{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T08:21:17Z","timestamp":1783498877736,"version":"3.55.0"},"reference-count":100,"publisher":"The Company of Biologists","issue":"16","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,8,15]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n               <jats:p>Myoglobin (Mb) is an important intracellular oxygen-binding hemoprotein found in the cytoplasm of skeletal and cardiac muscle tissue playing a well-known role in O2 storage and delivery. Within the last decade the knowledge about Mb's function has been considerably extended by the generation of myoglobin-deficient (myo\u2212\/\u2212) mice, which for the first time enabled the analysis of Mb's role in physiology without pharmacological intervention. Utilizing the myo\u2212\/\u2212 mice, it has been demonstrated that beyond its function in O2 supply Mb substantially contributes to nitric oxide (NO) homeostasis in the heart. By a dynamic cycle, in which a decrease in tissue O2 tension drives the conversion of Mb from being a NO scavenger under normoxia to a NO producer during hypoxia, mitochondrial respiration is reversibly adapted to the intracellular O2 tension. Therefore, Mb may act as an important O2 sensor through which NO can regulate muscle energetics and function. As Mb is widespread throughout the fauna, the diverse oxygen-dependent interactions between Mb and nitrogen oxides may not only be of relevance for mammals but also for other vertebrates as evidenced by comparable phenotypes of \u2018artificial\u2019 (myo\u2212\/\u2212 mice) and \u2018natural\u2019 Mb knockouts (icefish and amphibians). In conclusion, it seems likely that Mb's multifunctional properties create an environment characterized by a tightly adapted aerobic mitochondrial respiration and low levels of free radicals, and thus serve an essential and beneficial role within the myocardium, which appears to be functionally important over a wide range of species.<\/jats:p>","DOI":"10.1242\/jeb.041681","type":"journal-article","created":{"date-parts":[[2010,7,30]],"date-time":"2010-07-30T18:38:14Z","timestamp":1280515094000},"page":"2726-2733","source":"Crossref","is-referenced-by-count":53,"title":["Keeping the heart in balance: the functional interactions of myoglobin with nitrogen oxides"],"prefix":"10.1242","volume":"213","author":[{"given":"Ulrich","family":"Fl\u00f6gel","sequence":"first","affiliation":[{"name":"Cardiovascular Physiology, Heinrich Heine University, D-40225 D\u00fcsseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Fago","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Building 1131, Aarhus University, DK-8000 Aarhus C., Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tienush","family":"Rassaf","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology, Pulmonary Diseases and Angiology, D-40225 D\u00fcsseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042505550359900_R1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.niox.2007.10.004","article-title":"Differential NOS expression in freshwater and aestivating Protopterus dolloi (lungfish): heart vs kidney readjustments","volume":"18","author":"Amelio","year":"2008","journal-title":"Nitric Oxide"},{"key":"2021042505550359900_R2","first-page":"220","volume-title":"Hemoglobin and Myoglobin in Their Reactions With Ligands","author":"Antonini","year":"1971"},{"key":"2021042505550359900_R3","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1006\/abio.1996.0239","article-title":"Spectroscopic determination of cytochrome c oxidase content in tissues containing myoglobin or hemoglobin","volume":"237","author":"Balaban","year":"1996","journal-title":"Anal. Biochem."},{"key":"2021042505550359900_R4","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/416337a","article-title":"Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms","volume":"416","author":"Barouch","year":"2002","journal-title":"Nature"},{"key":"2021042505550359900_R5","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1006\/bbrc.1996.0008","article-title":"Mitochondrial nitric oxide synthase: a ubiquitous regulator of oxidative phosphorylation?","volume":"218","author":"Bates","year":"1996","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2021042505550359900_R6","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1146\/annurev.physiol.69.031905.162529","article-title":"Hypoxia tolerance in reptiles, amphibians, and fishes: life with variable oxygen availability","volume":"69","author":"Bickler","year":"2007","journal-title":"Annu. Rev. Physiol."