{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T10:03:17Z","timestamp":1784628197836,"version":"3.55.0"},"reference-count":142,"publisher":"The Company of Biologists","issue":"14","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"crossref","award":["RGPIN-2022-05267"],"award-info":[{"award-number":["RGPIN-2022-05267"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes for Health Research","doi-asserted-by":"crossref","award":["PJT 168882"],"award-info":[{"award-number":["PJT 168882"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes for Health Research","doi-asserted-by":"crossref","award":["RGPIN-2024-04932"],"award-info":[{"award-number":["RGPIN-2024-04932"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes for Health Research","doi-asserted-by":"crossref","award":["ARB 192062"],"award-info":[{"award-number":["ARB 192062"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004381","name":"Western University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004381","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The pathogenic yeast Candida albicans relies on morphogenesis \u2013 the transition from spherical yeast to filamentous hyphal forms \u2013 for infection. Although morphogenesis requires Ire1, a transmembrane protein that canonically initiates the unfolded protein response (UPR) through HAC1 mRNA splicing, the specific mechanisms linking Ire1 to filamentation remain unclear. Using transcriptome analysis, we found that the Ire1-dependent transcriptional response driving morphogenesis was fundamentally distinct from the canonical UPR response to proteotoxic stress, with minimal overlap between programs. Morphogenesis was associated with only limited HAC1 splicing compared to the robust splicing seen during proteotoxic stress, and HAC1 deletion only partially impaired filamentation, unlike the near-complete loss observed with IRE1 deletion. These findings establish that Ire1 regulates hyphal development through previously uncharacterized HAC1-independent pathways. We identify cell wall integrity as a key HAC1-independent mechanism, with Ire1 \u2013 but not Hac1 \u2013 being essential for cell wall stress tolerance and upregulation of cell wall biosynthesis genes during filamentation. Our data also reveal Ire1-dependent decreases in transcripts encoding secretory proteins during both proteotoxic stress and morphogenesis, consistent with a possible role for Ire1-mediated mRNA degradation in these processes. Given the essential role of Ire1 in pathogenesis and extensive development of Ire1-targeting compounds for mammalian systems, our findings position Ire1 as a highly promising druggable target for novel antifungal therapeutics and development of fungal-specific inhibitors.<\/jats:p>","DOI":"10.1242\/jcs.264610","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T07:53:06Z","timestamp":1781682786000},"source":"Crossref","is-referenced-by-count":0,"title":["Hac1-independent functions of Ire1 drive morphogenesis in\n                    <i>Candida albicans<\/i>\n                    through distinct transcriptional programs"],"prefix":"10.1242","volume":"139","author":[{"given":"Samuel","family":"Stack-Couture","sequence":"first","affiliation":[{"name":"The University of Western Ontario 1 Department of Anatomy and Cell Biology , , London, Ontario N6A 5C1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8119-8335","authenticated-orcid":false,"given":"Gabriela","family":"Nunes Marsiglio Librais","sequence":"additional","affiliation":[{"name":"The University of Western Ontario 1 Department of Anatomy and Cell Biology , , London, Ontario N6A 5C1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Lung","sequence":"additional","affiliation":[{"name":"The University of Western Ontario 1 Department of Anatomy and Cell Biology , , London, Ontario N6A 5C1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Genereaux","sequence":"additional","affiliation":[{"name":"The University of Western Ontario 1 Department of Anatomy and Cell Biology , , London, Ontario N6A 5C1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viola","family":"Halder","sequence":"additional","affiliation":[{"name":"University of Guelph 2 Department of Molecular and Cellular Biology , , Guelph, Ontario N1G 2W1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1280-6541","authenticated-orcid":false,"given":"Vanessa","family":"Dumeaux","sequence":"additional","affiliation":[{"name":"The University of Western Ontario 1 Department of Anatomy and Cell Biology , , London, Ontario N6A 5C1 ,","place":["Canada"]},{"name":"The University of Western Ontario 3 Department of Biochemistry , , London, Ontario N6A 5C1 ,","place":["Canada"]},{"name":"Lawson Research Institute, London Health Sciences Centre 4 Department of Oncology , , London, Ontario N6A 4V2 ,","place":["Canada"]},{"name":"Children's Health Research Institute, Lawson Health Research Institute 5 , London, Ontario N6C 2V5 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7119-8865","authenticated-orcid":false,"given":"Rebecca S.","family":"Shapiro","sequence":"additional","affiliation":[{"name":"University of Guelph 2 Department of Molecular and Cellular Biology , , Guelph, Ontario N1G 2W1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1614-176X","authenticated-orcid":false,"given":"Patrick","family":"Lajoie","sequence":"additional","affiliation":[{"name":"The University of Western Ontario 1 Department of Anatomy and Cell Biology , , London, Ontario N6A 5C1 ,","place":["Canada"]},{"name":"Children's Health Research Institute, Lawson Health Research Institute 5 , London, Ontario N6C 2V5 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2026,7,21]]},"reference":[{"key":"2026072105344710400_JCS264610C1","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.fgb.2010.03.009","article-title":"The Sko1 protein represses the yeast-to-hypha transition and regulates the oxidative stress response in Candida albicans","volume":"47","author":"Alonso-Monge","year":"2010","journal-title":"Fungal Genet. Biol."},{"key":"2026072105344710400_JCS264610C2","doi-asserted-by":"publisher","first-page":"R106","DOI":"10.1186\/gb-2010-11-10-r106","article-title":"Differential expression analysis for sequence count data","volume":"11","author":"Anders","year":"2010","journal-title":"Genome Biol."