{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T10:18:32Z","timestamp":1776161912656,"version":"3.50.1"},"reference-count":90,"publisher":"The Company of Biologists","issue":"2","license":[{"start":{"date-parts":[[2022,1,26]],"date-time":"2022-01-26T00:00:00Z","timestamp":1643155200000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01 GM107293"],"award-info":[{"award-number":["R01 GM107293"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R35 GM130311"],"award-info":[{"award-number":["R35 GM130311"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100008662","name":"Joachim Herz Stiftung","doi-asserted-by":"crossref","award":["#850022"],"award-info":[{"award-number":["#850022"]}],"id":[{"id":"10.13039\/100008662","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"crossref","award":["T32HD007520"],"award-info":[{"award-number":["T32HD007520"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Condensin is a multi-subunit structural maintenance of chromosomes (SMC) complex that binds to and compacts chromosomes. Here, we addressed the regulation of condensin binding dynamics using Caenorhabditis elegans condensin DC, which represses X chromosomes in hermaphrodites for dosage compensation. We established fluorescence recovery after photobleaching (FRAP) using the SMC4 homolog DPY-27 and showed that a well-characterized ATPase mutation abolishes DPY-27 binding to X chromosomes. Next, we performed FRAP in the background of several chromatin modifier mutants that cause varying degrees of X chromosome derepression. The greatest effect was in a null mutant of the H4K20me2 demethylase DPY-21, where the mobile fraction of condensin DC reduced from \u223c30% to 10%. In contrast, a catalytic mutant of dpy-21 did not regulate condensin DC mobility. Hi-C sequencing data from the dpy-21 null mutant showed little change compared to wild-type data, uncoupling Hi-C-measured long-range DNA contacts from transcriptional repression of the X chromosomes. Taken together, our results indicate that DPY-21 has a non-catalytic role in regulating the dynamics of condensin DC binding, which is important for transcription repression.<\/jats:p>","DOI":"10.1242\/jcs.258818","type":"journal-article","created":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T07:22:16Z","timestamp":1639725736000},"source":"Crossref","is-referenced-by-count":16,"title":["The histone H4 lysine 20 demethylase DPY-21 regulates the dynamics of condensin DC binding"],"prefix":"10.1242","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7702-5749","authenticated-orcid":false,"given":"Laura","family":"Breimann","sequence":"first","affiliation":[{"name":"Center for Genomics and Systems Biology, New York University 1 Department of Biology , , New York, NY 10003 , USA"},{"name":"Berlin Institute for Medical Systems Biology, Max Delbr\u00fcck Center for Molecular Medicine 2 , 10115 Berlin , Germany"},{"name":"Institute for Biology, Humboldt University of Berlin 3 , 10099 Berlin , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2194-8071","authenticated-orcid":false,"given":"Ana Karina","family":"Morao","sequence":"additional","affiliation":[{"name":"Center for Genomics and Systems Biology, New York University 1 Department of Biology , , New York, NY 10003 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9473-3093","authenticated-orcid":false,"given":"Jun","family":"Kim","sequence":"additional","affiliation":[{"name":"Center for Genomics and Systems Biology, New York University 1 Department of Biology , , New York, NY 10003 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0943-9063","authenticated-orcid":false,"given":"David","family":"Sebastian Jimenez","sequence":"additional","affiliation":[{"name":"Center for Genomics and Systems Biology, New York University 1 Department of Biology , , New York, NY 10003 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0975-3354","authenticated-orcid":false,"given":"Nina","family":"Maryn","sequence":"additional","affiliation":[{"name":"Center for Genomics and Systems Biology, New York University 1 Department of Biology , , New York, NY 10003 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4000-1863","authenticated-orcid":false,"given":"Krishna","family":"Bikkasani","sequence":"additional","affiliation":[{"name":"Center for Genomics and Systems Biology, New York University 1 Department of Biology , , New York, NY 