},{"key":"2021042505550359900_R7","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/0015-6264(75)90157-1","article-title":"The history and use of nitrate and nitrite in the curing of meat","volume":"13","author":"Binkerd","year":"1975","journal-title":"Food Cosmet. Toxicol."},{"key":"2021042505550359900_R8","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1046\/j.1471-4159.1994.63030910.x","article-title":"Nitric oxide-mediated inhibition of the mitochondrial respiratory chain in cultured astrocytes","volume":"63","author":"Bola\u00f1os","year":"1994","journal-title":"J. Neurochem."},{"key":"2021042505550359900_R9","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1039\/p19800001706","article-title":"Nitrosation and nitrosylation of haemoproteins and related compounds. Part 4. Pentaco-ordinate nitrosylprotohaem as the pigment of cooked cured meat. Direct evidence from E.S.Rw. spectroscopy","volume":"1","author":"Bonnett","year":"1980","journal-title":"J. Chem. Soc. Perkin Trans."},{"key":"2021042505550359900_R10","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1161\/01.RES.85.7.575","article-title":"Heterogeneous basal expression of nitric oxide synthase and superoxide dismutase isoforms in mammalian heart: implications for mechanisms governing indirect and direct nitric oxide-related effects","volume":"85","author":"Brahmajothi","year":"1999","journal-title":"Circ. Res."},{"key":"2021042505550359900_R11","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/S0891-5849(01)00805-X","article-title":"Hypothesis: the mitochondrial NO signaling pathway, and the transduction of nitrosative to oxidative cell signals: an alternative function for cytochrome C oxidase","volume":"32","author":"Brookes","year":"2002","journal-title":"Free Radic. Biol. Med."},{"key":"2021042505550359900_R12","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.bbabio.2004.03.016","article-title":"Inhibition of mitochondrial respiratory complex I by nitric oxide, peroxynitrite and S-nitrosothiols","volume":"1658","author":"Brown","year":"2004","journal-title":"Biochim. Biophys. Acta"},{"key":"2021042505550359900_R13","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0014-5793(94)01290-3","article-title":"Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase","volume":"356","author":"Brown","year":"1994","journal-title":"FEBS Lett."},{"key":"2021042505550359900_R14","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0968-0004(00)01698-4","article-title":"Nitric oxide, cytochrome-c oxidase and myoglobin","volume":"26","author":"Brunori","year":"2001","journal-title":"Trends Biochem. Sci."},{"key":"2021042505550359900_R15","doi-asserted-by":"crossref","first-page":"8483","DOI":"10.1073\/pnas.0408766102","article-title":"Neuroglobin, nitric oxide, and oxygen: functional pathways and conformational changes","volume":"102","author":"Brunori","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042505550359900_R16","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/nchembio734","article-title":"Nitrite is a signaling molecule and regulator of gene expression in mammalian tissues","volume":"1","author":"Bryan","year":"2005","journal-title":"Nat. Chem. Biol."},{"key":"2021042505550359900_R17","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/978-0-387-75434-5_13","article-title":"Regulation and role of neuroglobin and cytoglobin under hypoxia","volume":"618","author":"Burmester","year":"2007","journal-title":"Adv. Exp. Med Biol."},{"key":"2021042505550359900_R18","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1242\/jeb.128.1.469","article-title":"Evidence that myoglobin does not support heart performance at maximal levels of oxygen demand","volume":"128","author":"Canty","year":"1987","journal-title":"J. Exp. Biol."