{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T06:20:08Z","timestamp":1789021208959,"version":"build-2803163510"},"reference-count":79,"publisher":"The Company of Biologists","issue":"12","license":[{"start":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T00:00:00Z","timestamp":1719532800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100008349","name":"University of Duisburg-Essen","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008349","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>During acute viral infections, innate immune cells invade inflamed tissues and face hypoxic areas. Hypoxia-inducible factors (HIFs) adapt cellular responses towards these conditions. We wanted to investigate the effects of a loss of HIF-2\u03b1 in macrophages during acute Friend murine leukemia retrovirus (FV) infection in C57BL\/6 mice using a Cre\/loxP system. Remarkably, mice with floxed Hif-2a (Hif-2afl; Hif-2a is also known as Epas1) did not show any signs of FV infection independent of Cre activity. This prevented a detailed analysis of the role of macrophage HIF-2\u03b1 for FV infection but allowed us to study a model of unexpected FV resistance. Hif-2afl mice showed a significant decrease in the expression of the Atp6v1e2 gene encoding for the E2 subunit of the vacuolar H+-ATPase, which resulted in a decreased acidification of lysosomes and limited virus entry into the cell. These findings highlight that the insertion of loxP sites is not always without functional consequences and has established a phenotype in the floxed Hif-2a mouse, which is not only unexpected, but unwanted and is of relevance for the use of this mouse strain in (at least virus) experiments.<\/jats:p>","DOI":"10.1242\/jcs.261893","type":"journal-article","created":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T13:45:16Z","timestamp":1718027116000},"source":"Crossref","is-referenced-by-count":3,"title":["Reduced vacuolar ATPase protects mice from Friend virus infection \u2013 an unintended but instructive effect in <i>Hif-2afl<\/i> mice"],"prefix":"10.1242","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6848-3158","authenticated-orcid":false,"given":"Timm","family":"Schreiber","sequence":"first","affiliation":[{"name":"Institute of Physiology, University of Duisburg-Essen 1 , 45147 Essen , Germany"},{"name":"Institute of Physiology, Pathophysiology and Toxicology and Center for Biomedical Education and Research (ZBAF), University of Witten\/Herdecke 2 , 58455 Witten , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Koll","sequence":"additional","affiliation":[{"name":"Institute of Physiology, University of Duisburg-Essen 1 , 45147 Essen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2475-1525","authenticated-orcid":false,"given":"Claudia","family":"Padberg","sequence":"additional","affiliation":[{"name":"Institute of Physiology, University of Duisburg-Essen 1 , 45147 Essen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Buena","family":"de los Reyes","sequence":"additional","affiliation":[{"name":"Institute of Physiology, University of Duisburg-Essen 1 , 45147 Essen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6087-4883","authenticated-orcid":false,"given":"Theresa","family":"Quinting","sequence":"additional","affiliation":[{"name":"Institute of Physiology, University of Duisburg-Essen 1 , 45147 Essen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5199-5472","authenticated-orcid":false,"given":"Anna","family":"Malyshkina","sequence":"additional","affiliation":[{"name":"Institute of Physiology, University of Duisburg-Essen 1 , 45147 Essen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2740-3219","authenticated-orcid":false,"given":"Eric","family":"Metzen","sequence":"additional","affiliation":[{"name":"Institute of Physiology, University of Duisburg-Essen 1 , 45147 Essen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6397-6551","authenticated-orcid":false,"given":"Kathrin","family":"Sutter","sequence":"additional","affiliation":[{"name":"Institute for Virology, University Hospital Essen, University of Duisburg-Essen 3 , 45147 Essen , Germany"},{"name":"Institute for Research on HIV and AIDS-associated Diseases, University Hospital Essen, University of Duisburg-Essen 4 , 45147 Essen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9585-0531","authenticated-orcid":false,"given":"Joachim","family":"Fandrey","sequence":"additional","affiliation":[{"name":"Institute