{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T20:27:11Z","timestamp":1784838431427,"version":"3.55.0"},"reference-count":187,"publisher":"The Company of Biologists","issue":"21","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["1R35GM150892-01"],"award-info":[{"award-number":["1R35GM150892-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100006710","name":"Wayne State University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100006710","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Sphingolipids are essential for cell membrane structure and the regulation of organelle functions. Sphingolipid synthesis requires the coordinated activity of multiple organelles, including the endoplasmic reticulum, Golgi, lysosomes and mitochondria, which are connected via membrane contact sites. Metabolic remodeling of sphingolipid pathways is observed in aging and numerous age-related disorders. However, numerous studies have highlighted the complex and species-specific roles of sphingolipid metabolism in aging. In budding yeast, inhibition of sphingolipid synthesis extends lifespan by a mechanism that is poorly understood. Recent findings suggest that inhibition of sphingolipid synthesis in cells mimics methionine restriction, a condition known to extend lifespan across different experimental models. However, how sphingolipid remodeling alters cellular methionine levels, and whether this directly influences aging, remains unclear. In this Review, we explore the roles of sphingolipids in organelle function, highlighting their metabolic connections to methionine restriction and aging.<\/jats:p>","DOI":"10.1242\/jcs.264026","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T09:40:32Z","timestamp":1763113232000},"source":"Crossref","is-referenced-by-count":3,"title":["Sphingolipid and methionine metabolism in aging"],"prefix":"10.1242","volume":"138","author":[{"given":"Daniel","family":"Adebayo","sequence":"first","affiliation":[{"name":"Wayne State University 1 Department of Biological Sciences , , Detroit, Michigan 48202 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eseiwi","family":"Obaseki","sequence":"additional","affiliation":[{"name":"Wayne State University 1 Department of Biological Sciences , , Detroit, Michigan 48202 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kashvi","family":"Vasudeva","sequence":"additional","affiliation":[{"name":"Wayne State University 1 Department of Biological Sciences , , Detroit, Michigan 48202 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa","family":"Aboumourad","sequence":"additional","affiliation":[{"name":"Wayne State University 1 Department of Biological Sciences , , Detroit, Michigan 48202 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Sleiman","sequence":"additional","affiliation":[{"name":"Wayne State University 1 Department of Biological Sciences , , Detroit, Michigan 48202 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumit","family":"Bandyopadhyay","sequence":"additional","affiliation":[{"name":"Wayne State University 1 Department of Biological Sciences , , Detroit, Michigan 48202 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsey","family":"Kreinbring","sequence":"additional","affiliation":[{"name":"Wayne State University 1 Department of Biological Sciences , , Detroit, Michigan 48202 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4044-9597","authenticated-orcid":false,"given":"Hanaa","family":"Hariri","sequence":"additional","affiliation":[{"name":"Wayne State University 1 Department of Biological Sciences , , Detroit, Michigan 48202 ,","place":["USA"]},{"name":"Wayne State University 2 Department of Oncology , , Detroit, Michigan 48201 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2025,11,14]]},"reference":[{"key":"2025120806214200100_JCS264026C1","doi-asserted-by":"publisher","first-page":"e51357","DOI":"10.1371\/journal.pone.0051357","article-title":"Methionine-restricted C57BL\/6J mice are resistant to diet-induced obesity and insulin resistance but have low bone density","volume":"7","author":"Ables","year":"2012","journal-title":"PLoS ONE"},{"key":"2025120806214200100_JCS264026C2","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1007\/s00018-004-4254-1","article-title":"Enzymes of sphingolipid metabolism in Drosophila melanogaster","volume":"62","author":"Acharya","year":"2005","journal-title":"Cell. Mol. Life Sci."},{"key":"2025120806214200100_JCS264026C3","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.1016\/j.febslet.2006.02.061","article-title":"Level of M(IP)2C sphingolipid affects plant defensin sensitivity, oxidative stress resistance and chronological life-span in yeast","volume":"580","author":"Aerts","year":"2006","journal-title":"FEBS Lett."},{"key":"2025120806214200100_JCS264026C4","doi-asserted-by":"publisher","first-page":"1933","DOI":"10.1007\/s00018-008-8129-8","article-title":"Ydc1p ceramidase triggers organelle fragmentation, apoptosis and accelerated ageing in yeast","volume":"65","author":"Aerts","year":"2008","journal-title":"Cell. Mol. Life Sci."},{"key":"2025120806214200100_JCS264026C5","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1038\/ng.3256","article-title":"Biallelic mutations in SNX14 cause a syndromic form of cerebellar atrophy and lysosome-autophagosome dysfunction","volume":"47","author":"Akizu","year":"2015","journal-title":"Nat. Genet."},{"key":"2025120806214200100_JCS264026C6","doi-asserted-by":"publisher","first-page":"e42259","DOI":"10.7759\/cureus.42259","article-title":"Hyperhomocysteinemia and accelerated aging: the pathogenic role of increased homocysteine in atherosclerosis, osteoporosis, and neurodegeneration","volume":"15","author":"Alkaissi","year":"2023","journal-title":"Cureus"},{"key":"2025120806214200100_JCS264026C7","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1091\/mbc.E07-06-0604","article-title":"Isc1p plays a key role in hydrogen peroxide resistance and chronological lifespan through modulation of iron levels and apoptosis","volume":"19","author":"Almeida","year":"2008","journal-title":"Mol. Biol. Cell"},{"key":"2025120806214200100_JCS264026C8","doi-asserted-by":"publisher","first-page":"10.17912\/micropub.biology.000758","DOI":"10.17912\/micropub.biology.000758","article-title":"The impact of C. elegans ceramide glucosyltransferase enzymes on the beneficial effects of B. subtilis lifespan","volume":"2023","author":"Arvin","year":"2023","journal-title":"microPublication Biol"},{"key":"2025120806214200100_JCS264026C9","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/s41580-019-0185-4","article-title":"Lysosomes as dynamic regulators of cell and organismal homeostasis","volume":"21","author":"Ballabio","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2025120806214200100_JCS264026C10","first-page":"85","article-title":"Chapter Five - Lysosomal membrane contact sites: Integrative hubs for cellular communication and homeostasis","volume-title":"Current Topics in Membranes","author":"Bandyopadhyay","year":"2024"},{"key":"2025120806214200100_JCS264026C11","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1016\/j.csbj.2021.03.013","article-title":"Endocytosis of nutrient transporters in fungi: The ART of connecting signaling and trafficking","volume":"19","author":"Barata-Antunes","year":"2021","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"2025120806214200100_JCS264026C12","doi-asserted-by":"publisher","first-page":"e202103048","DOI":"10.1083\/jcb.202103048","article-title":"Cvm1 is a component of multiple vacuolar contact sites required for sphingolipid homeostasis","volume":"221","author":"Bisinski","year":"2022","journal-title":"J. Cell Biol."