{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:59:26Z","timestamp":1783486766019,"version":"3.55.0"},"reference-count":40,"publisher":"The Company of Biologists","issue":"15","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,8,1]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Previous studies in our laboratory have examined the loss of ultraviolet-sensitive (UVS) cones and UV sensitivity. This study looks at the question of regeneration of UVS cones and its topographic distribution, along with several other measures of the cone mosaic. Topography of the cone mosaic in rainbow trout smolts (post-metamorphic juveniles) was examined under normal growth conditions and during an exogenous thyroid hormone (TH) challenge. Growth of trout retina was studied over six weeks. Retinas sampled at 0, 3 and 6 weeks were embedded in EPON resin, and thick (1 \u03bcm) tangential sections were stained with Richardson's stain. Sites representing central ventral,ventral, temporal, dorsal and nasal retina were sampled. Variables measured were cone densities, mean double cone diameter and mean spacing between cones of the same type. These same variables were compared with those of fish that were challenged with l-thyroxin (T4), and regeneration of UVS cones was assessed. Principal components of the correlation matrix of all photoreceptor measurements were analysed using analysis of variance. Here, we show several interesting effects of thyroxin exposure on post-metamorphic rainbow trout: (1) controls at week 0 have a high density of UVS cones in the temporal and dorsal sampling regions and a high density of blue(short-wavelength)-sensitive (SWS) and double cones across all regions sampled; (2) both control and TH-treated fish had less abundant, larger and less tightly packed SWS and double cones and a lower density of UVS cones in the temporal and dorsal sampling regions three and six weeks into the experiment compared with the starting condition at week 0; (3) fish treated with TH had a higher UVS cone density in the nasal and ventral sampling regions and there were higher densities of SWS and double cones in the central ventral, temporal and ventral regions, but lower densities in the nasal sampling regions, relative to the controls. The regeneration of UVS cones into the ventral retinal hemisphere in post-juvenile salmonids has important implications for visually guided behavior.<\/jats:p>","DOI":"10.1242\/jeb.00470","type":"journal-article","created":{"date-parts":[[2003,6,21]],"date-time":"2003-06-21T16:06:40Z","timestamp":1056211600000},"page":"2665-2673","source":"Crossref","is-referenced-by-count":26,"title":["Regeneration of ultraviolet-sensitive cones in the retinal cone mosaic of thyroxin-challenged post-juvenile rainbow trout (<i>Oncorhynchus mykiss<\/i>)"],"prefix":"10.1242","volume":"206","author":[{"given":"Craig W.","family":"Hawryshyn","sequence":"first","affiliation":[{"name":"Department of Biology, University of Victoria, PO Box 3020 Stn. CSC,Victoria, British Columbia, Canada V8W 3N5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garnet","family":"Martens","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Victoria, PO Box 3020 Stn. CSC,Victoria, British Columbia, Canada V8W 3N5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Ted","family":"Allison","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Victoria, PO Box 3020 Stn. CSC,Victoria, British Columbia, Canada V8W 3N5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley R.","family":"Anholt","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Victoria, PO Box 3020 Stn. CSC,Victoria, British Columbia, Canada V8W 3N5"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042513164464200_REF1","doi-asserted-by":"crossref","unstructured":"Alexander, G., Sweeting, R. and McKeown, B.(1998). The effect of thyroid hormone and thyroid hormone blocker on visual pigment shifting in juvenile coho salmon (Oncorhynchus kisutch). 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