},{"key":"2021042505550359900_R19","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.bbabio.2009.03.008","article-title":"Nitrite modulates contractility of teleost (Anguilla anguilla and Chionodraco hamatus, i.e. the Antarctic hemoglobinless icefish) and frog (Rana esculenta) hearts","volume":"1787","author":"Cerra","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"2021042505550359900_R20","first-page":"H1166","article-title":"Nitrite oxidation of myoglobin in perfused myocardium: implications for energy coupling in respiration","volume":"271","author":"Chung","year":"1996","journal-title":"Am. J. Physiol."},{"key":"2021042505550359900_R21","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/0014-5793(94)00424-2","article-title":"Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide. Implications for neurodegenerative diseases","volume":"345","author":"Cleeter","year":"1994","journal-title":"FEBS Lett."},{"key":"2021042505550359900_R22","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/S0005-2728(99)00021-3","article-title":"Nitric oxide and iron proteins","volume":"1411","author":"Cooper","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"2021042505550359900_R23","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1038\/nm954","article-title":"Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation","volume":"9","author":"Cosby","year":"2003","journal-title":"Nat. Med."},{"key":"2021042505550359900_R24","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.cbpa.2005.07.015","article-title":"Nitric oxide control of lower vertebrate blood vessels by vasomotor nerves","volume":"142","author":"Donald","year":"2005","journal-title":"Comp. Biochem. Physiol. A Physiol."},{"key":"2021042505550359900_R25","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0162-0134(00)80291-3","article-title":"Oxidation of nitrogen oxides by bound dioxygen in hemoproteins","volume":"14","author":"Doyle","year":"1981","journal-title":"J. Inorg. Biochem."},{"key":"2021042505550359900_R26","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1172\/JCI22493","article-title":"Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver","volume":"115","author":"Duranski","year":"2005","journal-title":"J. Clin. Invest."},{"key":"2021042505550359900_R27","doi-asserted-by":"crossref","first-page":"11430","DOI":"10.1073\/pnas.0800700105","article-title":"Nitric oxide promotes distant organ protection: evidence for an endocrine role of nitric oxide","volume":"105","author":"Elrod","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042505550359900_R28","doi-asserted-by":"crossref","first-page":"44417","DOI":"10.1074\/jbc.M407126200","article-title":"Allosteric regulation and temperature dependence of oxygen binding in human neuroglobin and cytoglobin. Molecular mechanisms and physiological significance","volume":"279","author":"Fago","year":"2004","journal-title":"J. Biol. Chem."},{"key":"2021042505550359900_R29","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1073\/pnas.98.2.735","article-title":"Myoglobin: a scavenger of bioactive NO","volume":"98","author":"Fl\u00f6gel","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042505550359900_R30","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/mrm.21101","article-title":"In vivo 2D mapping of impaired murine cardiac energetics in NO-induced heart failure","volume":"57","author":"Fl\u00f6gel","year":"2007","journal-title":"Magn. Reson. Med."},{"key":"2021042505550359900_R31","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1073\/pnas.0508270103","article-title":"From the cover: hypoxia-inducible myoglobin expression in nonmuscle tissues","volume":"103","author":"Fraser","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042505550359900_R32","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1159\/000089884","article-title":"The amphibian globin gene repertoire as revealed by the Xenopus genome","volume":"112","author":"Fuchs","year":"2006","journal-title":"Cytogenet. Genome Res."},{"key":"2021042505550359900_R33","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jinorgbio.2004.10.003","article-title":"Nitric oxide dioxygenase function and mechanism of flavohemoglobin, hemoglobin, myoglobin and their associated reductases","volume":"99","author":"Gardner","year":"2005","journal-title":"J. Inorg. Biochem."