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Emerging data from both Mendelian and idiopathic forms of Parkinson's disease and parkinsonism syndromes supports a role for key players in CME in determining the risk of developing these neurodegenerative disorders. This Perspective summarizes the current genetic and functional evidence supporting a role for CME in Parkinson's disease, suggesting routes through which CME dysfunction could contribute to the etiopathogenesis of this disorder, and discussing the therapeutic potential for targeting CME in the context of neurodegeneration linked to Parkinson's disease and parkinsonism.<\/jats:p>","DOI":"10.1242\/jcs.264368","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T12:02:51Z","timestamp":1773144171000},"source":"Crossref","is-referenced-by-count":0,"title":["Clathrin-mediated endocytosis as an axis for the etiopathogenesis of Parkinson's disease"],"prefix":"10.1242","volume":"139","author":[{"given":"Amal","family":"Kaci","sequence":"first","affiliation":[{"name":"The Royal Veterinary College, Royal College Street 1 , Camden Town, NW1 0TU ,","place":["UK"]},{"name":"UCL School of Pharmacy 2 , Brunswick Square, London, WC1N 1AX ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Herbst","sequence":"additional","affiliation":[{"name":"The Royal Veterinary College, Royal College Street 1 , Camden Town, NW1 0TU ,","place":["UK"]},{"name":"Queen Square UCL Institute of Neurology 3 , Queen Square, London, WC1N 3BG ,","place":["UK"]},{"name":"Aligning Science Across Parkinson's (ASAP) Collaborative Research Network 4 , Chevy Chase, MD 20815 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Manzoni","sequence":"additional","affiliation":[{"name":"UCL School of Pharmacy 2 , Brunswick Square, London, WC1N 1AX ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4537-0489","authenticated-orcid":false,"given":"Patrick A.","family":"Lewis","sequence":"additional","affiliation":[{"name":"The Royal Veterinary College, Royal College Street 1 , Camden Town, NW1 0TU ,","place":["UK"]},{"name":"Queen Square UCL Institute of Neurology 3 , Queen Square, London, WC1N 3BG ,","place":["UK"]},{"name":"Aligning Science Across Parkinson's (ASAP) Collaborative Research Network 4 , Chevy Chase, MD 20815 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"key":"2026031008024595700_JCS264368C1","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.1093\/brain\/awae020","article-title":"Neurodevelopmental and synaptic defects in DNAJC6 parkinsonism, amenable to gene therapy","volume":"147","author":"Abela","year":"2024","journal-title":"Brain"},{"key":"2026031008024595700_JCS264368C2","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1016\/0092-8674(78)90276-3","article-title":"Immunocytochemical visualization of coated pits and vesicles in human fibroblasts: relation to low density lipoprotein receptor distribution","volume":"15","author":"Anderson","year":"1978","journal-title":"Cell"},{"key":"2026031008024595700_JCS264368C3","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.1016\/j.neuron.2023.02.001","article-title":"EndophilinA-dependent coupling between activity-induced calcium influx and synaptic autophagy is disrupted by a Parkinson-risk mutation","volume":"111","author":"Bademosi","year":"2023","journal-title":"Neuron"},{"key":"2026031008024595700_JCS264368C4","doi-asserted-by":"publisher","first-page":"ENEURO.0448-19.2020","DOI":"10.1523\/ENEURO.0448-19.2020","article-title":"Hsc70 ameliorates the vesicle recycling defects caused by excess alpha-synuclein at synapses","volume":"7","author":"Banks","year":"2020","journal-title":"eNeuro"},{"key":"2026031008024595700_JCS264368C5","doi-asserted-by":"publisher","first-page":"2626","DOI":"10.1073\/pnas.1318306111","article-title":"Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease","volume":"111","author":"Beilina","year":"2014","journal-title":"Proc. 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