},{"key":"2025120806214200100_JCS264026C13","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1146\/annurev-biochem-013118-111518","article-title":"Lysosomal glycosphingolipid storage diseases","volume":"88","author":"Breiden","year":"2019","journal-title":"Annu. Rev. Biochem."},{"key":"2025120806214200100_JCS264026C14","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1038\/nature08787","article-title":"Orm family proteins mediate sphingolipid homeostasis","volume":"463","author":"Breslow","year":"2010","journal-title":"Nature"},{"key":"2025120806214200100_JCS264026C15","doi-asserted-by":"publisher","first-page":"787","DOI":"10.3390\/jof9080787","article-title":"The yeast protein kinase Sch9 functions as a central nutrient-responsive hub that calibrates metabolic and stress-related responses","volume":"9","author":"Caligaris","year":"2023","journal-title":"J. Fungi"},{"key":"2025120806214200100_JCS264026C16","doi-asserted-by":"publisher","first-page":"e74602","DOI":"10.7554\/eLife.74602","article-title":"Systematic analysis of membrane contact sites in Saccharomyces cerevisiae uncovers modulators of cellular lipid distribution","volume":"11","author":"Castro","year":"2022","journal-title":"eLife"},{"key":"2025120806214200100_JCS264026C17","doi-asserted-by":"publisher","first-page":"132","DOI":"10.3389\/fgene.2017.00132","article-title":"Loss of sphingosine kinase alters life history traits and locomotor function in caenorhabditis elegans","volume":"8","author":"Chan","year":"2017","journal-title":"Front. Genet."},{"key":"2025120806214200100_JCS264026C18","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.cbpa.2021.08.002","article-title":"Synthetic probes and chemical tools in sphingolipid research","volume":"65","author":"Chen","year":"2021","journal-title":"Curr. Opin. Chem. Biol."},{"key":"2025120806214200100_JCS264026C19","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1007\/s12017-010-8132-8","article-title":"An introduction to sphingolipid metabolism and analysis by new technologies","volume":"12","author":"Chen","year":"2010","journal-title":"Neuromolecular Med."},{"key":"2025120806214200100_JCS264026C20","doi-asserted-by":"publisher","first-page":"17229","DOI":"10.1074\/jbc.C000229200","article-title":"Sphingolipids signal heat stress-induced ubiquitin-dependent proteolysis","volume":"275","author":"Chung","year":"2000","journal-title":"J. Biol. Chem."},{"key":"2025120806214200100_JCS264026C21","doi-asserted-by":"publisher","first-page":"35614","DOI":"10.1074\/jbc.M105653200","article-title":"Phytosphingosine as a specific inhibitor of growth and nutrient import in Saccharomyces cerevisiae","volume":"276","author":"Chung","year":"2001","journal-title":"J. Biol. Chem."},{"key":"2025120806214200100_JCS264026C22","doi-asserted-by":"publisher","first-page":"28872","DOI":"10.1074\/jbc.M300943200","article-title":"Sphingolipid requirement for generation of a functional V1 component of the vacuolar ATPase*","volume":"278","author":"Chung","year":"2003","journal-title":"J. Biol. Chem."},{"key":"2025120806214200100_JCS264026C23","doi-asserted-by":"publisher","first-page":"25152564231208250","DOI":"10.1177\/25152564231208250","article-title":"Mechanisms of nonvesicular ceramide transport","volume":"6","author":"Clausmeyer","year":"2023","journal-title":"Contact"},{"key":"2025120806214200100_JCS264026C24","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.bbalip.2006.08.005","article-title":"Yeast sphingolipids: recent developments in understanding biosynthesis, regulation, and function","volume":"1771","author":"Cowart","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"2025120806214200100_JCS264026C25","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1113\/JP275075","article-title":"Restoration of metabolic health by decreased consumption of branched-chain amino acids","volume":"596","author":"Cummings","year":"2018","journal-title":"J. Physiol."},{"key":"2025120806214200100_JCS264026C26","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.mad.2014.11.002","article-title":"Sphingolipid metabolism regulates development and lifespan in Caenorhabditis elegans","volume":"143-144","author":"Cutler","year":"2014","journal-title":"Mech. Ageing Dev."},{"key":"2025120806214200100_JCS264026C27","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.mce.2017.04.011","article-title":"Nutrition modulation of human aging: The calorie restriction paradigm","volume":"455","author":"Das","year":"2017","journal-title":"Mol. Cell. Endocrinol."},{"key":"2025120806214200100_JCS264026C28","doi-asserted-by":"publisher","first-page":"2612","DOI":"10.1007\/s00125-009-1482-9","article-title":"Link between plasma ceramides, inflammation and insulin resistance: association with serum IL-6 concentration in patients with coronary heart disease","volume":"52","author":"de Mello","year":"2009","journal-title":"Diabetologia"},{"key":"2025120806214200100_JCS264026C29","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1515\/hsz-2012-0119","article-title":"Mitophagy: mechanisms, pathophysiological roles, and analysis","volume":"393","author":"Ding","year":"2012","journal-title":"Biol. Chem."},{"key":"2025120806214200100_JCS264026C30","doi-asserted-by":"publisher","first-page":"15451","DOI":"10.1016\/S0021-9258(17)40700-9","article-title":"Cloning and characterization of LAG1, a longevity-assurance gene in yeast","volume":"269","author":"D'mello","year":"1994","journal-title":"J. Biol. Chem."},{"key":"2025120806214200100_JCS264026C31","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1042\/BST20220519","article-title":"Fundamental roles for inter-organelle communication in aging","volume":"50","author":"Donahue","year":"2022","journal-title":"Biochem. Soc. Trans."},{"key":"2025120806214200100_JCS264026C32","doi-asserted-by":"publisher","first-page":"100125","DOI":"10.1074\/jbc.RA120.015402","article-title":"A cell-nonautonomous mechanism of yeast chronological aging regulated by caloric restriction and one-carbon metabolism","volume":"296","author":"Enriquez-Hesles","year":"2021","journal-title":"J. Biol. Chem."},{"key":"2025120806214200100_JCS264026C33","doi-asserted-by":"publisher","first-page":"e1008745","DOI":"10.1371\/journal.pgen.1008745","article-title":"Uptake of exogenous serine is important to maintain sphingolipid homeostasis in Saccharomyces cerevisiae","volume":"16","author":"Esch","year":"2020","journal-title":"PLoS Genet."},{"key":"2025120806214200100_JCS264026C34","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1042\/BJ20031949","article-title":"Acyl-CoA-binding protein, Acb1p, is required for normal vacuole function and ceramide synthesis in Saccharomyces cerevisiae","volume":"380","author":"Faergeman","year":"2004","journal-title":"Biochem. J."},{"key":"2025120806214200100_JCS264026C35","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1534\/genetics.110.125567","article-title":"A genome-wide enhancer screen implicates sphingolipid composition in vacuolar ATPase function in saccharomyces cerevisiae","volume":"187","author":"Finnigan","year":"2011","journal-title":"Genetics"},{"key":"2025120806214200100_JCS264026C36","doi-asserted-by":"publisher","first-page":"2834","DOI":"10.1093\/emboj\/19.12.2834","article-title":"Increased protein kinase or decreased PP2A activity bypasses sphingoid base requirement in endocytosis","volume":"19","author":"Friant","year":"2000","journal-title":"EMBO J."},{"key":"2025120806214200100_JCS264026C37","doi-asserted-by":"publisher","first-page":"581","DOI":"10.3390\/cells9030581","article-title":"Sphingolipids and mitochondrial dynamic","volume":"9","author":"Fugio","year":"2020","journal-title":"Cells"},{"key":"2025120806214200100_JCS264026C38","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1083\/jcb.144.4.673","article-title":"Genetic evidence for ATP-dependent endoplasmic reticulum-to-Golgi apparatus trafficking of ceramide for sphingomyelin synthesis in Chinese hamster ovary cells","volume":"144","author":"Fukasawa","year":"1999","journal-title":"J. Cell Biol."