{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T07:09:25Z","timestamp":1777100965759,"version":"3.51.4"},"reference-count":80,"publisher":"The Company of Biologists","issue":"19","license":[{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"crossref","award":["1184885"],"award-info":[{"award-number":["1184885"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"crossref","award":["2009551"],"award-info":[{"award-number":["2009551"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"crossref","award":["1194406"],"award-info":[{"award-number":["1194406"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"crossref","award":["2027755"],"award-info":[{"award-number":["2027755"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"crossref","award":["DP230102124"],"award-info":[{"award-number":["DP230102124"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"crossref","award":["FT220100487"],"award-info":[{"award-number":["FT220100487"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Australian Infectious Disease Research Centre"},{"DOI":"10.13039\/501100001794","name":"The University of Queensland","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001794","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Histone deacetylase 7 (HDAC7) drives several immunometabolism-related processes in macrophages including lipopolysaccharide (LPS)-inducible glycolysis and inflammatory mediator production. Using an advanced biotin ligase TurboID system in human macrophages, we report 104 candidate HDAC7 interaction partners that might contribute to its immunometabolic functions. One such protein is the mitochondrial fission-promoting GTPase dynamin-related protein 1 (DRP1, also known as DNM1L), which associates with HDAC7 in cells. Using gain- and loss-of-function genetic approaches, we show that HDAC7 promotes LPS-inducible mitochondrial fission in macrophages, as well as DRP1-dependent metabolic and inflammatory responses. HDAC7 enzymatic activity was dispensable for LPS-inducible fission, as previously reported for LPS-inducible glycolysis. However, a pharmacological inhibitor of HDAC7 attenuated fission in primary human and mouse macrophages, implicating its acetyl-lysine docking function in this response. HDAC7 thus drives inducible mitochondrial fission in macrophages. Small molecules targeting the acetyl-lysine docking function of HDAC7 might have applications in preventing pathological processes driven by dysregulated mitochondrial fission.<\/jats:p>","DOI":"10.1242\/jcs.264376","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T07:49:48Z","timestamp":1756712988000},"source":"Crossref","is-referenced-by-count":3,"title":["Histone deacetylase 7 mediates lipopolysaccharide-inducible mitochondrial fission in macrophages"],"prefix":"10.1242","volume":"138","author":[{"given":"Rishika","family":"Abrol","sequence":"first","affiliation":[{"name":", The University of Queensland 1 Institute for Molecular Bioscience , Brisbane, QLD 4072 ,","place":["Australia"]},{"name":", The University of Queensland 2 Australian Infectious Diseases Research Centre , Brisbane, QLD 4072 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syeda Farhana","family":"Afroz","sequence":"additional","affiliation":[{"name":", The University of Queensland 1 Institute for Molecular Bioscience , Brisbane, QLD 4072 ,","place":["Australia"]},{"name":", The University of Queensland 2 Australian Infectious Diseases Research Centre , Brisbane, QLD 4072 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James E. B.","family":"Curson","sequence":"additional","affiliation":[{"name":", The University of Queensland 1 Institute for Molecular Bioscience , Brisbane, QLD 4072 ,","place":["Australia"]},{"name":", The University of Queensland 2 Australian Infectious Diseases Research Centre , Brisbane, QLD 4072 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karoline D.","family":"Raven","sequence":"additional","affiliation":[{"name":", The University of Queensland 1 Institute for Molecular Bioscience , Brisbane, QLD 4072 ,","place":["Australia"]},{"name":", The University of Queensland 2 Australian Infectious Diseases Research Centre , Brisbane, QLD 4072 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaustav","family":"Das Gupta","sequence":"additional","affiliation":[{"name":", The University of Queensland 1 Institute for Molecular Bioscience , Brisbane, QLD 4072 ,","place":["Australia"]},{"name":", The University of Queensland 2 Australian Infectious Diseases Research Centre , Brisbane, QLD 4072 ,","place":["Australia"]},{"name":"The Lundquist Institute for Biomedical Innovation at Harbor-University of California, Los Angeles Medical Center 3 Division of Infectious Disease , , Torrance, CA 90502 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberley S.","family":"Gunther","sequence":"additional","affiliation":[{"name":", The University of Queensland 1 Institute for Molecular Bioscience , Brisbane, QLD 4072 ,","place":["Australia"]},{"name":", The University of Queensland 2 Australian Infectious Diseases Research Centre , Brisbane, QLD 4072 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alun","family":"Jones","sequence":"additional","affiliation":[{"name":", The University of Queensland 1 Institute for Molecular Bioscience , Brisbane, QLD 4072 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert C.","family":"Reid","sequence":"additional","affiliation":[{"name":", The University of Queensland 1 Institute for Molecular Bioscience , Brisbane, QLD 4072 ,","place":["Australia"]},{"name":", The University of Queensland 2 Australian Infectious Diseases Research Centre , Brisbane, QLD 4072 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zherui","family":"Xiong","sequence":"additional","affiliation":[{"name":", The University of Queensland 1 Institute for Molecular Bioscience , Brisbane, QLD 4072 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer H.","family":"Gunter","sequence":"additional","affiliation":[{"name":"Queensland University of Technology (QUT), Australian Prostate Cancer Research Centre - Queensland, Centre for Genomics and Personalised Health, School of Biomedical Sciences, Translational Research Institute 4 , Brisbane, QLD 4102 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica A.","family":"Engel","sequence":"additional","affiliation":[{"name":"QIMR Berghofer Medical Research Institute 5 , Brisbane, QLD 4006 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian R.","family":"Engwerda","sequence":"additional","affiliation":[{"name":"QIMR Berghofer Medical Research Institute 5 , Brisbane, QLD 4006 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antje","family":"Blumenthal","sequence":"additional","affiliation":[{"name":", The University of Queensland 6 Frazer Institute , Brisbane, QLD 4102 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David P.","family":"Fairlie","sequence":"additional","affiliation":[{"name":", The University of Queensland 1 Institute for Molecular Bioscience , Brisbane, QLD 4072 ,","place":["Australia"]},{"name":", The University of Queensland 2 Australian Infectious Diseases Research Centre , Brisbane, QLD 4072 ,","place":["Australia"]},{"name":", Institute for Molecular Bioscience, The University of Queensland 7 ARC Centre of Excellence for Innovations in Peptide and Protein Science , Brisbane, QLD 4072 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert G.","family":"Parton","sequence":"additional","affiliation":[{"name":", The University of Queensland 1 Institute for Molecular Bioscience , Brisbane, QLD 4072 ,","place":["Australia"]},{"name":", The University of Queensland 8 Centre for Microscopy and Microanalysis , Brisbane, QLD 4072 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Zuryn","sequence":"additional","affiliation":[{"name":", Queensland Brain Institute, The University of Queensland 9 Clem Jones Centre for Ageing Dementia Research , Brisbane, QLD 4072 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronan","family":"Kapetanovic","sequence":"additional","affiliation":[{"name":", The University of Queensland 1 Institute for Molecular Bioscience , Brisbane, QLD 4072 ,","place":["Australia"]},{"name":", The University of Queensland 2 Australian Infectious Diseases Research Centre , Brisbane, QLD 4072 ,","place":["Australia"]},{"name":", Universit\u00e9 de Tours, Infectiologie et Sant\u00e9 Publique (ISP) 10 INRAE , Nouzilly 37380 ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1935-9043","authenticated-orcid":false,"given":"Divya","family":"Ramnath","sequence":"additional","affiliation":[{"name":", The University of Queensland 1 Institute for Molecular Bioscience , Brisbane, QLD 4072 ,","place":["Australia"]},{"name":", The University of Queensland 2 