{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:20:16Z","timestamp":1791854416052,"version":"4.3.4"},"reference-count":56,"publisher":"The Company of Biologists","issue":"21","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Deutsche Forschungsgemeinschaft","award":["SFB 1348"],"award-info":[{"award-number":["SFB 1348"]}],"id":[{"id":"https:\/\/ror.org\/018mejw64","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Deutsche Forschungsgemeinschaft","award":["EXC 1003-CiM"],"award-info":[{"award-number":["EXC 1003-CiM"]}],"id":[{"id":"https:\/\/ror.org\/018mejw64","id-type":"ROR","asserted-by":"crossref"}]},{"name":"University of M\u00fcnster","id":[{"id":"https:\/\/ror.org\/00pd74e08","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,11,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Epithelial morphogenesis and homeostasis depend on dynamic remodeling of cell\u2013cell junctions. Tricellular junctions (TCJs) control epithelial permeability and plasticity, yet how TCJs are remodeled remains unclear. In the Drosophila ovarian follicular epithelium, TCJs open transiently in a process called patency to allow passage of yolk proteins for uptake by the oocyte. Here, we investigated how a TGF-\u03b2 signaling gradient represses patency along the follicular epithelium. We show that TGF-\u03b2 signaling blocks patency cell-autonomously by strengthening E-Cadherin (E-Cad, also known as Shg)-based adhesion through inducing E-Cad transcription and preventing E-Cad removal from vertices. Elevated E-Cad levels alone were not sufficient to block patency, implying that additional TGF-\u03b2-dependent mechanisms stabilize E-Cad at vertices. We identify p120-catenin (p120ctn) upregulation as a mechanism that may contribute to strengthened adhesion. In parallel, TGF-\u03b2 signaling activates myosin II through Rho\u2013Rok signaling. However, myosin II activity is dispensable for TGF-\u03b2-mediated patency suppression. Thus, our findings suggest that TGF-\u03b2 signaling controls TCJ remodeling in follicle cells primarily by reinforcing E-Cad-based adhesion, disentangling the roles of adhesion and actomyosin contractility in maintaining TCJ integrity and revealing how a morphogen gradient spatially patterns epithelial permeability.<\/jats:p>","DOI":"10.1242\/jcs.264997","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T10:02:51Z","timestamp":1786615371000},"source":"Crossref","is-referenced-by-count":1,"title":["TGF-\u03b2 signaling modulates adhesion and actomyosin contractility to pattern epithelial permeability in\n                    <i>Drosophila<\/i>\n                    ovaries"],"prefix":"10.1242","volume":"139","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9231-7417","authenticated-orcid":false,"given":"Harshath","family":"Amal","sequence":"first","affiliation":[{"name":"Institute of Integrative Cell Biology and Physiology, Cells in Motion (CiM) Interfaculty Centre, University of M\u00fcnster , 48149 M\u00fcnster ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thea","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Institute of Integrative Cell Biology and Physiology, Cells in Motion (CiM) Interfaculty Centre, University of M\u00fcnster , 48149 M\u00fcnster ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Lohrberg","sequence":"additional","affiliation":[{"name":"Institute of Integrative Cell Biology and Physiology, Cells in Motion (CiM) Interfaculty Centre, University of M\u00fcnster , 48149 M\u00fcnster ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0634-3368","authenticated-orcid":false,"given":"Stefan","family":"Luschnig","sequence":"additional","affiliation":[{"name":"Institute of Integrative Cell Biology and Physiology, Cells in Motion (CiM) Interfaculty Centre, University of M\u00fcnster , 48149 M\u00fcnster ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2026,10,12]]},"reference":[{"key":"2026101209314775900_JCS264997C1","doi-asserted-by":"publisher","first-page":"iyad200","DOI":"10.1093\/genetics\/iyad200","article-title":"Bone morphogenetic protein signaling: the pathway and its regulation","volume":"226","author":"Akiyama","year":"2023","journal-title":"Genetics"},{"key":"2026101209314775900_JCS264997C2","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/nmeth.1896","article-title":"OMERO: flexible, model-driven data management for experimental biology","volume":"9","author":"Allan","year":"2012","journal-title":"Nat. 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