},{"key":"2025120806214200100_JCS264026C39","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1038\/nrm1423","article-title":"The cell biology of lysosomal storage disorders","volume":"5","author":"Futerman","year":"2004","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2025120806214200100_JCS264026C40","doi-asserted-by":"publisher","first-page":"22515","DOI":"10.1074\/jbc.M413472200","article-title":"Synthesis of sphingolipids with very long chain fatty acids but not ergosterol is required for routing of newly synthesized plasma membrane ATPase to the cell surface of yeast *","volume":"280","author":"Gaigg","year":"2005","journal-title":"J. Biol. Chem."},{"key":"2025120806214200100_JCS264026C41","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1038\/s41586-019-1437-3","article-title":"Dietary methionine influences therapy in mouse cancer models and alters human metabolism","volume":"572","author":"Gao","year":"2019","journal-title":"Nature"},{"key":"2025120806214200100_JCS264026C42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-1-4419-6741-1_1","article-title":"An overview of sphingolipid metabolism: from synthesis to breakdown","volume":"688","author":"Gault","year":"2010","journal-title":"Adv. Exp. Med. Biol."},{"key":"2025120806214200100_JCS264026C43","doi-asserted-by":"publisher","first-page":"2475","DOI":"10.1007\/s00125-009-1546-x","article-title":"Ceramides: A new player in the inflammation\u2013insulin resistance paradigm?","volume":"52","author":"Gill","year":"2009","journal-title":"Diabetologia"},{"key":"2025120806214200100_JCS264026C44","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1021\/acschembio.2c00120","article-title":"Vacuole-specific lipid release for tracking intracellular lipid metabolism and transport in saccharomyces cerevisiae","volume":"17","author":"Girik","year":"2022","journal-title":"ACS Chem. Biol."},{"key":"2025120806214200100_JCS264026C45","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1007\/978-1-4419-6741-1_8","article-title":"Ceramide-1-phosphate in cell survival and inflammatory signaling","volume-title":"Sphingolipids as Signaling and Regulatory Molecules","author":"G\u00f3mez-Mu\u00f1oz","year":"2010"},{"key":"2025120806214200100_JCS264026C46","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.mad.2018.07.004","article-title":"Regulation of metabolic health by essential dietary amino acids","volume":"177","author":"Green","year":"2019","journal-title":"Mech. Ageing Dev."},{"key":"2025120806214200100_JCS264026C47","doi-asserted-by":"publisher","first-page":"5851","DOI":"10.1073\/pnas.0911617107","article-title":"Orm1 and Orm2 are conserved endoplasmic reticulum membrane proteins regulating lipid homeostasis and protein quality control","volume":"107","author":"Han","year":"2010","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2025120806214200100_JCS264026C48","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/s1388-1981(03)00059-3","article-title":"Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism","volume":"1632","author":"Hanada","year":"2003","journal-title":"Biochim. Biophys. Acta"},{"key":"2025120806214200100_JCS264026C49","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1038\/nature02188","article-title":"Molecular machinery for non-vesicular trafficking of ceramide","volume":"426","author":"Hanada","year":"2003","journal-title":"Nature"},{"key":"2025120806214200100_JCS264026C50","doi-asserted-by":"publisher","first-page":"RP89938","DOI":"10.7554\/eLife.89938.3","article-title":"Membrane contact sites regulate vacuolar fission via sphingolipid metabolism","volume":"12","author":"Hanaoka","year":"2024","journal-title":"eLife"},{"key":"2025120806214200100_JCS264026C51","doi-asserted-by":"crossref","first-page":"R163","DOI":"10.1016\/j.cub.2004.01.049","article-title":"Lipid metabolism: ceramide transfer protein adds a new dimension","volume":"14","author":"Hannun","year":"2004","journal-title":"Curr. Biol."},{"key":"2025120806214200100_JCS264026C52","doi-asserted-by":"publisher","first-page":"25847","DOI":"10.1074\/jbc.R200008200","article-title":"The Ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind","volume":"277","author":"Hannun","year":"2002","journal-title":"J. Biol. Chem."},{"key":"2025120806214200100_JCS264026C53","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1083\/jcb.201808119","article-title":"Mdm1 maintains endoplasmic reticulum homeostasis by spatially regulating lipid droplet biogenesis","volume":"218","author":"Hariri","year":"2019","journal-title":"J. Cell Biol."},{"key":"2025120806214200100_JCS264026C54","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1007\/s10495-015-1108-2","article-title":"Autophagy in the light of sphingolipid metabolism","volume":"20","author":"Harvald","year":"2015","journal-title":"Apoptosis"},{"key":"2025120806214200100_JCS264026C55","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1016\/j.bbalip.2010.05.003","article-title":"Roles for dysfunctional sphingolipid metabolism in Alzheimer's disease neuropathogenesis","volume":"1801","author":"Haughey","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"2025120806214200100_JCS264026C56","doi-asserted-by":"publisher","first-page":"3679","DOI":"10.1074\/jbc.M209170200","article-title":"The uracil transporter Fur4p associates with lipid rafts","volume":"278","author":"Hearn","year":"2003","journal-title":"J. Biol. Chem."},{"key":"2025120806214200100_JCS264026C57","doi-asserted-by":"publisher","first-page":"2023.09.18.557036","DOI":"10.1101\/2023.09.18.557036","article-title":"The sterol transporter STARD3 transports sphingosine at ER-lysosome contact sites","author":"Hempelmann","year":"2023","journal-title":"bioRxiv"},{"key":"2025120806214200100_JCS264026C58","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1083\/jcb.201503088","article-title":"Mdm1\/Snx13 is a novel ER-endolysosomal interorganelle tethering protein","volume":"210","author":"Henne","year":"2015","journal-title":"J. Cell Biol."},{"key":"2025120806214200100_JCS264026C59","doi-asserted-by":"publisher","first-page":"7846","DOI":"10.18632\/aging.202849","article-title":"Enhancing lifespan of budding yeast by pharmacological lowering of amino acid pools","volume":"13","author":"Hepowit","year":"2021","journal-title":"Aging"},{"key":"2025120806214200100_JCS264026C60","doi-asserted-by":"publisher","first-page":"472","DOI":"10.18632\/aging.204485","article-title":"Reduced sphingolipid biosynthesis modulates proteostasis networks to enhance longevity","volume":"15","author":"Hepowit","year":"2023","journal-title":"Aging"},{"key":"2025120806214200100_JCS264026C61","doi-asserted-by":"publisher","first-page":"jcs260675","DOI":"10.1242\/jcs.260675","article-title":"Art2 mediates selective endocytosis of methionine transporters during adaptation to sphingolipid depletion","volume":"136","author":"Hepowit","year":"2023","journal-title":"J. Cell Sci."},{"key":"2025120806214200100_JCS264026C62","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1152\/physrev.2001.81.4.1689","article-title":"The organizing potential of sphingolipids in intracellular membrane transport","volume":"81","author":"Holthuis","year":"2001","journal-title":"Physiol. Rev."},{"key":"2025120806214200100_JCS264026C63","doi-asserted-by":"publisher","first-page":"3687","DOI":"10.1002\/j.1460-2075.1994.tb06678.x","article-title":"Ceramide synthesis enhances transport of GPI-anchored proteins to the Golgi apparatus in yeast","volume":"13","author":"Horvath","year":"1994","journal-title":"EMBO J."