{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:36:54Z","timestamp":1791261414876,"version":"4.1.0"},"reference-count":60,"publisher":"The Company of Biologists","issue":"23","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,12,1]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                  <jats:p>We investigated the effects of various heavy metals such as copper, zinc and cadmium, as well as acute thermal stress, on the signalling mechanisms involved in the protection and\/or apoptosis of Mytilus galloprovincialis mantle and gill tissues. The results of our studies revealed that mantle and gill tissues differentially respond to the stressful stimuli examined. In the mantle tissue, 1 \u03bcmol l\u20131Cu2+ and 50 \u03bcmol l\u20131 Zn2+ induced a transient p38-MAPK activation, whereas 1 \u03bcmol l\u20131Cd2+ induced a biphasic profile of the kinase phosphorylation with maximal values at 15 and 120 min of treatment, respectively. Furthermore, 1\u03bcmol l\u20131 SB203580 abolished the Cu2+-induced kinase phosphorylation. In gills, both Cu2+ and Zn2+induced a considerably higher p38-MAPK activation, which remained elevated for at least 60 min, whereas Cd2+ induced a maximal kinase activation within 60 min of treatment. Hypothermia (4\u00b0C) induced a moderate kinase phosphorylation (maximised at 30 min), whereas hyperthermia (30\u00b0C) induced a rapid (within 15 min) p38-MAPK phosphorylation that remained considerably above basal levels for at least 2 h. Our studies on the synergistic effect of hyperthermia and Cu2+ revealed that these two stressful stimuli are additive in the mantle tissue, inducing an almost double p38-MAPK activation. Further studies on the involvement of the p38-MAPK signalling pathway in tissue-specific pro- or anti-apoptotic events revealed that identical stressful stimuli possibly lead to apoptotic death via the caspase-3 activation in the mantle tissue and to anti-apoptotic events possibly via the induction of Hsp70 overexpression in the gill tissue.<\/jats:p>","DOI":"10.1242\/jeb.01924","type":"journal-article","created":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T13:23:20Z","timestamp":1134134600000},"page":"4427-4436","source":"Crossref","is-referenced-by-count":104,"title":["Acute thermal stress and various heavy metals induce tissue-specific pro-or anti-apoptotic events\n                    <i>via<\/i>\n                    the p38-MAPK signal transduction pathway in\n                    <i>Mytilus galloprovincialis<\/i>\n                    (Lam.)"],"prefix":"10.1242","volume":"208","author":[{"given":"Erene","family":"Kefaloyianni","sequence":"first","affiliation":[{"name":"Department of Animal and Human Physiology, School of Biology, Faculty of Sciences, University of Athens, Panepistimioupolis, Athens 157 84,Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Gourgou","sequence":"additional","affiliation":[{"name":"Department of Animal and Human Physiology, School of Biology, Faculty of Sciences, University of Athens, Panepistimioupolis, Athens 157 84,Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Ferle","sequence":"additional","affiliation":[{"name":"Department of Animal and Human Physiology, School of Biology, Faculty of Sciences, University of Athens, Panepistimioupolis, Athens 157 84,Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efstathios","family":"Kotsakis","sequence":"additional","affiliation":[{"name":"Department of Animal and Human Physiology, School of Biology, Faculty of Sciences, University of Athens, Panepistimioupolis, Athens 157 84,Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Gaitanaki","sequence":"additional","affiliation":[{"name":"Department of Animal and Human Physiology, School of Biology, Faculty of Sciences, University of Athens, Panepistimioupolis, Athens 157 84,Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isidoros","family":"Beis","sequence":"additional","affiliation":[{"name":"Department of Animal and Human Physiology, School of Biology, Faculty of Sciences, University of Athens, Panepistimioupolis, Athens 157 84,Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042510450497300_REF1","doi-asserted-by":"crossref","unstructured":"Aggeli, I.-K. 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