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Feeding did not affect plasma glucose or urea concentrations, however, total plasma ammonia rose during feeding, peaking between 3 and 24 h following the ingestion of a meal, three-fold above resting control values (\u223c300 \u03bcmol ml\u20131). This increase in plasma ammonia was accompanied by an increase in net ammonia flux to the water (\u223ctwofold higher in fed fish versus unfed fish). The arterial blood also became alkaline with increases in pH and plasma [HCO3\u2013] between 3 and 12 h following feeding, representing the first measurement of an alkaline tide in a marine teleost. There was no evidence of respiratory compensation for the measured metabolic alkalosis, as PaCO2 remained unchanged throughout the post-feeding period. However, in contrast to an earlier study on freshwater-acclimated trout, fed fish did not exhibit a compensating increase in net base excretion, but rather took in additional base from the external seawater, amounting to \u223c8490 \u03bcmol kg\u20131 over 48 h. In vitro experiments suggest that at least a portion of the alkaline tide was eliminated through increased HCO3\u2013 secretion coupled to Cl\u2013absorption in the intestinal tract. This did not occur in the intestine of freshwater-acclimated trout. The marked effects of the external salinity(seawater versus freshwater) on different post-feeding patterns of acid\u2013base balance are discussed.<\/jats:p>","DOI":"10.1242\/jeb.027862","type":"journal-article","created":{"date-parts":[[2009,6,26]],"date-time":"2009-06-26T17:38:49Z","timestamp":1246037929000},"page":"2159-2166","source":"Crossref","is-referenced-by-count":41,"title":["Post-prandial metabolic alkalosis in the seawater-acclimated trout: the alkaline tide comes in"],"prefix":"10.1242","volume":"212","author":[{"given":"Carol","family":"Bucking","sequence":"first","affiliation":[{"name":"McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4K1 and Bamfield Marine Sciences Center, 100 Pachena Road, Bamfield, British Columbia, Canada V0R 1B0"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John L.","family":"Fitzpatrick","sequence":"additional","affiliation":[{"name":"McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4K1 and Bamfield Marine Sciences Center, 100 Pachena Road, Bamfield, British Columbia, Canada V0R 1B0"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunita R.","family":"Nadella","sequence":"additional","affiliation":[{"name":"McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4K1 and Bamfield Marine Sciences Center, 100 Pachena Road, Bamfield, British Columbia, Canada V0R 1B0"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris M.","family":"Wood","sequence":"additional","affiliation":[{"name":"McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4K1 and Bamfield Marine Sciences Center, 100 Pachena Road, Bamfield, British Columbia, Canada V0R 1B0"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042511553389000_REF1","doi-asserted-by":"crossref","unstructured":"Barthe, L., Woodley, J. and Houin, G. 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