},{"key":"2021042505550359900_R34","doi-asserted-by":"crossref","first-page":"10378","DOI":"10.1073\/pnas.95.18.10378","article-title":"Nitric oxide dioxygenase: an enzymic function for flavohemoglobin","volume":"95","author":"Gardner","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042505550359900_R35","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.niox.2008.10.006","article-title":"Morphological and physiological study of the cardiac NOS\/NO system in the Antarctic (Hb-\/Mb-) icefish Chaenocephalus aceratus and in the red-blooded Trematomus bernacchii","volume":"20","author":"Garofalo","year":"2009","journal-title":"Nitric Oxide Biol. Chem."},{"key":"2021042505550359900_R36","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.cbpa.2009.04.621","article-title":"The Antarctic hemoglobinless icefish, fifty five years later: a unique cardiocirculatory interplay of disaptation and phenotypic plasticity","volume":"154","author":"Garofalo","year":"2009","journal-title":"Comp Biochem. Physiol A Physiol."},{"key":"2021042505550359900_R37","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1038\/27681","article-title":"Mice without myoglobin","volume":"395","author":"Garry","year":"1998","journal-title":"Nature"},{"key":"2021042505550359900_R38","first-page":"H633","article-title":"Endocardial endothelium mediates luminal ACh-NO signaling in isolated frog heart","volume":"276","author":"Gattuso","year":"1999","journal-title":"Am. J. Physiol."},{"key":"2021042505550359900_R39","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3354\/dao052011","article-title":"Cardiac performance in Salmo salar with infectious salmon anaemia (ISA): putative role of nitric oxide","volume":"52","author":"Gattuso","year":"2002","journal-title":"Dis. Aquat. Org."},{"key":"2021042505550359900_R40","doi-asserted-by":"crossref","first-page":"11038","DOI":"10.1074\/jbc.273.18.11038","article-title":"Production of nitric oxide by mitochondria","volume":"273","author":"Giulivi","year":"1998","journal-title":"J. Biol. Chem."},{"key":"2021042505550359900_R41","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1038\/nchembio1105-308","article-title":"The emerging biology of the nitrite anion","volume":"1","author":"Gladwin","year":"2005","journal-title":"Nat. Chem. Biol."},{"key":"2021042505550359900_R42","doi-asserted-by":"crossref","first-page":"10495","DOI":"10.1073\/pnas.96.18.10495","article-title":"Disruption of myoglobin in mice induces multiple compensatory mechanisms","volume":"96","author":"G\u00f6decke","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042505550359900_R43","doi-asserted-by":"crossref","first-page":"21761","DOI":"10.1074\/jbc.M302573200","article-title":"Myoglobin protects the heart from inducible nitric-oxide synthase (iNOS)-mediated nitrosative stress","volume":"278","author":"G\u00f6decke","year":"2003","journal-title":"J. Biol. Chem."},{"key":"2021042505550359900_R44","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.1242\/jeb.043075","article-title":"Myoglobin's old and new clothes: from molecular structure to function in living cells","volume":"213","author":"Gros","year":"2010","journal-title":"J. Exp. Biol."},{"key":"2021042505550359900_R45","doi-asserted-by":"crossref","first-page":"6505","DOI":"10.1016\/S0021-9258(18)50397-5","article-title":"Metmyoglobin reductase. Identification and purification of a reduced nicotinamide adenine dinucleotide-dependent enzyme from bovine heart which reduces metmyoglobin","volume":"254","author":"Hagler","year":"1979","journal-title":"J. Biol. Chem."},{"key":"2021042505550359900_R46","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1161\/hh0102.102757","article-title":"Cardiac-specific overexpression of inducible nitric oxide synthase does not result in severe cardiac dysfunction","volume":"90","author":"Heger","year":"2002","journal-title":"Circ. Res."},{"key":"2021042505550359900_R47","doi-asserted-by":"crossref","first-page":"10256","DOI":"10.1073\/pnas.0801336105","article-title":"Nitrite reductase activity of myoglobin regulates respiration and cellular viability in myocardial ischemia-reperfusion injury","volume":"105","author":"Hendgen-Cotta","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042505550359900_R48","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.1242\/jeb.041178","article-title":"Unmasking the Janus face of myoglobin in health and disease","volume":"213","author":"Hendgen-Cotta","year":"2010","journal-title":"J. Exp. Biol."