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Previously, we discovered that the plasma membrane-localized fission yeast polycystin homolog Pkd2p is an essential protein required for cytokinesis; however, its role remains unclear. Here, we isolated a novel temperature-sensitive pkd2 mutant, pkd2-B42. Among the strong growth defects of this mutant, the most striking was that many mutant cells often lost a significant portion of their volume in just 5\u2005min followed by a gradual recovery, a process that we termed \u2018deflation\u2019. Unlike cell lysis, deflation did not result in plasma membrane rupture and occurred independently of cell cycle progression. The tip extension of pkd2-B42 cells was 80% slower than that of wild-type cells, and their turgor pressure was 50% lower. Both pkd2-B42 and the hypomorphic depletion mutant pkd2-81KD partially rescued mutants of the septation initiation network (SIN), a yeast Hippo-related signaling pathway, by preventing cell lysis, enhancing septum formation and doubling the number of Sid2p and Mob1p molecules at the spindle pole bodies. We conclude that Pkd2p promotes cell size expansion during interphase by regulating turgor pressure and antagonizes the SIN during cytokinesis.<\/jats:p>\n                  <jats:p>This article has an associated First Person interview with the first author of the paper.<\/jats:p>","DOI":"10.1242\/jcs.259046","type":"journal-article","created":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T06:02:06Z","timestamp":1643608926000},"source":"Crossref","is-referenced-by-count":16,"title":["Fission yeast polycystin Pkd2p promotes cell size expansion and antagonizes the Hippo-related SIN pathway"],"prefix":"10.1242","volume":"135","author":[{"given":"Debatrayee","family":"Sinha","sequence":"first","affiliation":[{"name":"The University of Toledo 1 Department of Biological Sciences , , 2801 West Bancroft St, Toledo, OH 43606 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denisa","family":"Ivan","sequence":"additional","affiliation":[{"name":"The University of Toledo 1 Department of Biological Sciences , , 2801 West Bancroft St, Toledo, OH 43606 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellie","family":"Gibbs","sequence":"additional","affiliation":[{"name":"Wellesley College 2 Department of Biological Sciences , , 106 Central Street, Wellesley, MA 02482 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madhurya","family":"Chetluru","sequence":"additional","affiliation":[{"name":"The University of Toledo 1 Department of Biological Sciences , , 2801 West Bancroft St, Toledo, OH 43606 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7999-2900","authenticated-orcid":false,"given":"John","family":"Goss","sequence":"additional","affiliation":[{"name":"Wellesley College 2 Department of Biological Sciences , , 106 Central Street, Wellesley, MA 02482 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2768-6570","authenticated-orcid":false,"given":"Qian","family":"Chen","sequence":"additional","affiliation":[{"name":"The University of Toledo 1 Department of Biological Sciences , , 2801 West Bancroft St, Toledo, OH 43606 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2022,2,21]]},"reference":[{"key":"2022081909082649700_JCS259046C1","doi-asserted-by":"publisher","first-page":"8400","DOI":"10.1038\/ncomms9400","article-title":"Wall mechanics and exocytosis define the shape of growth domains in fission yeast","volume":"6","author":"Abenza","year":"2015","journal-title":"Nat. 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