of Physiology, University of Duisburg-Essen 1 , 45147 Essen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3788-1054","authenticated-orcid":false,"given":"Sandra","family":"Winning","sequence":"additional","affiliation":[{"name":"Institute of Physiology, University of Duisburg-Essen 1 , 45147 Essen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2024,6,28]]},"reference":[{"key":"2024062810205796100_JCS261893C1","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1038\/mt.2008.232","article-title":"Hypoxia enhances the replication of oncolytic herpes simplex virus","volume":"17","author":"Aghi","year":"2008","journal-title":"Mol. Ther."},{"key":"2024062810205796100_JCS261893C2","first-page":"324","article-title":"Nuclear protein kinase C activity is decreased in Friend erythroleukemia cells induced to differentiate","volume":"20","author":"Beckman","year":"1992","journal-title":"Exp. Hematol."},{"key":"2024062810205796100_JCS261893C3","first-page":"2598","article-title":"Entry of human cytomegalovirus into retinal pigment epithelial and endothelial cells by endocytosis","volume":"40","author":"Bodaghi","year":"1999","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2024062810205796100_JCS261893C4","first-page":"1887","article-title":"Erythropoiesis in Friend leukemia: red blood cell survival and ferrokinetics","volume":"26","author":"Brodsky","year":"1966","journal-title":"Cancer Res."},{"key":"2024062810205796100_JCS261893C5","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1073\/pnas.76.1.425","article-title":"Identification of a non-H-2 gene (Rfv-3) influencing recovery from viremia and leukemia induced by Friend virus complex","volume":"76","author":"Chesebro","year":"1979","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2024062810205796100_JCS261893C6","doi-asserted-by":"publisher","first-page":"2097","DOI":"10.1128\/jvi.67.4.2097-2102.1993","article-title":"Retroviral infection and expression of cationic amino acid transporters in rodent hepatocytes","volume":"67","author":"Closs","year":"1993","journal-title":"J. Virol."},{"key":"2024062810205796100_JCS261893C7","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/0042-6822(92)90200-9","article-title":"Human cytomegalovirus penetrates host cells by pH-independent fusion at the cell surface","volume":"191","author":"Compton","year":"1992","journal-title":"Virology"},{"key":"2024062810205796100_JCS261893C8","doi-asserted-by":"publisher","first-page":"8960","DOI":"10.1128\/JVI.78.17.8960-8970.2004","article-title":"Replication and cytopathic effect of oncolytic vesicular stomatitis virus in hypoxic tumor cells in vitro and in vivo","volume":"78","author":"Connor","year":"2004","journal-title":"J. Virol."},{"key":"2024062810205796100_JCS261893C9","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1038\/nrmicro817","article-title":"Virus entry: molecular mechanisms and biomedical applications","volume":"2","author":"Dimitrov","year":"2004","journal-title":"Nat. Rev. Microbiol."},{"key":"2024062810205796100_JCS261893C10","doi-asserted-by":"publisher","first-page":"6554","DOI":"10.1128\/JVI.72.8.6554-6558.1998","article-title":"Characterization of a live-attenuated retroviral vaccine demonstrates protection via immune mechanisms","volume":"72","author":"Dittmer","year":"1998","journal-title":"J. Virol."},{"key":"2024062810205796100_JCS261893C11","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1093\/femsre\/fuz012","article-title":"Friend retrovirus studies reveal complex interactions between intrinsic, innate and adaptive immunity","volume":"43","author":"Dittmer","year":"2019","journal-title":"FEMS Microbiol. Rev."