{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T15:27:36Z","timestamp":1789658856280,"version":"4.0.1"},"reference-count":51,"publisher":"The Company of Biologists","issue":"17","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-2\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["32370908"],"award-info":[{"award-number":["32370908"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Natural Science Foundation of China","award":["32571001"],"award-info":[{"award-number":["32571001"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Fundamental Research Funds for the Central Universities of China","award":["KJJQ2026001"],"award-info":[{"award-number":["KJJQ2026001"]}]},{"name":"Fundamental Research Funds for the Central Universities of China","award":["RENCAI2025035"],"award-info":[{"award-number":["RENCAI2025035"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>TRIM28, a member of the tripartite motif (TRIM) family, functions as a transcriptional coregulator involved in maintaining genome stability during mitosis. In this study, we explored the role of TRIM28 in mouse oocyte meiotic maturation, where transcriptional activity is barely detectable. We found that TRIM28 was constitutively expressed during the early stages of oocyte meiotic maturation, with predominant nuclear localization in germinal vesicle (GV)-stage oocytes. TRIM28 depletion caused defective germinal vesicle breakdown (GVBD), but oocytes that successfully underwent GVBD displayed unimpaired first polar body (PB1) extrusion. TRIM28 depletion impaired CDK1 activity and reduced cyclin B1 levels, leading to a delay in the G2\/M transition. This delay might be caused by altered levels of HDAC2-mediated H4K12ac and H3K4me2-modulated H3K9me2 in nonsurrounded nucleolus (NSN)-type GV oocytes, which decreased transcription activity. Additionally, TRIM28-depleted oocytes exhibited elevated \u03b3-H2A.X expression, accompanied by aberrant expression of CHK1 and CHK2, as well as dysregulated expression of RAD51, which collectively contributed to GVBD failure in mouse oocytes. In conclusion, our findings indicate that TRIM28 participates in the regulation of the G2\/M transition during mouse oocyte meiotic maturation, acting through the modulation of histone modifications and DNA damage repair.<\/jats:p>","DOI":"10.1242\/jcs.264992","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T07:13:56Z","timestamp":1786346036000},"source":"Crossref","is-referenced-by-count":1,"title":["TRIM28 regulates the G2\/M transition via histone modification and DNA damage repair during mouse oocyte meiosis"],"prefix":"10.1242","volume":"139","author":[{"given":"Rui-Jie","family":"Ma","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agricultural University 1 , Nanjing 210095 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Meng","family":"Tang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agricultural University 1 , Nanjing 210095 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping-Shuang","family":"Lu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agricultural University 1 , Nanjing 210095 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao-Lin","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agricultural University 1 , Nanjing 210095 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Qian","family":"Ju","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agricultural University 1 , Nanjing 210095 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Ping","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agricultural University 1 , Nanjing 210095 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun-Huan","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agricultural University 1 , Nanjing 210095 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agricultural University 1 , Nanjing 210095 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5060-1742","authenticated-orcid":false,"given":"Shao-Chen","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agricultural University 1 , Nanjing 210095 ,","place":["China"]},{"name":"Key Laboratory of Research on Clinical Molecular Diagnosis for High Incidence Diseases in Western Guangxi of Guangxi Higher Education Institutions, Affiliated Hospital of Youjiang Medical University for Nationalities 2 , Baise 533000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"2026091604533947300_JCS264992C1","doi-asserted-by":"publisher","first-page":"2476","DOI":"10.1093\/hmg\/dds061","article-title":"Cdk1, but not Cdk2, is the sole Cdk that is essential and sufficient to drive resumption of meiosis in mouse oocytes","volume":"21","author":"Adhikari","year":"2012","journal-title":"Hum. 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