10003 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Carrozza","sequence":"additional","affiliation":[{"name":"Center for Genomics and Systems Biology, New York University 1 Department of Biology , , New York, NY 10003 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6093-9560","authenticated-orcid":false,"given":"Sarah E.","family":"Albritton","sequence":"additional","affiliation":[{"name":"Center for Genomics and Systems Biology, New York University 1 Department of Biology , , New York, NY 10003 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1643-0756","authenticated-orcid":false,"given":"Maxwell","family":"Kramer","sequence":"additional","affiliation":[{"name":"Center for Genomics and Systems Biology, New York University 1 Department of Biology , , New York, NY 10003 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5473-6713","authenticated-orcid":false,"given":"Lena Annika","family":"Street","sequence":"additional","affiliation":[{"name":"Center for Genomics and Systems Biology, New York University 1 Department of Biology , , New York, NY 10003 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0775-3032","authenticated-orcid":false,"given":"Kustrim","family":"Cerimi","sequence":"additional","affiliation":[{"name":"Berlin Institute for Medical Systems Biology, Max Delbr\u00fcck Center for Molecular Medicine 2 , 10115 Berlin , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0227-7428","authenticated-orcid":false,"given":"Vic-Fabienne","family":"Schumann","sequence":"additional","affiliation":[{"name":"Berlin Institute for Medical Systems Biology, Max Delbr\u00fcck Center for Molecular Medicine 2 , 10115 Berlin , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6358-2576","authenticated-orcid":false,"given":"Ella","family":"Bahry","sequence":"additional","affiliation":[{"name":"Berlin Institute for Medical Systems Biology, Max Delbr\u00fcck Center for Molecular Medicine 2 , 10115 Berlin , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0276-494X","authenticated-orcid":false,"given":"Stephan","family":"Preibisch","sequence":"additional","affiliation":[{"name":"Berlin Institute for Medical Systems Biology, Max Delbr\u00fcck Center for Molecular Medicine 2 , 10115 Berlin , Germany"},{"name":"Janelia Research Campus, Howard Hughes Medical Institute 4 , Ashburn, VA 20147 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5157-9313","authenticated-orcid":false,"given":"Andrew","family":"Woehler","sequence":"additional","affiliation":[{"name":"Berlin Institute for Medical Systems Biology, Max Delbr\u00fcck Center for Molecular Medicine 2 , 10115 Berlin , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7297-1648","authenticated-orcid":false,"given":"Sevin\u00e7","family":"Ercan","sequence":"additional","affiliation":[{"name":"Center for Genomics and Systems Biology, New York University 1 Department of Biology , , New York, NY 10003 , USA"},{"name":"Berlin Institute for Medical Systems Biology, Max Delbr\u00fcck Center for Molecular Medicine 2 , 10115 Berlin , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2022,1,26]]},"reference":[{"key":"2024061307262330600_JCS258818C1","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.tig.2017.09.010","article-title":"Caenorhabditis elegans dosage compensation: insights into condensin- mediated gene regulation","volume":"34","author":"Albritton","year":"2018","journal-title":"Trends Genet."},{"key":"2024061307262330600_JCS258818C2","doi-asserted-by":"publisher","first-page":"e23629","DOI":"10.7554\/eLife.23645","article-title":"Cooperation between a hierarchical set of recruitment sites targets the X chromosome for dosage compensation","volume":"6","author":"Albritton","year":"2017","journal-title":"eLife"},{"key":"2024061307262330600_JCS258818C3","doi-asserted-by":"publisher","first-page":"9354","DOI":"10.1038\/s41598-019-45839-z","article-title":"The ENCODE blacklist: identification of problematic regions of the genome","volume":"9","author":"Amemiya","year":"2019","journal-title":"Sci. Rep."