},{"key":"2024062810205796100_JCS261893C12","doi-asserted-by":"publisher","first-page":"C392","DOI":"10.1152\/ajpcell.00442.2020","article-title":"The H+-ATPase (V-ATPase): from proton pump to signaling complex in health and disease","volume":"320","author":"Eaton","year":"2021","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"2024062810205796100_JCS261893C13","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/S0092-8674(01)00507-4","article-title":"C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation","volume":"107","author":"Epstein","year":"2001","journal-title":"Cell"},{"key":"2024062810205796100_JCS261893C14","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1038\/nrm2272","article-title":"Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology","volume":"8","author":"Forgac","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2024062810205796100_JCS261893C15","doi-asserted-by":"publisher","first-page":"7701","DOI":"10.1128\/jvi.67.12.7701-7704.1993","article-title":"The human T-cell leukemia\/lymphotropic virus type I p12I protein cooperates with the E5 oncoprotein of bovine papillomavirus in cell transformation and binds the 16-kilodalton subunit of the vacuolar H+ ATPase","volume":"67","author":"Franchini","year":"1993","journal-title":"J. Virol."},{"key":"2024062810205796100_JCS261893C16","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1038\/sj.bjp.0703921","article-title":"The transport activity of the human cationic amino acid transporter hCAT-1 is downregulated by activation of protein kinase C","volume":"132","author":"Gr\u00e4f","year":"2001","journal-title":"Br. J. Pharmacol."},{"key":"2024062810205796100_JCS261893C17","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/S0006-291X(02)02468-3","article-title":"Expression, purification, and characterization of subunit E, an essential subunit of the vacuolar ATPase","volume":"298","author":"Gr\u00fcber","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2024062810205796100_JCS261893C18","doi-asserted-by":"publisher","first-page":"2301","DOI":"10.1073\/pnas.0608382104","article-title":"Acute postnatal ablation of Hif-2\u03b1 results in anemia","volume":"104","author":"Gruber","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2024062810205796100_JCS261893C19","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1038\/nrm1959","article-title":"Mechanisms of pathogen entry through the endosomal compartments","volume":"7","author":"Gruenberg","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2024062810205796100_JCS261893C20","doi-asserted-by":"publisher","first-page":"2306","DOI":"10.1128\/jvi.69.4.2306-2312.1995","article-title":"Requirement for vacuolar proton-ATPase activity during entry of influenza virus into cells","volume":"69","author":"Guinea","year":"1995","journal-title":"J. Virol."},{"key":"2024062810205796100_JCS261893C21","doi-asserted-by":"publisher","first-page":"6761","DOI":"10.1128\/JVI.77.12.6761-6768.2003","article-title":"Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) contains hypoxia response elements: relevance to lytic induction by hypoxia","volume":"77","author":"Haque","year":"2003","journal-title":"J. Virol."},{"key":"2024062810205796100_JCS261893C22","doi-asserted-by":"publisher","first-page":"7811","DOI":"10.1073\/pnas.94.15.7811","article-title":"Immunity to retroviral infection: the Friend virus model","volume":"94","author":"Hasenkrug","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2024062810205796100_JCS261893C23","doi-asserted-by":"publisher","first-page":"2059","DOI":"10.1128\/jvi.68.4.2059-2064.1994","article-title":"Recovery from Friend disease in mice with reduced major histocompatibility complex class I expression","volume":"68","author":"Hasenkrug","year":"1994","journal-title":"J. Virol."},{"key":"2024062810205796100_JCS261893C24","doi-asserted-by":"publisher","first-page":"e34795","DOI":"10.1371\/journal.pone.0034795","article-title":"Human cytomegalovirus entry into dendritic cells occurs via a macropinocytosis-like pathway in a pH-independent and cholesterol-dependent manner","volume":"7","author":"Haspot","year":"2012","journal-title":"PLoS ONE"},{"key":"2024062810205796100_JCS261893C25","doi-asserted-by":"publisher","first-page":"127","DOI":"10.3389\/fphys.2019.00127","article-title":"Reciprocal regulation of V-ATPase and glycolytic pathway elements in health and disease","volume":"10","author":"Hayek","year":"2019","journal-title":"Front. Physiol."},{"key":"2024062810205796100_JCS261893C26","doi-asserted-by":"publisher","first-page":"6910","DOI":"10.1038\/s41598-017-07023-z","article-title":"Blockade of dengue virus infection and viral cytotoxicity in neuronal cells in vitro and in vivo by targeting endocytic pathways","volume":"7","author":"Ho","year":"2017","journal-title":"Sci. Rep."},{"key":"2024062810205796100_JCS261893C27","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1038\/ni.2169","article-title":"Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virus","volume":"13","author":"Honke","year":"2011","journal-title":"Nat. Immunol."