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Here, using mass spectrometry and super-resolution microscopy, we identified 180\u2005nm receptor complexes comprised of MERTK, \u03b22 integrins and several associated signaling molecules. Efferocytosis was found to be dependent on both MERTK and \u03b22 integrins, with MERTK inducing the conformational change of \u03b22 integrins from low to high-affinity via a PI3K-dependent pathway, with the active integrins then mediating the expansion of an efferocytic synapse around the apoptotic cell. This synapse was highly structured, with MERTK retained by ligand-induced clustering in the synapse centre, while \u03b22 integrins and actin form a Src family kinase and FAK-dependent expanding ring that defined the leading edge of the efferocytic synapse. These findings provide new insights into the function of this crucial homeostatic receptor and provide new insights into how MERTK mutations and signaling defects might contribute to inflammatory and autoimmune diseases.<\/jats:p>","DOI":"10.1242\/jcs.264792","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T09:39:48Z","timestamp":1771580388000},"source":"Crossref","is-referenced-by-count":8,"title":["MERTK coordinates efferocytosis by regulating integrin localization and activation"],"prefix":"10.1242","volume":"139","author":[{"given":"Brandon H.","family":"Dickson","sequence":"first","affiliation":[{"name":"Immunity and Inflammation Centre, The University of Western Ontario Department of Microbiology and Immunology, and the Western Infection , , London, Ontario, N6A 5C1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarannum","family":"Tasnim","sequence":"additional","affiliation":[{"name":"Immunity and Inflammation Centre, The University of Western Ontario Department of Microbiology and Immunology, and the Western Infection , , London, Ontario, N6A 5C1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel A.","family":"Nicholson","sequence":"additional","affiliation":[{"name":"Immunity and Inflammation Centre, The University of Western Ontario Department of Microbiology and Immunology, and the Western Infection , , London, Ontario, N6A 5C1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Stanlake","sequence":"additional","affiliation":[{"name":"Immunity and Inflammation Centre, The University of Western Ontario Department of Microbiology and Immunology, and the Western Infection , , London, Ontario, N6A 5C1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Austin L.","family":"Lam","sequence":"additional","affiliation":[{"name":"Immunity and Inflammation Centre, The University of Western Ontario Department of Microbiology and Immunology, and the Western Infection , , London, Ontario, N6A 5C1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela M.","family":"Vrieze","sequence":"additional","affiliation":[{"name":"Immunity and Inflammation Centre, The University of Western Ontario Department of Microbiology and Immunology, and the Western Infection , , London, Ontario, N6A 5C1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eoin N.","family":"Blythe","sequence":"additional","affiliation":[{"name":"Immunity and Inflammation Centre, The University of Western Ontario Department of Microbiology and Immunology, and the Western Infection , , London, Ontario, N6A 5C1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory A.","family":"Dekaban","sequence":"additional","affiliation":[{"name":"Immunity and Inflammation Centre, The University of Western Ontario Department of Microbiology and Immunology, and the Western Infection , , London, Ontario, N6A 5C1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2392-468X","authenticated-orcid":false,"given":"Bryan","family":"Heit","sequence":"additional","affiliation":[{"name":"Immunity and Inflammation Centre, The University of Western Ontario Department of Microbiology and Immunology, and the Western Infection , , London, Ontario, N6A 5C1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2026,3,25]]},"reference":[{"key":"2026032504313605900_JCS264792C1","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/S0165-2478(01)00251-6","article-title":"Involvement of pp125FAK and p60SRC in the signaling through Fc gamma RII-Fc gamma RIII in murine macrophages","volume":"78","author":"Antonieta Cote-V\u00e9lez","year":"2001","journal-title":"Immunol. 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