},{"key":"2025120806214200100_JCS264026C64","doi-asserted-by":"publisher","first-page":"565316","DOI":"10.1155\/2011\/565316","article-title":"Apoptotic sphingolipid ceramide in cancer therapy","volume":"2011","author":"Huang","year":"2011","journal-title":"J. Lipids"},{"key":"2025120806214200100_JCS264026C65","doi-asserted-by":"publisher","first-page":"e1002493","DOI":"10.1371\/journal.pgen.1002493","article-title":"Down-regulating sphingolipid synthesis increases yeast lifespan","volume":"8","author":"Huang","year":"2012","journal-title":"PLoS Genet."},{"key":"2025120806214200100_JCS264026C66","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/j.bbalip.2013.08.006","article-title":"Sphingolipids and Lifespan Regulation","volume":"1841","author":"Huang","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"2025120806214200100_JCS264026C67","doi-asserted-by":"publisher","first-page":"539","DOI":"10.3389\/fcell.2020.00539","article-title":"Lipid rafts, sphingolipids, and ergosterol in yeast vacuole fusion and maturation","volume":"8","author":"Hurst","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"2025120806214200100_JCS264026C68","doi-asserted-by":"publisher","first-page":"e58246","DOI":"10.7554\/eLife.58246","article-title":"Complementary \u03b1-arrestin-ubiquitin ligase complexes control nutrient transporter endocytosis in response to amino acids","volume":"9","author":"Ivashov","year":"2020","journal-title":"eLife"},{"key":"2025120806214200100_JCS264026C69","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41419-017-0105-5","article-title":"Mitochondria-associated membranes in aging and senescence: structure, function, and dynamics","volume":"9","author":"Janikiewicz","year":"2018","journal-title":"Cell Death Dis."},{"key":"2025120806214200100_JCS264026C70","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1007\/s11064-007-9297-x","article-title":"Gene expression alterations in the sphingolipid metabolism pathways during progression of dementia and Alzheimer's disease: a shift toward ceramide accumulation at the earliest recognizable stages of Alzheimer's disease?","volume":"32","author":"Katsel","year":"2007","journal-title":"Neurochem. Res."},{"key":"2025120806214200100_JCS264026C71","doi-asserted-by":"publisher","first-page":"30279","DOI":"10.1074\/jbc.M605032200","article-title":"Efficient trafficking of ceramide from the endoplasmic reticulum to the golgi apparatus requires a VAMP-associated protein-interacting FFAT Motif of CERT *","volume":"281","author":"Kawano","year":"2006","journal-title":"J. Biol. Chem."},{"key":"2025120806214200100_JCS264026C72","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.plipres.2016.04.001","article-title":"Synthesis and degradation pathways, functions, and pathology of ceramides and epidermal acylceramides","volume":"63","author":"Kihara","year":"2016","journal-title":"Prog. Lipid Res."},{"key":"2025120806214200100_JCS264026C73","doi-asserted-by":"publisher","first-page":"105496","DOI":"10.1016\/j.jbc.2023.105496","article-title":"Intracellular sphingolipid sorting drives membrane phase separation in the yeast vacuole","volume":"300","author":"Kim","year":"2024","journal-title":"J. Biol. Chem."},{"key":"2025120806214200100_JCS264026C74","doi-asserted-by":"publisher","first-page":"e45890","DOI":"10.1371\/journal.pone.0045890","article-title":"ASM-3 acid sphingomyelinase functions as a positive regulator of the DAF-2\/AGE-1 signaling pathway and serves as a novel anti-aging target","volume":"7","author":"Kim","year":"2012","journal-title":"PLoS ONE"},{"key":"2025120806214200100_JCS264026C75","doi-asserted-by":"publisher","first-page":"2386","DOI":"10.1016\/j.neuron.2022.04.020","article-title":"Dysregulation of organelle membrane contact sites in neurological diseases","volume":"110","author":"Kim","year":"2022","journal-title":"Neuron"},{"key":"2025120806214200100_JCS264026C76","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1016\/j.cellsig.2007.12.006","article-title":"The sphingolipid salvage pathway in ceramide metabolism and signaling","volume":"20","author":"Kitatani","year":"2008","journal-title":"Cell. Signal."},{"key":"2025120806214200100_JCS264026C77","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1128\/mr.54.3.266-292.1990","article-title":"The fungal vacuole: composition, function, and biogenesis","volume":"54","author":"Klionsky","year":"1990","journal-title":"Microbiol. Rev."},{"key":"2025120806214200100_JCS264026C78","doi-asserted-by":"publisher","first-page":"2044","DOI":"10.1038\/cdd.2017.128","article-title":"Sphingolipid accumulation causes mitochondrial dysregulation and cell death","volume":"24","author":"Knupp","year":"2017","journal-title":"Cell Death Differ."},{"key":"2025120806214200100_JCS264026C79","doi-asserted-by":"publisher","first-page":"7832","DOI":"10.1038\/s41467-023-43550-2","article-title":"Early-adult methionine restriction reduces methionine sulfoxide and extends lifespan in Drosophila","volume":"14","author":"Kosakamoto","year":"2023","journal-title":"Nat. Commun."},{"key":"2025120806214200100_JCS264026C80","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1111\/acel.12266","article-title":"Methionine restriction slows down senescence in human diploid fibroblasts","volume":"13","author":"Kozie\u0142","year":"2014","journal-title":"Aging Cell"},{"key":"2025120806214200100_JCS264026C81","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/S2213-8587(19)30151-2","article-title":"2 years of calorie restriction and cardiometabolic risk (CALERIE): exploratory outcomes of a multicentre, phase 2, randomised controlled trial","volume":"7","author":"Kraus","year":"2019","journal-title":"Lancet Diabetes Endocrinol."},{"key":"2025120806214200100_JCS264026C82","doi-asserted-by":"publisher","first-page":"6920","DOI":"10.1523\/JNEUROSCI.20-18-06920.2000","article-title":"Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity","volume":"20","author":"Kruman","year":"2000","journal-title":"J. Neurosci."},{"key":"2025120806214200100_JCS264026C83","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1038\/s43587-022-00309-6","article-title":"Sphingolipids accumulate in aged muscle, and their reduction counteracts sarcopenia","volume":"2","author":"Laurila","year":"2022","journal-title":"Nat. Aging"},{"key":"2025120806214200100_JCS264026C84","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1096\/fj.201700300R","article-title":"Lipotoxic very-long-chain ceramides cause mitochondrial dysfunction, oxidative stress, and cell death in cardiomyocytes","volume":"32","author":"Law","year":"2018","journal-title":"FASEB J."},{"key":"2025120806214200100_JCS264026C85","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/s41556-018-0244-7","article-title":"The lysosome as a cellular centre for signalling, metabolism and quality control","volume":"21","author":"Lawrence","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"2025120806214200100_JCS264026C86","doi-asserted-by":"publisher","first-page":"22395","DOI":"10.1074\/jbc.M200450200","article-title":"Ceramide biosynthesis is required for the formation of the oligomeric H+-ATPase Pma1p in the yeast endoplasmic reticulum","volume":"277","author":"Lee","year":"2002","journal-title":"J. Biol. Chem."},{"key":"2025120806214200100_JCS264026C87","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1111\/nyas.12973","article-title":"Methionine restriction and life-span control","volume":"1363","author":"Lee","year":"2016","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"2025120806214200100_JCS264026C88","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1111\/acel.12238","article-title":"Methionine restriction restores a younger metabolic phenotype in adult mice with alterations in fibroblast growth factor 21","volume":"13","author":"Lees","year":"2014","journal-title":"Aging Cell"},{"key":"2025120806214200100_JCS264026C89","doi-asserted-by":"publisher","first-page":"5379","DOI":"10.1038\/s41467-025-60603-w","article-title":"Enhancing autophagy by redox regulation extends lifespan in Drosophila","volume":"16","author":"Lennicke","year":"2025","journal-title":"Nat. Commun."