Australian Infectious Diseases Research Centre , Brisbane, QLD 4072 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0406-8139","authenticated-orcid":false,"given":"Matthew J.","family":"Sweet","sequence":"additional","affiliation":[{"name":", The University of Queensland 1 Institute for Molecular Bioscience , Brisbane, QLD 4072 ,","place":["Australia"]},{"name":", The University of Queensland 2 Australian Infectious Diseases Research Centre , Brisbane, QLD 4072 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2025,10,10]]},"reference":[{"key":"2025101008464152700_JCS264376C1","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1007\/978-1-0716-2449-4_18","article-title":"Quantifying regulated mitochondrial fission in macrophages","volume-title":"Effector-Triggered Immunity: Methods and Protocols","author":"Afroz","year":"2022"},{"key":"2025101008464152700_JCS264376C2","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1042\/BST20220014","article-title":"Mitochondrial dynamics in macrophages: divide to conquer or unite to survive?","volume":"51","author":"Afroz","year":"2023","journal-title":"Biochem. Soc. Trans."},{"key":"2025101008464152700_JCS264376C3","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.3389\/fimmu.2018.01605","article-title":"Diverse roles of mitochondria in immune responses: novel insights into immuno-metabolism","volume":"9","author":"Angajala","year":"2018","journal-title":"Front. Immunol."},{"key":"2025101008464152700_JCS264376C4","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1042\/BJ20100131","article-title":"Dual roles for MEF2A and MEF2D during human macrophage terminal differentiation and c-Jun expression","volume":"430","author":"Aude-Garcia","year":"2010","journal-title":"Biochem. J."},{"key":"2025101008464152700_JCS264376C5","doi-asserted-by":"publisher","first-page":"51218","DOI":"10.1074\/jbc.M409271200","article-title":"Cytoplasmic sequestration of HDAC7 from mitochondrial and nuclear compartments upon initiation of apoptosis","volume":"279","author":"Bakin","year":"2004","journal-title":"J. Biol. Chem."},{"key":"2025101008464152700_JCS264376C6","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/13014","article-title":"The dynamin-related GTPase Dnm1 regulates mitochondrial fission in yeast","volume":"1","author":"Bleazard","year":"1999","journal-title":"Nat. Cell Biol."},{"key":"2025101008464152700_JCS264376C7","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1038\/nbt.4201","article-title":"Efficient proximity labeling in living cells and organisms with TurboID","volume":"36","author":"Branon","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"2025101008464152700_JCS264376C8","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.cell.2016.05.035","article-title":"Mitochondrial dynamics controls T cell fate through metabolic programming","volume":"166","author":"Buck","year":"2016","journal-title":"Cell"},{"key":"2025101008464152700_JCS264376C9","doi-asserted-by":"publisher","first-page":"110155","DOI":"10.1016\/j.celrep.2021.110155","article-title":"SIRT2 regulates mitochondrial dynamics and reprogramming via MEK1-ERK-DRP1 and AKT1-DRP1 axes","volume":"37","author":"Cha","year":"2021","journal-title":"Cell Rep."},{"key":"2025101008464152700_JCS264376C10","doi-asserted-by":"publisher","first-page":"E87","DOI":"10.1152\/ajpendo.00457.2019","article-title":"A pipeline for multidimensional confocal analysis of mitochondrial morphology, function, and dynamics in pancreatic \u03b2-cells","volume":"318","author":"Chaudhry","year":"2020","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"2025101008464152700_JCS264376C11","doi-asserted-by":"publisher","first-page":"e0184129","DOI":"10.1371\/journal.pone.0184129","article-title":"Prediction and analysis of essential genes using the enrichments of gene ontology and KEGG pathways","volume":"12","author":"Chen","year":"2017","journal-title":"PLoS ONE"},{"key":"2025101008464152700_JCS264376C12","doi-asserted-by":"publisher","first-page":"e2312111121","DOI":"10.1073\/pnas.2312111121","article-title":"Class IIa HDAC4 and HDAC7 cooperatively regulate gene transcription in Th17 cell differentiation","volume":"121","author":"Cheung","year":"2024","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2025101008464152700_JCS264376C13","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1038\/sj.embor.7401062","article-title":"Reversible phosphorylation of Drp1 by cyclic AMP-dependent protein kinase and calcineurin regulates mitochondrial fission and cell death","volume":"8","author":"Cribbs","year":"2007","journal-title":"EMBO Rep."