},{"key":"2026072105344710400_JCS264610C3","first-page":"204","article-title":"Profile of candidiasis in HIV infected patients","volume":"4","author":"Anwar","year":"2012","journal-title":"Iran J. Microbiol."},{"key":"2026072105344710400_JCS264610C4","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: tool for the unification of biology. The gene ontology consortium","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat. Genet."},{"key":"2026072105344710400_JCS264610C5","doi-asserted-by":"publisher","first-page":"3797","DOI":"10.1534\/g3.117.300224","article-title":"Filamentation involves two overlapping, but distinct, programs of filamentation in the pathogenic fungus","volume":"7","author":"Azadmanesh","year":"2017","journal-title":"G3 (Bethesda)"},{"key":"2026072105344710400_JCS264610C6","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.cell.2010.06.006","article-title":"A surveillance pathway monitors the fitness of the endoplasmic reticulum to control its inheritance","volume":"142","author":"Babour","year":"2010","journal-title":"Cell"},{"key":"2026072105344710400_JCS264610C7","doi-asserted-by":"publisher","first-page":"2834","DOI":"10.1093\/bioinformatics\/btab203","article-title":"STREME: accurate and versatile sequence motif discovery","volume":"37","author":"Bailey","year":"2021","journal-title":"Bioinformatics"},{"key":"2026072105344710400_JCS264610C8","doi-asserted-by":"publisher","first-page":"W39","DOI":"10.1093\/nar\/gkv416","article-title":"The MEME Suite","volume":"43","author":"Bailey","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"2026072105344710400_JCS264610C9","doi-asserted-by":"publisher","first-page":"2381","DOI":"10.1128\/mcb.4.11.2381-2388.1984","article-title":"Asparagine-linked glycosylation in Saccharomyces cerevisiae: genetic analysis of an early step","volume":"4","author":"Barnes","year":"1984","journal-title":"Mol. Cell. Biol."},{"key":"2026072105344710400_JCS264610C10","doi-asserted-by":"publisher","first-page":"118740","DOI":"10.1016\/j.lfs.2020.118740","article-title":"The molecular mechanism and functional diversity of UPR signaling sensor IRE1","volume":"265","author":"Bashir","year":"2021","journal-title":"Life Sci."},{"key":"2026072105344710400_JCS264610C11","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.1128\/EC.00236-07","article-title":"Candida albicans Sfl1 suppresses flocculation and filamentation","volume":"6","author":"Bauer","year":"2007","journal-title":"Eukaryot. Cell"},{"key":"2026072105344710400_JCS264610C12","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/j.mib.2006.10.007","article-title":"Morphogenesis and cell cycle progression in Candida albicans","volume":"9","author":"Berman","year":"2006","journal-title":"Curr. Opin. Microbiol."},{"key":"2026072105344710400_JCS264610C13","doi-asserted-by":"publisher","first-page":"e0147222","DOI":"10.1128\/spectrum.01472-22","article-title":"A deep learning approach to capture the essence of Candida albicans morphologies","volume":"10","author":"Bettauer","year":"2022","journal-title":"Microbiol. Spectr."},{"key":"2026072105344710400_JCS264610C14","doi-asserted-by":"publisher","first-page":"e1000752","DOI":"10.1371\/journal.ppat.1000752","article-title":"An extensive circuitry for cell wall regulation in Candida albicans","volume":"6","author":"Blankenship","year":"2010","journal-title":"PLoS Pathog."},{"key":"2026072105344710400_JCS264610C15","doi-asserted-by":"publisher","first-page":"57","DOI":"10.3390\/jof3040057","article-title":"Global and multi-national prevalence of fungal diseases-estimate precision","volume":"3","author":"Bongomin","year":"2017","journal-title":"J. Fungi. (Basel)"},{"key":"2026072105344710400_JCS264610C16","doi-asserted-by":"publisher","first-page":"9546","DOI":"10.1073\/pnas.0914005107","article-title":"Independent filtering increases detection power for high-throughput experiments","volume":"107","author":"Bourgon","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026072105344710400_JCS264610C17","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1126\/science.277.5322.105","article-title":"Control of filament formation in Candida albicans by the transcriptional repressor TUP1","volume":"277","author":"Braun","year":"1997","journal-title":"Science"},{"key":"2026072105344710400_JCS264610C18","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1093\/genetics\/155.1.57","article-title":"TUP1, CPH1 and EFG1 make independent contributions to filamentation in candida albicans","volume":"155","author":"Braun","year":"2000","journal-title":"Genetics"},{"key":"2026072105344710400_JCS264610C19","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1093\/genetics\/156.1.31","article-title":"Identification and characterization of TUP1-regulated genes in Candida albicans","volume":"156","author":"Braun","year":"2000","journal-title":"Genetics"},{"key":"2026072105344710400_JCS264610C20","doi-asserted-by":"publisher","first-page":"4753","DOI":"10.1093\/emboj\/20.17.4753","article-title":"NRG1, a repressor of filamentous growth in C.albicans, is down-regulated during filament induction","volume":"20","author":"Braun","year":"2001","journal-title":"EMBO J."},{"key":"2026072105344710400_JCS264610C21","doi-asserted-by":"publisher","first-page":"2186","DOI":"10.1128\/MCB.00013-15","article-title":"Cleavage of BLOC1S1 mRNA by IRE1 Is sequence specific, temporally separate from XBP1 splicing, and dispensable for cell viability under acute endoplasmic reticulum stress","volume":"35","author":"Bright","year":"2015","journal-title":"Mol. Cell. Biol."},{"key":"2026072105344710400_JCS264610C22","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s13040-019-0204-1","article-title":"ViSEAGO: a Bioconductor package for clustering biological functions using Gene Ontology and semantic similarity","volume":"12","author":"Brionne","year":"2019","journal-title":"BioData Min."},{"key":"2026072105344710400_JCS264610C23","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1017\/S1355838200991787","article-title":"The yeast antiviral proteins Ski2p, Ski3p, and Ski8p exist as a complex in vivo","volume":"6","author":"Brown","year":"2000","journal-title":"RNA"},{"key":"2026072105344710400_JCS264610C24","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1111\/cmi.12091","article-title":"Two unlike cousins: Candida albicans and C. glabrata infection strategies","volume":"15","author":"Brunke","year":"2013","journal-title":"Cell. Microbiol."