},{"key":"2024061307262330600_JCS258818C4","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq\u2014a Python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics"},{"key":"2024061307262330600_JCS258818C5","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.devcel.2019.08.004","article-title":"X Chromosome domain architecture regulates caenorhabditis elegans lifespan but not dosage compensation","volume":"51","author":"Anderson","year":"2019","journal-title":"Dev. Cell"},{"key":"2024061307262330600_JCS258818C6","doi-asserted-by":"publisher","first-page":"2516865719862249","DOI":"10.1177\/2516865719862249","article-title":"Noncatalytic function of a JmjC domain protein disrupts heterochromatin","volume":"12","author":"Bao","year":"2019","journal-title":"Epigenetics Insights"},{"key":"2024061307262330600_JCS258818C7","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1038\/s41592-019-0582-9","article-title":"ilastik: interactive machine learning for (bio)image analysis","volume":"16","author":"Berg","year":"2019","journal-title":"Nat. Methods"},{"key":"2024061307262330600_JCS258818C8","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.cell.2017.07.041","article-title":"Dynamic control of X chromosome conformation and repression by a histone H4K20 demethylase","volume":"171","author":"Brejc","year":"2017","journal-title":"Cell"},{"key":"2024061307262330600_JCS258818C9","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.gde.2019.04.010","article-title":"Loop formation by SMC complexes: turning heads, bending elbows, and fixed anchors","volume":"55","author":"Cacciatore","year":"2019","journal-title":"Curr. Opin. Genet. Dev."},{"key":"2024061307262330600_JCS258818C10","doi-asserted-by":"publisher","first-page":"e1006614","DOI":"10.1371\/journal.pgen.1006614","article-title":"An SMC-like protein binds and regulates Caenorhabditis elegans condensins","volume":"13","author":"Chao","year":"2017","journal-title":"PLoS Genet."},{"key":"2024061307262330600_JCS258818C11","doi-asserted-by":"publisher","first-page":"e68918","DOI":"10.7554\/eLife.68918","article-title":"Linker histone H1.8 inhibits chromatin-binding of condensins and DNA topoisomerase II to tune chromosome length and individualization","volume":"10","author":"Choppakatla","year":"2021","journal-title":"Elife"},{"key":"2024061307262330600_JCS258818C12","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.devcel.2017.06.014","article-title":"Drosophila histone demethylase KDM4A has enzymatic and non-enzymatic roles in controlling heterochromatin integrity","volume":"42","author":"Colmenares","year":"2017","journal-title":"Dev. Cell"},{"key":"2024061307262330600_JCS258818C13","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1038\/nature14450","article-title":"Condensin-driven remodelling of X chromosome topology during dosage compensation","volume":"523","author":"Crane","year":"2015","journal-title":"Nature"},{"key":"2024061307262330600_JCS258818C14","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1126\/science.1092938","article-title":"Recruitment and spreading of the C. elegans dosage compensation complex along X chromosomes","volume":"303","author":"Csankovszki","year":"2004","journal-title":"Science"},{"key":"2024061307262330600_JCS258818C15","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.cub.2008.12.006","article-title":"Three distinct condensin complexes control C. elegans chromosome dynamics","volume":"19","author":"Csankovszki","year":"2009","journal-title":"Curr. Biol."},{"key":"2024061307262330600_JCS258818C16","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.sbi.2019.03.009","article-title":"The functional importance of structure in unstructured protein regions","volume":"56","author":"Davey","year":"2019","journal-title":"Curr. Opin. Struc. Biol."},{"key":"2024061307262330600_JCS258818C17","doi-asserted-by":"publisher","first-page":"dev.145722","DOI":"10.1242\/dev.145722","article-title":"A histone H4 lysine 20 methyltransferase couples environmental cues to sensory neuron control of developmental plasticity","volume":"144","author":"Delaney","year":"2017","journal-title":"Development"},{"key":"2024061307262330600_JCS258818C18","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1534\/genetics.118.301532","article-title":"Robust genome editing with short single-stranded and long, partially single-stranded DNA donors in Caenorhabditis elegans","volume":"210","author":"Dokshin","year":"2018","journal-title":"Genetics"},{"key":"2024061307262330600_JCS258818C19","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.cels.2016.07.002","article-title":"Juicer provides a one-click system for analyzing loop-resolution Hi-C experiments","volume":"3","author":"Durand","year":"2016","journal-title":"Cell Syst."