},{"key":"2021042505550359900_R49","doi-asserted-by":"crossref","first-page":"6223","DOI":"10.1021\/bi0475929","article-title":"Mechanistic studies of the oxygen-mediated oxidation of nitrosylhemoglobin","volume":"44","author":"Herold","year":"2005","journal-title":"Biochemistry"},{"key":"2021042505550359900_R50","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1161\/01.CIR.93.8.1556","article-title":"Calcium responsiveness in regional myocardial short-term hibernation and stunning in the in situ porcine heart. Inotropic responses to postextrasystolic potentiation and intracoronary calcium","volume":"93","author":"Heusch","year":"1996","journal-title":"Circulation"},{"key":"2021042505550359900_R51","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1152\/jappl.1981.51.3.746","article-title":"Skeletal muscle cytochrome c and myoglobin, endurance, and frequency of training","volume":"51","author":"Hickson","year":"1981","journal-title":"J. Appl. Physiol."},{"key":"2021042505550359900_R52","doi-asserted-by":"crossref","first-page":"9568","DOI":"10.1021\/ja00074a023","article-title":"Photochemistry of nitric oxide adducts of water-soluble iron(III) porphyrin and ferrihemoproteins studied by nanosecond laser photolysis","volume":"115","author":"Hoshino","year":"1993","journal-title":"J. Am. Chem. Soc."},{"key":"2021042505550359900_R53","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1172\/JCI24650","article-title":"Enzymatic function of hemoglobin as a nitrite reductase that produces NO under allosteric control","volume":"115","author":"Huang","year":"2005","journal-title":"J. Clin. Invest."},{"key":"2021042505550359900_R54","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1161\/01.RES.61.6.866","article-title":"Endothelium-derived relaxing factor from pulmonary artery and vein possesses pharmacologic and chemical properties identical to those of nitric oxide radical","volume":"61","author":"Ignarro","year":"1987","journal-title":"Circ. Res."},{"key":"2021042505550359900_R55","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1242\/jeb.204.10.1719","article-title":"Nitric oxide modulates cardiac performance in the heart of Anguilla anguilla","volume":"204","author":"Imbrogno","year":"2001","journal-title":"J. Exp. Biol."},{"key":"2021042505550359900_R56","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1242\/jeb.041442","article-title":"Regulation of myoglobin expression","volume":"213","author":"Kanatous","year":"2010","journal-title":"J. Exp. Biol."},{"key":"2021042505550359900_R57","doi-asserted-by":"crossref","first-page":"31437","DOI":"10.1074\/jbc.273.47.31437","article-title":"Nitric oxide suppression of apoptosis occurs in association with an inhibition of Bcl-2 cleavage and cytochrome c release","volume":"273","author":"Kim","year":"1998","journal-title":"J. Biol. Chem."},{"key":"2021042505550359900_R58","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0014-5793(95)01429-2","article-title":"S-nitrosoglutathione induces formation of nitrosylmyoglobin in isolated hearts during cardioplegic ischemia \u2013 an electron spin resonance study","volume":"378","author":"Konorev","year":"1996","journal-title":"FEBS Lett."},{"key":"2021042505550359900_R59","first-page":"H985","article-title":"Role of myoglobin as a scavenger of cellular NO in myocardium","volume":"286","author":"Kreutzer","year":"2004","journal-title":"Am. J. Physiol."},{"key":"2021042505550359900_R60","doi-asserted-by":"crossref","first-page":"8137","DOI":"10.1073\/pnas.91.17.8137","article-title":"Simulation of the diffusion and reaction of endogenously produced nitric oxide","volume":"91","author":"Lancaster","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042505550359900_R61","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1006\/jmcc.2001.1378","article-title":"Mitochondrial dysfunction in cardiac disease: ischemia-reperfusion, aging, and heart failure","volume":"33","author":"Lesnefsky","year":"2001","journal-title":"J. Mol. Cell Cardiol."