":false,"given":"Melisa J.","family":"Andrade","sequence":"first","affiliation":[{"name":"Department of Cell and Molecular Biology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India"},{"name":"Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, Queensland 4059, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9428-9009","authenticated-orcid":false,"given":"Derek R.","family":"Van Lonkhuyzen","sequence":"additional","affiliation":[{"name":"Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, Queensland 4059, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9928-5864","authenticated-orcid":false,"given":"Zee","family":"Upton","sequence":"additional","affiliation":[{"name":"Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, Queensland 4059, Australia"},{"name":"Skin Research Institute of Singapore, Agency for Science, Technology and Research, Singapore138648"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2368-5490","authenticated-orcid":false,"given":"Kapaettu","family":"Satyamoorthy","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2021,6,17]]},"reference":[{"key":"2021061709033143900_JCS255786C1","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1016\/0092-8674(95)90289-9","article-title":"Mammalian DNA nucleotide excision repair reconstituted with purified protein components","volume":"80","author":"Aboussekhra","year":"1995","journal-title":"Cell"},{"key":"2021061709033143900_JCS255786C2","doi-asserted-by":"publisher","first-page":"7186","DOI":"10.1073\/pnas.94.14.7186","article-title":"Interaction between replication protein A and p53 is disrupted after UV damage in a DNA repair-dependent manner","volume":"94","author":"Abramova","year":"1997","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2021061709033143900_JCS255786C3","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00117","article-title":"IGF-binding proteins: why do they exist and why are there so many?","volume":"9","author":"Allard","year":"2018","journal-title":"Front. Endocrinol."},{"key":"2021061709033143900_JCS255786C4","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.bbrc.2009.06.088","article-title":"Focal adhesion kinase (FAK) activates and stabilizes IGF-1 receptor","volume":"387","author":"Andersson","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2021061709033143900_JCS255786C5","doi-asserted-by":"publisher","first-page":"111951","DOI":"10.1016\/j.jphotobiol.2020.111951","article-title":"Insulin-like growth factor-I rescue of primary keratinocytes from pre- and post-ultraviolet B radiation effects","volume":"209","author":"Andrade","year":"2020","journal-title":"J. Photochem. Photobiol. B Biol."},{"key":"2021061709033143900_JCS255786C6","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1016\/j.dnarep.2004.03.028","article-title":"Replication protein A phosphorylation and the cellular response to DNA damage","volume":"3","author":"Binz","year":"2004","journal-title":"DNA Repair"},{"key":"2021061709033143900_JCS255786C7","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1093\/nar\/gkh265","article-title":"Phosphatidyl inositol 3\u2013kinase\u2013like serine\/threonine protein kinases (PIKKs) are required for DNA damage\u2013induced phosphorylation of the 32 kDa subunit of replication protein A at threonine 21","volume":"32","author":"Block","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"2021061709033143900_JCS255786C8","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1038\/377552a0","article-title":"Radiation-induced cell cycle arrest compromised by p21 deficiency","volume":"377","author":"Brugarolas","year":"1995","journal-title":"Nature"},{"key":"2021061709033143900_JCS255786C9","doi-asserted-by":"publisher","first-page":"11949","DOI":"10.1016\/S0021-9258(19)49788-3","article-title":"Identification of the forms of insulin-like growth factor-binding proteins produced by human fibroblasts and the mechanisms that regulate their secretion","volume":"267","author":"Camacho-Hubner","year":"1992","journal-title":"J. Biol. Chem."},{"key":"2021061709033143900_JCS255786C10","doi-asserted-by":"publisher","first-page":"2622","DOI":"10.1002\/jcb.24137","article-title":"SPARC\/SFN interaction, suppresses type I collagen in dermal fibroblasts","volume":"113","author":"Chavez-Mu\u00f1oz","year":"2012","journal-title":"J. Cell. Biochem."},{"key":"2021061709033143900_JCS255786C11","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1042\/bj20020072","article-title":"UVB-mediated activation of p38 mitogen-activated protein kinase enhances resistance of normal human keratinocytes to apoptosis by stabilizing cytoplasmic p53","volume":"365","author":"Chouinard","year":"2002","journal-title":"Biochem. J."