{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T06:03:44Z","timestamp":1783749824341,"version":"3.55.0"},"reference-count":51,"publisher":"The Company of Biologists","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Desmosome diseases are caused by dysfunction of desmosomes, which anchor intermediate filaments (IFs) at sites of cell\u2013cell adhesion. For many decades, the focus of attention has been on the role of actin filament-associated adherens junctions in development and disease, especially cancer. However, interference with the function of desmosomes, their molecular constituents or their attachments to IFs has now emerged as a major contributor to a variety of diseases affecting different tissues and organs including skin, heart and the digestive tract. The first Alpine desmosome disease meeting (ADDM) held in Grainau, Germany, in October 2022 brought together international researchers from the basic sciences with clinical experts from diverse fields to share and discuss their ideas and concepts on desmosome function and dysfunction in the different cell types involved in desmosome diseases. Besides the prototypic desmosomal diseases pemphigus and arrhythmogenic cardiomyopathy, the role of desmosome dysfunction in inflammatory bowel diseases and eosinophilic esophagitis was discussed.<\/jats:p>","DOI":"10.1242\/jcs.260832","type":"journal-article","created":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T12:00:39Z","timestamp":1672747239000},"source":"Crossref","is-referenced-by-count":22,"title":["Meeting report \u2013 Desmosome dysfunction and disease: Alpine desmosome disease meeting"],"prefix":"10.1242","volume":"136","author":[{"given":"Volker","family":"Spindler","sequence":"first","affiliation":[{"name":"University of Basel 1 Department of Biomedicine , , 4056 Basel , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda","family":"Gerull","sequence":"additional","affiliation":[{"name":"Comprehensive Heart Failure Center 2 , Department of Internal Medicine I , , 97080 W\u00fcrzburg , Germany"},{"name":"University Hospital W\u00fcrzburg 2 , Department of Internal Medicine I , , 97080 W\u00fcrzburg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen J.","family":"Green","sequence":"additional","affiliation":[{"name":"Feinberg School of Medicine, Northwestern University 3 Department of Pathology , , Chicago, IL 60611 , USA . Department of Dermatology , , Chicago, Illinois , USA"},{"name":"Feinberg School of Medicine, Northwestern University 3 Department of Pathology , , Chicago, IL 60611 , USA . Department of Dermatology , , Chicago, Illinois , USA"},{"name":"Department of Dermatology, Feinberg School of Medicine, Northwestern University 4 , Chicago, Illinois , USA . , Chicago, Illinois , USA"},{"name":"Robert H. Lurie Comprehensive Cancer Center, Northwestern University 4 , Chicago, Illinois , USA . , Chicago, Illinois , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew P.","family":"Kowalczyk","sequence":"additional","affiliation":[{"name":"Penn State College of Medicine, The Pennsylvania State University 5 Department of Dermatology , , Hershey, PA 17033 , USA"},{"name":"Penn State College of Medicine, The Pennsylvania State University 6 Department of Cellular & Molecular Physiology , , Hershey, PA 17033 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf","family":"Leube","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Cellular Anatomy, RWTH Aachen University 7 , 52057 Aachen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali J.","family":"Marian","sequence":"additional","affiliation":[{"name":"Center for Cardiovascular Genetics, Institute of Molecular Medicine, The University of Texas Health Science Center 8 , Houston, TX 77030 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik","family":"Milting","sequence":"additional","affiliation":[{"name":"Erich und Hanna Klessmann-Institut f\u00fcr Kardiovaskul\u00e4re Forschung und Entwicklung, Klinik f\u00fcr Thorax- und Kardiovaskularchirurgie, Herz und Diabeteszentrum NRW, Universit\u00e4tsklinikum der Ruhr-Universit\u00e4t Bochum 9 , Georgstr. 11, 32545 Bad Oeynhausen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliane J.","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"University of Bern, Bern, Switzerland. Department for BioMedical Research, Molecular Dermatology and Stem Cell Research, University of Bern 10 Dermfocus, Vetsuisse Faculty , , CH-3008 Bern , Switzerland"},{"name":"Inselspital, Bern University Hospital, University of Bern, CH-3010 Bern, Switzerland. Institute of Animal Pathology, Vetsuisse Faculty, University of Bern 11 Department of Dermatology , , CH-3012 Bern , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carien","family":"Niessen","sequence":"additional","affiliation":[{"name":"Cologne Excellence Cluster on Stress Responses in Aging-associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC), University Hospital of Cologne, University of Cologne 12 Department Cell Biology of the Skin , , 50931 Cologne , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimee S.","family":"Payne","sequence":"additional","affiliation":[{"name":"Perelman School of Medicine, University of Pennsylvania 13 Department of Dermatology , , Philadelphia, Pennsylvania , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Schlegel","sequence":"additional","affiliation":[{"name":"Vascular and Paediatric Surgery University Hospital W\u00fcrzburg 14 Department of General, Visceral, Transplant , , Wuerzburg 97080 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enno","family":"Schmidt","sequence":"additional","affiliation":[{"name":"University of L\u00fcbeck, 23538 L\u00fcbeck 15 Department of Dermatology , , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Strnad","sequence":"additional","affiliation":[{"name":"Medical Clinic III, Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital RWTH Aachen 16 , Pauwelsstr. 30, 52074, Aachen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritva","family":"Tikkanen","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry, Medical Faculty, University of Giessen 17 , Friedrichstrasse 24, 35392 Giessen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Vielmuth","sequence":"additional","affiliation":[{"name":"Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, Ludwig-Maximilians-Universit\u00e4t LMU Munich 18 , 80336 Munich , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Waschke","sequence":"additional","affiliation":[{"name":"Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, Ludwig-Maximilians-Universit\u00e4t LMU Munich 18 , 80336 Munich , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2023,1,3]]},"reference":[{"key":"2023010312003343900_JCS260832C1","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/0092-8674(91)90360-B","article-title":"Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion","volume":"67","author":"Amagai","year":"1991","journal-title":"Cell"},{"key":"2023010312003343900_JCS260832C2","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1111\/pcmr.12826","article-title":"Keratinocyte cadherin desmoglein 1 controls melanocyte behavior through paracrine signaling","volume":"33","author":"Arnette","year":"2020","journal-title":"Pigment Cell Melanoma Res."},{"key":"2023010312003343900_JCS260832C3","doi-asserted-by":"publisher","first-page":"e201906153","DOI":"10.1083\/jcb.201906153","article-title":"Protein exchange is reduced in calcium-independent epithelial junctions","volume":"219","author":"Bartle","year":"2020","journal-title":"J. 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