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Using multi-disciplinary techniques and 59 tissues (53 oral and stomach cancer tumor tissue samples from Indian individuals with cancer and six non-cancer oral and stomach tissue samples), we showed that p53 amyloid load and cancer grades are highly correlated. Furthermore, next-generation sequencing (NGS) data suggest that not only mutant p53 (e.g. single-nucleotide variants, deletions, and insertions) but wild-type p53 also formed amyloids either in the nucleus (50%) and\/or in the cytoplasm in most cancer tissues. Interestingly, in all these cancer tissues, p53 displays a loss of DNA-binding and transcriptional activities, suggesting that the level of amyloid load correlates with the degree of loss and an increase in cancer grades. The p53 amyloids also sequester higher amounts of the related p63 and p73 (also known as TP63 and TP73, respectively) protein in higher-grade tumor tissues. The data suggest p53 misfolding and\/or aggregation, and subsequent amyloid formation, lead to loss of the tumor-suppressive function and the gain of oncogenic function, aggravation of which might determine the cancer grade.<\/jats:p>","DOI":"10.1242\/jcs.261017","type":"journal-article","created":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T05:24:32Z","timestamp":1692941072000},"source":"Crossref","is-referenced-by-count":19,"title":["p53 amyloid pathology is correlated with higher cancer grade irrespective of the mutant or wild-type form"],"prefix":"10.1242","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8557-5780","authenticated-orcid":false,"given":"Shinjinee","family":"Sengupta","sequence":"first","affiliation":[{"name":"Indian Institute of Technology Bombay 1 Department of Bioscience and Bioengineering , , Mumbai 400076 , India"},{"name":"Amity Institute of Molecular Medicine and Stem Cell Research, Amity University Noida, Uttar Pradesh, 2 201303 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namrata","family":"Singh","sequence":"additional","affiliation":[{"name":"Indian Institute of Technology Bombay 1 Department of Bioscience and Bioengineering , , Mumbai 400076 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4063-5919","authenticated-orcid":false,"given":"Ajoy","family":"Paul","sequence":"additional","affiliation":[{"name":"Indian Institute of Technology Bombay 1 Department of Bioscience and Bioengineering , , Mumbai 400076 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8923-0248","authenticated-orcid":false,"given":"Debalina","family":"Datta","sequence":"additional","affiliation":[{"name":"Indian Institute of Technology Bombay 1 Department of Bioscience and Bioengineering , , Mumbai 400076 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8153-8651","authenticated-orcid":false,"given":"Debdeep","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Indian Institute of Technology Bombay 1 Department of Bioscience and Bioengineering , , Mumbai 400076 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Semanti","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Indian Institute of Technology Bombay 1 Department of Bioscience and Bioengineering , , Mumbai 400076 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3157-2998","authenticated-orcid":false,"given":"Laxmikant","family":"Gadhe","sequence":"additional","affiliation":[{"name":"Indian Institute of Technology Bombay 1 Department of Bioscience and Bioengineering , , Mumbai 400076 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyoti","family":"Devi","sequence":"additional","affiliation":[{"name":"Indian Institute of Technology Bombay 1 Department of Bioscience and Bioengineering , , Mumbai 400076 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeshwanth","family":"Mahesh","sequence":"additional","affiliation":[{"name":"Centre for BioSystems Science and Engineering, Indian Institute of Science Bengaluru 3 , Bengaluru, Karnataka 560012 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6631-2109","authenticated-orcid":false,"given":"Mohit Kumar","family":"Jolly","sequence":"additional","affiliation":[{"name":"Centre for BioSystems Science and Engineering, Indian Institute of Science Bengaluru 3 , Bengaluru, Karnataka 560012 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9110-1565","authenticated-orcid":false,"given":"Samir K.","family":"Maji","sequence":"additional","affiliation":[{"name":"Indian Institute of Technology Bombay 1 Department of Bioscience and Bioengineering , , Mumbai 400076 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2023,9,8]]},"reference":[{"key":"2023090808183903600_JCS261017C1","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1038\/sj.cdd.4400737","article-title":"Pathogenesis of prion diseases: a progress report","volume":"7","author":"Aguzzi","year":"2000","journal-title":"Cell Death Differ."},{"key":"2023090808183903600_JCS261017C2","doi-asserted-by":"publisher","first-page":"5463","DOI":"10.1038\/s41467-021-25550-2","article-title":"\u0394133p53\u03b2 isoform pro-invasive activity is regulated through an aggregation-dependent mechanism in cancer cells","volume":"12","author":"Arsic","year":"2021","journal-title":"Nat. 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