},{"key":"2021061709033143900_JCS255786C12","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.molcel.2010.09.019","article-title":"The DNA damage response: making it safe to play with knives","volume":"40","author":"Ciccia","year":"2010","journal-title":"Mol. Cell"},{"key":"2021061709033143900_JCS255786C13","doi-asserted-by":"publisher","first-page":"32587","DOI":"10.1074\/jbc.M111106200","article-title":"Insulin-like growth factor-1-mediated AKT activation postpones the onset of ultraviolet B-induced apoptosis, providing more time for cyclobutane thymine dimer removal in primary human keratinocytes","volume":"277","author":"Decraene","year":"2002","journal-title":"J. Biol. Chem."},{"key":"2021061709033143900_JCS255786C14","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1093\/carcin\/bgr231","article-title":"Regulation of Cdk7 activity through a phosphatidylinositol (3)-kinase\/PKC-\u03b9-mediated signaling cascade in glioblastoma","volume":"33","author":"Desai","year":"2012","journal-title":"Carcinogenesis"},{"key":"2021061709033143900_JCS255786C15","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1128\/MCB.20.4.1436-1447.2000","article-title":"Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics","volume":"20","author":"Dickson","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"2021061709033143900_JCS255786C16","doi-asserted-by":"publisher","first-page":"100","DOI":"10.3389\/fendo.2020.00100","article-title":"Insulin-Like Growth Factor Binding Protein-5 in Physiology and Disease","volume":"11","author":"Duan","year":"2020","journal-title":"Front. Endocrinol."},{"key":"2021061709033143900_JCS255786C17","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/0092-8674(93)90500-P","article-title":"WAF1, a potential mediator of p53 tumor suppression","volume":"75","author":"El-Deiry","year":"1993","journal-title":"Cell"},{"key":"2021061709033143900_JCS255786C18","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1111\/exd.12637","article-title":"Insulin-like growth factor-I and UVB photoprotection in human keratinocytes","volume":"24","author":"Fernandez","year":"2015","journal-title":"Exp. Dermatol."},{"key":"2021061709033143900_JCS255786C19","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1210\/er.2001-0033","article-title":"Cellular actions of the insulin-like growth factor binding proteins","volume":"23","author":"Firth","year":"2002","journal-title":"Endocr. Rev."},{"key":"2021061709033143900_JCS255786C20","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1080\/21541264.2018.1553483","article-title":"Cdk7: a kinase at the core of transcription and in the crosshairs of cancer drug discovery","volume":"10","author":"Fisher","year":"2019","journal-title":"Transcription"},{"key":"2021061709033143900_JCS255786C21","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1002\/path.1712","article-title":"Insulin\u2013like growth factor ligands, receptors, and binding proteins in cancer","volume":"205","author":"Foulstone","year":"2005","journal-title":"J. Pathol."},{"key":"2021061709033143900_JCS255786C22","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1002\/jcb.10424","article-title":"SPARC regulates cell cycle progression in mesangial cells via its inhibition of IGF\u2013dependent signaling","volume":"88","author":"Francki","year":"2003","journal-title":"J. Cell. Biochem."},{"key":"2021061709033143900_JCS255786C23","doi-asserted-by":"crossref","DOI":"10.1128\/9781555816704","volume-title":"DNA Repair and Mutagenesis","author":"Friedberg","year":"2005"},{"key":"2021061709033143900_JCS255786C24","doi-asserted-by":"publisher","first-page":"480","DOI":"10.3109\/07357909509024911","article-title":"Insulin-like growth factor-1 inhibits cell death induced by anticancer drugs in the MCF-7 cells: involvement of growth factors in drug resistance","volume":"13","author":"Geier","year":"1995","journal-title":"Cancer Invest."},{"key":"2021061709033143900_JCS255786C25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1023\/A:1006208721167","article-title":"Insulin-like growth factor (IGF)-I rescues breast cancer cells from chemotherapy-induced cell death--proliferative and anti-apoptotic effects","volume":"56","author":"Gooch","year":"1999","journal-title":"Breast Cancer Res. Treat."},{"key":"2021061709033143900_JCS255786C26","doi-asserted-by":"publisher","first-page":"30359","DOI":"10.1074\/jbc.M009698200","article-title":"Akt down-regulation of p38 signaling provides a novel mechanism of vascular endothelial growth factor-mediated cytoprotection in endothelial cells","volume":"276","author":"Gratton","year":"2001","journal-title":"J. Biol. Chem."