},{"key":"2026072105344710400_JCS264610C25","doi-asserted-by":"publisher","first-page":"e0127923","DOI":"10.1128\/aac.01279-23","article-title":"Limitations of antifungal prophylaxis in preventing invasive surgical site infections after liver transplant surgery","volume":"68","author":"Carugati","year":"2024","journal-title":"Antimicrob. Agents Chemother."},{"key":"2026072105344710400_JCS264610C26","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.devcel.2019.08.017","article-title":"Transfer of the septin ring to cytokinetic remnants in ER stress directs age-sensitive cell-cycle re-entry","volume":"51","author":"Chao","year":"2019","journal-title":"Dev. Cell"},{"key":"2026072105344710400_JCS264610C27","doi-asserted-by":"publisher","first-page":"3646","DOI":"10.1128\/AAC.49.9.3646-3651.2005","article-title":"Inactivation of sterol Delta5,6-desaturase attenuates virulence in Candida albicans","volume":"49","author":"Chau","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"2026072105344710400_JCS264610C28","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1083\/jcb.201008071","article-title":"Attenuation of yeast UPR is essential for survival and is mediated by IRE1 kinase","volume":"193","author":"Chawla","year":"2011","journal-title":"J. Cell Biol."},{"key":"2026072105344710400_JCS264610C29","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1158\/1541-7786.MCR-05-0181","article-title":"Identification of mitogen-activated protein kinase signaling pathways that confer resistance to endoplasmic reticulum stress in Saccharomyces cerevisiae","volume":"3","author":"Chen","year":"2005","journal-title":"Mol. Cancer Res."},{"key":"2026072105344710400_JCS264610C30","doi-asserted-by":"publisher","first-page":"e1002177","DOI":"10.1371\/journal.ppat.1002177","article-title":"Unique evolution of the UPR pathway with a novel bZIP transcription factor, Hxl1, for controlling pathogenicity of Cryptococcus neoformans","volume":"7","author":"Cheon","year":"2011","journal-title":"PLoS Pathog."},{"key":"2026072105344710400_JCS264610C31","doi-asserted-by":"publisher","first-page":"76","DOI":"10.3389\/fgene.2014.00076","article-title":"Physiological roles of regulated Ire1 dependent decay","volume":"5","author":"Coelho","year":"2014","journal-title":"Front. Genet."},{"key":"2026072105344710400_JCS264610C32","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/j.molcel.2018.07.019","article-title":"Integrated functions of membrane property sensors and a hidden side of the unfolded protein response","volume":"71","author":"Covino","year":"2018","journal-title":"Mol. Cell"},{"key":"2026072105344710400_JCS264610C33","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/S0092-8674(00)81360-4","article-title":"A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response","volume":"87","author":"Cox","year":"1996","journal-title":"Cell"},{"key":"2026072105344710400_JCS264610C34","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1016\/0092-8674(93)90648-A","article-title":"Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase","volume":"73","author":"Cox","year":"1993","journal-title":"Cell"},{"key":"2026072105344710400_JCS264610C35","doi-asserted-by":"publisher","first-page":"2231","DOI":"10.1038\/s41564-025-02094-5","article-title":"Ume6 protein complexes connect morphogenesis, adherence and hypoxic genes to shape Candida albicans biofilm architecture","volume":"10","author":"Do","year":"2025","journal-title":"Nat. Microbiol."},{"key":"2026072105344710400_JCS264610C36","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"2026072105344710400_JCS264610C37","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1093\/nar\/30.1.207","article-title":"Gene expression omnibus: NCBI gene expression and hybridization array data repository","volume":"30","author":"Edgar","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"2026072105344710400_JCS264610C38","doi-asserted-by":"publisher","first-page":"6497","DOI":"10.1038\/s41467-021-26850-3","article-title":"Leveraging machine learning essentiality predictions and chemogenomic interactions to identify antifungal targets","volume":"12","author":"Fu","year":"2021","journal-title":"Nat. Commun."},{"key":"2026072105344710400_JCS264610C39","doi-asserted-by":"publisher","first-page":"iyad031","DOI":"10.1093\/genetics\/iyad031","article-title":"The gene ontology knowledgebase in 2023","volume":"224","author":"Gene Ontology Consortium","year":"2023","journal-title":"Genetics"},{"key":"2026072105344710400_JCS264610C40","doi-asserted-by":"publisher","first-page":"1629132","DOI":"10.3389\/fmicb.2025.1629132","article-title":"Impairment in global protein synthesis uncouples UPR gene induction from mRNA splicing in","volume":"16","author":"Geronimo","year":"2025","journal-title":"Front. Microbiol."},{"key":"2026072105344710400_JCS264610C41","doi-asserted-by":"publisher","first-page":"855229","DOI":"10.3389\/fcimb.2022.855229","article-title":"Everyone's favorite gene in : a comprehensive literature review","volume":"12","author":"Glazier","year":"2022","journal-title":"Front. Cell Infect. Microbiol."},{"key":"2026072105344710400_JCS264610C42","doi-asserted-by":"publisher","first-page":"15692","DOI":"10.1074\/jbc.REV120.010218","article-title":"Small molecule strategies to harness the unfolded protein response: where do we go from here?","volume":"295","author":"Grandjean","year":"2020","journal-title":"J. Biol. Chem."},{"key":"2026072105344710400_JCS264610C43","doi-asserted-by":"publisher","first-page":"R24","DOI":"10.1186\/gb-2007-8-2-r24","article-title":"Quantifying similarity between motifs","volume":"8","author":"Gupta","year":"2007","journal-title":"Genome Biol."},{"key":"2026072105344710400_JCS264610C44","doi-asserted-by":"publisher","first-page":"e29216","DOI":"10.7554\/eLife.29216","article-title":"Regulated Ire1-dependent mRNA decay requires no-go mRNA degradation to maintain endoplasmic reticulum homeostasis in","volume":"6","author":"Guydosh","year":"2017","journal-title":"eLife"},{"key":"2026072105344710400_JCS264610C45","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1038\/s41596-018-0122-6","article-title":"Design, execution, and analysis of CRISPR-Cas9-based deletions and genetic interaction networks in the fungal pathogen Candida albicans","volume":"14","author":"Halder","year":"2019","journal-title":"Nat. Protoc."