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Embryonic wound healing is driven by the collective movement of the cells around the lesion. The cells adjacent to the wound polarize the cytoskeletal protein actin and the molecular motor non-muscle myosin II, which accumulate at the wound edge forming a supracellular cable around the wound. Adherens junction proteins, including E-cadherin, are internalized from the wound edge and localize to former tricellular junctions at the wound margin, in a process necessary for cytoskeletal polarity. We found that the cells adjacent to wounds in the Drosophila embryonic epidermis polarized Talin, a core component of cell\u2013extracellular matrix (ECM) adhesions, which preferentially accumulated at the wound edge. Integrin knockdown and inhibition of integrin binding delayed wound closure and reduced actin polarization and dynamics around the wound. Additionally, disrupting integrins caused a defect in E-cadherin reinforcement at tricellular junctions along the wound edge, suggesting crosstalk between integrin-based and cadherin-based adhesions. Our results show that cell\u2013ECM adhesion contributes to embryonic wound repair and reveal an interplay between cell\u2013cell and cell\u2013ECM adhesion in the collective cell movements that drive rapid wound healing.<\/jats:p>","DOI":"10.1242\/jcs.261138","type":"journal-article","created":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T05:12:49Z","timestamp":1700111569000},"source":"Crossref","is-referenced-by-count":12,"title":["Integrin-based adhesions promote cell\u2013cell junction and cytoskeletal remodelling to drive embryonic wound healing"],"prefix":"10.1242","volume":"137","author":[{"given":"Michelle","family":"Ly","sequence":"first","affiliation":[{"name":"Institute of Biomedical Engineering, University of Toronto 1 , Toronto, ON M5S 3G9 , Canada"},{"name":"Ted Rogers Centre for Heart Research, University of Toronto 2 Translational Biology and Engineering Program , , Toronto, ON M5G 1M1 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Schimmer","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering, University of Toronto 1 , Toronto, ON M5S 3G9 , Canada"},{"name":"Ted Rogers Centre for Heart Research, University of Toronto 2 Translational Biology and Engineering Program , , Toronto, ON M5G 1M1 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond","family":"Hawkins","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering, University of Toronto 1 , Toronto, ON M5S 3G9 , Canada"},{"name":"Ted Rogers Centre for Heart Research, University of Toronto 2 Translational Biology and Engineering Program , , Toronto, ON M5G 1M1 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8191-7528","authenticated-orcid":false,"given":"Katheryn","family":"E. 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