},{"key":"2021061709033143900_JCS255786C27","doi-asserted-by":"publisher","first-page":"3908","DOI":"10.1074\/jbc.M111.287441","article-title":"Repair-specific functions of replication protein A","volume":"287","author":"Hass","year":"2012","journal-title":"J. Biol. Chem."},{"key":"2021061709033143900_JCS255786C28","doi-asserted-by":"publisher","first-page":"18185","DOI":"10.1074\/jbc.M011490200","article-title":"Insulin-like growth factor-I (IGF-I) receptor activation rescues UV-damaged cells through a p38 signaling pathway. Potential role of the IGF-I receptor in DNA repair","volume":"276","author":"Heron-Milhavet","year":"2001","journal-title":"J. Biol. Chem."},{"key":"2021061709033143900_JCS255786C29","doi-asserted-by":"publisher","first-page":"7109","DOI":"10.1074\/jbc.M113.520429","article-title":"A small molecule inhibitor of monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA) inhibits repair of interstrand DNA cross-link, enhances DNA double strand break, and sensitizes cancer cells to cisplatin","volume":"289","author":"Inoue","year":"2014","journal-title":"J. Biol. Chem."},{"key":"2021061709033143900_JCS255786C30","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1083\/jcb.121.3.679","article-title":"Extracellular matrix contains insulin-like growth factor binding protein-5: potentiation of the effects of IGF-I","volume":"121","author":"Jones","year":"1993","journal-title":"J. Cell Biol."},{"key":"2021061709033143900_JCS255786C31","doi-asserted-by":"publisher","first-page":"26574","DOI":"10.1074\/jbc.M114.597088","article-title":"DNA repair synthesis and ligation affect the processing of excised oligonucleotides generated by human nucleotide excision repair","volume":"289","author":"Kemp","year":"2014","journal-title":"J. Biol. Chem."},{"key":"2021061709033143900_JCS255786C32","doi-asserted-by":"publisher","first-page":"356","DOI":"10.3390\/molecules22030356","article-title":"Impact of age and insulin-like growth factor-1 on DNA damage responses in UV-irradiated human skin","volume":"22","author":"Kemp","year":"2017","journal-title":"Molecules"},{"key":"2021061709033143900_JCS255786C33","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1074\/jbc.M116.765883","article-title":"Insulin-like growth factor 1 receptor signaling is required for optimal ATR-CHK1 kinase signaling in ultraviolet B (UVB)-irradiated human keratinocytes","volume":"292","author":"Kemp","year":"2017","journal-title":"J. Biol. Chem."},{"key":"2021061709033143900_JCS255786C34","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1111\/j.1524-475X.2007.00210.x","article-title":"Keratinocyte conditioned medium abrogates the modulatory effects of IGF-1 and TGF-\u03b21 on collagenase expression in dermal fibroblasts","volume":"15","author":"Kilani","year":"2007","journal-title":"Wound Repair. Regen."},{"key":"2021061709033143900_JCS255786C35","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1002\/(SICI)1097-0215(19990129)80:3&lt;431::AID-IJC16&gt;3.0.CO;2-5","article-title":"Activation of the insulin-like growth factor-1 receptor promotes the survival of human keratinocytes following ultraviolet B irradiation","volume":"80","author":"Kuhn","year":"1999","journal-title":"Int. J. Cancer"},{"key":"2021061709033143900_JCS255786C36","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1038\/sj.jid.5701127","article-title":"UVB-induced activation of NF-kappaB is regulated by the IGF-1R and dependent on p38 MAPK","volume":"128","author":"Lewis","year":"2008","journal-title":"J. Invest. Dermatol."},{"key":"2021061709033143900_JCS255786C37","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.1091\/mbc.e07-10-1041","article-title":"UVB-induced senescence in human keratinocytes requires a functional insulin-like growth factor-1 receptor and p53","volume":"19","author":"Lewis","year":"2008","journal-title":"Mol. Biol. Cell"},{"key":"2021061709033143900_JCS255786C38","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1038\/onc.2009.440","article-title":"The IGF-1\/IGF-1R signaling axis in the skin: a new role for the dermis in aging-associated skin cancer","volume":"29","author":"Lewis","year":"2010","journal-title":"Oncogene"},{"key":"2021061709033143900_JCS255786C39","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.cdtm.2019.08.006","article-title":"Cyclin-dependent kinase 7 inhibitor THZ1 in cancer therapy","volume":"5","author":"Li","year":"2019","journal-title":"Chronic Diseases and Translational