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Here, we show that conditional deletion of the phosphoinositide 5\u2032-phosphatase gene Inpp5e, mutation of which is causative of Joubert syndrome, in terminally developed mouse olfactory sensory neurons (OSNs), leads to a dramatic remodeling of ciliary phospholipids that is accompanied by marked elongation of cilia. Phosphatidylinositol (4,5)-bisphosphate [PI(4,5)P2], which is normally restricted to the proximal segment redistributed to the entire length of cilia in Inpp5e knockout mice with a reduction in phosphatidylinositol (3,4)-bisphosphate [PI(3,4)P2] and elevation of phosphatidylinositol (3,4,5)-trisphosphate [PI(3,4,5)P3] in the dendritic knob. The redistribution of phosphoinositides impaired odor adaptation, resulting in less efficient recovery and altered inactivation kinetics of the odor-evoked electrical response and the odor-induced elevation of cytoplasmic Ca2+. Gene replacement of Inpp5e through adenoviral expression restored the ciliary localization of PI(4,5)P2 and odor response kinetics in OSNs. Our findings support the role of phosphoinositides as a modulator of the odor response and in ciliary biology of native multi-ciliated OSNs.<\/jats:p>","DOI":"10.1242\/jcs.258364","type":"journal-article","created":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T18:55:13Z","timestamp":1616784913000},"source":"Crossref","is-referenced-by-count":24,"title":["INPP5E controls ciliary localization of phospholipids and the odor response in olfactory sensory neurons"],"prefix":"10.1242","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0633-9067","authenticated-orcid":false,"given":"Kirill","family":"Ukhanov","sequence":"first","affiliation":[{"name":"University of Florida, Department of Pharmacology and Therapeutics, Gainesville, FL 32603, USA"},{"name":"University of Florida, Center for Smell and Taste, FL 32610-0267, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cedric","family":"Uytingco","sequence":"additional","affiliation":[{"name":"University of Florida, Department of Pharmacology and Therapeutics, Gainesville, FL 32603, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warren","family":"Green","sequence":"additional","affiliation":[{"name":"University of Florida, Department of Pharmacology and Therapeutics, Gainesville, FL 32603, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian","family":"Zhang","sequence":"additional","affiliation":[{"name":"University of Florida, Department of Pharmacology and Therapeutics, Gainesville, FL 32603, USA"},{"name":"University of Florida, Center for Smell and Taste, FL 32610-0267, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephane","family":"Schurmans","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Genetics, GIGA-Molecular Biology of Disease, University of Li\u00e8ge, Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0451-2703","authenticated-orcid":false,"given":"Jeffrey R.","family":"Martens","sequence":"additional","affiliation":[{"name":"University of Florida, Department of Pharmacology and Therapeutics, Gainesville, FL 32603, USA"},{"name":"University of Florida, Center for Smell and Taste, FL 32610-0267, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2021,5,11]]},"reference":[{"key":"2021070114155575500_JCS258364C1","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.1016\/j.cub.2009.08.045","article-title":"The CIL-1 PI 5-Phosphatase localizes TRP polycystins to cilia and activates sperm in C. elegans","volume":"19","author":"Bae","year":"2009","journal-title":"Curr. 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