{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T06:08:21Z","timestamp":1700114901057},"reference-count":55,"publisher":"The Company of Biologists","issue":"1","license":[{"start":{"date-parts":[[1983,7,1]],"date-time":"1983-07-01T00:00:00Z","timestamp":425865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1983,7,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Quantitative X-ray microanalysis of frozen freeze-dried sections of mouse cortex have been used to determine the concentrations of Na, Mg, P, S, Cl, K, Ca and Cd in normal mice and those subjected to 0\u00b77 \u03bcmol of cadmium chloride in two subcutaneous injections. These injections result in tissue levels of approximately 100 mg Cd\/kg dry weight (&amp;lt;1 mM) in whole kidney when analysed by atomic absorption spectrometry.<\/jats:p>\n               <jats:p>There were distinct and characteristic differences \u2013 \u2018fingerprints\u2019 \u2013 in the elemental composition of both cytoplasm and mitochondria in proximal and distal tubules of normal mice that were disturbed by the cadmium treatment.<\/jats:p>\n               <jats:p>The most significant effect of the cadmium injections was a highly significant increase in the sulphur content of the cytoplasm and mitochondria of distal tubules and a loss in concentration of Mg, P, Cl, K, and particularly Na, from the mitochondria. These results are discussed in the light of current concepts of metallothionein induction (metallothionein is a sulphur-rich protein that acts to bind, amongst other metals, cadmium) and the lack of damage observed in the distal tubules.<\/jats:p>","DOI":"10.1242\/jcs.62.1.319","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T21:07:42Z","timestamp":1619471262000},"page":"319-338","source":"Crossref","is-referenced-by-count":10,"title":["X-Ray Microanalysis Of Proximal And Distal Tubule Cells In The Mouse Kidney, And The Influence Of Cadmium On The Concentration Of Natural Intracellular Elements"],"prefix":"10.1242","volume":"62","author":[{"given":"Marion D.","family":"Kendall","sequence":"first","affiliation":[{"name":"Department of Anatomy, St Thomas\u2019s Hospital Medical School, London SEI 7EH ALICE WARLEY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Warley","sequence":"additional","affiliation":[{"name":"University of Birmingham Department of Microbiology, South west Campus , , Birmingham"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. K.","family":"Nicholson","sequence":"additional","affiliation":[{"name":"Toxicology Unit, Department of Pharmacology, School of Pharmacy, Brunswick Square, London WC1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. C.","family":"Appleton","sequence":"additional","affiliation":[{"name":"University of Cambridge Physiological Laboratory , , Downing Street, Cambridge,U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[1983,7,1]]},"reference":[{"key":"2023111604543173400_JOCES_62_1_319C1","first-page":"247","volume-title":"In Analytical and Quantitative Methods in Microscopy","author":"Appleton","year":"1977"},{"key":"2023111604543173400_JOCES_62_1_319C2","first-page":"148","volume-title":"In Electron Probe Microanalysis in Biology","author":"Appleton","year":"1978"},{"key":"2023111604543173400_JOCES_62_1_319C3","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1038\/266854a0","article-title":"X-ray microanalysis of freeze-dried ultrathin frozen sections of a regulating epithelium from the snail Otala","volume":"266","author":"Appleton","year":"1977","journal-title":"Nature, Land"},{"key":"2023111604543173400_JOCES_62_1_319C4","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/BF00237729","article-title":"Ionic gradients within mantle-collar epithelial cells of the land snail Otala lactea","volume":"199","author":"Appleton","year":"1979","journal-title":"Cell Tiss. 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