{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:22:56Z","timestamp":1790518976350,"version":"4.1.0"},"reference-count":49,"publisher":"The Company of Biologists","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,2,15]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                  <jats:p>The steady-state and kinetic properties of Na+ and K+currents of inner (white) and outer (red) muscles of zebrafish larvae 4\u20136 days post-fertilization (d.p.f.) are described. In inner muscle, the outward currents were half-activated at \u20131.0 mV and half-inactivated at\u201330.4 mV, and completely inactivated within 100 ms of depolarization. The inward currents of inner fibres were half-activated at \u20137.3 mV and half-inactivated at \u201374.5 mV and completely inactivated within 5 ms of depolarization. Inner muscle fibres were found to support action potentials,while no action potentials could be evoked in outer muscles. In inner muscle fibres, all tested levels of depolarizing current above a threshold value evoked only one action potential. However, spiking at frequencies of up to 200 cycles s\u20131 was evoked by the injection of depolarizing pulses separated by short hyperpolarizing currents. We suggest that the properties of the inward sodium and outward potassium currents permit high frequency firing in response to a pulsatile depolarizing input of the kind expected in fast swimming, whilst safeguarding against tetany during a strong depolarization.<\/jats:p>","DOI":"10.1242\/jeb.00839","type":"journal-article","created":{"date-parts":[[2004,1,27]],"date-time":"2004-01-27T17:15:27Z","timestamp":1075223727000},"page":"841-852","source":"Crossref","is-referenced-by-count":31,"title":["Sodium and potassium currents of larval zebrafish muscle fibres"],"prefix":"10.1242","volume":"207","author":[{"given":"Steven D.","family":"Buckingham","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, University of Alberta, CW-405 Biological Sciences Building, Edmonton, Alberta, T6G 2E9, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Declan W.","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Alberta, CW-405 Biological Sciences Building, Edmonton, Alberta, T6G 2E9, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042523431046800_REF1","doi-asserted-by":"crossref","unstructured":"Adrian, R. 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