{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T20:39:54Z","timestamp":1720643994025},"reference-count":24,"publisher":"The Company of Biologists","issue":"1","license":[{"start":{"date-parts":[[1982,6,1]],"date-time":"1982-06-01T00:00:00Z","timestamp":391737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1982,6,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>The influence of tubulin-binding agents on the infiltration of murine MB6A lymphosarcoma and TA3 mammary carcinoma cells into primary rat hepatocyte cultures was studied. Colchicin, nocodazole and vinblastin reduced the number of infiltrating lymphosarcoma cells, probably by interfering with the adhesion of these cells to the exposed hepatocyte surface. However, the subsequent infiltration of cells that did adhere was not affected or even slightly stimulated. The reduced adhesion appears to be due to an effect on both the MB6A cells and the hepatocytes.<\/jats:p>\n               <jats:p>In contrast, adhesion of TA3 cells was not reduced and infiltration was markedly enhanced by these agents, due to an effect on the TA3 cells but probably not on the hepatocytes.<\/jats:p>\n               <jats:p>These observations support previously described morphological evidence for differences between the infiltration mechanisms of the two tumour cell types. It is concluded that the system within the hepatocytes involved in adhesiveness of the exposed surface to MB6A cells is distinct from that mediating other types of adhesion. The tendency of TA3 cells to invaginate hepatocytes may be due to disturbances in tubulin-dependent processes.<\/jats:p>","DOI":"10.1242\/jcs.55.1.233","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T20:55:35Z","timestamp":1619470535000},"page":"233-245","source":"Crossref","is-referenced-by-count":21,"title":["Effect of tubulin-binding agents on the infiltration of tumour cells into primary hepatocyte cultures"],"prefix":"10.1242","volume":"55","author":[{"given":"Ed","family":"Roos","sequence":"first","affiliation":[{"name":"Division of Cell Biology, The Netherlands Cancer Institute, 121 Plesmanlaan, 1066 CX Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilja V.","family":"Van de Pavert","sequence":"additional","affiliation":[{"name":"Division of Cell Biology, The Netherlands Cancer Institute, 121 Plesmanlaan, 1066 CX Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[1982,6,1]]},"reference":[{"key":"2023070423260808800_JOCES_55_1_233C1","first-page":"443","article-title":"Microtubules and the structure and function of cell surfaces","volume-title":"In Microtubules","author":"Berlin","year":"1979"},{"key":"2023070423260808800_JOCES_55_1_233C2","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/0014-4827(78)90240-9","article-title":"Colchicine and cytochalasin B (CB) effects on random movement, spreading and adhesion of mouse macrophages","volume":"111","author":"Cheung","year":"1978","journal-title":"Expl Cell Res"},{"key":"2023070423260808800_JOCES_55_1_233C3","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1016\/0309-1651(80)90050-8","article-title":"Effects of nocodazole, a new synthetic microtubule inhibitor, on movement and spreading of mouse peritoneal macrophages","volume":"4","author":"Cheung","year":"1980","journal-title":"Cell Biol. 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