},{"key":"2024062810205796100_JCS261893C28","doi-asserted-by":"publisher","first-page":"5405","DOI":"10.1128\/jvi.63.12.5405-5412.1989","article-title":"Fv-4 resistance gene: a truncated endogenous murine leukemia virus with ecotropic interference properties","volume":"63","author":"Ikeda","year":"1989","journal-title":"J. Virol."},{"key":"2024062810205796100_JCS261893C29","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1126\/science.1059817","article-title":"HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing","volume":"292","author":"Ivan","year":"2001","journal-title":"Science"},{"key":"2024062810205796100_JCS261893C30","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1126\/science.1059796","article-title":"Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation","volume":"292","author":"Jaakkola","year":"2001","journal-title":"Science"},{"key":"2024062810205796100_JCS261893C31","doi-asserted-by":"publisher","first-page":"7067","DOI":"10.1074\/jbc.274.11.7067","article-title":"Up-regulation of the Pit-2 phosphate transporter\/retrovirus receptor by protein kinase C epsilon","volume":"274","author":"Jobbagy","year":"1999","journal-title":"J. Biol. Chem."},{"key":"2024062810205796100_JCS261893C32","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1128\/jvi.20.2.436-440.1976","article-title":"Mouse strain resistant to N-, B-, and NB-tropic murine leukemia viruses","volume":"20","author":"Kai","year":"1976","journal-title":"J. Virol."},{"key":"2024062810205796100_JCS261893C33","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1023\/A:1025724814656","article-title":"Assembly and regulation of the yeast vacuolar H+-ATPase","volume":"35","author":"Kane","year":"2003","journal-title":"J. Bioenerg. Biomembr."},{"key":"2024062810205796100_JCS261893C34","doi-asserted-by":"publisher","first-page":"5018","DOI":"10.1128\/JVI.75.11.5018-5026.2001","article-title":"Infectious entry by amphotropic as well as ecotropic murine leukemia viruses occurs through an endocytic pathway","volume":"75","author":"Katen","year":"2001","journal-title":"J. Virol."},{"key":"2024062810205796100_JCS261893C35","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1212\/WNL.0000000000001860","article-title":"The autophagy-lysosomal pathway: general concepts and clinical implications","volume":"85","author":"Kenney","year":"2015","journal-title":"Neurology"},{"key":"2024062810205796100_JCS261893C36","doi-asserted-by":"publisher","first-page":"8551","DOI":"10.3390\/ijms21228551","article-title":"The importance of Hypoxia-Inducible Factors (HIF-1 and HIF-2) for the pathophysiology of inflammatory bowel disease","volume":"21","author":"Kerber","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"2024062810205796100_JCS261893C37","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.virol.2009.06.015","article-title":"Removal of either N-glycan site from the envelope receptor binding domain of Moloney and Friend but not AKV mouse ecotropic gammaretroviruses alters receptor usage","volume":"391","author":"Knoper","year":"2009","journal-title":"Virology"},{"key":"2024062810205796100_JCS261893C38","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/978-3-642-68069-4_5","article-title":"Genetic resistance to Friend virus-induced erythroleukemia and immunosuppression","volume":"92","author":"Kumar","year":"1981","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"2024062810205796100_JCS261893C39","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1084\/jem.147.2.422","article-title":"Mechanisms of genetic resistance to Friend virus leukemia in mice. IV. Identification of a gene (Fv-3) regulating immunosuppression in vitro, and its distinction from Fv-2 and genes regulating marrow allograft reactivity","volume":"147","author":"Kumar","year":"1978","journal-title":"J. Exp. Med."},{"key":"2024062810205796100_JCS261893C40","first-page":"1117","article-title":"Mechanism of genetic resistance to Friend virus leukemia in mice. V. Relevance of Fv-3 gene in the regulation of in vivo immunosuppression","volume":"61","author":"Kumar","year":"1978","journal-title":"J. Natl. Cancer Inst."