{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T02:53:57Z","timestamp":1790996037133,"version":"4.1.0"},"reference-count":53,"publisher":"The Company of Biologists","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,3,15]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>The increased metabolic rate during digestion is associated with changes in arterial acid\u2013base parameters that are caused by gastric acid secretion(the `alkaline tide'). Net transfer of HCl to the stomach lumen causes an increase in plasma HCO3\u2013 levels, but arterial pH does not change because of a ventilatory compensation that counters the metabolic alkalosis. It seems, therefore, that ventilation is controlled to preserve pH and not PCO2 during the postprandial period. To investigate this possibility, we determined arterial acid\u2013base parameters and the metabolic response to digestion in the snake Boa constrictor, where gastric acid secretion was inhibited pharmacologically by oral administration of omeprazole.<\/jats:p><jats:p>The increase in oxygen consumption of omeprazole-treated snakes after ingestion of 30% of their own body mass was quantitatively similar to the response in untreated snakes, although the peak of the metabolic response occurred later (36 h versus 24 h). Untreated control animals exhibited a large increase in arterial plasma HCO3\u2013 concentration of approximately 12 mmol l\u20131, but arterial pH only increased by 0.12 pH units because of a simultaneous increase in arterial PCO2 by about 10 mmHg. Omeprazole virtually abolished the changes in arterial pH and plasma HCO3\u2013 concentration during digestion and there was no increase in arterial PCO2. The increased arterial PCO2 during digestion is not caused, therefore, by the increased metabolism during digestion or a lower ventilatory responsiveness to ventilatory stimuli during a presumably relaxed state in digestion. Furthermore, the constant arterial PCO2, in the absence of an alkaline tide, of omeprazole-treated snakes strongly suggests that pH rather than PCO2 normally affects chemoreceptor activity and ventilatory drive.<\/jats:p>","DOI":"10.1242\/jeb.00896","type":"journal-article","created":{"date-parts":[[2004,3,9]],"date-time":"2004-03-09T18:07:50Z","timestamp":1078855670000},"page":"1379-1385","source":"Crossref","is-referenced-by-count":60,"title":["Ventilatory compensation of the alkaline tide during digestion in the snake<i>Boa constrictor<\/i>"],"prefix":"10.1242","volume":"207","author":[{"given":"Denis V.","family":"Andrade","sequence":"first","affiliation":[{"name":"Departamento de Zoologia, Universidade Estadual Paulista, 13506-900, Rio Claro SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Felipe","family":"De Toledo","sequence":"additional","affiliation":[{"name":"Departamento de Zoologia, Universidade Estadual Paulista, 13506-900, Rio Claro SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augusto S.","family":"Abe","sequence":"additional","affiliation":[{"name":"Departamento de Zoologia, Universidade Estadual Paulista, 13506-900, Rio Claro SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Zoophysiology, Aarhus University, 8000 Aarhus C,Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042509383905800_REF1","doi-asserted-by":"crossref","unstructured":"Andersen, J. 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