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The latter is a monolayer of cells, situated between the neural retina and the chroroid vasculature, that is essential for photoreceptor homeostasis and function. Myeloid bodies operate in an environment of high oxygen tension and chronic light exposure where phagocytosis of photoreceptor outer segments takes place, resulting in photo-oxidative stress. Over time, such damage can result in pigment epithelium cell death, retinal degeneration and blindness. The purpose of myeloid bodies is unknown. Here, unusually large myeloid bodies are described, with cisternae perpendicular to the basal epithelium (Bruch's) membrane, that occur throughout the differentiated retina of the sablefish Anoplopoma fimbria, a marine fish with early life history exposure to the full spectrum of light. Immunogold labelling of thin sections was used to demonstrate exclusive cisternal binding of short-wavelength (blue) light-absorbing opsins and a zeaxanthin carotenoid-associated enzyme. Because blue light is highly efficient at inducing photo-oxidation, the sequestration of these compounds within myeloid bodies suggests that the smooth endoplasmic reticulum has an optical role in filtering light to prevent photo-oxidative damage.<\/jats:p>","DOI":"10.1242\/jcs.264938","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T07:00:21Z","timestamp":1783321221000},"source":"Crossref","is-referenced-by-count":1,"title":["Potential role of myeloid bodies in protection against photo-oxidative damage of the retinal pigment epithelium"],"prefix":"10.1242","volume":"139","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2588-9243","authenticated-orcid":false,"given":"I\u00f1igo","family":"Novales Flamarique","sequence":"first","affiliation":[{"name":"Simon Fraser University 1 Department of Biological Sciences , , Burnaby, BC V5A 1S6 ,","place":["Canada"]},{"name":"University of Victoria 2 Department of Biology , , Victoria, BC V5A 1S6 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"key":"2026091404323985800_JCS264938C1","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1007\/BF00319160","article-title":"Biogenesis of myeloid bodies in regenerating newt (Notophthalmus viridescens) retinal pigment epithelium","volume":"268","author":"Abran","year":"1992","journal-title":"Cell Tissue Res."},{"key":"2026091404323985800_JCS264938C2","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1016\/0014-4835(92)90029-R","article-title":"Phospholipid composition of myeloid bodies from chick retinal pigment epithelium","volume":"54","author":"Abran","year":"1992","journal-title":"Exp. 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