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Dysfunctional desmosomes, resulting from pathogenic variants in genes encoding desmosomal components, autoantibodies targeting desmosomal adhesion molecules or inflammation, cause the life-threatening diseases arrhythmogenic cardiomyopathy and pemphigus and contribute to the pathogenesis of inflammatory bowel diseases. The Alpine Desmosome Disease Meeting 2024 (ADDM 2024), held in Grainau, Germany in October 2024, connected international researchers from basic sciences with clinical experts from dermatology, cardiology, gastroenterology and surgery. The participants discussed recent advances, identified hot topics in desmosome biology and disease and provided new concepts for pathogenesis and treatment approaches.<\/jats:p>","DOI":"10.1242\/jcs.263796","type":"journal-article","created":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T08:35:41Z","timestamp":1737534941000},"source":"Crossref","is-referenced-by-count":9,"title":["Meeting report \u2013 Alpine desmosome disease meeting 2024: advances and emerging topics in desmosomes and related diseases"],"prefix":"10.1242","volume":"138","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1182-5422","authenticated-orcid":false,"given":"Jens","family":"Waschke","sequence":"first","affiliation":[{"name":"Institute of Anatomy, Faculty of Medicine, Ludwig-Maximilians-Universit\u00e4t LMU Munich 1 Chair of Vegetative Anatomy , , 80336 Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Amagai","sequence":"additional","affiliation":[{"name":"Keio University 2 Department of Dermatology , , 160-8582 Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Becker","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Erlangen, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg 3 Department of Medicine 1 , , 91054 Erlangen-N\u00fcrnberg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Delmar","sequence":"additional","affiliation":[{"name":"NYU Grossman School of Medicine 4 The Leon H Charney Division of Cardiology , , New York, NY 10016 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Firat","family":"Duru","sequence":"additional","affiliation":[{"name":"Clinic for Cardiology, University Heart Center Zurich and Center for Translational and Experimental Cardiology (CTEC), University of Zurich 5 Department of Cardiac Arrhythmia and Electrophysiology , , 8952 Zurich ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Garrod","sequence":"additional","affiliation":[{"name":"University of Manchester 6 Faculty of Biology, Medicine and Health , , Michael Smith Building, Oxford Road, Manchester M13 9PT ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda","family":"Gerull","sequence":"additional","affiliation":[{"name":"Comprehensive Heart Failure Center 7 , Department of Internal Medicine I , , 97080 W\u00fcrzburg ,","place":["Germany"]},{"name":"University Hospital W\u00fcrzburg 7 , Department of Internal Medicine I , , 97080 W\u00fcrzburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen J.","family":"Green","sequence":"additional","affiliation":[{"name":"Feinberg School of Medicine, Northwestern University 8 Department of Pathology , , Chicago, IL 60611 ,","place":["USA"]},{"name":"Feinberg School of Medicine, Northwestern University 9 Department of Dermatology , , Chicago, IL 60611 ,","place":["USA"]},{"name":"Robert H. 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