},{"key":"2024062810205796100_JCS261893C41","doi-asserted-by":"publisher","first-page":"2782","DOI":"10.1128\/jvi.61.9.2782-2792.1987","article-title":"The membrane glycoprotein of Friend spleen focus-forming virus: evidence that the cell surface component is required for pathogenesis and that it binds to a receptor","volume":"61","author":"Li","year":"1987","journal-title":"J. Virol."},{"key":"2024062810205796100_JCS261893C42","doi-asserted-by":"publisher","first-page":"306","DOI":"10.4049\/jimmunol.1400490","article-title":"Tetherin promotes the innate and adaptive cell-mediated immune response against retrovirus infection in vivo","volume":"193","author":"Li","year":"2014","journal-title":"J. Immunol."},{"key":"2024062810205796100_JCS261893C43","doi-asserted-by":"publisher","first-page":"20425","DOI":"10.1038\/srep20425","article-title":"Tetherin\/BST-2 promotes dendritic cell activation and function during acute retrovirus infection","volume":"6","author":"Li","year":"2016","journal-title":"Sci. Rep."},{"key":"2024062810205796100_JCS261893C44","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1038\/s41467-019-13965-x","article-title":"Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection","volume":"11","author":"Li","year":"2020","journal-title":"Nat. Commun."},{"key":"2024062810205796100_JCS261893C45","doi-asserted-by":"publisher","first-page":"18097","DOI":"10.1073\/pnas.1113694108","article-title":"Tetherin is a key effector of the antiretroviral activity of type I interferon in vitro and in vivo","volume":"108","author":"Liberatore","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2024062810205796100_JCS261893C46","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1016\/S0140-6736(64)91043-8","article-title":"Genetic basis of susceptibility to viral leukaemogenesis","volume":"2","author":"Lilly","year":"1964","journal-title":"Lancet"},{"key":"2024062810205796100_JCS261893C47","doi-asserted-by":"publisher","first-page":"4163","DOI":"10.1128\/jvi.67.7.4163-4168.1993","article-title":"Transgenic Fv-4 mice resistant to Friend virus","volume":"67","author":"Limjoco","year":"1993","journal-title":"J. Virol."},{"key":"2024062810205796100_JCS261893C48","doi-asserted-by":"publisher","first-page":"677","DOI":"10.3390\/v3060677","article-title":"Gammaretroviral vectors: biology, technology and application","volume":"3","author":"Maetzig","year":"2011","journal-title":"Viruses"},{"key":"2024062810205796100_JCS261893C49","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1111\/j.1462-5822.2010.01556.x","article-title":"Influenza A virus-induced early activation of ERK and PI3K mediates V-ATPase-dependent intracellular pH change required for fusion","volume":"13","author":"Marjuki","year":"2010","journal-title":"Cell. Microbiol."},{"key":"2024062810205796100_JCS261893C50","doi-asserted-by":"publisher","first-page":"D933","DOI":"10.1093\/nar\/gkac958","article-title":"Ensembl 2023","volume":"51","author":"Martin","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"2024062810205796100_JCS261893C51","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1002\/j.1460-2075.1988.tb02839.x","article-title":"Human immunodeficiency virus infection of CD4-bearing cells occurs by a pH-independent mechanism","volume":"7","author":"McClure","year":"1988","journal-title":"EMBO J."},{"key":"2024062810205796100_JCS261893C52","first-page":"52","article-title":"Pathogenesis of mouse leukemia caused by Friend virus","volume":"19","author":"Metcalf","year":"1959","journal-title":"Cancer Res."},{"key":"2024062810205796100_JCS261893C53","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1111\/j.1476-5381.2011.01346.x","article-title":"The proton translocation domain of cellular vacuolar ATPase provides a target for the treatment of influenza A virus infections","volume":"164","author":"M\u00fcller","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"2024062810205796100_JCS261893C54","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1038\/nrm729","article-title":"The vacuolar (H+)-ATPases--nature's most versatile proton pumps","volume":"3","author":"Nishi","year":"2002","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2024062810205796100_JCS261893C55","first-page":"23","article-title":"Inheritance of susceptibility to Friend mouse leukemia virus. 3. Susceptibility of F1 and genotypes of F2 and backcross progeny","volume":"36","author":"Odaka","year":"1966","journal-title":"Jpn. J. Exp. Med."