},{"key":"2025120806214200100_JCS264026C90","doi-asserted-by":"publisher","first-page":"15036","DOI":"10.1073\/pnas.93.26.15036","article-title":"Methionine residues as endogenous antioxidants in proteins","volume":"93","author":"Levine","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025120806214200100_JCS264026C91","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1016\/j.bbamcr.2008.08.003","article-title":"The yeast lysosome-like vacuole: endpoint and crossroads","volume":"1793","author":"Li","year":"2009","journal-title":"Biochim. Biophys. Acta (BBA)\u2013 Mol. Cell Res."},{"key":"2025120806214200100_JCS264026C92","doi-asserted-by":"publisher","first-page":"797320","DOI":"10.3389\/fragi.2021.797320","article-title":"Implications of sphingolipids on aging and age-related diseases","volume":"2","author":"Li","year":"2022","journal-title":"Front. Aging"},{"key":"2025120806214200100_JCS264026C93","doi-asserted-by":"publisher","first-page":"9531","DOI":"10.1021\/acs.jmedchem.2c00395","article-title":"Overview of methionine Adenosyltransferase 2A (MAT2A) as an anticancer target: structure, function, and inhibitors","volume":"65","author":"Li","year":"2022","journal-title":"J. Med. Chem."},{"key":"2025120806214200100_JCS264026C94","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1016\/j.cell.2008.09.025","article-title":"Arrestin-related ubiquitin-ligase adaptors regulate endocytosis and protein turnover at the cell surface","volume":"135","author":"Lin","year":"2008","journal-title":"Cell"},{"key":"2025120806214200100_JCS264026C95","doi-asserted-by":"publisher","first-page":"214","DOI":"10.3390\/cells11020214","article-title":"One-carbon metabolism: pulling the strings behind aging and neurodegeneration","volume":"11","author":"Lionaki","year":"2022","journal-title":"Cells"},{"key":"2025120806214200100_JCS264026C96","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1111\/acel.12107","article-title":"Reducing sphingolipid synthesis orchestrates global changes to extend yeast lifespan","volume":"12","author":"Liu","year":"2013","journal-title":"Aging Cell"},{"key":"2025120806214200100_JCS264026C97","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1083\/jcb.201606059","article-title":"An inducible ER\u2013Golgi tether facilitates ceramide transport to alleviate lipotoxicity","volume":"216","author":"Liu","year":"2016","journal-title":"J. Cell Biol."},{"key":"2025120806214200100_JCS264026C98","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1111\/acel.12338","article-title":"Interventions to slow aging in humans: are we ready?","volume":"14","author":"Longo","year":"2015","journal-title":"Aging Cell"},{"key":"2025120806214200100_JCS264026C99","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1016\/j.exger.2008.06.014","article-title":"Mitochondrial biogenesis and healthy aging","volume":"43","author":"L\u00f3pez-Lluch","year":"2008","journal-title":"Exp. Gerontol."},{"key":"2025120806214200100_JCS264026C100","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1096\/fj.08-118414","article-title":"Methionine in proteins defends against oxidative stress","volume":"23","author":"Luo","year":"2009","journal-title":"FASEB J."},{"key":"2025120806214200100_JCS264026C101","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1016\/j.cell.2011.09.054","article-title":"TORC1 regulates endocytosis via Npr1-mediated phosphoinhibition of a ubiquitin ligase adaptor","volume":"147","author":"MacGurn","year":"2011","journal-title":"Cell"},{"key":"2025120806214200100_JCS264026C102","doi-asserted-by":"publisher","first-page":"4436","DOI":"10.1038\/sj.emboj.7601330","article-title":"Substrate\u2013mediated remodeling of methionine transport by multiple ubiquitin\u2013dependent mechanisms in yeast cells","volume":"25","author":"Menant","year":"2006","journal-title":"EMBO J."},{"key":"2025120806214200100_JCS264026C103","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1126\/science.1168532","article-title":"Protection of C. elegans from anoxia by HYL-2 ceramide synthase","volume":"324","author":"Menuz","year":"2009","journal-title":"Science"},{"key":"2025120806214200100_JCS264026C104","doi-asserted-by":"publisher","first-page":"25843","DOI":"10.1074\/jbc.R200009200","article-title":"De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway","volume":"277","author":"Merrill","year":"2002","journal-title":"J. Biol. Chem."},{"key":"2025120806214200100_JCS264026C105","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1007\/s12017-010-8121-y","article-title":"Alterations of the sphingolipid pathway in Alzheimer's disease: new biomarkers and treatment targets?","volume":"12","author":"Mielke","year":"2010","journal-title":"Neuromolecular Med."},{"key":"2025120806214200100_JCS264026C106","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1016\/j.cmet.2023.06.008","article-title":"When a calorie is not just a calorie: Diet quality and timing as mediators of metabolism and healthy aging","volume":"35","author":"Mihaylova","year":"2023","journal-title":"Cell Metab."},{"key":"2025120806214200100_JCS264026C107","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.phrs.2010.09.007","article-title":"(R)-\u03b1-Lipoic acid treatment restores ceramide balance in aging rat cardiac mitochondria","volume":"63","author":"Monette","year":"2011","journal-title":"Pharmacol. Res."},{"key":"2025120806214200100_JCS264026C108","doi-asserted-by":"publisher","first-page":"e70087","DOI":"10.1371\/journal.pone.0070087","article-title":"Functional loss of two ceramide synthases elicits autophagy-dependent lifespan extension in C. elegans","volume":"8","author":"Mosbech","year":"2013","journal-title":"PLoS ONE"},{"key":"2025120806214200100_JCS264026C109","doi-asserted-by":"publisher","first-page":"e03779","DOI":"10.7554\/eLife.03779","article-title":"TORC2-dependent protein kinase Ypk1 phosphorylates ceramide synthase to stimulate synthesis of complex sphingolipids","volume":"3","author":"Muir","year":"2014","journal-title":"eLife"},{"key":"2025120806214200100_JCS264026C110","doi-asserted-by":"publisher","first-page":"7899","DOI":"10.1073\/pnas.91.17.7899","article-title":"The LCB2 gene of Saccharomyces and the related LCB1 gene encode subunits of serine palmitoyltransferase, the initial enzyme in sphingolipid synthesis","volume":"91","author":"Nagiec","year":"1994","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2025120806214200100_JCS264026C111","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1038\/nrm2708","article-title":"Dynamics and diversity in autophagy mechanisms: lessons from yeast","volume":"10","author":"Nakatogawa","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2025120806214200100_JCS264026C112","doi-asserted-by":"publisher","first-page":"R741","DOI":"10.1016\/j.cub.2012.07.024","article-title":"Ageing as a risk factor for disease","volume":"22","author":"Niccoli","year":"2012","journal-title":"Curr. Biol."},{"key":"2025120806214200100_JCS264026C113","doi-asserted-by":"publisher","first-page":"1856","DOI":"10.1111\/j.1600-0854.2009.00990.x","article-title":"Arrestin-mediated endocytosis of yeast plasma membrane transporters","volume":"10","author":"Nikko","year":"2009","journal-title":"Traffic"},{"key":"2025120806214200100_JCS264026C114","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1023\/a:1007675508413","article-title":"The endosomal-lysosomal system of neurons in Alzheimer's disease pathogenesis: a review","volume":"25","author":"Nixon","year":"2000","journal-title":"Neurochem. Res."