{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:21:38Z","timestamp":1790724098870,"version":"4.1.0"},"reference-count":25,"publisher":"The Company of Biologists","issue":"9","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"DOI":"10.13039\/501100013209","name":"Hellenic Foundation for Research and Innovation","doi-asserted-by":"crossref","award":["HFRI\u2013FM17C3-0869"],"award-info":[{"award-number":["HFRI\u2013FM17C3-0869"]}],"id":[{"id":"10.13039\/501100013209","id-type":"DOI","asserted-by":"crossref"}]},{"name":"General Secretariat for Research and Innovation of the Greek Ministry of Development"},{"name":"European Union \u2013 NextGenerationEU","award":["TAEDR-0535850"],"award-info":[{"award-number":["TAEDR-0535850"]}]},{"name":"Flagship Actions in Interdisciplinary Scientific Areas with Special Interest in Connection to the Productive Fabric"},{"name":"European Commission Research Executive Agency","award":["GA-101087071"],"award-info":[{"award-number":["GA-101087071"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Peroxisome proliferator-activated receptors (PPARs), such as PPAR\u03b4, are transcription factors that play a pivotal role in energy and fat metabolism. PPAR\u03b4 activates genes involved in lipid and glucose metabolism and is expressed in various human tissues, including all brain regions and especially neurons, where it regulates lipid homeostasis and contributes to neuroprotection. However, the precise molecular mechanisms underlying these protective effects remain poorly understood. Here, we identify the Caenorhabditis elegans nuclear hormone receptor NHR-85 as a putative orthologue of human PPAR\u03b4. Furthermore, we show that NHR-85 functions as an essential regulator of fat and energy metabolism, with significant impact on mitochondrial homeostasis, at least in part through modulation of mitophagy. Finally, we find that NHR-85 prevents \u03b1-synuclein aggregation in a nematode model of Parkinson's disease, suggesting that it might play a protective role in neurodegenerative diseases. Our results indicate that NHR-85 is a functional orthologue of PPAR\u03b4 and support the use of C. elegans as a powerful in vivo model for dissecting PPAR\u03b4-related metabolic and neurodegenerative processes.<\/jats:p>","DOI":"10.1242\/jcs.263651","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T08:35:00Z","timestamp":1744360500000},"source":"Crossref","is-referenced-by-count":6,"title":["NHR-85 modulates mitochondrial and lipid homeostasis to protect against \u03b1-synuclein aggregation in <i>C. elegans<\/i>"],"prefix":"10.1242","volume":"138","author":[{"given":"Dikaia","family":"Tsagkari","sequence":"first","affiliation":[{"name":"Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas 1 , Heraklion 70013, Crete ,","place":["Greece"]},{"name":"School of Medicine, University of Crete 2 Division of Basic Sciences , , Heraklion 71003, Crete ,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Markaki","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas 1 , Heraklion 70013, Crete ,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5253-1466","authenticated-orcid":false,"given":"Nektarios","family":"Tavernarakis","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas 1 , Heraklion 70013, Crete ,","place":["Greece"]},{"name":"School of Medicine, University of Crete 2 Division of Basic Sciences , , Heraklion 71003, Crete ,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2025,5,9]]},"reference":[{"key":"2025051405163793300_JCS263651C1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11011-019-00500-6","article-title":"Erucic acid, a nutritional PPARdelta-ligand may influence Huntington's disease pathogenesis","volume":"35","author":"Altinoz","year":"2020","journal-title":"Metab. 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