Medicine"},{"key":"2021061709033143900_JCS255786C40","doi-asserted-by":"publisher","first-page":"3388","DOI":"10.1073\/pnas.78.6.3388","article-title":"Distribution of UV light-induced damage in a defined sequence of human DNA: detection of alkaline-sensitive lesions at pyrimidine nucleoside-cytidine sequences","volume":"78","author":"Lippke","year":"1981","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2021061709033143900_JCS255786C41","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1093\/carcin\/bgn026","article-title":"FAK and IGF-IR interact to provide survival signals in human pancreatic adenocarcinoma cells","volume":"29","author":"Liu","year":"2008","journal-title":"Carcinogenesis"},{"key":"2021061709033143900_JCS255786C42","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1016\/j.molonc.2016.06.002","article-title":"Insulin-like growth factor-1 receptor regulates repair of ultraviolet B-induced DNA damage in human keratinocytes in vivo","volume":"10","author":"Loesch","year":"2016","journal-title":"Mol. Oncol."},{"key":"2021061709033143900_JCS255786C43","doi-asserted-by":"publisher","first-page":"2067","DOI":"10.1016\/j.str.2004.08.013","article-title":"The crystal structure of human CDK7 and its protein recognition properties","volume":"12","author":"Lolli","year":"2004","journal-title":"Structure"},{"key":"2021061709033143900_JCS255786C44","doi-asserted-by":"publisher","first-page":"e0223894","DOI":"10.1371\/journal.pone.0223894","article-title":"Additive effects of a small molecular PCNA inhibitor PCNA-I1S and DNA damaging agents on growth inhibition and DNA damage in prostate and lung cancer cells","volume":"14","author":"Lu","year":"2019","journal-title":"PLoS ONE"},{"key":"2021061709033143900_JCS255786C45","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/cr.2014.147","article-title":"RPA-coated single-stranded DNA as a platform for post-translational modifications in the DNA damage response","volume":"25","author":"Mar\u00e9chal","year":"2015","journal-title":"Cell Res."},{"key":"2021061709033143900_JCS255786C46","doi-asserted-by":"publisher","first-page":"E536","DOI":"10.1152\/ajpendo.1999.276.3.E536","article-title":"HaCaT human keratinocytes express IGF-II, IGFBP-6, and an acid-activated protease with activity against IGFBP-6","volume":"276","author":"Marinaro","year":"1999","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"2021061709033143900_JCS255786C47","first-page":"1476","article-title":"Kinase inhibitors of HER2\/AKT pathway induce ERK phosphorylation via a FOXO-dependent feedback loop","volume":"7","author":"Matkar","year":"2017","journal-title":"Am. J. Cancer Res."},{"key":"2021061709033143900_JCS255786C48","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1007\/s11010-007-9538-y","article-title":"The role of stratifin in fibroblast\u2013keratinocyte interaction","volume":"305","author":"Medina","year":"2007","journal-title":"Mol. Cell. Biochem."},{"key":"2021061709033143900_JCS255786C49","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.bcp.2014.10.013","article-title":"Chemical inhibitor targeting the replication protein A-DNA interaction increases the efficacy of Pt-based chemotherapy in lung and ovarian cancer","volume":"93","author":"Mishra","year":"2015","journal-title":"Biochem. Pharmacol."},{"key":"2021061709033143900_JCS255786C50","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1111\/j.1751-1097.1989.tb05578.x","article-title":"The biology of the (6-4) photoproduct","volume":"49","author":"Mitchell","year":"1989","journal-title":"Photochem. Photobiol."},{"key":"2021061709033143900_JCS255786C51","doi-asserted-by":"publisher","first-page":"2415","DOI":"10.1074\/jbc.270.6.2415","article-title":"Reconstitution of human DNA repair excision nuclease in a highly defined system","volume":"270","author":"Mu","year":"1995","journal-title":"J. Biol. Chem."},{"key":"2021061709033143900_JCS255786C52","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.1038\/sj.onc.1206327","article-title":"IGF-1 activates p21 to inhibit UV-induced cell death","volume":"22","author":"Murray","year":"2003","journal-title":"Oncogene"},{"key":"2021061709033143900_JCS255786C53","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1016\/j.jid.2015.12.023","article-title":"Sustained Akt activity is required to maintain cell viability in seborrheic keratosis, a benign epithelial tumor","volume":"136","author":"Neel","year":"2016","journal-title":"J. Investig. Dermatol."