},{"key":"2024061307262330600_JCS258818C20","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1038\/ng1983","article-title":"X chromosome repression by localization of the C. elegans dosage compensation machinery to sites of transcription initiation","volume":"39","author":"Ercan","year":"2007","journal-title":"Nat. Genet."},{"key":"2024061307262330600_JCS258818C21","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.1016\/j.cub.2009.09.047","article-title":"The C. elegans dosage compensation complex propagates dynamically and independently of X chromosome sequence","volume":"19","author":"Ercan","year":"2009","journal-title":"Curr. Biol."},{"key":"2024061307262330600_JCS258818C89","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1038\/35042517","article-title":"Functional genomic analysis of C","volume":"408","author":"Fraser","year":"2000","journal-title":"elegans chromosome I by systematic RNA interference. Nature"},{"key":"2024061307262330600_JCS258818C22","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1038\/ng.248","article-title":"Single-copy insertion of transgenes in Caenorhabditis elegans","volume":"40","author":"Fr\u00f8kj\u00e6r-Jensen","year":"2008","journal-title":"Nat. Genet."},{"key":"2024061307262330600_JCS258818C23","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1101\/sqb.2017.82.034710","article-title":"Emerging evidence of chromosome folding by loop extrusion","volume":"82","author":"Fudenberg","year":"2017","journal-title":"Cold Spring Harbor Symp. Quant. Biol."},{"key":"2024061307262330600_JCS258818C24","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.cub.2005.12.040","article-title":"Condensin I Stabilizes chromosomes mechanically through a dynamic interaction in live cells","volume":"16","author":"Gerlich","year":"2006","journal-title":"Curr. Biol."},{"key":"2024061307262330600_JCS258818C25","doi-asserted-by":"publisher","first-page":"2162","DOI":"10.1016\/j.bpj.2016.02.041","article-title":"Chromosome compaction by active loop extrusion","volume":"110","author":"Goloborodko","year":"2016","journal-title":"Biophys. J."},{"key":"2024061307262330600_JCS258818C26","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1038\/nmeth.3256","article-title":"A general method to improve fluorophores for live-cell and single-molecule microscopy","volume":"12","author":"Grimm","year":"2015","journal-title":"Nat. Methods"},{"key":"2024061307262330600_JCS258818C27","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1038\/nmeth.4403","article-title":"A general method to fine-tune fluorophores for live-cell and in vivo imaging","volume":"14","author":"Grimm","year":"2017","journal-title":"Nat. Methods"},{"key":"2024061307262330600_JCS258818C28","doi-asserted-by":"publisher","first-page":"3341","DOI":"10.1007\/s00018-020-03489-9","article-title":"Biological roles of LSD1 beyond its demethylase activity","volume":"77","author":"Gu","year":"2020","journal-title":"Cell. Mol. Life Sci."},{"key":"2024061307262330600_JCS258818C29","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1364\/OL.33.000156","article-title":"Efficient subpixel image registration algorithms","volume":"33","author":"Guizar-Sicairos","year":"2008","journal-title":"Opt. Lett."},{"key":"2024061307262330600_JCS258818C30","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/j.cell.2017.04.013","article-title":"The cohesin release factor WAPL restricts chromatin loop extension","volume":"169","author":"Haarhuis","year":"2017","journal-title":"Cell"},{"key":"2024061307262330600_JCS258818C31","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1101\/gad.968302","article-title":"C. elegans condensin promotes mitotic chromosome architecture, centromere organization, and sister chromatid segregation during mitosis and meiosis","volume":"16","author":"Hagstrom","year":"2002","journal-title":"Genes Dev."},{"key":"2024061307262330600_JCS258818C32","doi-asserted-by":"publisher","first-page":"R1266","DOI":"10.1016\/j.cub.2018.08.034","article-title":"Towards a unified model of SMC complex function","volume":"28","author":"Hassler","year":"2018","journal-title":"Curr. Biol."