{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T16:53:56Z","timestamp":1784998436286,"version":"3.55.0"},"reference-count":57,"publisher":"The Company of Biologists","issue":"14","license":[{"start":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T00:00:00Z","timestamp":1753833600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100013306","name":"National Institute of Science Education and Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100013306","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001502","name":"Department of Atomic Energy, Government of India","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001502","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Mitochondrial appearance distinctively reflects cellular stress. Hypoxia, one of the most fundamental stressors, drives tumor progression, impacting mitochondrial structure and function. RAS homolog family member A (RHOA), a key regulator of cell motility, is frequently upregulated in response to hypoxia across cancers. However, its behavior under hypoxic conditions in gastric cancer (GC) remains largely unexplored. Additionally, to what extent the role of RHOA in cell motility is mediated through an influence on mitochondrial reshaping is elusive. Here, we show that an elevated RHOA level in GC cells triggers mitochondrial shape changes, from tubular to the stress-associated lasso and donut, correlating with increased reactive oxygen species (ROS). However, RHOA-overexpressing cells experiencing hypoxia exhibited increased migration, despite reduced mitochondrial fission and ROS levels. RHO-associated coiled-coil kinase (ROCK) inhibition impaired mitochondrial shape changes, suggesting it has a role in mitochondrial remodeling. These results indicate a unique adaptive response to hypoxia, where RHOA upregulation increases motility and modulates mitochondrial plasticity in GC cells. In summary, RHOA-mediated mitochondrial reshaping might serve as a key regulator in tumor cell adaptation and migration in low-oxygen environments.<\/jats:p>","DOI":"10.1242\/jcs.263690","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T09:48:55Z","timestamp":1751449735000},"source":"Crossref","is-referenced-by-count":4,"title":["RHOA-dependent regulation of mitochondrial remodeling and cell motility in hypoxia-exposed gastric epithelial cells"],"prefix":"10.1242","volume":"138","author":[{"given":"Aranya","family":"Pal","sequence":"first","affiliation":[{"name":"School of Biological Sciences, National Institute of Science Education and Research (NISER) Bhubaneswar, An OCC of Homi Bhabha National Institute 1 , P.O. Bhimpur-Padanpur, Via Jatni, Dist. Khurda 752050, Odisha ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabin","family":"Bawali","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, National Institute of Science Education and Research (NISER) Bhubaneswar, An OCC of Homi Bhabha National Institute 1 , P.O. Bhimpur-Padanpur, Via Jatni, Dist. Khurda 752050, Odisha ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhisek","family":"Brahma","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, National Institute of Science Education and Research (NISER) Bhubaneswar, An OCC of Homi Bhabha National Institute 1 , P.O. Bhimpur-Padanpur, Via Jatni, Dist. Khurda 752050, Odisha ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smruti Ranjan","family":"Rana","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, National Institute of Science Education and Research (NISER) Bhubaneswar, An OCC of Homi Bhabha National Institute 1 , P.O. Bhimpur-Padanpur, Via Jatni, Dist. Khurda 752050, Odisha ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh","family":"Mohapatra","sequence":"additional","affiliation":[{"name":"Institute of Life Sciences 2 Department of Infectious Disease Biology , , NALCO Square, Chandrasekharpur, Bhubaneswar, Odisha, 751023 ,","place":["India"]},{"name":"Regional Centre for Biotechnology 3 , 3rd Milestone, Faridabad-Gurgaon Expressway, Faridabad Rd, Faridabad, Haryana, 121001 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debashish","family":"Chakraborty","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, National Institute of Science Education and Research (NISER) Bhubaneswar, An OCC of Homi Bhabha National Institute 1 , P.O. Bhimpur-Padanpur, Via Jatni, Dist. Khurda 752050, Odisha ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indrajit","family":"Poirah","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, National Institute of Science Education and Research (NISER) Bhubaneswar, An OCC of Homi Bhabha National Institute 1 , P.O. Bhimpur-Padanpur, Via Jatni, Dist. Khurda 752050, Odisha ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supriya","family":"Samal","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, National Institute of Science Education and Research (NISER) Bhubaneswar, An OCC of Homi Bhabha National Institute 1 , P.O. Bhimpur-Padanpur, Via Jatni, Dist. Khurda 752050, Odisha ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smaran","family":"Banerjee","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, National Institute of Science Education and Research (NISER) Bhubaneswar, An OCC of Homi Bhabha National Institute 1 , P.O. Bhimpur-Padanpur, Via Jatni, Dist. Khurda 752050, Odisha ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duane T.","family":"Smoot","sequence":"additional","affiliation":[{"name":"Meharry Medical Center 4 Department of Medicine , , Nashville, TN 37208 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Ashktorab","sequence":"additional","affiliation":[{"name":"Howard University 5 Department of Medicine , , Washington DC 20060 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7292-6644","authenticated-orcid":false,"given":"Asima","family":"Bhattacharyya","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, National Institute of Science Education and Research (NISER) Bhubaneswar, An OCC of Homi Bhabha National Institute 1 , P.O. Bhimpur-Padanpur, Via Jatni, Dist. Khurda 752050, Odisha ,","place":["India"]},{"name":"Centre for Interdisciplinary Sciences, National Institute of Science Education and Research 6 , Bhubaneswar, Dist. Khurda 752050, Odisha ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2025,7,30]]},"reference":[{"key":"2025073004474360000_JCS263690C1","doi-asserted-by":"publisher","first-page":"e461","DOI":"10.1038\/cddis.2012.213","article-title":"Computational classification of mitochondrial shapes reflects stress and redox state","volume":"4","author":"Ahmad","year":"2013","journal-title":"Cell Death Dis."},{"key":"2025073004474360000_JCS263690C2","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1016\/j.bbabio.2006.04.013","article-title":"The relationship between mitochondrial shape and function and the cytoskeleton","volume":"1757","author":"Anesti","year":"2006","journal-title":"Biochim. Biophys. 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