},{"key":"2021061709033143900_JCS255786C54","doi-asserted-by":"publisher","first-page":"521","DOI":"10.5772\/22387","article-title":"Disruption of protein\u2013DNA interactions: an opportunity for cancer chemotherapy","volume-title":"DNA Repair and Human Health","author":"Neher","year":"2011"},{"key":"2021061709033143900_JCS255786C55","doi-asserted-by":"publisher","first-page":"3778","DOI":"10.7150\/jca.30359","article-title":"Anti-tumor drug THZ1 suppresses TGF\u03b22-mediated EMT in lens epithelial cells via Notch and TGF\u03b2\/Smad signaling pathway","volume":"10","author":"Ning","year":"2019","journal-title":"J. Cancer"},{"key":"2021061709033143900_JCS255786C56","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1083\/jcb.201006011","article-title":"Replication protein A safeguards genome integrity by controlling NER incision events","volume":"192","author":"Overmeer","year":"2011","journal-title":"J. Cell Biol."},{"key":"2021061709033143900_JCS255786C57","doi-asserted-by":"publisher","first-page":"995","DOI":"10.15252\/embj.201695534","article-title":"AKT-phosphorylated FOXO1 suppresses ERK activation and chemoresistance by disrupting IQGAP1-MAPK interaction","volume":"36","author":"Pan","year":"2017","journal-title":"EMBO J."},{"key":"2021061709033143900_JCS255786C58","doi-asserted-by":"publisher","first-page":"932","DOI":"10.4161\/cc.10.6.15012","article-title":"p21WAF1 is component of a positive feedback loop that maintains the p53 transcriptional program","volume":"10","author":"Pang","year":"2011","journal-title":"Cell Cycle"},{"key":"2021061709033143900_JCS255786C59","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1074\/jbc.272.1.154","article-title":"Insulin-like growth factor 1 inhibits apoptosis using the phosphatidylinositol 3\u2032-kinase and mitogen-activated protein kinase pathways","volume":"272","author":"P\u00e1rrizas","year":"1997","journal-title":"J. Biol. Chem."},{"key":"2021061709033143900_JCS255786C60","doi-asserted-by":"publisher","first-page":"F49","DOI":"10.1152\/ajprenal.00032.2009","article-title":"Interplay between Akt and p38 MAPK pathways in the regulation of renal tubular cell apoptosis associated with diabetic nephropathy","volume":"298","author":"Rane","year":"2010","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"2021061709033143900_JCS255786C61","doi-asserted-by":"publisher","first-page":"4445","DOI":"10.1210\/en.2005-0467","article-title":"Insulin-like growth factor binding protein-2 binding to extracellular matrix plays a critical role in neuroblastoma cell proliferation, migration, and invasion","volume":"146","author":"Russo","year":"2005","journal-title":"Endocrinology"},{"key":"2021061709033143900_JCS255786C62","doi-asserted-by":"publisher","first-page":"2675","DOI":"10.1128\/MCB.26.7.2675-2687.2006","article-title":"Insulin-like growth factor 1 receptor signaling regulates skin development and inhibits skin keratinocyte differentiation","volume":"26","author":"Sadagurski","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"2021061709033143900_JCS255786C63","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1007\/s12079-007-0010-2","article-title":"Specific inhibitor of MEK-mediated cross-talk between ERK and p38 MAPK during differentiation of human osteosarcoma cells","volume":"1","author":"Shimo","year":"2007","journal-title":"J. Cell Commun. Signal."},{"key":"2021061709033143900_JCS255786C64","doi-asserted-by":"publisher","first-page":"3189","DOI":"10.1158\/0008-5472.CAN-09-3422","article-title":"Targeted inhibition of Replication Protein A reveals cytotoxic activity, synergy with chemotherapeutic DNA-damaging agents, and insight into cellular function","volume":"70","author":"Shuck","year":"2010","journal-title":"Cancer Res."},{"key":"2021061709033143900_JCS255786C65","doi-asserted-by":"publisher","first-page":"3789","DOI":"10.1038\/onc.2012.556","article-title":"Various modes of cell death induced by DNA damage","volume":"32","author":"Surova","year":"2013","journal-title":"Oncogene"},{"key":"2021061709033143900_JCS255786C66","doi-asserted-by":"publisher","first-page":"2233","DOI":"10.3390\/ijms19082233","article-title":"Restraining AKT1 phosphorylation attenuates the repair of radiation-induced DNA double-strand breaks and reduces the survival of irradiated cancer cells","volume":"19","author":"Szymonowicz","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"2021061709033143900_JCS255786C67","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1111\/acel.12219","article-title":"Insulin-like growth factor-1 regulates the SIRT1-p53 pathway in cellular senescence","volume":"13","author":"Tran","year":"2014","journal-title":"Aging Cell"},{"key":"2021061709033143900_JCS255786C68","doi-asserted-by":"publisher","first-page":"3250","DOI":"10.4161\/cc.21611","article-title":"Disruption of the protein interaction between FAK and IGF-1R inhibits melanoma tumor growth","volume":"11","author":"Ucar","year":"2012","journal-title":"Cell Cycle (Georgetown, Tex.)"