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Successful viral infection relies on tactical viral strategies to derail or antagonize host innate immune defenses, in particular the production of type I interferons (IFNs) by infected cells. Viruses can thwart intracellular sensing systems that elicit IFN gene expression (that is, RIG-I-like receptors and the cGAS\u2013STING axis) or obstruct signaling elicited by IFNs. In this Cell Science at a Glance article and the accompanying poster, we review the current knowledge about the major mechanisms employed by viruses to inhibit the activity of intracellular pattern-recognition receptors and their downstream signaling cascades leading to IFN-based antiviral host defenses. Advancing our understanding of viral immune evasion might spur unprecedented opportunities to develop new antiviral compounds or vaccines to prevent viral infectious diseases.<\/jats:p>","DOI":"10.1242\/jcs.260682","type":"journal-article","created":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T05:06:56Z","timestamp":1687324016000},"source":"Crossref","is-referenced-by-count":46,"title":["Viral evasion of the interferon response at a glance"],"prefix":"10.1242","volume":"136","author":[{"given":"Junji","family":"Zhu","sequence":"first","affiliation":[{"name":", Cleveland Clinic Florida Research and Innovation Center , Port St. Lucie, FL 34987 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy","family":"Chiang","sequence":"additional","affiliation":[{"name":", Cleveland Clinic Florida Research and Innovation Center , Port St. Lucie, FL 34987 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2163-2598","authenticated-orcid":false,"given":"Michaela U.","family":"Gack","sequence":"additional","affiliation":[{"name":", Cleveland Clinic Florida Research and Innovation Center , Port St. Lucie, FL 34987 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2023,6,21]]},"reference":[{"key":"2023062109054240500_JCS260682C1","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1038\/ni.1779","article-title":"RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate","volume":"10","author":"Ablasser","year":"2009","journal-title":"Nat. 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