},{"key":"2024061307262330600_JCS258818C33","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1038\/ncb2702","article-title":"Kdm2b maintains murine embryonic stem cell status by recruiting PRC1 complex to CpG islands of developmental genes","volume":"15","author":"He","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"2024061307262330600_JCS258818C34","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1016\/j.cell.2016.01.033","article-title":"Condensin-based chromosome organization from bacteria to vertebrates","volume":"164","author":"Hirano","year":"2016","journal-title":"Cell"},{"key":"2024061307262330600_JCS258818C35","doi-asserted-by":"publisher","first-page":"2664","DOI":"10.1038\/sj.emboj.7600264","article-title":"Positive and negative regulation of SMC-DNA interactions by ATP and accessory proteins","volume":"23","author":"Hirano","year":"2004","journal-title":"EMBO J."},{"key":"2024061307262330600_JCS258818C36","doi-asserted-by":"publisher","first-page":"3070","DOI":"10.1091\/mbc.e08-01-0057","article-title":"Molecular and genetic analysis of condensin function in vertebrate cells","volume":"19","author":"Hudson","year":"2008","journal-title":"Mol. Biol. Cell"},{"key":"2024061307262330600_JCS258818C37","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1101\/gad.1751109","article-title":"A condensin-like dosage compensation complex acts at a distance to control expression throughout the genome","volume":"23","author":"Jans","year":"2009","journal-title":"Genes Dev."},{"key":"2024061307262330600_JCS258818C38","doi-asserted-by":"publisher","first-page":"e1004680","DOI":"10.1371\/journal.pgen.1004680","article-title":"The chromosomal association of the Smc5\/6 complex depends on cohesion and predicts the level of sister chromatid entanglement","volume":"10","author":"Jeppsson","year":"2014","journal-title":"PLoS Genet."},{"key":"2024061307262330600_JCS258818C39","first-page":"2021.03.23.436694","article-title":"Condensin DC spreads linearly and bidirectionally from recruitment sites to create loop-anchored TADs in C. elegans","author":"Jimenez","year":"2021","journal-title":"Biorxiv"},{"key":"2024061307262330600_JCS258818C40","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1038\/nsmb.1688","article-title":"An acetylated form of histone H2A.Z regulates chromosome architecture in Schizosaccharomyces pombe","volume":"16","author":"Kim","year":"2009","journal-title":"Nat. Struct. Mol. Biol."},{"key":"2024061307262330600_JCS258818C41","doi-asserted-by":"publisher","first-page":"R36","DOI":"10.1186\/gb-2013-14-4-r36","article-title":"TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions","volume":"14","author":"Kim","year":"2013","journal-title":"Genome Biol."},{"key":"2024061307262330600_JCS258818C42","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1083\/jcb.153.7.1341","article-title":"Kinetics of core histones in living human cells little exchange of H3 and H4 and some rapid exchange of H2b","volume":"153","author":"Kimura","year":"2001","journal-title":"J. Cell Biol."},{"key":"2024061307262330600_JCS258818C43","doi-asserted-by":"publisher","first-page":"11972","DOI":"10.1073\/pnas.220326097","article-title":"Dual roles of the 11S regulatory subcomplex in condensin functions","volume":"97","author":"Kimura","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2024061307262330600_JCS258818C44","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.devcel.2015.01.034","article-title":"Balancing acts of two HEAT subunits of condensin I support dynamic assembly of chromosome axes","volume":"33","author":"Kinoshita","year":"2015","journal-title":"Dev. Cell"},{"key":"2024061307262330600_JCS258818C45","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.molcel.2020.04.026","article-title":"Human condensin I and II drive extensive ATP-Dependent compaction of nucleosome-bound DNA","volume":"79","author":"Kong","year":"2020","journal-title":"Mol. Cell"},{"key":"2024061307262330600_JCS258818C46","doi-asserted-by":"publisher","first-page":"e1005698","DOI":"10.1016\/j.molcel.2020.04.026","article-title":"Developmental dynamics of X-Chromosome dosage compensation by the DCC and H4K20me1 in C. elegans","volume":"11","author":"Kramer","year":"2015","journal-title":"PLoS Genet."},{"key":"2024061307262330600_JCS258818C47","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1016\/j.cell.2017.09.008","article-title":"Structural basis for a safety-belt mechanism that anchors condensin to chromosomes","volume":"171","author":"Kschonsak","year":"2017","journal-title":"Cell"},{"key":"2024061307262330600_JCS258818C48","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat. Methods"},{"key":"2024061307262330600_JCS258818C49","doi-asserted-by":"publisher","first-page":"473","DOI":"10.3389\/fgene.2014.00473","article-title":"Condensin-mediated chromosome organization and gene regulation","volume":"5","author":"Lau","year":"2014","journal-title":"Front. Genet."