},{"key":"2024062810205796100_JCS261893C56","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.virol.2004.06.020","article-title":"Hypoxia enhances human B19 erythrovirus gene expression in primary erythroid cells","volume":"327","author":"Pillet","year":"2004","journal-title":"Virology"},{"key":"2024062810205796100_JCS261893C57","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1084\/jem.133.6.1219","article-title":"A major genetic locus affecting resistance to infection with murine leukemia viruses: I. Tissue culture studies of naturally occurring viruses","volume":"133","author":"Pincus","year":"1971","journal-title":"J. Exp. Med."},{"key":"2024062810205796100_JCS261893C58","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1084\/jem.133.6.1234","article-title":"A major genetic locus affecting resistance to infection with murine leukemia viruses. II. Apparent identity to a major locus described for resistance to friend murine leukemia virus","volume":"133","author":"Pincus","year":"1971","journal-title":"J. Exp. Med."},{"key":"2024062810205796100_JCS261893C59","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1084\/jem.150.5.1174","article-title":"Viral specificity of H-2-restricted T killer cells directed against syngeneic tumors induced by Gross, Friend, or Rauscher leukemia virus","volume":"150","author":"Plata","year":"1979","journal-title":"J. Exp. Med."},{"key":"2024062810205796100_JCS261893C60","doi-asserted-by":"publisher","first-page":"11421","DOI":"10.1016\/S0021-9258(18)98973-8","article-title":"Anoxia induces human immunodeficiency virus expression in infected T cell lines","volume":"266","author":"Polonis","year":"1991","journal-title":"J. Biol. Chem."},{"key":"2024062810205796100_JCS261893C61","doi-asserted-by":"publisher","first-page":"2243","DOI":"10.1128\/JVI.73.3.2243-2252.1999","article-title":"Hypoxia blocks in vivo initiation of simian virus 40 replication at a stage preceding origin unwinding","volume":"73","author":"Riedinger","year":"1999","journal-title":"J. Virol."},{"key":"2024062810205796100_JCS261893C62","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/0166-0934(91)90105-9","article-title":"Production of monoclonal antibodies reactive with a denatured form of the Friend murine leukemia virus gp70 envelope protein: use in a focal infectivity assay, immunohistochemical studies, electron microscopy and western blotting","volume":"34","author":"Robertson","year":"1991","journal-title":"J. Virol. Methods"},{"key":"2024062810205796100_JCS261893C63","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1128\/JVI.80.2.710-722.2006","article-title":"Human cytomegalovirus entry into epithelial and endothelial cells depends on genes UL128 to UL150 and occurs by endocytosis and low-pH fusion","volume":"80","author":"Ryckman","year":"2006","journal-title":"J. Virol."},{"key":"2024062810205796100_JCS261893C64","doi-asserted-by":"publisher","DOI":"10.3390\/v11060524","article-title":"Bafilomycin A1 and U18666A efficiently impair ZIKV infection","volume":"11","author":"Sabino","year":"2019","journal-title":"Viruses"},{"key":"2024062810205796100_JCS261893C65","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"2024062810205796100_JCS261893C66","doi-asserted-by":"publisher","first-page":"17236","DOI":"10.1038\/s41598-017-17324-y","article-title":"Hypoxia-inducible factor 1\u03b1 is essential for macrophage-mediated erythroblast proliferation in acute friend retrovirus infection","volume":"7","author":"Schreiber","year":"2017","journal-title":"Sci. Rep."},{"key":"2024062810205796100_JCS261893C67","doi-asserted-by":"publisher","first-page":"4469","DOI":"10.1128\/JVI.02441-09","article-title":"The m74 gene product of Murine Cytomegalovirus (MCMV) is a functional homolog of human CMV gO and determines the entry pathway of MCMV\u25bf","volume":"84","author":"Scrivano","year":"2010","journal-title":"J. Virol."},{"key":"2024062810205796100_JCS261893C68","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1038\/sj.gt.3302448","article-title":"Effect of hypoxia on Ad5 infection, transgene expression and replication","volume":"12","author":"Shen","year":"2005","journal-title":"Gene Ther."