},{"key":"2025101008464152700_JCS264376C14","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1007\/s00125-016-4113-2","article-title":"HDAC7 is overexpressed in human diabetic islets and impairs insulin secretion in rat islets and clonal beta cells","volume":"60","author":"Daneshpajooh","year":"2017","journal-title":"Diabetologia"},{"key":"2025101008464152700_JCS264376C15","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1007\/s00592-018-1201-4","article-title":"MC1568 improves insulin secretion in islets from type 2 diabetes patients and rescues \u03b2-cell dysfunction caused by Hdac7 upregulation","volume":"55","author":"Daneshpajooh","year":"2018","journal-title":"Acta Diabetol."},{"key":"2025101008464152700_JCS264376C16","doi-asserted-by":"publisher","first-page":"2712","DOI":"10.1016\/j.celrep.2020.02.007","article-title":"Class IIa histone deacetylases drive toll-like receptor-inducible glycolysis and macrophage inflammatory responses via pyruvate kinase M2","volume":"30","author":"Das Gupta","year":"2020","journal-title":"Cell Rep."},{"key":"2025101008464152700_JCS264376C17","doi-asserted-by":"publisher","first-page":"e2212813120","DOI":"10.1073\/pnas.2212813120","article-title":"HDAC7 is an immunometabolic switch triaging danger signals for engagement of antimicrobial versus inflammatory responses in macrophages","volume":"120","author":"Das Gupta","year":"2023","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2025101008464152700_JCS264376C18","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.pharmthera.2018.10.001","article-title":"Endothelins in inflammatory neurological diseases","volume":"194","author":"D'Orl\u00e9ans-Juste","year":"2019","journal-title":"Pharmacol. Ther."},{"key":"2025101008464152700_JCS264376C19","doi-asserted-by":"publisher","first-page":"3917","DOI":"10.1096\/fj.09-136630","article-title":"SUMOylation of the mitochondrial fission protein Drp1 occurs at multiple nonconsensus sites within the B domain and is linked to its activity cycle","volume":"23","author":"Figueroa-Romero","year":"2009","journal-title":"FASEB J."},{"key":"2025101008464152700_JCS264376C20","doi-asserted-by":"publisher","first-page":"35826","DOI":"10.1074\/jbc.M104935200","article-title":"Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo","volume":"276","author":"Fischle","year":"2001","journal-title":"J. Biol. Chem."},{"key":"2025101008464152700_JCS264376C21","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1016\/j.cell.2020.02.041","article-title":"Toll-like receptors and the control of immunity","volume":"180","author":"Fitzgerald","year":"2020","journal-title":"Cell"},{"key":"2025101008464152700_JCS264376C22","doi-asserted-by":"publisher","first-page":"E34","DOI":"10.1038\/s41586-019-1296-y","article-title":"Mitochondrial fission requires DRP1 but not dynamins","volume":"570","author":"Fonseca","year":"2019","journal-title":"Nature"},{"key":"2025101008464152700_JCS264376C23","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1038\/s41392-023-01588-0","article-title":"Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets","volume":"8","author":"Gao","year":"2023","journal-title":"Signal Transduct. Target Ther."},{"key":"2025101008464152700_JCS264376C24","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1038\/s41580-020-0210-7","article-title":"The cell biology of mitochondrial membrane dynamics","volume":"21","author":"Giacomello","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2025101008464152700_JCS264376C25","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1038\/nature21409","article-title":"Class IIa HDAC inhibition reduces breast tumours and metastases through anti-tumour macrophages","volume":"543","author":"Guerriero","year":"2017","journal-title":"Nature"},{"key":"2025101008464152700_JCS264376C26","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1111\/j.1476-5381.2010.00637.x","article-title":"Antifibrotic activity of an inhibitor of histone deacetylases in DOCA\u2013salt hypertensive rats","volume":"159","author":"Iyer","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"2025101008464152700_JCS264376C27","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.immuni.2015.02.005","article-title":"Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization","volume":"42","author":"Jha","year":"2015","journal-title":"Immunity"},{"key":"2025101008464152700_JCS264376C28","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1111\/imcb.12363","article-title":"Lipopolysaccharide promotes Drp1-dependent mitochondrial fission and associated inflammatory responses in macrophages","volume":"98","author":"Kapetanovic","year":"2020","journal-title":"Immunol. Cell Biol."