},{"key":"2024061307262330600_JCS258818C50","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/1756-8935-7-31","article-title":"The C. elegans dosage compensation complex mediates interphase X chromosome compaction","volume":"7","author":"Lau","year":"2014","journal-title":"Epigenetics Chromatin"},{"key":"2024061307262330600_JCS258818C51","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1038\/s41594-020-0457-x","article-title":"Cryo-EM structures of holo condensin reveal a subunit flip-flop mechanism","volume":"27","author":"Lee","year":"2020","journal-title":"Nat. Struct. Mol. Biol."},{"key":"2024061307262330600_JCS258818C52","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1038\/nature09272","article-title":"PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression","volume":"466","author":"Liu","year":"2010","journal-title":"Nature"},{"key":"2024061307262330600_JCS258818C53","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"2024061307262330600_JCS258818C54","doi-asserted-by":"publisher","first-page":"e119","DOI":"10.1093\/nar\/gks701","article-title":"A benchmark for chromatin binding measurements in live cells","volume":"40","author":"Mazza","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"2024061307262330600_JCS258818C55","doi-asserted-by":"publisher","DOI":"10.1895\/wormbook.1.8.1","article-title":"X-Chromosome dosage compensation","volume-title":"WormBook","author":"Meyer","year":"2005"},{"key":"2024061307262330600_JCS258818C56","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1158\/1541-7786.MCR-19-0748","article-title":"Lysine-specific demethylase 1 mediates AKT activity and promotes epithelial-to-mesenchymal transition in PIK3CA-mutant colorectal cancer","volume":"18","author":"Miller","year":"2020","journal-title":"Mol. Cancer Res."},{"key":"2024061307262330600_JCS258818C57","doi-asserted-by":"publisher","first-page":"2003","DOI":"10.1016\/j.celrep.2016.01.066","article-title":"Control of Smc coiled coil architecture by the ATPase heads facilitates targeting to chromosomal ParB\/parS and release onto flanking DNA","volume":"14","author":"Minnen","year":"2016","journal-title":"Cell Reports"},{"key":"2024061307262330600_JCS258818C58","doi-asserted-by":"publisher","first-page":"e57142","DOI":"10.1371\/journal.pone.0057142","article-title":"WormSizer: high-throughput analysis of nematode size and shape","volume":"8","author":"Moore","year":"2013","journal-title":"PLos ONE"},{"key":"2024061307262330600_JCS258818C59","doi-asserted-by":"publisher","first-page":"492","DOI":"10.3109\/10409238.2013.833891","article-title":"Quantifying transcription factor kinetics: at work or at play?","volume":"48","author":"Mueller","year":"2013","journal-title":"Crit. Rev. Biochem. Mol."},{"key":"2024061307262330600_JCS258818C60","doi-asserted-by":"publisher","first-page":"201717730","DOI":"10.1073\/pnas.1717730115","article-title":"Chromatin organization by an interplay of loop extrusion and compartmental segregation","volume":"115","author":"Nuebler","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2024061307262330600_JCS258818C61","doi-asserted-by":"publisher","first-page":"genetics.301217.2018","DOI":"10.1534\/genetics.118.301217","article-title":"Condensin depletion causes genome decompaction without altering the level of global gene expression in saccharomyces cerevisiae","volume":"210","author":"Paul","year":"2018","journal-title":"Genetics"},{"key":"2024061307262330600_JCS258818C62","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1007\/s00294-018-0899-4","article-title":"Condensin action and compaction","volume":"65","author":"Paul","year":"2018","journal-title":"Curr. Genet."},{"key":"2024061307262330600_JCS258818C63","doi-asserted-by":"publisher","first-page":"e1000699","DOI":"10.1371\/journal.pgen.1000699","article-title":"Restricting dosage compensation complex binding to the X chromosomes by H2A.Z\/HTZ-1","volume":"5","author":"Petty","year":"2009","journal-title":"PLoS Genet."