},{"key":"2026072105344710400_JCS264610C46","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1016\/j.cell.2009.07.017","article-title":"IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates","volume":"138","author":"Han","year":"2009","journal-title":"Cell"},{"key":"2026072105344710400_JCS264610C47","doi-asserted-by":"publisher","first-page":"e0080423","DOI":"10.1128\/msphere.00804-23","article-title":"Manganese homeostasis modulates fungal virulence and stress tolerance in","volume":"9","author":"Henry","year":"2024","journal-title":"mSphere"},{"key":"2026072105344710400_JCS264610C48","doi-asserted-by":"publisher","first-page":"106","DOI":"10.3390\/cells7080106","article-title":"The unfolded protein response pathway in the yeast Kluyveromyces lactis. A comparative view among yeast species","volume":"7","author":"Hern\u00e1ndez-Elvira","year":"2018","journal-title":"Cells"},{"key":"2026072105344710400_JCS264610C49","doi-asserted-by":"publisher","first-page":"e201909165","DOI":"10.1083\/jcb.201909165","article-title":"Stress sensor Ire1 deploys a divergent transcriptional program in response to lipid bilayer stress","volume":"219","author":"Ho","year":"2020","journal-title":"J. Cell Biol."},{"key":"2026072105344710400_JCS264610C50","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1126\/science.1129631","article-title":"Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response","volume":"313","author":"Hollien","year":"2006","journal-title":"Science"},{"key":"2026072105344710400_JCS264610C51","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1083\/jcb.200903014","article-title":"Regulated Ire1-dependent decay of messenger RNAs in mammalian cells","volume":"186","author":"Hollien","year":"2009","journal-title":"J. Cell Biol."},{"key":"2026072105344710400_JCS264610C52","doi-asserted-by":"publisher","first-page":"e00290-20","DOI":"10.1128\/mBio.00290-20","article-title":"The Proteasome governs fungal morphogenesis via functional connections with Hsp90 and cAMP-protein kinase a signaling","volume":"11","author":"Hossain","year":"2020","journal-title":"mBio"},{"key":"2026072105344710400_JCS264610C53","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1111\/mmi.14148","article-title":"Multiple roles and diverse regulation of the Ras\/cAMP\/protein kinase A pathway in Candida albicans","volume":"111","author":"Huang","year":"2019","journal-title":"Mol. Microbiol."},{"key":"2026072105344710400_JCS264610C54","doi-asserted-by":"publisher","first-page":"794855","DOI":"10.3389\/fmicb.2021.794855","article-title":"Adaptation to endoplasmic reticulum stress in relies on the activity of the Hog1 mitogen-activated protein kinase","volume":"12","author":"Husain","year":"2021","journal-title":"Front. Microbiol."},{"key":"2026072105344710400_JCS264610C55","doi-asserted-by":"publisher","first-page":"8308","DOI":"10.1038\/s41598-017-08239-9","article-title":"The Candida albicans HIR histone chaperone regulates the yeast-to-hyphae transition by controlling the sensitivity to morphogenesis signals","volume":"7","author":"Jenull","year":"2017","journal-title":"Sci. Rep."},{"key":"2026072105344710400_JCS264610C56","doi-asserted-by":"publisher","first-page":"1477463","DOI":"10.3389\/fcimb.2024.1477463","article-title":"The mammalian Ire1 inhibitor, 4\u00b58C, exhibits broad anti-Aspergillus activity in vitro and in a treatment model of fungal keratitis","volume":"14","author":"Kamath","year":"2024","journal-title":"Front. Cell Infect. Microbiol."},{"key":"2026072105344710400_JCS264610C57","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1139\/g06-046","article-title":"Determination of mRNA half-lives in Candida albicans using thiolutin as a transcription inhibitor","volume":"49","author":"Kebaara","year":"2006","journal-title":"Genome"},{"key":"2026072105344710400_JCS264610C58","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1186\/s12879-024-09442-6","article-title":"Drug-resistant oral candidiasis in patients with HIV infection: a systematic review and meta-analysis","volume":"24","author":"Keyvanfar","year":"2024","journal-title":"BMC Infect. Dis."},{"key":"2026072105344710400_JCS264610C59","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1111\/j.1365-2443.2005.00921.x","article-title":"Yeast unfolded protein response pathway regulates expression of genes for anti-oxidative stress and for cell surface proteins","volume":"11","author":"Kimata","year":"2006","journal-title":"Genes Cells"},{"key":"2026072105344710400_JCS264610C60","doi-asserted-by":"publisher","first-page":"e00048","DOI":"10.7554\/eLife.00048","article-title":"The unfolded protein response in fission yeast modulates stability of select mRNAs to maintain protein homeostasis","volume":"1","author":"Kimmig","year":"2012","journal-title":"eLife"},{"key":"2026072105344710400_JCS264610C61","doi-asserted-by":"publisher","first-page":"233","DOI":"10.4161\/cib.2.3.8097","article-title":"The cell wall and endoplasmic reticulum stress responses are coordinately regulated in Saccharomyces cerevisiae","volume":"2","author":"Krysan","year":"2009","journal-title":"Commun. Integr. Biol."},{"key":"2026072105344710400_JCS264610C62","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/0006-291X(74)90925-5","article-title":"Tunicamycin \u2014 An inhibitor of yeast glycoprotein synthesis","volume":"58","author":"Kuo","year":"1974","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2026072105344710400_JCS264610C63","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1091\/mbc.e11-12-0995","article-title":"Kar2p availability defines distinct forms of endoplasmic reticulum stress in living cells","volume":"23","author":"Lajoie","year":"2012","journal-title":"Mol. Biol. Cell"},{"key":"2026072105344710400_JCS264610C64","doi-asserted-by":"publisher","first-page":"8885","DOI":"10.1073\/pnas.1105564108","article-title":"Dual and opposing roles of the unfolded protein response regulated by IRE1alpha and XBP1 in proinsulin processing and insulin secretion","volume":"108","author":"Lee","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026072105344710400_JCS264610C65","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.4014\/jmb.1405.05012","article-title":"GST2 is required for nitrogen starvation-induced filamentous growth in Candida albicans","volume":"24","author":"Lee","year":"2014","journal-title":"J. Microbiol. Biotechnol."