},{"key":"2025120806214200100_JCS264026C115","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1002\/1873-3468.14808","article-title":"Lipid droplets and fatty acid-induced lipotoxicity: in a nutshell","volume":"598","author":"Obaseki","year":"2024","journal-title":"FEBS Lett."},{"key":"2025120806214200100_JCS264026C116","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.1126\/science.8456305","article-title":"Programmed cell death induced by ceramide","volume":"259","author":"Obeid","year":"1993","journal-title":"Science"},{"key":"2025120806214200100_JCS264026C117","doi-asserted-by":"publisher","first-page":"2053","DOI":"10.1007\/PL00000836","article-title":"Sphingolipids in mammalian cell signalling","volume":"58","author":"Ohanian","year":"2001","journal-title":"Cell. Mol. Life Sci."},{"key":"2025120806214200100_JCS264026C118","doi-asserted-by":"publisher","first-page":"18439","DOI":"10.1073\/pnas.1005572107","article-title":"ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis","volume":"107","author":"Ohno","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025120806214200100_JCS264026C119","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1093\/jn\/123.2.269","article-title":"Low methionine ingestion by rats extends life span","volume":"123","author":"Orentreich","year":"1993","journal-title":"J. Nutr."},{"key":"2025120806214200100_JCS264026C120","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.arr.2018.10.010","article-title":"Homocysteine and age-associated disorders","volume":"49","author":"Ostrakhovitch","year":"2019","journal-title":"Ageing Res. Rev."},{"key":"2025120806214200100_JCS264026C121","doi-asserted-by":"publisher","first-page":"3632","DOI":"10.1002\/1873-3468.13863","article-title":"The role of sphingolipids in endoplasmic reticulum stress","volume":"594","author":"Park","year":"2020","journal-title":"FEBS Lett."},{"key":"2025120806214200100_JCS264026C122","doi-asserted-by":"publisher","first-page":"e13034","DOI":"10.1111\/acel.13034","article-title":"Methionine metabolism and methyltransferases in the regulation of aging and lifespan extension across species","volume":"18","author":"Parkhitko","year":"2019","journal-title":"Aging Cell"},{"key":"2025120806214200100_JCS264026C123","doi-asserted-by":"publisher","first-page":"e2110387118","DOI":"10.1073\/pnas.2110387118","article-title":"A genetic model of methionine restriction extends Drosophila health- and lifespan","volume":"118","author":"Parkhitko","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025120806214200100_JCS264026C124","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1007\/s10863-015-9602-3","article-title":"Sphingolipids and mitochondrial apoptosis","volume":"48","author":"Patwardhan","year":"2016","journal-title":"J. Bioenerg. Biomembr."},{"key":"2025120806214200100_JCS264026C125","doi-asserted-by":"publisher","first-page":"826688","DOI":"10.3389\/fcell.2022.826688","article-title":"Structural predictions of the SNX-RGS proteins suggest they belong to a new class of lipid transfer proteins","volume":"10","author":"Paul","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"2025120806214200100_JCS264026C126","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1146\/annurev-cellbio-111315-125125","article-title":"The lysosome as a regulatory hub","volume":"32","author":"Perera","year":"2016","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"2025120806214200100_JCS264026C127","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1083\/jcb.201708068","article-title":"Sphingolipids activate the endoplasmic reticulum stress surveillance pathway","volume":"217","author":"Pi\u00f1a","year":"2018","journal-title":"J. Cell Biol."},{"key":"2025120806214200100_JCS264026C128","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1083\/jcb.201208152","article-title":"Lysosomal storage disorders: the cellular impact of lysosomal dysfunction","volume":"199","author":"Platt","year":"2012","journal-title":"J. Cell Biol."},{"key":"2025120806214200100_JCS264026C129","doi-asserted-by":"publisher","first-page":"3531-3531","DOI":"10.4161\/cc.22041","article-title":"Chronological and replicative lifespan in yeast: do they meet in the middle?","volume":"11","author":"Polymenis","year":"2012","journal-title":"Cell Cycle"},{"key":"2025120806214200100_JCS264026C130","doi-asserted-by":"publisher","first-page":"178910","DOI":"10.1155\/2013\/178910","article-title":"Sphingolipid metabolic pathway: an overview of major roles played in human diseases","volume":"2013","author":"Pralhada Rao","year":"2013","journal-title":"J. Lipids"},{"key":"2025120806214200100_JCS264026C131","doi-asserted-by":"publisher","first-page":"5793","DOI":"10.3390\/ijms22115793","article-title":"A comprehensive review: sphingolipid metabolism and implications of disruption in sphingolipid homeostasis","volume":"22","author":"Quinville","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"2025120806214200100_JCS264026C132","doi-asserted-by":"publisher","first-page":"ar117","DOI":"10.1091\/mbc.E24-03-0121","article-title":"Dysregulation of ceramide metabolism causes phytoceramide-dependent induction of the unfolded protein response","volume":"35","author":"Rajakumar","year":"2024","journal-title":"Mol. Biol. Cell"},{"key":"2025120806214200100_JCS264026C133","doi-asserted-by":"publisher","first-page":"11364","DOI":"10.1073\/pnas.0705049104","article-title":"Ceramide transfer protein function is essential for normal oxidative stress response and lifespan","volume":"104","author":"Rao","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025120806214200100_JCS264026C134","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1079\/BJN20041116","article-title":"Effect of a methionine-supplemented diet on the blood pressure of Sprague-Dawley and deoxycorticosterone acetate-salt hypertensive rats","volume":"91","author":"Robin","year":"2004","journal-title":"Br. J. Nutr."},{"key":"2025120806214200100_JCS264026C135","doi-asserted-by":"publisher","first-page":"e1004347","DOI":"10.1371\/journal.pgen.1004347","article-title":"Lifespan extension by methionine restriction requires autophagy-dependent vacuolar acidification","volume":"10","author":"Ruckenstuhl","year":"2014","journal-title":"PLoS Genet."},{"key":"2025120806214200100_JCS264026C136","doi-asserted-by":"publisher","first-page":"17887","DOI":"10.1021\/jacs.0c06652","article-title":"A Small Molecule Fluorogenic Probe for the Detection of Sphingosine in Living Cells","volume":"142","author":"Rudd","year":"2020","journal-title":"J. Am. Chem. Soc."},{"key":"2025120806214200100_JCS264026C137","doi-asserted-by":"publisher","first-page":"138","DOI":"10.4161\/cbt.11.2.14624","article-title":"Dysregulation of sphingolipid metabolism in cancer","volume":"11","author":"Ryland","year":"2011","journal-title":"Cancer Biol. Ther."},{"key":"2025120806214200100_JCS264026C138","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1016\/j.molcel.2009.10.021","article-title":"GM1-Ganglioside accumulation at the mitochondria-associated ER membranes links er stress to Ca2+-dependent mitochondrial apoptosis","volume":"36","author":"Sano","year":"2009","journal-title":"Mol. Cell"},{"key":"2025120806214200100_JCS264026C139","doi-asserted-by":"publisher","first-page":"39793","DOI":"10.1074\/jbc.M007721200","article-title":"Identification of ISC1 (YER019w) as inositol phosphosphingolipid phospholipase C in Saccharomyces cerevisiae","volume":"275","author":"Sawai","year":"2000","journal-title":"J. Biol. Chem."