},{"key":"2024061307262330600_JCS258818C64","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1038\/nsmb.2831","article-title":"Association of condensin with chromosomes depends on DNA binding by its HEAT-repeat subunits","volume":"21","author":"Piazza","year":"2014","journal-title":"Nat. Struct. Mol. Biol."},{"key":"2024061307262330600_JCS258818C65","doi-asserted-by":"publisher","first-page":"W160","DOI":"10.1093\/nar\/gkw257","article-title":"deepTools2: a next generation web server for deep-sequencing data analysis","volume":"44","author":"Ram\u00edrez","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"2024061307262330600_JCS258818C66","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1038\/s41467-017-02525-w","article-title":"High-resolution TADs reveal DNA sequences underlying genome organization in flies","volume":"9","author":"Ram\u00edrez","year":"2018","journal-title":"Nat. Commun."},{"key":"2024061307262330600_JCS258818C67","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/1751-0473-7-6","article-title":"Bio-samtools: Ruby bindings for SAMtools, a library for accessing BAM files containing high-throughput sequence alignments","volume":"7","author":"Ramirez-Gonzalez","year":"2012","journal-title":"Source Code Biol. Med."},{"key":"2024061307262330600_JCS258818C68","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"2024061307262330600_JCS258818C69","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1080\/15384101.2020.1719585","article-title":"Priming chromatin for segregation: functional roles of mitotic histone modifications","volume":"19","author":"Schmitz","year":"2020","journal-title":"Cell Cycle"},{"key":"2024061307262330600_JCS258818C70","doi-asserted-by":"publisher","first-page":"e47630","DOI":"10.15252\/embr.201847630","article-title":"The non\u2013specific lethal (NSL) complex at the crossroads of transcriptional control and cellular homeostasis","volume":"20","author":"Sheikh","year":"2019","journal-title":"EMBO Rep."},{"key":"2024061307262330600_JCS258818C90","doi-asserted-by":"publisher","DOI":"10.1895\/wormbook.1.101.1","volume-title":"Maintenance of C. elegans, WormBook","author":"Stiernagle","year":"2006"},{"key":"2024061307262330600_JCS258818C71","doi-asserted-by":"publisher","first-page":"genetics.302254.2019","DOI":"10.1534\/genetics.119.302254","article-title":"Binding of an X-specific condensin correlates with a reduction in active histone modifications at gene regulatory elements","volume":"212","author":"Street","year":"2019","journal-title":"Genetics"},{"key":"2024061307262330600_JCS258818C72","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.molcel.2018.11.020","article-title":"Condensin-dependent chromatin compaction represses transcription globally during quiescence","volume":"73","author":"Swygert","year":"2019","journal-title":"Mol. Cell"},{"key":"2024061307262330600_JCS258818C73","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/j.molcel.2018.11.020","article-title":"Condensin association with histone H2A shapes mitotic chromosomes","volume":"474","author":"Tada","year":"2011","journal-title":"Nature"},{"key":"2024061307262330600_JCS258818C74","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1016\/j.molcel.2012.09.011","article-title":"Epigenetic regulation of condensin-mediated genome organization during the cell cycle and upon DNA damage through histone H3 lysine 56 acetylation","volume":"48","author":"Tanaka","year":"2012","journal-title":"Mol. Cell"},{"key":"2024061307262330600_JCS258818C75","doi-asserted-by":"publisher","first-page":"2308","DOI":"10.1016\/j.celrep.2018.04.082","article-title":"Cell-cycle regulation of dynamic chromosome association of the condensin complex","volume":"23","author":"Thadani","year":"2018","journal-title":"Cell Reports"},{"key":"2024061307262330600_JCS258818C76","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1038\/nrm.2016.30","article-title":"SMC complexes: from DNA to chromosomes","volume":"17","author":"Uhlmann","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2024061307262330600_JCS258818C77","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1016\/j.cell.2018.03.072","article-title":"The energetics and physiological impact of cohesin extrusion","volume":"173","author":"Vian","year":"2018","journal-title":"Cell"},{"key":"2024061307262330600_JCS258818C78","doi-asserted-by":"publisher","first-page":"e1002933","DOI":"10.1371\/journal.pgen.1002933","article-title":"H4K20me1 contributes to downregulation of X-linked genes for C. elegans dosage compensation","volume":"8","author":"Vielle","year":"2012","journal-title":"PLoS Genet."