},{"key":"2026072105344710400_JCS264610C66","doi-asserted-by":"publisher","first-page":"104432","DOI":"10.1016\/j.isci.2022.104432","article-title":"Functional analysis of the kinome reveals Hrr25 as a regulator of antifungal susceptibility","volume":"25","author":"Lee","year":"2022","journal-title":"iScience"},{"key":"2026072105344710400_JCS264610C67","doi-asserted-by":"publisher","first-page":"106145","DOI":"10.1016\/j.isci.2023.106145","article-title":"Functional genomic analysis of protein kinases reveals modulators of morphogenesis in diverse environments","volume":"26","author":"Lee","year":"2023","journal-title":"iScience"},{"key":"2026072105344710400_JCS264610C68","doi-asserted-by":"publisher","first-page":"7310","DOI":"10.1038\/s41467-021-27597-7","article-title":"Decoding non-canonical mRNA decay by the endoplasmic-reticulum stress sensor IRE1\u03b1","volume":"12","author":"Le Thomas","year":"2021","journal-title":"Nat. Commun."},{"key":"2026072105344710400_JCS264610C69","doi-asserted-by":"publisher","first-page":"iyaf001","DOI":"10.1093\/genetics\/iyaf001","article-title":"The Candida Genome Database: annotation and visualization updates","volume":"229","author":"Lew-Smith","year":"2025","journal-title":"Genetics"},{"key":"2026072105344710400_JCS264610C70","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1111\/apm.12006","article-title":"Oropharyngeal Candida colonization in human immunodeficiency virus infected patients","volume":"121","author":"Li","year":"2013","journal-title":"APMIS"},{"key":"2026072105344710400_JCS264610C71","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"2026072105344710400_JCS264610C72","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"2026072105344710400_JCS264610C73","doi-asserted-by":"publisher","first-page":"10","DOI":"10.14806\/ej.17.1.200","article-title":"Cutadapt removes adapter sequences from high-throughput sequencing reads","volume":"17","author":"Martin","year":"2011","journal-title":"EMBnet J."},{"key":"2026072105344710400_JCS264610C74","doi-asserted-by":"publisher","first-page":"e58613","DOI":"10.1371\/journal.pone.0058613","article-title":"A core filamentation response network in candida albicans is restricted to eight genes","volume":"8","author":"Martin","year":"2013","journal-title":"PLoS ONE"},{"key":"2026072105344710400_JCS264610C75","doi-asserted-by":"publisher","first-page":"6331","DOI":"10.1038\/s41467-022-34133-8","article-title":"Termination of the unfolded protein response is guided by ER stress-induced HAC1 mRNA nuclear retention","volume":"13","author":"Matabishi-Bibi","year":"2022","journal-title":"Nat. Commun."},{"key":"2026072105344710400_JCS264610C76","doi-asserted-by":"publisher","first-page":"106172","DOI":"10.1016\/j.jinf.2024.106172","article-title":"The modern face of esophageal candidiasis in an oncology center: Correlating clinical manifestations, endoscopic grade, and pathological data in 323 contemporary cancer patients","volume":"89","author":"Matsuo","year":"2024","journal-title":"J. Infect."},{"key":"2026072105344710400_JCS264610C77","doi-asserted-by":"publisher","first-page":"119","DOI":"10.4161\/viru.22913","article-title":"Candida albicans pathogenicity mechanisms","volume":"4","author":"Mayer","year":"2013","journal-title":"Virulence"},{"key":"2026072105344710400_JCS264610C78","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1128\/AAC.50.2.580-586.2006","article-title":"Fluconazole treatment is effective against a Candida albicans erg3\/erg3 mutant in vivo despite in vitro resistance","volume":"50","author":"Miyazaki","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"2026072105344710400_JCS264610C79","doi-asserted-by":"publisher","first-page":"e1003160","DOI":"10.1371\/journal.ppat.1003160","article-title":"Dissection of Ire1 Functions Reveals Stress Response Mechanisms Uniquely Evolved in Candida glabrata","volume":"9","author":"Miyazaki","year":"2013","journal-title":"PLoS Pathog."},{"key":"2026072105344710400_JCS264610C80","doi-asserted-by":"publisher","first-page":"2873","DOI":"10.1091\/mbc.E15-02-0074","article-title":"Ire1-mediated decay in mammalian cells relies on mRNA sequence, structure, and translational status","volume":"26","author":"Moore","year":"2015","journal-title":"Mol. Biol. Cell"},{"key":"2026072105344710400_JCS264610C81","doi-asserted-by":"publisher","first-page":"2583","DOI":"10.1002\/j.1460-2075.1992.tb05323.x","article-title":"A 22 bp cis-acting element is necessary and sufficient for the induction of the yeast KAR2 (BiP) gene by unfolded proteins","volume":"11","author":"Mori","year":"1992","journal-title":"EMBO J."},{"key":"2026072105344710400_JCS264610C82","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1016\/0092-8674(93)90521-Q","article-title":"A transmembrane protein with a cdc2+\/CDC28-related kinase activity is required for signaling from the ER to the nucleus","volume":"74","author":"Mori","year":"1993","journal-title":"Cell"},{"key":"2026072105344710400_JCS264610C83","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1046\/j.1365-2443.1996.d01-274.x","article-title":"Signalling from endoplasmic reticulum to nucleus: transcription factor with a basic-leucine zipper motif is required for the unfolded protein-response pathway","volume":"1","author":"Mori","year":"1996","journal-title":"Genes Cells"},{"key":"2026072105344710400_JCS264610C84","doi-asserted-by":"publisher","first-page":"jkaa043","DOI":"10.1093\/g3journal\/jkaa043","article-title":"Global translational landscape of the Candida albicans morphological transition","volume":"11","author":"Mundodi","year":"2021","journal-title":"G3 (Bethesda)"},{"key":"2026072105344710400_JCS264610C85","doi-asserted-by":"publisher","first-page":"3452","DOI":"10.1091\/mbc.e02-05-0272","article-title":"Transcription profiling of Candida albicans cells undergoing the yeast-to-hyphal transition","volume":"13","author":"Nantel","year":"2002","journal-title":"Mol. Biol. Cell"},{"key":"2026072105344710400_JCS264610C86","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1083\/jcb.150.1.77","article-title":"The unfolded protein response regulates multiple aspects of secretory and membrane protein biogenesis and endoplasmic reticulum quality control","volume":"150","author":"Ng","year":"2000","journal-title":"J. Cell Biol."