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Although SG assembly and disassembly during acute stress have been extensively characterized, their regulation under chronic stress remains poorly understood. We have previously shown that chronic stress preconditioning suppresses the earliest stages of SG assembly through translation-dependent mechanisms. Whether chronic stress also impaired subsequent SG maturation remained unknown. Here, we demonstrate that chronic stress limits SG maturation by disrupting the MYH9-dependent interaction network centered on the core SG nucleator G3BP1. Loss of this interaction reduces SG size and impairs docking between SGs and processing bodies (PBs), thereby restricting the maturation of nascent SGs. In parallel, chronic stress decreases expression of the SG nucleator UBAP2L, an essential regulator of SG\u2013PB docking, further exacerbating these defects. Together, our findings identify chronic stress as a regulator of the MYH9\u2013G3BP1\u2013UBAP2L axis and reveal that chronic stress inhibits SG maturation through translation-independent mechanisms.<\/jats:p>","DOI":"10.1242\/jcs.264801","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T10:21:35Z","timestamp":1787307695000},"source":"Crossref","is-referenced-by-count":1,"title":["Chronic stress disrupts the network among stress granules, processing bodies and motor proteins"],"prefix":"10.1242","volume":"139","author":[{"given":"Yuichiro","family":"Adachi","sequence":"first","affiliation":[{"name":"Brigham and Women's Hospital 1 Division of Rheumatology, Inflammation and Immunity , , Boston, MA 02115 ,","place":["USA"]},{"name":"Harvard Medical School 2 Department of Medicine , , Boston, MA 02115 ,","place":["USA"]},{"name":"Institute of Biomedical Sciences, Tokushima University Graduate School 3 Department of Clinical Nutrition and Food Management , , Tokushima, 770-8503 ,","place":["Japan"]},{"name":"Institute of Photonics and Human Health Frontier, Tokushima University 4 Laboratory of Clinical Nutrition , , Tokushima, 770-8503 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3762-2770","authenticated-orcid":false,"given":"Masashi","family":"Masuda","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences, Tokushima University Graduate School 3 Department of Clinical Nutrition and Food Management , , Tokushima, 770-8503 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Taketani","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences, Tokushima University Graduate School 3 Department of Clinical Nutrition and Food Management , , Tokushima, 770-8503 ,","place":["Japan"]},{"name":"Institute of Photonics and Human Health Frontier, Tokushima University 4 Laboratory of Clinical Nutrition , , Tokushima, 770-8503 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital 1 Division of Rheumatology, Inflammation and Immunity , , Boston, MA 02115 ,","place":["USA"]},{"name":"Harvard Medical School 2 Department of Medicine , , Boston, MA 02115 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel V.","family":"Ivanov","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital 1 Division of Rheumatology, Inflammation and Immunity , , Boston, MA 02115 ,","place":["USA"]},{"name":"Harvard Medical School 2 Department of Medicine , , Boston, MA 02115 ,","place":["USA"]},{"name":"Harvard Initiative for RNA Medicine 5 , Boston, MA 02115 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"key":"2026100108344362600_JCS264801C1","doi-asserted-by":"publisher","first-page":"114556","DOI":"10.1016\/j.isci.2025.114556","article-title":"Chronic stress antagonizes formation of stress granules","volume":"29","author":"Adachi","year":"2025","journal-title":"iScience"},{"key":"2026100108344362600_JCS264801C2","doi-asserted-by":"publisher","first-page":"4827","DOI":"10.1007\/s00018-020-03565-0","article-title":"Stress granule subtypes: an emerging link to neurodegeneration","volume":"77","author":"Advani","year":"2020","journal-title":"Cell. 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