},{"key":"2025120806214200100_JCS264026C140","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1111\/bph.14446","article-title":"Regulators of the transsulfuration pathway","volume":"176","author":"Sbodio","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"2025120806214200100_JCS264026C141","doi-asserted-by":"publisher","first-page":"971","DOI":"10.3390\/membranes11120971","article-title":"Membrane contact sites in yeast: control hubs of sphingolipid homeostasis","volume":"11","author":"Schlarmann","year":"2021","journal-title":"Membranes"},{"key":"2025120806214200100_JCS264026C142","doi-asserted-by":"publisher","first-page":"e101433","DOI":"10.15252\/embj.2018101433","article-title":"Endosome and Golgi\u2013associated degradation (EGAD) of membrane proteins regulates sphingolipid metabolism","volume":"38","author":"Schmidt","year":"2019","journal-title":"EMBO J."},{"key":"2025120806214200100_JCS264026C143","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1083\/jcb.200907074","article-title":"Membrane expansion alleviates endoplasmic reticulum stress independently of the unfolded protein response","volume":"187","author":"Schuck","year":"2009","journal-title":"J. Cell Biol."},{"key":"2025120806214200100_JCS264026C144","doi-asserted-by":"publisher","first-page":"42446","DOI":"10.1074\/jbc.M111.287383","article-title":"Alteration of ceramide synthase 6\/C16-ceramide induces activating transcription factor 6-mediated endoplasmic reticulum (ER) stress and apoptosis via perturbation of cellular Ca2+ and ER\/Golgi membrane network","volume":"286","author":"Senkal","year":"2011","journal-title":"J. Biol. Chem."},{"key":"2025120806214200100_JCS264026C145","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1016\/j.cmet.2017.02.010","article-title":"Ceramide Is Metabolized to Acylceramide and Stored in Lipid Droplets","volume":"25","author":"Senkal","year":"2017","journal-title":"Cell Metab."},{"key":"2025120806214200100_JCS264026C146","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1091\/mbc.e12-10-0753","article-title":"TORC1-regulated protein kinase Npr1 phosphorylates Orm to stimulate complex sphingolipid synthesis","volume":"24","author":"Shimobayashi","year":"2013","journal-title":"MBoC"},{"key":"2025120806214200100_JCS264026C147","doi-asserted-by":"publisher","first-page":"2712","DOI":"10.1091\/mbc.e17-05-0335","article-title":"Sphingolipids facilitate age asymmetry of membrane proteins in dividing yeast cells","volume":"28","author":"Singh","year":"2017","journal-title":"MBoC"},{"key":"2025120806214200100_JCS264026C148","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1128\/jb.179.5.1513-1520.1997","article-title":"Suppressor gene analysis reveals an essential role for sphingolipids in transport of glycosylphosphatidylinositol-anchored proteins in Saccharomyces cerevisiae","volume":"179","author":"Skrzypek","year":"1997","journal-title":"J. Bacteriol."},{"key":"2025120806214200100_JCS264026C149","doi-asserted-by":"publisher","first-page":"e12244","DOI":"10.1371\/journal.pone.0012244","article-title":"Homocysteine-lowering by B Vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial","volume":"5","author":"Smith","year":"2010","journal-title":"PLoS ONE"},{"key":"2025120806214200100_JCS264026C150","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1146\/annurev-biochem-060815-014422","article-title":"Dietary protein, metabolism, and aging","volume":"85","author":"Soultoukis","year":"2016","journal-title":"Annu. Rev. Biochem."},{"key":"2025120806214200100_JCS264026C151","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1111\/j.1474-9726.2008.00385.x","article-title":"Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in C. elegans","volume":"7","author":"Steinkraus","year":"2008","journal-title":"Aging Cell"},{"key":"2025120806214200100_JCS264026C152","doi-asserted-by":"publisher","first-page":"9998","DOI":"10.1073\/pnas.1217775110","article-title":"Sulfatides are required for renal adaptation to chronic metabolic acidosis","volume":"110","author":"Stettner","year":"2013","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2025120806214200100_JCS264026C153","doi-asserted-by":"publisher","first-page":"2701","DOI":"10.1194\/jlr.M700356-JLR200","article-title":"Anionic lipids activate group IVA cytosolic phospholipase A2 via distinct and separate mechanisms","volume":"48","author":"Subramanian","year":"2007","journal-title":"J. Lipid Res."},{"key":"2025120806214200100_JCS264026C154","doi-asserted-by":"publisher","first-page":"311","DOI":"10.2174\/1568005043340597","article-title":"IPC synthase as a useful target for antifungal drugs","volume":"4","author":"Sugimoto","year":"2004","journal-title":"Curr. Drug Targets Infect Disord."},{"key":"2025120806214200100_JCS264026C155","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1194\/jlr.R026682","article-title":"Role of sulfatide in normal and pathological cells and tissues","volume":"53","author":"Takahashi","year":"2012","journal-title":"J. Lipid Res."},{"key":"2025120806214200100_JCS264026C156","doi-asserted-by":"publisher","first-page":"102118","DOI":"10.1016\/j.jbc.2022.102118","article-title":"Regulation of the lysosome by sphingolipids: potential role in aging","volume":"298","author":"Tang","year":"2022","journal-title":"J. Biol. Chem."},{"key":"2025120806214200100_JCS264026C157","doi-asserted-by":"publisher","first-page":"2369","DOI":"10.1099\/mic.0.000187","article-title":"Alteration of complex sphingolipid composition and its physiological significance in yeast Saccharomyces cerevisiae lacking vacuolar ATPase","volume":"161","author":"Tani","year":"2015","journal-title":"Microbiology (Read.)"},{"key":"2025120806214200100_JCS264026C158","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/s11357-008-9046-3","article-title":"Genetic analysis of hyl-1, the C. elegans homolog of LAG1\/LASS1","volume":"30","author":"Tedesco","year":"2008","journal-title":"Age (Dordr)"},{"key":"2025120806214200100_JCS264026C159","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.bbalip.2015.10.004","article-title":"Ceramide signaling targets the PP2A-like protein phosphatase Sit4p to impair vacuolar function, vesicular trafficking and autophagy in Isc1p deficient cells","volume":"1861","author":"Teixeira","year":"2016","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"2025120806214200100_JCS264026C160","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/s41514-023-00125-1","article-title":"SAM, SAH and C. elegans longevity: insights from a partial AHCY deficiency model","volume":"9","author":"Thapa","year":"2023","journal-title":"npj Aging"},{"key":"2025120806214200100_JCS264026C161","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/j.ajhg.2014.10.007","article-title":"Mutations in SNX14 cause a distinctive autosomal-recessive cerebellar ataxia and intellectual disability syndrome","volume":"95","author":"Thomas","year":"2014","journal-title":"Am. J. Hum. Genet."},{"key":"2025120806214200100_JCS264026C162","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1111\/acel.12025","article-title":"A metabolic signature predicts biological age in mice","volume":"12","author":"Tom\u00e1s-Loba","year":"2013","journal-title":"Aging Cell"},{"key":"2025120806214200100_JCS264026C163","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1083\/jcb.201301039","article-title":"Direct imaging reveals stable, micrometer-scale lipid domains that segregate proteins in live cells","volume":"202","author":"Toulmay","year":"2013","journal-title":"J. Cell Biol."},{"key":"2025120806214200100_JCS264026C164","doi-asserted-by":"publisher","first-page":"2702","DOI":"10.1172\/JCI97949","article-title":"Role of sphingolipids in senescence: implication in aging and age-related diseases","volume":"128","author":"Trayssac","year":"2018","journal-title":"J. Clin. Invest."