},{"key":"2026072105344710400_JCS264610C87","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1111\/j.1365-2958.1992.tb00864.x","article-title":"IRE1 encodes a putative protein kinase containing a membrane-spanning domain and is required for inositol phototrophy in Saccharomyces cerevisiae","volume":"6","author":"Nikawa","year":"1992","journal-title":"Mol. Microbiol."},{"key":"2026072105344710400_JCS264610C88","doi-asserted-by":"publisher","first-page":"4222","DOI":"10.1093\/nar\/24.21.4222","article-title":"Saccharomyces cerevisiae IRE2\/HAC1 is involved in IRE1-mediated KAR2 expression","volume":"24","author":"Nikawa","year":"1996","journal-title":"Nucleic Acids Res."},{"key":"2026072105344710400_JCS264610C89","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.cell.2011.10.048","article-title":"A recently evolved transcriptional network controls biofilm development in Candida albicans","volume":"148","author":"Nobile","year":"2012","journal-title":"Cell"},{"key":"2026072105344710400_JCS264610C90","doi-asserted-by":"publisher","first-page":"6265","DOI":"10.1093\/nar\/gkq452","article-title":"Identification of a consensus element recognized and cleaved by IRE1 alpha","volume":"38","author":"Oikawa","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"2026072105344710400_JCS264610C91","doi-asserted-by":"publisher","first-page":"18026","DOI":"10.1038\/nrdp.2018.26","article-title":"Invasive candidiasis","volume":"4","author":"Pappas","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"key":"2026072105344710400_JCS264610C92","doi-asserted-by":"publisher","first-page":"980","DOI":"10.3389\/fmicb.2018.00980","article-title":"Oropharyngeal candidosis in HIV-infected patients-an update","volume":"9","author":"Patil","year":"2018","journal-title":"Front. Microbiol."},{"key":"2026072105344710400_JCS264610C93","doi-asserted-by":"publisher","first-page":"100182","DOI":"10.1016\/j.xpro.2020.100182","article-title":"A quantitative imaging-based protocol for yeast growth and survival on agar plates","volume":"1","author":"Petropavlovskiy","year":"2020","journal-title":"STAR Protoc."},{"key":"2026072105344710400_JCS264610C94","doi-asserted-by":"publisher","first-page":"e64","DOI":"10.1371\/journal.pbio.0050064","article-title":"Als3 is a Candida albicans invasin that binds to cadherins and induces endocytosis by host cells","volume":"5","author":"Phan","year":"2007","journal-title":"PLoS Biol."},{"key":"2026072105344710400_JCS264610C95","doi-asserted-by":"publisher","first-page":"3520","DOI":"10.1091\/mbc.e11-04-0295","article-title":"Membrane aberrancy and unfolded proteins activate the endoplasmic reticulum stress sensor Ire1 in different ways","volume":"22","author":"Promlek","year":"2011","journal-title":"Mol. Biol. Cell"},{"key":"2026072105344710400_JCS264610C96","doi-asserted-by":"publisher","first-page":"2546","DOI":"10.1093\/nar\/gkad1258","article-title":"Thiolutin has complex effects in vivo but is a direct inhibitor of RNA polymerase II in vitro","volume":"52","author":"Qiu","year":"2024","journal-title":"Nucleic Acids Res.."},{"key":"2026072105344710400_JCS264610C97","doi-asserted-by":"publisher","first-page":"e1010283","DOI":"10.1371\/journal.ppat.1010283","article-title":"The protein kinase Ire1 has a Hac1-independent essential role in iron uptake and virulence of Candida albicans","volume":"18","author":"Ram\u00edrez-Zavala","year":"2022","journal-title":"PLoS Pathog."},{"key":"2026072105344710400_JCS264610C98","doi-asserted-by":"publisher","first-page":"iyab131","DOI":"10.1093\/genetics\/iyab131","article-title":"The SAGA and NuA4 component Tra1 regulates Candida albicans drug resistance and pathogenesis","volume":"219","author":"Razzaq","year":"2021","journal-title":"Genetics"},{"key":"2026072105344710400_JCS264610C99","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1046\/j.1365-2958.2003.03697.x","article-title":"Large-scale essential gene identification in Candida albicans and applications to antifungal drug discovery","volume":"50","author":"Roemer","year":"2003","journal-title":"Mol. Microbiol."},{"key":"2026072105344710400_JCS264610C100","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1128\/EC.00034-10","article-title":"Adaptations of Candida albicans for growth in the mammalian intestinal tract","volume":"9","author":"Rosenbach","year":"2010","journal-title":"Eukaryot. Cell"},{"key":"2026072105344710400_JCS264610C101","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1083\/jcb.201007077","article-title":"Homeostatic adaptation to endoplasmic reticulum stress depends on Ire1 kinase activity","volume":"193","author":"Rubio","year":"2011","journal-title":"J. Cell Biol."},{"key":"2026072105344710400_JCS264610C102","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/jof4010001","article-title":"The CWI pathway: regulation of the transcriptional adaptive response to cell wall stress in yeast","volume":"4","author":"Sanz","year":"2017","journal-title":"J. Fungi. (Basel)"},{"key":"2026072105344710400_JCS264610C103","doi-asserted-by":"publisher","first-page":"2172","DOI":"10.1038\/s41467-025-57360-1","article-title":"Crucial roles of Grr1 in splicing and translation of HAC1 mRNA upon unfolded stress response","volume":"16","author":"Sato","year":"2025","journal-title":"Nat. Commun."},{"key":"2026072105344710400_JCS264610C104","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat. Protoc."