},{"key":"2025101008464152700_JCS264376C29","doi-asserted-by":"publisher","first-page":"4942","DOI":"10.1038\/s41598-017-05232-0","article-title":"Polymorphic regulation of mitochondrial fission and fusion modifies phenotypes of microglia in neuroinflammation","volume":"7","author":"Katoh","year":"2017","journal-title":"Sci. Rep."},{"key":"2025101008464152700_JCS264376C30","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.ejphar.2008.01.026","article-title":"TAK-242 selectively suppresses Toll-like receptor 4-signaling mediated by the intracellular domain","volume":"584","author":"Kawamoto","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"2025101008464152700_JCS264376C31","doi-asserted-by":"publisher","first-page":"461","DOI":"10.3389\/fimmu.2014.00461","article-title":"Toll-like receptor signaling pathways","volume":"5","author":"Kawasaki","year":"2014","journal-title":"Front. Immunol."},{"key":"2025101008464152700_JCS264376C32","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1159\/000516780","article-title":"Metabolic regulation of macrophage activation","volume":"14","author":"Kolliniati","year":"2022","journal-title":"J. Innate Immun."},{"key":"2025101008464152700_JCS264376C33","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.jneuroim.2019.03.012","article-title":"Toll-like receptors in the pathogenesis of neuroinflammation","volume":"332","author":"Kumar","year":"2019","journal-title":"J. Neuroimmunol."},{"key":"2025101008464152700_JCS264376C34","doi-asserted-by":"publisher","first-page":"17335","DOI":"10.1073\/pnas.0706487104","article-title":"Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases","volume":"104","author":"Lahm","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025101008464152700_JCS264376C35","doi-asserted-by":"publisher","first-page":"34201","DOI":"10.1074\/jbc.M405179200","article-title":"Phosphorylation of the histone deacetylase 7 modulates its stability and association with 14-3-3 proteins","volume":"279","author":"Li","year":"2004","journal-title":"J. Biol. Chem."},{"key":"2025101008464152700_JCS264376C36","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","article-title":"The Molecular Signatures Database (MSigDB) hallmark gene set collection","volume":"1","author":"Liberzon","year":"2015","journal-title":"Cell Syst."},{"key":"2025101008464152700_JCS264376C80","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"2025101008464152700_JCS264376C37","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1038\/nchembio.1223","article-title":"Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group","volume":"9","author":"Lobera","year":"2013","journal-title":"Nat. Chem. Biol."},{"key":"2025101008464152700_JCS264376C38","doi-asserted-by":"publisher","first-page":"14133","DOI":"10.1038\/ncomms14133","article-title":"SCIMP is a transmembrane non-TIR TLR adaptor that promotes proinflammatory cytokine production from macrophages","volume":"8","author":"Luo","year":"2017","journal-title":"Nat. Commun."},{"key":"2025101008464152700_JCS264376C39","doi-asserted-by":"publisher","first-page":"4819","DOI":"10.1074\/jbc.M110.146860","article-title":"Neuroprotection by histone deacetylase-7 (HDAC7) occurs by inhibition of c-jun expression through a deacetylase-independent mechanism","volume":"286","author":"Ma","year":"2011","journal-title":"J. Biol. Chem."},{"key":"2025101008464152700_JCS264376C40","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1242\/jcs.034850","article-title":"Splicing of HDAC7 modulates the SRF-myocardin complex during stem-cell differentiation towards smooth muscle cells","volume":"122","author":"Margariti","year":"2009","journal-title":"J. Cell Sci."