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Targeting the EMT program to selectively eliminate CSCs is a promising way to improve cancer therapy. Salinomycin (Sal), a K+\/H+ ionophore, was identified as highly selective towards CSC-like cells, but its mechanism of action and selectivity remains elusive. Here, we show that Sal, similar to monensin and nigericin, disturbs the function of the Golgi. Sal alters the expression of Golgi-related genes and leads to marked changes in Golgi morphology, particularly in cells that have undergone EMT. Moreover, Golgi-disturbing agents severely affect post-translational modifications of proteins, including protein processing, glycosylation and secretion. We discover that the alterations induced by Golgi-disturbing agents specifically affect the viability of EMT cells. Collectively, our work reveals a novel vulnerability related to the EMT, suggesting an important role for the Golgi in the EMT and that targeting the Golgi could represent a novel therapeutic approach against CSCs.<\/jats:p>","DOI":"10.1242\/jcs.260934","type":"journal-article","created":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T03:03:20Z","timestamp":1691377400000},"source":"Crossref","is-referenced-by-count":9,"title":["Salinomycin disturbs Golgi function and specifically affects cells in epithelial-to-mesenchymal transition"],"prefix":"10.1242","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9850-0561","authenticated-orcid":false,"given":"Marko","family":"Marjanovi\u0107","sequence":"first","affiliation":[{"name":"Ru\u0111er Bo\u0161kovi\u0107 Institute 1 Division of Molecular Medicine , , Bijeni\u010dka c. 54, 10000 Zagreb , Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3772-7006","authenticated-orcid":false,"given":"Ana-Matea","family":"Mikecin Dra\u017ei\u0107","sequence":"additional","affiliation":[{"name":"Ru\u0111er Bo\u0161kovi\u0107 Institute 1 Division of Molecular Medicine , , Bijeni\u010dka c. 54, 10000 Zagreb , Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5290-6945","authenticated-orcid":false,"given":"Marija","family":"Mio\u010d","sequence":"additional","affiliation":[{"name":"Ru\u0111er Bo\u0161kovi\u0107 Institute 1 Division of Molecular Medicine , , Bijeni\u010dka c. 54, 10000 Zagreb , Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1025-5595","authenticated-orcid":false,"given":"Mladen","family":"Parad\u017eik","sequence":"additional","affiliation":[{"name":"Ru\u0111er Bo\u0161kovi\u0107 Institute 1 Division of Molecular Medicine , , Bijeni\u010dka c. 54, 10000 Zagreb , Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6245-8880","authenticated-orcid":false,"given":"Filip","family":"Kli\u010dek","sequence":"additional","affiliation":[{"name":"GENOS, Glycoscience Research Laboratory 2 , Borongajska c. 83, 10000 Zagreb , Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7338-2017","authenticated-orcid":false,"given":"Mislav","family":"Novokmet","sequence":"additional","affiliation":[{"name":"GENOS, Glycoscience Research Laboratory 2 , Borongajska c. 83, 10000 Zagreb , Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1840-9560","authenticated-orcid":false,"given":"Gordan","family":"Lauc","sequence":"additional","affiliation":[{"name":"GENOS, Glycoscience Research Laboratory 2 , Borongajska c. 83, 10000 Zagreb , Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7165-2722","authenticated-orcid":false,"given":"Marijeta","family":"Kralj","sequence":"additional","affiliation":[{"name":"Ru\u0111er Bo\u0161kovi\u0107 Institute 1 Division of Molecular Medicine , , Bijeni\u010dka c. 54, 10000 Zagreb , Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2023,9,1]]},"reference":[{"key":"2023090111345174300_JCS260934C1","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.ejmech.2018.12.057","article-title":"A medicinal chemistry perspective on salinomycin as a potent anticancer and anti-CSCs agent","volume":"164","author":"Antoszczak","year":"2019","journal-title":"Eur. 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