},{"key":"2025120806214200100_JCS264026C165","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1042\/BST20180120","article-title":"Lipids and lipid domains of the yeast vacuole","volume":"46","author":"Tsuji","year":"2018","journal-title":"Biochem. Soc. Trans."},{"key":"2025120806214200100_JCS264026C166","doi-asserted-by":"publisher","first-page":"16880","DOI":"10.1016\/S0021-9258(17)44844-7","article-title":"1,2-Diacylglycerol and ceramide levels in insulin-resistant tissues of the rat in vivo","volume":"265","author":"Turinsky","year":"1990","journal-title":"J. Biol. Chem."},{"key":"2025120806214200100_JCS264026C167","doi-asserted-by":"publisher","first-page":"109076","DOI":"10.1016\/j.celrep.2021.109076","article-title":"Aging-dependent mitochondrial dysfunction mediated by ceramide signaling inhibits antitumor T cell response","volume":"35","author":"Vaena","year":"2021","journal-title":"Cell Rep."},{"key":"2025120806214200100_JCS264026C168","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1038\/sj.emboj.7600562","article-title":"Lip1p: a novel subunit of acyl-CoA ceramide synthase","volume":"24","author":"Vall\u00e9e","year":"2005","journal-title":"EMBO J."},{"key":"2025120806214200100_JCS264026C169","author":"Varki","year":"2015","journal-title":"Essentials of Glycobiology"},{"key":"2025120806214200100_JCS264026C170","doi-asserted-by":"publisher","first-page":"3878","DOI":"10.1242\/jcs.207910","article-title":"Pib2 and the EGO complex are both required for activation of TORC1","volume":"130","author":"Varlakhanova","year":"2017","journal-title":"J. Cell Sci."},{"key":"2025120806214200100_JCS264026C171","doi-asserted-by":"publisher","first-page":"jcs260554","DOI":"10.1242\/jcs.260554","article-title":"Lsp1 partially substitutes for Pil1 function in eisosome assembly under stress conditions","volume":"136","author":"Vesela","year":"2023","journal-title":"J. Cell Sci."},{"key":"2025120806214200100_JCS264026C172","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1042\/BJ20120712","article-title":"A novel pathway of ceramide metabolism in Saccharomyces cerevisiae","volume":"447","author":"Voynova","year":"2012","journal-title":"Biochem. J."},{"key":"2025120806214200100_JCS264026C173","doi-asserted-by":"publisher","first-page":"4946","DOI":"10.1038\/sj.emboj.7601933","article-title":"Pkh\u2013kinases control eisosome assembly and organization","volume":"26","author":"Walther","year":"2007","journal-title":"EMBO J."},{"key":"2025120806214200100_JCS264026C174","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1083\/jcb.201404115","article-title":"A sterol-enriched vacuolar microdomain mediates stationary phase lipophagy in budding yeast","volume":"206","author":"Wang","year":"2014","journal-title":"J. Cell Biol."},{"key":"2025120806214200100_JCS264026C175","doi-asserted-by":"publisher","first-page":"5073","DOI":"10.1038\/s41467-021-25398-6","article-title":"Saturated very long chain fatty acid configures glycosphingolipid for lysosome homeostasis in long-lived C. elegans","volume":"12","author":"Wang","year":"2021","journal-title":"Nat. Commun."},{"key":"2025120806214200100_JCS264026C176","doi-asserted-by":"publisher","first-page":"1381889","DOI":"10.3389\/fnins.2024.1381889","article-title":"Systems genetics identifies methionine as a high risk factor for Alzheimer's disease","volume":"18","author":"Wang","year":"2024","journal-title":"Front. Neurosci."},{"key":"2025120806214200100_JCS264026C177","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1002\/2211-5463.13605","article-title":"Glycosphingolipids within membrane contact sites influence their function as signaling hubs in neurodegenerative diseases","volume":"13","author":"Weesner","year":"2023","journal-title":"FEBS Open Biol."},{"key":"2025120806214200100_JCS264026C178","doi-asserted-by":"publisher","first-page":"RP90522","DOI":"10.7554\/eLife.90522","article-title":"Inhibition of CERS1 in skeletal muscle exacerbates age-related muscle dysfunction","volume":"12","author":"Wohlwend","year":"2024","journal-title":"eLife"},{"key":"2025120806214200100_JCS264026C179","doi-asserted-by":"publisher","first-page":"e114889","DOI":"10.15252\/embj.2023114889","article-title":"Structure and mechanism of a eukaryotic ceramide synthase complex","volume":"42","author":"Xie","year":"2023","journal-title":"EMBO J."},{"key":"2025120806214200100_JCS264026C180","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.tibs.2024.12.009","article-title":"Mechanisms and rationales of SAM homeostasis","volume":"50","author":"Xing","year":"2025","journal-title":"Trends Biochem. Sci."},{"key":"2025120806214200100_JCS264026C181","doi-asserted-by":"publisher","first-page":"e202102001","DOI":"10.1083\/jcb.202102001","article-title":"Lysosome biogenesis: regulation and functions","volume":"220","author":"Yang","year":"2021","journal-title":"J. Cell Biol."},{"key":"2025120806214200100_JCS264026C182","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1007\/s00018-010-0260-7","article-title":"Role of Drosophila alkaline ceramidase (Dacer) in Drosophila development and longevity","volume":"67","author":"Yang","year":"2010","journal-title":"Cell. Mol. Life Sci."},{"key":"2025120806214200100_JCS264026C183","doi-asserted-by":"publisher","first-page":"21124","DOI":"10.18632\/oncotarget.8195","article-title":"Aging-related elevation of sphingoid bases shortens yeast chronological life span by compromising mitochondrial function","volume":"7","author":"Yi","year":"2016","journal-title":"Oncotarget"},{"key":"2025120806214200100_JCS264026C184","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1111\/j.1474-9726.2012.00865.x","article-title":"Human serum metabolic profiles are age dependent","volume":"11","author":"Yu","year":"2012","journal-title":"Aging Cell"},{"key":"2025120806214200100_JCS264026C185","doi-asserted-by":"publisher","first-page":"e01961","DOI":"10.1128\/spectrum.01961-22","article-title":"Microdomain protein Nce102 is a local sensor of plasma membrane sphingolipid balance","volume":"10","author":"Zahumensk\u00fd","year":"2022","journal-title":"Microbiol. Spectrum"},{"key":"2025120806214200100_JCS264026C186","doi-asserted-by":"publisher","first-page":"2824","DOI":"10.1093\/emboj\/19.12.2824","article-title":"Sphingoid base synthesis requirement for endocytosis in Saccharomyces cerevisiae","volume":"19","author":"Zanolari","year":"2000","journal-title":"EMBO J."},{"key":"2025120806214200100_JCS264026C187","doi-asserted-by":"publisher","first-page":"eaba1306","DOI":"10.1126\/sciadv.aba1306","article-title":"Life span extension by glucose restriction is abrogated by methionine supplementation: Cross-talk between glucose and methionine and implication of methionine as a key regulator of life span","volume":"6","author":"Zou","year":"2020","journal-title":"Sci. Adv."}],"container-title":["Journal of Cell Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/jcs\/article-pdf\/doi\/10.1242\/jcs.264026\/3673366\/jcs264026.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/jcs\/article-pdf\/doi\/10.1242\/jcs.264026\/3673366\/jcs264026.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T11:21:49Z","timestamp":1765192909000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/jcs\/article\/138\/21\/jcs264026\/369826\/Sphingolipid-and-methionine-metabolism-in-aging"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,1]]},"references-count":187,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2025,11,1]]}},"URL":"https:\/\/doi.org\/10.1242\/jcs.264026","relation":{},"ISSN":["0021-9533","1477-9137"],"issn-type":[{"value":"0021-9533","type":"print"},{"value":"1477-9137","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,1]]},"article-number":"jcs264026"}}