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The farnesylated prelamin A variant produced in HGPS, termed progerin, alters actin\u2013nuclear interactions mediated by nesprin-2 and SUN2 linker of nucleoskeleton and cytoskeleton (LINC) complexes, resulting in defective cell polarization. To explore further how prelamin A causes these cellular defects, we examined other disease-causing variants that prevent cleavage of lamin A or reduce the activity of the processing enzyme ZMPSTE24. Accumulation of prelamin A or an uncleaved variant in cells reduced diffusional mobilities of nesprin-2 and SUN2 and inhibited their function in cell polarization in a farnesylation-dependent manner. Expression of short carboxyl-terminal tail fragments of prelamin A variants disrupted cell polarity in a farnesylation-dependent fashion. These results show that retention of the farnesyl moiety in the tails of prelamin A or its variants is the common element responsible for disrupting actin force transmission to the nucleus in premature aging syndromes and support the idea that altered function of actin-dependent LINC complexes is a critical component of premature aging.<\/jats:p>","DOI":"10.1242\/jcs.264488","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T07:33:47Z","timestamp":1776756827000},"source":"Crossref","is-referenced-by-count":3,"title":["Farnesylated prelamin A induces fibroblast polarity defects in premature aging disorders by inhibiting nesprin-2\u2013SUN2 LINC complex function"],"prefix":"10.1242","volume":"139","author":[{"given":"Chonkit","family":"Lio","sequence":"first","affiliation":[{"name":"University of Macau 1 Faculty of Health Science , , Taipa, Macau ,","place":["China"]},{"name":"MOE Frontier Science Centre for Precision Oncology, University of Macau 2 , Taipa, Macau ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5461-7469","authenticated-orcid":false,"given":"Yuexia","family":"Wang","sequence":"additional","affiliation":[{"name":"Columbia University 3 Department of Medicine , , New York, NY 10032 ,","place":["USA"]},{"name":"Columbia University 4 Department of Pathology and Cell Biology , , New York, NY 10032 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0478-9378","authenticated-orcid":false,"given":"Paige C.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Columbia University 5 Department of Biological Sciences , , New York, NY 10027 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutao","family":"Li","sequence":"additional","affiliation":[{"name":"University of Macau 1 Faculty of Health Science , , Taipa, Macau ,","place":["China"]},{"name":"MOE Frontier Science Centre for Precision Oncology, University of Macau 2 , Taipa, Macau ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0698-6224","authenticated-orcid":false,"given":"Susumu","family":"Antoku","sequence":"additional","affiliation":[{"name":"Columbia University 4 Department of Pathology and Cell Biology , , New York, NY 10032 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7810-9688","authenticated-orcid":false,"given":"Cecilia","family":"\u00d6stlund","sequence":"additional","affiliation":[{"name":"Columbia University 3 Department of Medicine , , New York, NY 10032 ,","place":["USA"]},{"name":"Columbia University 4 Department of Pathology and Cell Biology , , New York, NY 10032 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Yeon","family":"Shin","sequence":"additional","affiliation":[{"name":"Columbia University 3 Department of Medicine , , New York, NY 10032 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7063-7889","authenticated-orcid":false,"given":"Howard J.","family":"Worman","sequence":"additional","affiliation":[{"name":"Columbia University 3 Department of Medicine , , New York, NY 10032 ,","place":["USA"]},{"name":"Columbia University 4 Department of Pathology and Cell Biology , , New York, NY 10032 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4431-2033","authenticated-orcid":false,"given":"Wakam","family":"Chang","sequence":"additional","affiliation":[{"name":"University of Macau 1 Faculty of Health Science , , Taipa, Macau ,","place":["China"]},{"name":"MOE Frontier Science Centre for Precision Oncology, University of Macau 2 , Taipa, Macau ,","place":["China"]},{"name":"Columbia University 4 Department of Pathology and Cell Biology , , New York, NY 10032 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3903-7380","authenticated-orcid":false,"given":"Gregg G.","family":"Gundersen","sequence":"additional","affiliation":[{"name":"Columbia University 4 Department of Pathology and Cell Biology , , New York, NY 10032 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2026,5,18]]},"reference":[{"key":"2026051805513706800_JCS264488C1","doi-asserted-by":"publisher","first-page":"1995","DOI":"10.1093\/hmg\/ddg213","article-title":"Zinc metalloproteinase, ZMPSTE24, is mutated in mandibuloacral dysplasia","volume":"12","author":"Agarwal","year":"2003","journal-title":"Hum. 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