},{"key":"2021061709033143900_JCS255786C69","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1038\/381713a0","article-title":"Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21","volume":"381","author":"Waldman","year":"1996","journal-title":"Nature"},{"key":"2021061709033143900_JCS255786C70","doi-asserted-by":"publisher","first-page":"45737","DOI":"10.1074\/jbc.M300574200","article-title":"Epidermal growth factor receptor-dependent, NF-\u03baB-independent activation of the phosphatidylinositol 3-kinase\/Akt pathway inhibits ultraviolet irradiation-induced caspases-3, -8, and -9 in human keratinocytes","volume":"278","author":"Wang","year":"2003","journal-title":"J. Biol. Chem."},{"key":"2021061709033143900_JCS255786C71","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1097\/00000372-197900120-00003","article-title":"Apoptosis. Its nature and implications for dermatopathology","volume":"1","author":"Weedon","year":"1979","journal-title":"Am. J. Dermatopathol."},{"key":"2021061709033143900_JCS255786C72","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2016.00159","article-title":"Insulin-like growth factor 1 signaling axis meets p53 genome protection pathways","volume":"6","author":"Werner","year":"2016","journal-title":"Front. Oncol."},{"key":"2021061709033143900_JCS255786C73","first-page":"22","article-title":"Increased p53-dependent apoptosis by the insulin-like growth factor binding protein IGFBP-3 in human colonic adenoma-derived cells","volume":"60","author":"Williams","year":"2000","journal-title":"Cancer Res."},{"key":"2021061709033143900_JCS255786C74","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1146\/annurev.biochem.66.1.61","article-title":"Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism","volume":"66","author":"Wold","year":"1997","journal-title":"Annu. Rev. Biochem."},{"key":"2021061709033143900_JCS255786C75","doi-asserted-by":"publisher","first-page":"951724","DOI":"10.1155\/2012\/951724","article-title":"Akt: a double-edged sword in cell proliferation and genome stability","volume":"2012","author":"Xu","year":"2012","journal-title":"J. Oncol."},{"key":"2021061709033143900_JCS255786C76","doi-asserted-by":"publisher","first-page":"32553","DOI":"10.1074\/jbc.M803963200","article-title":"The p38 mitogen-activated protein kinase augments nucleotide excision repair by mediating DDB2 degradation and chromatin relaxation","volume":"283","author":"Zhao","year":"2008","journal-title":"J. Biol. Chem."},{"key":"2021061709033143900_JCS255786C77","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1159\/000092093","article-title":"Mitogen-activated protein kinase signaling, oxygen sensors and hypoxic induction of neurogenesis","volume":"3","author":"Zhou","year":"2006","journal-title":"Neurodegener. Dis."},{"key":"2021061709033143900_JCS255786C78","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.brainres.2004.05.115","article-title":"Neurogenesis response to hypoxia-induced cell death: map kinase signal transduction mechanisms","volume":"1021","author":"Zhou","year":"2004","journal-title":"Brain Res."},{"key":"2021061709033143900_JCS255786C79","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1002\/jcp.20622","article-title":"Functions of human replication protein A (RPA): from DNA replication to DNA damage and stress responses","volume":"208","author":"Zou","year":"2006","journal-title":"J. Cell. Physiol."}],"container-title":["Journal of Cell Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.biologists.com\/jcs\/article-pdf\/doi\/10.1242\/jcs.255786\/2070721\/jcs255786.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/jcs\/article-pdf\/doi\/10.1242\/jcs.255786\/2080482\/jcs255786.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/jcs\/article-pdf\/doi\/10.1242\/jcs.255786\/2080482\/jcs255786.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T09:04:09Z","timestamp":1623920649000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/jcs\/article\/134\/12\/jcs255786\/269160\/RPA-facilitates-rescue-of-keratinocytes-from-UVB"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,15]]},"references-count":79,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,6,15]]}},"URL":"https:\/\/doi.org\/10.1242\/jcs.255786","relation":{},"ISSN":["0021-9533","1477-9137"],"issn-type":[{"type":"print","value":"0021-9533"},{"type":"electronic","value":"1477-9137"}],"subject":[],"published":{"date-parts":[[2021,6,15]]},"article-number":"jcs255786"}}