{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T14:02:10Z","timestamp":1774274530531,"version":"3.50.1"},"reference-count":52,"publisher":"The Company of Biologists","issue":"21","license":[{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"crossref","award":["1\/1\/3\/JRF-2017\/HRD"],"award-info":[{"award-number":["1\/1\/3\/JRF-2017\/HRD"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"crossref","award":["SR\/WOS-A\/LS-61\/2017"],"award-info":[{"award-number":["SR\/WOS-A\/LS-61\/2017"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"crossref","award":["BT\/PR9048\/MED\/97\/145\/20 13"],"award-info":[{"award-number":["BT\/PR9048\/MED\/97\/145\/20 13"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"crossref","award":["DST-SERB"],"award-info":[{"award-number":["DST-SERB"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"crossref","award":["EEQ\/2018\/00053"],"award-info":[{"award-number":["EEQ\/2018\/00053"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007741","name":"University of Hyderabad","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007741","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Johns Hopkins University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Growth signals and immune responses in cancer typically originate in the same compartments. In early stages of tumor development, inflammatory cells trigger responses against growing cancers. At a molecular level, it is unclear how the innate immune system recognizes tumorigenesis. At later stages, cancer cells resist cell death and evade immune detection, thereby suppressing anti-tumor responses and promoting cancer hallmarks. Often, chronic inflammatory responses become tumor friendly and incline towards tumorigenesis disturbing metabolic signaling, thereby rewiring nutritional supply for cancer growth. The precise connecting link between cancer, nutrition and metabolism remains unclear. Drosophila provides an ideal platform to explore the links between hyperactive immune signaling, defective fat metabolism and pseudotumor formation. Therefore, we examined the effects of methotrexate on these pathophysiological processes in larvae with hyperactive Toll\/NF-\u03baB pathway. We determined that both chemical (methotrexate) and genetic [rescue of Ubc9\u2212\/\u2212 mutants by introducing a wild-type copy of Cactus (negative regulator of the Toll pathway)] interventions alleviated abnormalities associated with Toll\/NF-\u03baB hyperactivity and its influence on insulin signaling. Our study underscores drug repurposing studies and provides insights into how immune\u2013metabolic crosstalk rewires inflammation-driven tumorigenesis.<\/jats:p>","DOI":"10.1242\/jcs.263816","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T10:09:01Z","timestamp":1762164541000},"source":"Crossref","is-referenced-by-count":2,"title":["Methotrexate alleviates chronic inflammation in a\n                    <i>Drosophila<\/i>\n                    model"],"prefix":"10.1242","volume":"138","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5441-6955","authenticated-orcid":false,"given":"Dushyant K.","family":"Gautam","sequence":"first","affiliation":[{"name":"School of Life Sciences, University of Hyderabad 1 Department of Biochemistry , , Hyderabad, TS 500046 ,","place":["India"]},{"name":"School of Medicine, Johns Hopkins University 2 Cardiology Department , , Baltimore, MD 21201 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4482-7750","authenticated-orcid":false,"given":"Willem","family":"Buys","sequence":"additional","affiliation":[{"name":"Institute for Cell Engineering, Johns Hopkins School of Medicine 3 , Baltimore, MD 21201 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeeshan","family":"Ahmad","sequence":"additional","affiliation":[{"name":"School of Life Sciences, University of Hyderabad 1 Department of Biochemistry , , Hyderabad, TS 500046 ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0912-5796","authenticated-orcid":false,"given":"Ravi K.","family":"Gutti","sequence":"additional","affiliation":[{"name":"School of Life Sciences, University of Hyderabad 1 Department of Biochemistry , , Hyderabad, TS 500046 ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3057-2160","authenticated-orcid":false,"given":"Indira","family":"Paddibhatla","sequence":"additional","affiliation":[{"name":"School of Life Sciences, University of Hyderabad 1 Department of Biochemistry , , Hyderabad, TS 500046 ,","place":["India"]},{"name":"School of Medicine, Johns Hopkins University 2 Cardiology Department , , Baltimore, MD 21201 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2025,11,3]]},"reference":[{"key":"2025110305085052700_JCS263816C1","doi-asserted-by":"publisher","first-page":"12441","DOI":"10.3390\/ijms252212441","article-title":"Drug repurposing for cancer treatment: a comprehensive review","volume":"25","author":"Al Khzem","year":"2024","journal-title":"Int. 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