},{"key":"2024062810205796100_JCS261893C69","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1038\/296577a0","article-title":"A host gene controlling early anaemia or polycythaemia induced by Friend erythroleukaemia virus","volume":"296","author":"Shibuya","year":"1982","journal-title":"Nature"},{"key":"2024062810205796100_JCS261893C70","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/0092-8674(82)90141-6","article-title":"Host control of susceptibility to erythroleukemia and to the types of leukemia induced by Friend murine leukemia virus: initial and late stages","volume":"31","author":"Shibuya","year":"1982","journal-title":"Cell"},{"key":"2024062810205796100_JCS261893C71","doi-asserted-by":"publisher","first-page":"e1002284","DOI":"10.1371\/journal.ppat.1002284","article-title":"Noninfectious retrovirus particles drive the APOBEC3\/Rfv3 dependent neutralizing antibody response","volume":"7","author":"Smith","year":"2011","journal-title":"PLoS Pathog."},{"key":"2024062810205796100_JCS261893C72","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/0092-8674(87)90542-3","article-title":"pH-independent HIV entry into CD4-positive T cells via virus envelope fusion to the plasma membrane","volume":"49","author":"Stein","year":"1987","journal-title":"Cell"},{"key":"2024062810205796100_JCS261893C73","doi-asserted-by":"publisher","first-page":"L1115","DOI":"10.1152\/ajplung.2001.280.6.L1115","article-title":"Bafilomycin A(1) inhibits rhinovirus infection in human airway epithelium: effects on endosome and ICAM-1","volume":"280","author":"Suzuki","year":"2001","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2024062810205796100_JCS261893C74","doi-asserted-by":"publisher","first-page":"3716","DOI":"10.1172\/JCI84433","article-title":"Hypoxia-dependent regulation of inflammatory pathways in immune cells","volume":"126","author":"Taylor","year":"2016","journal-title":"J. Clin. Invest."},{"key":"2024062810205796100_JCS261893C75","doi-asserted-by":"publisher","first-page":"11244","DOI":"10.1128\/JVI.75.22.11244-11248.2001","article-title":"Fv-4: identification of the defect in Env and the mechanism of resistance to ecotropic murine leukemia virus","volume":"75","author":"Taylor","year":"2001","journal-title":"J. Virol."},{"key":"2024062810205796100_JCS261893C76","doi-asserted-by":"publisher","first-page":"1260419","DOI":"10.1126\/science.1260419","article-title":"Proteomics. Tissue-based map of the human proteome","volume":"347","author":"Uhl\u00e9n","year":"2015","journal-title":"Science"},{"key":"2024062810205796100_JCS261893C77","doi-asserted-by":"publisher","first-page":"7327","DOI":"10.1074\/jbc.RA120.013280","article-title":"The viral protein U (Vpu)-interacting host protein ATP6V0C down-regulates cell-surface expression of tetherin and thereby contributes to HIV-1 release","volume":"295","author":"Waheed","year":"2020","journal-title":"J. Biol. Chem."},{"key":"2024062810205796100_JCS261893C78","doi-asserted-by":"publisher","first-page":"e00004-19","DOI":"10.1128\/mBio.00004-19","article-title":"Infection of B cell follicle-resident cells by friend retrovirus occurs during acute infection and is maintained during viral persistence","volume":"10","author":"Windmann","year":"2019","journal-title":"mBio"},{"key":"2024062810205796100_JCS261893C79","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1089\/ars.2022.0004","article-title":"Oxygen sensing in innate immune cells: how inflammation broadens classical hypoxia-inducible factor regulation in myeloid cells","volume":"37","author":"Winning","year":"2022","journal-title":"Antioxid Redox Signal."}],"container-title":["Journal of Cell Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/jcs\/article-pdf\/doi\/10.1242\/jcs.261893\/3469228\/jcs261893.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/jcs\/article-pdf\/doi\/10.1242\/jcs.261893\/3529876\/jcs261893.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/jcs\/article-pdf\/doi\/10.1242\/jcs.261893\/3529876\/jcs261893.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T10:21:23Z","timestamp":1719570083000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/jcs\/article\/137\/12\/jcs261893\/358949\/Reduced-vacuolar-ATPase-protects-mice-from-Friend"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,15]]},"references-count":79,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,6,15]]}},"URL":"https:\/\/doi.org\/10.1242\/jcs.261893","relation":{},"ISSN":["0021-9533","1477-9137"],"issn-type":[{"value":"0021-9533","type":"print"},{"value":"1477-9137","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,15]]},"article-number":"jcs261893"}}