},{"key":"2024061307262330600_JCS258818C79","doi-asserted-by":"publisher","first-page":"2309","DOI":"10.1083\/jcb.201801048","article-title":"A quantitative map of human Condensins provides new insights into mitotic chromosome architecture","volume":"217","author":"Walther","year":"2018","journal-title":"J. Cell Biol."},{"key":"2024061307262330600_JCS258818C80","doi-asserted-by":"publisher","first-page":"1710","DOI":"10.1128\/MCB.06546-11","article-title":"Caenorhabditis elegans dosage compensation regulates histone H4 chromatin state on X Chromosomes","volume":"32","author":"Wells","year":"2012","journal-title":"Mol. Cell. Biol."},{"key":"2024061307262330600_JCS258818C81","doi-asserted-by":"publisher","first-page":"e06659","DOI":"10.7554\/eLife.06659","article-title":"SMC condensin entraps chromosomal DNA by an ATP hydrolysis dependent loading mechanism in Bacillus subtilis","volume":"4","author":"Wilhelm","year":"2015","journal-title":"eLife"},{"key":"2024061307262330600_JCS258818C82","doi-asserted-by":"publisher","first-page":"gky504","DOI":"10.1093\/nar\/gky504","article-title":"Galaxy HiCExplorer: a web server for reproducible Hi-C data analysis, quality control and visualization","volume":"46","author":"Wolff","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"2024061307262330600_JCS258818C83","doi-asserted-by":"publisher","first-page":"W177","DOI":"10.1093\/nar\/gkaa220","article-title":"Galaxy HiCExplorer 3: a web server for reproducible Hi-C, capture Hi-C and single-cell Hi-C data analysis, quality control and visualization","volume":"48","author":"Wolff","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"2024061307262330600_JCS258818C84","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1038\/nrg2794","article-title":"Condensin and cohesin complexity: the expanding repertoire of functions","volume":"11","author":"Wood","year":"2010","journal-title":"Nat. Rev. Genet."},{"key":"2024061307262330600_JCS258818C85","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1091\/mbc.E18-06-0402","article-title":"Single-molecule dynamics of the P granule scaffold MEG-3 in the Caenorhabditis elegans zygote","volume":"30","author":"Wu","year":"2019","journal-title":"Mol. Biol. Cell"},{"key":"2024061307262330600_JCS258818C86","doi-asserted-by":"publisher","first-page":"6519","DOI":"10.1242\/dev.00886","article-title":"Recruitment of C. elegans dosage compensation proteins for gene-specific versus chromosome-wide repression","volume":"130","author":"Yonker","year":"2003","journal-title":"Development"},{"key":"2024061307262330600_JCS258818C87","doi-asserted-by":"publisher","first-page":"3963","DOI":"10.1242\/jcs.185710","article-title":"HEAT repeats - versatile arrays of amphiphilic helices working in crowded environments?","volume":"129","author":"Yoshimura","year":"2016","journal-title":"J. Cell Sci."},{"key":"2024061307262330600_JCS258818C88","doi-asserted-by":"publisher","first-page":"e1700191","DOI":"10.1126\/sciadv.1700191","article-title":"Condensin II is anchored by TFIIIC and H3K4me3 in the mammalian genome and supports the expression of active dense gene clusters","volume":"3","author":"Yuen","year":"2017","journal-title":"Sci. Adv."}],"container-title":["Journal of Cell Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/jcs\/article-pdf\/doi\/10.1242\/jcs.258818\/2123787\/jcs258818.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/jcs\/article-pdf\/doi\/10.1242\/jcs.258818\/3489795\/jcs258818.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/jcs\/article-pdf\/doi\/10.1242\/jcs.258818\/3489795\/jcs258818.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T03:28:11Z","timestamp":1718249291000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/jcs\/article\/135\/2\/jcs258818\/274115\/The-histone-H4-lysine-20-demethylase-DPY-21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,15]]},"references-count":90,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,1,15]]}},"URL":"https:\/\/doi.org\/10.1242\/jcs.258818","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.04.11.438056","asserted-by":"object"}]},"ISSN":["0021-9533","1477-9137"],"issn-type":[{"value":"0021-9533","type":"print"},{"value":"1477-9137","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,15]]},"article-number":"jcs258818"}}