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Superior cervical ganglion-10 (SCG10, also known as stathmin-2 or STMN2) is a well-known regulator of microtubule dynamics in neurons, but its functions in the peripheral nervous system remain largely unknown. Here, we show that Scg10 knockout mice exhibit severely progressive motor and sensory dysfunctions with significant sciatic nerve myelination deficits and neuromuscular degeneration. Additionally, increased microtubule stability, shown by a significant increase in tubulin acetylation and decrease in tubulin tyrosination, and decreased axonal transport were observed in Scg10 knockout dorsal root ganglion (DRG) neurons. Furthermore, SCG10 depletion impaired axon regeneration in both injured mouse sciatic nerve and cultured DRG neurons following replating, and the impaired axon regeneration was found to be induced by a lack of SCG10-mediated microtubule dynamics in the neurons. Thus, our results highlight the importance of SCG10 in peripheral axon maintenance and regeneration.<\/jats:p>","DOI":"10.1242\/jcs.260490","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T08:40:57Z","timestamp":1686127257000},"source":"Crossref","is-referenced-by-count":23,"title":["SCG10 is required for peripheral axon maintenance and regeneration in mice"],"prefix":"10.1242","volume":"136","author":[{"given":"Yuanjun","family":"Li","sequence":"first","affiliation":[{"name":"College of Life Sciences, Peking University 1 Ministry of Education Key Laboratory of Cell Proliferation and Differentiation , , Beijing 100871 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1036-767X","authenticated-orcid":false,"given":"Yonglu","family":"Tian","sequence":"additional","affiliation":[{"name":"School of Psychological and Cognitive Sciences, Peking University 2 , Beijing 100871 , China"},{"name":"IDG\/McGovern Institute for Brain Research, Peking University 3 , Beijing 100871 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiayuhe","family":"Pei","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Peking University 1 Ministry of Education Key Laboratory of Cell Proliferation and Differentiation , , Beijing 100871 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3797-4023","authenticated-orcid":false,"given":"Pengli","family":"Zheng","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Peking University 1 Ministry of Education Key Laboratory of Cell Proliferation and Differentiation , , Beijing 100871 , China"},{"name":"Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University 4 , Beijing 100871 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linqing","family":"Miao","sequence":"additional","affiliation":[{"name":"Beijing Advanced Innovation Center for Intelligent Robots and Systems, Beijing Institute of Technology 5 , Beijing 100081 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingjun","family":"Li","sequence":"additional","affiliation":[{"name":"Center for Quantitative Biology, Peking University 6 , Beijing 100871 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxiong","family":"Luo","sequence":"additional","affiliation":[{"name":"Center for Quantitative Biology, Peking University 6 , Beijing 100871 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peixun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital 7 , Beijing 100044 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8436-5266","authenticated-orcid":false,"given":"Baoguo","family":"Jiang","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital 7 , Beijing 100044 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7611-0631","authenticated-orcid":false,"given":"Junlin","family":"Teng","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Peking University 1 Ministry of Education Key Laboratory of Cell Proliferation and Differentiation , , Beijing 100871 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8233-2572","authenticated-orcid":false,"given":"Ning","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience, Translational Medicine Institute, Health Science Center, Xi'an Jiaotong University 8 , Xi'an 710061 , China"},{"name":"School of Basic Medical Sciences, Health Science Center, Xi'an Jiaotong University 9 Department of Physiology and Pathophysiology , , Xi'an 710061 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8406-011X","authenticated-orcid":false,"given":"Jianguo","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Peking University 1 Ministry of Education Key Laboratory of Cell Proliferation and Differentiation , , Beijing 100871 , China"},{"name":"Center for Quantitative Biology, Peking University 6 , Beijing 100871 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2023,6,26]]},"reference":[{"key":"2023062607554913600_JCS260490C1","doi-asserted-by":"publisher","first-page":"3642","DOI":"10.1093\/hmg\/ddq280","article-title":"KBP interacts with SCG10, linking Goldberg-Shprintzen syndrome to microtubule dynamics and neuronal differentiation","volume":"19","author":"Alves","year":"2010","journal-title":"Hum. 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