{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T18:51:00Z","timestamp":1780512660277,"version":"3.54.1"},"reference-count":18,"publisher":"The Company of Biologists","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,5,1]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>The present study examined the role of branchial and orobranchial O2 chemoreceptors in the cardiorespiratory responses, aquatic surface respiration (ASR), and the development of inferior lip swelling in tambaqui during prolonged (6 h) exposure to hypoxia. Intact fish (control) and three groups of denervated fish (bilateral denervation of cranial nerves IX+X(to the gills), of cranial nerves V+VII (to the orobranchial cavity) or of cranial nerves V alone), were exposed to severe hypoxia(PwO2=10 mmHg) for 360 min. Respiratory frequency(fr) and heart rate (fh) were recorded simultaneously with ASR. Intact (control) fish increased fr, ventilation amplitude (VAMP) and developed hypoxic bradycardia in the first 60 min of hypoxia. The bradycardia,however, abated progressively and had returned to normoxic levels by the last hour of exposure to hypoxia. The changes in respiratory frequency and the hypoxic bradycardia were eliminated by denervation of cranial nerves IX and X but were not affected by denervation of cranial nerves V or V+VII. The VAMP was not abolished by the various denervation protocols. The fh in fish with denervation of cranial nerves V or V+VII, however, did not recover to control values as in intact fish. After 360 min of exposure to hypoxia only the intact and IX+X denervated fish performed ASR. Denervation of cranial nerve V abolished the ASR behavior. However, all (control and denervated (IX+X, V and V+VII) fish developed inferior lip swelling. These results indicate that ASR is triggered by O2 chemoreceptors innervated by cranial nerve V but that other mechanisms, such as a direct effect of hypoxia on the lip tissue, trigger lip swelling.<\/jats:p>","DOI":"10.1242\/jeb.02199","type":"journal-article","created":{"date-parts":[[2006,4,18]],"date-time":"2006-04-18T19:40:11Z","timestamp":1145389211000},"page":"1709-1715","source":"Crossref","is-referenced-by-count":53,"title":["The role of branchial and orobranchial O2 chemoreceptors in the control of aquatic surface respiration in the neotropical fish tambaqui(<i>Colossoma macropomum<\/i>): progressive responses to prolonged hypoxia"],"prefix":"10.1242","volume":"209","author":[{"given":"Luiz H.","family":"Florindo","sequence":"first","affiliation":[{"name":"Department of Zoology and Botany, Sa\u0303o Paulo State University\u2013UNESP, Sa\u0303o Jose\u0301 do Rio Preto, SP,Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cle\u0301o A. C.","family":"Leite","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences, Federal University of Sa\u0303o Carlos, 13565-905 Sa\u0303o Carlos, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana L.","family":"Kalinin","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences, Federal University of Sa\u0303o Carlos, 13565-905 Sa\u0303o Carlos, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen G.","family":"Reid","sequence":"additional","affiliation":[{"name":"Division of Life Sciences, University of Toronto at Scarborough,Scarborough, OT, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William K.","family":"Milsom","sequence":"additional","affiliation":[{"name":"Department of Zoology, University of British Columbia, Vancouver, BC,Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. Tadeu","family":"Rantin","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences, Federal University of Sa\u0303o Carlos, 13565-905 Sa\u0303o Carlos, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042510583257200_REF1","doi-asserted-by":"crossref","unstructured":"Burleson, M. L. and Smatresk, N. J. (1990). Effects of sectioning cranial nerves IX and X on cardiovascular and ventilatory reflex responses to hypoxia and NaCN in channel catfish. J. Exp. Biol.154,407-420.","DOI":"10.1242\/jeb.154.1.407"},{"key":"2021042510583257200_REF2","doi-asserted-by":"crossref","unstructured":"Butler, P. J., Taylor, E. W. and Short, S.(1977). The effect of sectioning cranial nerves V, VII, IX and X on the cardiac response of the dogfish Scyliorhinus canicula to environmental hypoxia. J. Exp. 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Extrabranchial chemoreceptors involved in respiratory reflexes in the neotropical fish; Colossoma macropomum (the tambaqui). J. Exp. Biol.205,1765-1774.","DOI":"10.1242\/jeb.205.12.1765"},{"key":"2021042510583257200_REF7","doi-asserted-by":"crossref","unstructured":"Perry, S. F., Kinkead, R. and Fritsche, R.(1992). Are circulating catecholamines involved in the control of breathing by fishes? Rev. Fish Biol. Fish. 2, 65-83.","DOI":"10.1007\/BF00042917"},{"key":"2021042510583257200_REF8","doi-asserted-by":"crossref","unstructured":"Perry, S. F., Reid, S. G., Gilmour, K. M., Boijink, C. L.,Lopes, J. M., Milsom, W. K. and Rantin, F. T. (2004). A comparison of adrenergic stress responses in three tropical teleosts exposed to hypoxia. Am. J. Physiol.287,R188-R197.","DOI":"10.1152\/ajpregu.00706.2003"},{"key":"2021042510583257200_REF9","doi-asserted-by":"crossref","unstructured":"Randall, D. J. and Taylor, E. W. (1991). Evidence of a role for catecholamines in the control of breathing in fish. Rev. Fish Biol. Fish.1,139-157.","DOI":"10.1007\/BF00157582"},{"key":"2021042510583257200_REF10","unstructured":"Rantin, F. T. and Kalinin, A. L. (1996). Cardiorespiratory function and aquatic surface respiration in Colossoma macropomum exposed to graded and acute hypoxia. In Physiology and Biochemistry of the Fishes of the Amazon (ed. A. L. Val, V. M. F. Almeida-Val and D. J. Randall), pp. 169-180. Manaus: INPA."},{"key":"2021042510583257200_REF11","doi-asserted-by":"crossref","unstructured":"Rantin, F. T., Guerra, C. D. R., Kalinin, A. L. and Glass, M. L. (1998). The influence of aquatic surface respiration (ASR)on cardio-respiratory of the serrasalmid fish Piaractus mesopotamicus.Comp. Biochem. Physiol.119A,991-997.","DOI":"10.1016\/S1095-6433(98)00016-6"},{"key":"2021042510583257200_REF12","unstructured":"Rantin, F. T., Florindo, L. H., Kalinin, A. L., Reid, S. G. and Milsom, W. K. (2002). 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Chemoreflex control of respiration in an air-breathing fish. In Chemoreceptors and Chemoreflex in Breathing \u2013 Cellular and Molecular Aspects(ed. R. E. Lahiri, R. O. Forster II, O. Davies and A. I. Pack), pp.52-59. London: Oxford University Press."},{"key":"2021042510583257200_REF16","doi-asserted-by":"crossref","unstructured":"Sundin, L., Reid, S. G., Kalinin, A. L., Rantin, F. T. and Milsom, W. K. (1999). Cardiovascular and respiratory reflexes: the tropical fish trai\u0301ra (Hoplias malabaricus)O2 chemoresponses. Respir. Physiol.116,181-199.","DOI":"10.1016\/S0034-5687(99)00041-9"},{"key":"2021042510583257200_REF17","doi-asserted-by":"crossref","unstructured":"Sundin, L., Reid, S. G., Rantin, F. T. and Milsom, W. K.(2000). Branchial receptors and cardiorespiratory reflexes in a neotropical fish, the tambaqui (Colossoma macropomum). J. Exp. 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