},{"key":"2025101008464152700_JCS264376C41","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1124\/mol.110.068064","article-title":"TAK-242 (resatorvid), a small-molecule inhibitor of Toll-like receptor (TLR) 4 signaling, binds selectively to TLR4 and interferes with interactions between TLR4 and its adaptor molecules","volume":"79","author":"Matsunaga","year":"2011","journal-title":"Mol. Pharmacol."},{"key":"2025101008464152700_JCS264376C42","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1111\/j.1742-4658.2012.08631.x","article-title":"N-terminal phosphorylation of protein phosphatase\u20032A\/B\u03b22 regulates translocation to mitochondria, dynamin-related protein\u20031 dephosphorylation, and neuronal survival","volume":"280","author":"Merrill","year":"2013","journal-title":"FEBS J."},{"key":"2025101008464152700_JCS264376C43","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/j.cell.2016.08.064","article-title":"Succinate dehydrogenase supports metabolic repurposing of mitochondria to drive inflammatory macrophages","volume":"167","author":"Mills","year":"2016","journal-title":"Cell"},{"key":"2025101008464152700_JCS264376C44","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1016\/j.omtn.2022.01.004","article-title":"Chemical modification of uridine modulates mRNA-mediated proinflammatory and antiviral response in primary human macrophages","volume":"27","author":"Moradian","year":"2022","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"2025101008464152700_JCS264376C45","doi-asserted-by":"publisher","first-page":"e465","DOI":"10.1038\/cddis.2012.201","article-title":"TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1","volume":"4","author":"Moujalled","year":"2013","journal-title":"Cell Death Dis."},{"key":"2025101008464152700_JCS264376C46","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.immuni.2013.06.018","article-title":"The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism","volume":"39","author":"Murphy","year":"2013","journal-title":"Immunity"},{"key":"2025101008464152700_JCS264376C47","doi-asserted-by":"publisher","first-page":"14291","DOI":"10.3390\/ijms241814291","article-title":"Altered mitochondrial function and accelerated aging phenotype in neural stem cells derived from Dnm1l knockout embryonic stem cells","volume":"24","author":"Na","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"2025101008464152700_JCS264376C48","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1002\/glia.23587","article-title":"Lipopolysaccharide-induced alteration of mitochondrial morphology induces a metabolic shift in microglia modulating the inflammatory response in vitro and in vivo","volume":"67","author":"Nair","year":"2019","journal-title":"Glia"},{"key":"2025101008464152700_JCS264376C49","doi-asserted-by":"publisher","first-page":"e148438","DOI":"10.1172\/jci.insight.148438","article-title":"The TGF-\u03b2\/HDAC7 axis suppresses TCA cycle metabolism in renal cancer","volume":"6","author":"Nam","year":"2021","journal-title":"JCI Insight"},{"key":"2025101008464152700_JCS264376C50","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1038\/s41590-020-0758-6","article-title":"The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation","volume":"21","author":"Ng","year":"2020","journal-title":"Nat. Immunol."},{"key":"2025101008464152700_JCS264376C51","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1084\/jem.20151570","article-title":"Immunometabolism governs dendritic cell and macrophage function","volume":"213","author":"O'Neill","year":"2016","journal-title":"J. Exp. Med."},{"key":"2025101008464152700_JCS264376C52","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1189\/jlb.0807585","article-title":"Expression of Gal4-dependent transgenes in cells of the mononuclear phagocyte system labeled with enhanced cyan fluorescent protein using Csf1r-Gal4VP16\/UAS-ECFP double-transgenic mice","volume":"83","author":"Ovchinnikov","year":"2008","journal-title":"J. Leucocyte Biol."},{"key":"2025101008464152700_JCS264376C53","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.cmet.2014.12.005","article-title":"Pyruvate kinase M2 regulates Hif-1\u03b1 activity and IL-1\u03b2 induction and is a critical determinant of the warburg effect in LPS-activated macrophages","volume":"21","author":"Palsson-McDermott","year":"2015","journal-title":"Cell Metab."},{"key":"2025101008464152700_JCS264376C54","doi-asserted-by":"publisher","first-page":"15489","DOI":"10.1038\/srep15489","article-title":"Defective mitochondrial fission augments NLRP3 inflammasome activation","volume":"5","author":"Park","year":"2015","journal-title":"Sci. Rep."