},{"key":"2026072105344710400_JCS264610C105","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"2026072105344710400_JCS264610C106","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1091\/mbc.e08-08-0809","article-title":"The unfolded protein response is induced by the cell wall integrity mitogen-activated protein kinase signaling cascade and is required for cell wall integrity in Saccharomyces cerevisiae","volume":"20","author":"Scrimale","year":"2009","journal-title":"Mol. Biol. Cell"},{"key":"2026072105344710400_JCS264610C107","doi-asserted-by":"publisher","first-page":"2936","DOI":"10.1002\/pmic.200701097","article-title":"Candida albicans biofilm formation is associated with increased anti-oxidative capacities","volume":"8","author":"Seneviratne","year":"2008","journal-title":"Proteomics"},{"key":"2026072105344710400_JCS264610C108","doi-asserted-by":"publisher","first-page":"3238","DOI":"10.3390\/jcm12093238","article-title":"Invasive fungal infections after liver transplantation","volume":"12","author":"Senoner","year":"2023","journal-title":"J. Clin. Med."},{"key":"2026072105344710400_JCS264610C109","doi-asserted-by":"publisher","first-page":"1824","DOI":"10.3390\/jcm9061824","article-title":"Invasive fungal diseases in kidney transplant recipients: risk factors for mortality","volume":"9","author":"Seok","year":"2020","journal-title":"J. Clin. Med."},{"key":"2026072105344710400_JCS264610C110","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1016\/j.cub.2009.03.017","article-title":"Hsp90 orchestrates temperature-dependent Candida albicans morphogenesis via Ras1-PKA signaling","volume":"19","author":"Shapiro","year":"2009","journal-title":"Curr. Biol."},{"key":"2026072105344710400_JCS264610C111","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1128\/MMBR.00045-10","article-title":"Regulatory circuitry governing fungal development, drug resistance, and disease","volume":"75","author":"Shapiro","year":"2011","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"2026072105344710400_JCS264610C112","doi-asserted-by":"publisher","first-page":"1152552","DOI":"10.3389\/fcimb.2023.1152552","article-title":"A 3-year study of infections among patients with malignancy: etiologic agents and antifungal susceptibility profile","volume":"13","author":"Sharifi","year":"2023","journal-title":"Front. Cell Infect. Microbiol."},{"key":"2026072105344710400_JCS264610C113","doi-asserted-by":"publisher","first-page":"9445","DOI":"10.1038\/s41598-019-45817-5","article-title":"The fungal histone acetyl transferase Gcn5 controls virulence of the human pathogen candida albicans through multiple pathways","volume":"9","author":"Shivarathri","year":"2019","journal-title":"Sci. Rep."},{"key":"2026072105344710400_JCS264610C114","doi-asserted-by":"publisher","first-page":"639","DOI":"10.2217\/fmb.12.28","article-title":"Invasive fungal infections in solid organ transplant recipients","volume":"7","author":"Shoham","year":"2012","journal-title":"Future Microbiol."},{"key":"2026072105344710400_JCS264610C115","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1016\/S0092-8674(01)00494-9","article-title":"Serial regulation of transcriptional regulators in the yeast cell cycle","volume":"106","author":"Simon","year":"2001","journal-title":"Cell"},{"key":"2026072105344710400_JCS264610C116","doi-asserted-by":"publisher","first-page":"e13307","DOI":"10.1111\/cmi.13307","article-title":"The protein kinase Ire1 impacts pathogenicity of Candida albicans by regulating homeostatic adaptation to endoplasmic reticulum stress","volume":"23","author":"Sircaik","year":"2021","journal-title":"Cell. Microbiol."},{"key":"2026072105344710400_JCS264610C117","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1002\/yea.320110402","article-title":"Cloning and heterologous expression of the Candida albicans gene PMI 1 encoding phosphomannose isomerase","volume":"11","author":"Smith","year":"1995","journal-title":"Yeast"},{"key":"2026072105344710400_JCS264610C118","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1093\/jac\/dkad139","article-title":"Invasive candidiasis: current clinical challenges and unmet needs in adult populations","volume":"78","author":"Soriano","year":"2023","journal-title":"J. Antimicrob. Chemother."},{"key":"2026072105344710400_JCS264610C119","doi-asserted-by":"publisher","first-page":"79","DOI":"10.3390\/jof7020079","article-title":"The Virulence Factors and Clinical Manifestations of Infection","volume":"7","author":"Talapko","year":"2021","journal-title":"J. Fungi. (Basel)"},{"key":"2026072105344710400_JCS264610C120","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1016\/j.celrep.2014.09.016","article-title":"Ire1 has distinct catalytic mechanisms for XBP1\/HAC1 splicing and RIDD","volume":"9","author":"Tam","year":"2014","journal-title":"Cell Rep."},{"key":"2026072105344710400_JCS264610C121","doi-asserted-by":"publisher","first-page":"e00497-17","DOI":"10.1128\/mSphere.00497-17","article-title":"The genomic landscape of the fungus-specific SWI\/SNF complex subunit, Snf6, in","volume":"2","author":"Tebbji","year":"2017","journal-title":"mSphere"},{"key":"2026072105344710400_JCS264610C122","doi-asserted-by":"publisher","first-page":"D785","DOI":"10.1093\/nar\/gkac1041","article-title":"YEASTRACT+: a portal for the exploitation of global transcription regulation and metabolic model data in yeast biotechnology and pathogenesis","volume":"51","author":"Teixeira","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"2026072105344710400_JCS264610C123","doi-asserted-by":"publisher","first-page":"6","DOI":"10.3390\/pathogens5010006","article-title":"How chemotherapy increases the risk of systemic candidiasis in cancer patients: current paradigm and future directions","volume":"5","author":"Teoh","year":"2016","journal-title":"Pathogens"},{"key":"2026072105344710400_JCS264610C124","doi-asserted-by":"publisher","first-page":"20597","DOI":"10.1073\/pnas.1117184109","article-title":"The unfolded protein response supports cellular robustness as a broad-spectrum compensatory pathway","volume":"108","author":"Thibault","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026072105344710400_JCS264610C125","doi-asserted-by":"publisher","first-page":"fov095","DOI":"10.1093\/femsyr\/fov095","article-title":"The activity of RTA2, a downstream effector of the calcineurin pathway, is required during tunicamycin-induced ER stress response in Candida albicans","volume":"15","author":"Thomas","year":"2015","journal-title":"FEMS Yeast Res."},{"key":"2026072105344710400_JCS264610C126","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1002\/pro.4218","article-title":"PANTHER: Making genome-scale phylogenetics accessible to all","volume":"31","author":"Thomas","year":"2022","journal-title":"Protein Sci."