},{"key":"2025101008464152700_JCS264376C55","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1016\/j.molcel.2015.08.001","article-title":"MAPL SUMOylation of Drp1 stabilizes an ER\/mitochondrial platform required for cell death","volume":"59","author":"Prudent","year":"2015","journal-title":"Mol. Cell"},{"key":"2025101008464152700_JCS264376C56","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1002\/JLB.2MR1021-260R","article-title":"The histone deacetylase Hdac7 supports LPS-inducible glycolysis and Il-1\u03b2 production in murine macrophages via distinct mechanisms","volume":"111","author":"Ramnath","year":"2022","journal-title":"J. Leukoc. Biol."},{"key":"2025101008464152700_JCS264376C57","doi-asserted-by":"publisher","first-page":"101599","DOI":"10.1016\/j.redox.2020.101599","article-title":"Role of mitochondrial fission-related genes in mitochondrial morphology and energy metabolism in mouse embryonic stem cells","volume":"36","author":"Seo","year":"2020","journal-title":"Redox Biol."},{"key":"2025101008464152700_JCS264376C58","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.it.2011.04.001","article-title":"Histone deacetylases as regulators of inflammation and immunity","volume":"32","author":"Shakespear","year":"2011","journal-title":"Trends Immunol."},{"key":"2025101008464152700_JCS264376C59","doi-asserted-by":"publisher","first-page":"25362","DOI":"10.1074\/jbc.M113.496281","article-title":"Histone deacetylase 7 promotes Toll-like receptor 4-dependent proinflammatory gene expression in macrophages","volume":"288","author":"Shakespear","year":"2013","journal-title":"J. Biol. Chem."},{"key":"2025101008464152700_JCS264376C60","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.it.2018.02.009","article-title":"Lysine deacetylases and regulated glycolysis in macrophages","volume":"39","author":"Shakespear","year":"2018","journal-title":"Trends Immunol."},{"key":"2025101008464152700_JCS264376C61","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1515\/revneuro-2022-0056","article-title":"Mitochondrial fission mediated by Drp1-Fis1 pathway and neurodegenerative diseases","volume":"34","author":"Shi","year":"2023","journal-title":"Rev. Neurosci."},{"key":"2025101008464152700_JCS264376C62","doi-asserted-by":"publisher","first-page":"3059","DOI":"10.1016\/j.celrep.2018.11.018","article-title":"Drp1 controls effective T cell immune-surveillance by regulating T cell migration, proliferation, and cMyc-dependent metabolic reprogramming","volume":"25","author":"Simula","year":"2018","journal-title":"Cell Rep."},{"key":"2025101008464152700_JCS264376C63","doi-asserted-by":"publisher","first-page":"107598","DOI":"10.1016\/j.intimp.2021.107598","article-title":"MCP-1: Function, regulation, and involvement in disease","volume":"101","author":"Singh","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"2025101008464152700_JCS264376C64","doi-asserted-by":"publisher","first-page":"3350","DOI":"10.1111\/febs.15327","article-title":"Glycolysis - a key player in the inflammatory response","volume":"287","author":"Soto-Heredero","year":"2020","journal-title":"FEBS J."},{"key":"2025101008464152700_JCS264376C65","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1002\/JLB.2HI0420-160R","article-title":"Frontline Science: LPS-inducible SLC30A1 drives human macrophage-mediated zinc toxicity against intracellular Escherichia coli","volume":"109","author":"Stocks","year":"2021","journal-title":"J. Leukoc. Biol."},{"key":"2025101008464152700_JCS264376C66","doi-asserted-by":"publisher","first-page":"D447","DOI":"10.1093\/nar\/gku1003","article-title":"STRING v10: protein\u2013protein interaction networks, integrated over the tree of life","volume":"43","author":"Szklarczyk","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"2025101008464152700_JCS264376C67","doi-asserted-by":"publisher","first-page":"11521","DOI":"10.1074\/jbc.M607279200","article-title":"Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission","volume":"282","author":"Taguchi","year":"2007","journal-title":"J. Biol. Chem."