},{"key":"2026072105344710400_JCS264610C127","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/S0092-8674(00)80835-1","article-title":"Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation","volume":"101","author":"Travers","year":"2000","journal-title":"Cell"},{"key":"2026072105344710400_JCS264610C128","doi-asserted-by":"publisher","first-page":"6440","DOI":"10.1093\/emboj\/19.23.6440","article-title":"LHS1 and SIL1 provide a lumenal function that is essential for protein translocation into the endoplasmic reticulum","volume":"19","author":"Tyson","year":"2000","journal-title":"EMBO J."},{"key":"2026072105344710400_JCS264610C129","doi-asserted-by":"publisher","first-page":"2668","DOI":"10.1093\/emboj\/cdg256","article-title":"Haploinsufficiency-based large-scale forward genetic analysis of filamentous growth in the diploid human fungal pathogen C.albicans","volume":"22","author":"Uhl","year":"2003","journal-title":"EMBO J."},{"key":"2026072105344710400_JCS264610C130","doi-asserted-by":"publisher","first-page":"e1007270","DOI":"10.1371\/journal.pgen.1007270","article-title":"Tuning Hsf1 levels drives distinct fungal morphogenetic programs with depletion impairing Hsp90 function and overexpression expanding the target space","volume":"14","author":"Veri","year":"2018","journal-title":"PLoS Genet."},{"key":"2026072105344710400_JCS264610C131","doi-asserted-by":"publisher","first-page":"foaa005","DOI":"10.1093\/femsyr\/foaa005","article-title":"Transcriptional control of hyphal morphogenesis in Candida albicans","volume":"20","author":"Villa","year":"2020","journal-title":"FEMS Yeast Res."},{"key":"2026072105344710400_JCS264610C132","doi-asserted-by":"publisher","first-page":"e0043621","DOI":"10.1128\/mSphere.00436-21","article-title":"Intravital imaging of candida albicans identifies differential and filamentation phenotypes for transcription factor deletion mutants","volume":"6","author":"Wakade","year":"2021","journal-title":"mSphere"},{"key":"2026072105344710400_JCS264610C133","doi-asserted-by":"publisher","first-page":"e0085122","DOI":"10.1128\/mbio.00851-22","article-title":"Candida albicans Filamentation Does Not Require the cAMP-PKA Pathway","volume":"13","author":"Wakade","year":"2022","journal-title":"mBio"},{"key":"2026072105344710400_JCS264610C134","doi-asserted-by":"publisher","first-page":"e0078523","DOI":"10.1128\/msphere.00785-23","article-title":"The role of the transcriptional repressor during filamentation and disseminated candidiasis is strain dependent","volume":"9","author":"Wakade","year":"2024","journal-title":"mSphere"},{"key":"2026072105344710400_JCS264610C135","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1126\/science.1209038","article-title":"The unfolded protein response: from stress pathway to homeostatic regulation","volume":"334","author":"Walter","year":"2011","journal-title":"Science"},{"key":"2026072105344710400_JCS264610C136","doi-asserted-by":"publisher","first-page":"1648467","DOI":"10.3389\/fmicb.2025.1648467","article-title":"Ire1 inhibitors attenuate pathogenicity and demonstrate potential for application in antifungal therapy","volume":"16","author":"Wang","year":"2025","journal-title":"Front. Microbiol."},{"key":"2026072105344710400_JCS264610C137","doi-asserted-by":"publisher","first-page":"e12963","DOI":"10.1111\/cmi.12963","article-title":"On-site secretory vesicle delivery drives filamentous growth in the fungal pathogen Candida albicans","volume":"21","author":"Weiner","year":"2019","journal-title":"Cell. Microbiol."},{"key":"2026072105344710400_JCS264610C138","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1016\/j.fgb.2008.06.001","article-title":"Impact of the unfolded protein response upon genome-wide expression patterns, and the role of Hac1 in the polarized growth, of Candida albicans","volume":"45","author":"Wimalasena","year":"2008","journal-title":"Fungal Genet. Biol."},{"key":"2026072105344710400_JCS264610C139","doi-asserted-by":"publisher","first-page":"e1006487","DOI":"10.1371\/journal.pgen.1006487","article-title":"Bypass of Candida albicans filamentation\/biofilm regulators through diminished expression of protein Kinase Cak1","volume":"12","author":"Woolford","year":"2016","journal-title":"PLoS Genet."},{"key":"2026072105344710400_JCS264610C140","doi-asserted-by":"publisher","first-page":"e0227221","DOI":"10.1128\/mBio.02272-21","article-title":"Tunicamycin potentiates antifungal drug tolerance via aneuploidy in Candida albicans","volume":"12","author":"Yang","year":"2021","journal-title":"mBio"},{"key":"2026072105344710400_JCS264610C141","doi-asserted-by":"publisher","first-page":"20221062","DOI":"10.1515\/biol-2022-1062","article-title":"Effects of Ire1 gene on virulence and pathogenicity of","volume":"20","author":"Zhao","year":"2025","journal-title":"Open Life Sci."},{"key":"2026072105344710400_JCS264610C142","doi-asserted-by":"publisher","first-page":"3926","DOI":"10.1038\/s41467-024-48093-8","article-title":"Hyphal Als proteins act as CR3 ligands to promote immune responses against Candida albicans","volume":"15","author":"Zhou","year":"2024","journal-title":"Nat. Commun."}],"container-title":["Journal of Cell Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/jcs\/article-pdf\/doi\/10.1242\/jcs.264610\/3704594\/jcs264610.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/jcs\/article-pdf\/doi\/10.1242\/jcs.264610\/3708854\/jcs264610.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/jcs\/article-pdf\/doi\/10.1242\/jcs.264610\/3708854\/jcs264610.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T09:34:59Z","timestamp":1784626499000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/jcs\/article\/139\/14\/jcs264610\/372286\/Hac1-independent-functions-of-Ire1-drive"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,15]]},"references-count":142,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2026,7,15]]}},"URL":"https:\/\/doi.org\/10.1242\/jcs.264610","relation":{},"ISSN":["0021-9533","1477-9137"],"issn-type":[{"value":"0021-9533","type":"print"},{"value":"1477-9137","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,15]]},"article-number":"jcs264610"}}