},{"key":"2025101008464152700_JCS264376C68","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1016\/j.cell.2010.01.022","article-title":"Pattern recognition receptors and inflammation","volume":"140","author":"Takeuchi","year":"2010","journal-title":"Cell"},{"key":"2025101008464152700_JCS264376C69","doi-asserted-by":"publisher","first-page":"7693","DOI":"10.1007\/s00018-021-03978-5","article-title":"Metabolic regulation of RA macrophages is distinct from RA fibroblasts and blockade of glycolysis alleviates inflammatory phenotype in both cell types","volume":"78","author":"Umar","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"2025101008464152700_JCS264376C70","doi-asserted-by":"publisher","first-page":"lqae028","DOI":"10.1093\/nargab\/lqae028","article-title":"mRNAid, an open-source platform for therapeutic mRNA design and optimization strategies","volume":"6","author":"Vostrosablin","year":"2024","journal-title":"NAR Genom. Bioinform."},{"key":"2025101008464152700_JCS264376C71","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1083\/jcb.200903065","article-title":"The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice","volume":"186","author":"Wakabayashi","year":"2009","journal-title":"J. Cell Biol."},{"key":"2025101008464152700_JCS264376C72","doi-asserted-by":"publisher","first-page":"2805","DOI":"10.1111\/febs.16437","article-title":"Histone deacetylase 7: a signalling hub controlling development, inflammation, metabolism and disease","volume":"290","author":"Wang","year":"2023","journal-title":"FEBS J."},{"key":"2025101008464152700_JCS264376C73","doi-asserted-by":"publisher","first-page":"1230168","DOI":"10.3389\/fendo.2023.1230168","article-title":"New therapeutic directions in type II diabetes and its complications: mitochondrial dynamics","volume":"14","author":"Wang","year":"2023","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"2025101008464152700_JCS264376C74","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/s41420-022-00813-z","article-title":"KLF2 up-regulates IRF4\/HDAC7 to protect neonatal rats from hypoxic-ischemic brain damage","volume":"8","author":"Wu","year":"2022","journal-title":"Cell Death Discov."},{"key":"2025101008464152700_JCS264376C75","doi-asserted-by":"publisher","first-page":"e4178-e4178","DOI":"10.21769\/BioProtoc.4178","article-title":"Proximity dependent biotin labelling in zebrafish for proteome and interactome profiling","volume":"11","author":"Xiong","year":"2021","journal-title":"Bio-Protoc."},{"key":"2025101008464152700_JCS264376C76","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3892\/ijo.2022.5373","article-title":"Receptor for activated C kinase 1 promotes cervical cancer lymph node metastasis via the glycolysis-dependent AKT\/mTOR signaling","volume":"61","author":"Xu","year":"2022","journal-title":"Int. J. Oncol."},{"key":"2025101008464152700_JCS264376C77","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS"},{"key":"2025101008464152700_JCS264376C78","doi-asserted-by":"publisher","first-page":"9255","DOI":"10.1002\/jcp.27605","article-title":"Lipopolysaccharide\u2013induced proliferation and glycolysis in airway smooth muscle cells via activation of Drp1","volume":"234","author":"Zhang","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"2025101008464152700_JCS264376C79","doi-asserted-by":"publisher","first-page":"e60728","DOI":"10.3791\/60728","article-title":"TurboID-based proximity labeling for in planta identification of protein-protein interaction networks","volume":"159","author":"Zhang","year":"2020","journal-title":"J. Vis. Exp."}],"container-title":["Journal of Cell Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/jcs\/article-pdf\/doi\/10.1242\/jcs.264376\/3663114\/jcs264376.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/jcs\/article-pdf\/doi\/10.1242\/jcs.264376\/3668499\/jcs264376.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/jcs\/article-pdf\/doi\/10.1242\/jcs.264376\/3668499\/jcs264376.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T12:46:49Z","timestamp":1760100409000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/jcs\/article\/138\/19\/jcs264376\/369461\/Histone-deacetylase-7-mediates-lipopolysaccharide"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,1]]},"references-count":80,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2025,10,1]]}},"URL":"https:\/\/doi.org\/10.1242\/jcs.264376","relation":{},"ISSN":["0021-9533","1477-9137"],"issn-type":[{"value":"0021-9533","type":"print"},{"value":"1477-9137","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,1]]},"article-number":"jcs264376"}}