},{"key":"2021042505550359900_R62","first-page":"H47","article-title":"Changes in NO bioavailability regulate cardiac O2 consumption: control by intramitochondrial SOD2 and intracellular myoglobin","volume":"286","author":"Li","year":"2004","journal-title":"Am. J. Physiol."},{"key":"2021042505550359900_R63","doi-asserted-by":"crossref","first-page":"15699","DOI":"10.1016\/S0021-9258(17)36315-9","article-title":"Myoglobin: cytochrome b5 interactions and the kinetic mechanism of metmyoglobin reductase","volume":"260","author":"Livingston","year":"1985","journal-title":"J. Biol. Chem."},{"key":"2021042505550359900_R64","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/BF00584292","article-title":"The oxygen pressure histogram in the left ventricular myocardium of the dog","volume":"356","author":"L\u00f6sse","year":"1975","journal-title":"Pfl\u00fcgers Arch."},{"key":"2021042505550359900_R65","doi-asserted-by":"crossref","first-page":"H2132","DOI":"10.1152\/ajpheart.00147.2003","article-title":"Hypoxia-induced left ventricular dysfunction in myoglobin-deficient mice","volume":"285","author":"Mammen","year":"2003","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"2021042505550359900_R66","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1161\/hh0701.089753","article-title":"Adaptive mechanisms that preserve cardiac function in mice without myoglobin","volume":"88","author":"Meeson","year":"2001","journal-title":"Circ. Res."},{"key":"2021042505550359900_R67","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1242\/jeb.025171","article-title":"Nitric oxide increases myocardial efficiency in the hypoxia-tolerant turtle Trachemys scripta","volume":"212","author":"Misfeldt","year":"2009","journal-title":"J. Exp. Biol."},{"key":"2021042505550359900_R68","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1007\/s00217-003-0668-5","article-title":"Spectral characterisation of red pigment in Italian-type dry-cured ham. Increasing lipophilicity during processing and maturation","volume":"216","author":"M\u00f8ller","year":"2003","journal-title":"Eur. Food Res. Technol."},{"key":"2021042505550359900_R69","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1242\/jeb.041624","article-title":"Roles of nitric oxide, nitrite and myoglobin on myocardial efficiency in trout (Oncorhynchus mykiss) and goldfish (Carassius auratus): implications for hypoxia tolerance","volume":"213","author":"Pedersen","year":"2010","journal-title":"J. Exp. Biol."},{"key":"2021042505550359900_R70","volume-title":"Nitrite curing of meat: the N-nitrosamine problem and nitrite alternatives","author":"Pegg","year":"2000"},{"key":"2021042505550359900_R71","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1161\/CIRCRESAHA.107.152488","article-title":"Nitrite reductase function of deoxymyoglobin. Oxygen sensor and regulator of cardiac energetics and function","volume":"100","author":"Rassaf","year":"2007","journal-title":"Circ. Res."},{"key":"2021042505550359900_R72","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1042\/BJ20090716","article-title":"Nitric oxide stimulates myoglobin gene and protein expression in vascular smooth muscle","volume":"423","author":"Rayner","year":"2009","journal-title":"Biochem. J."},{"key":"2021042505550359900_R73","first-page":"31","article-title":"The nitric oxide cycle in mammals and nitrite reducing activity of heme-containing proteins","volume":"40","author":"Reutov","year":"1994","journal-title":"Vopr. Med. Khim."},{"key":"2021042505550359900_R74","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1152\/jappl.2001.91.6.2679","article-title":"Skeletal muscle intracellular PO2 assessed by myoglobin desaturation: response to graded exercise","volume":"91","author":"Richardson","year":"2001","journal-title":"J. Appl. Physiol."},{"key":"2021042505550359900_R75","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1113\/jphysiol.2005.102327","article-title":"Human skeletal muscle intracellular oxygenation: the impact of ambient oxygen availability","volume":"571","author":"Richardson","year":"2006","journal-title":"J. Physiol."},{"key":"2021042505550359900_R76","doi-asserted-by":"crossref","first-page":"3633","DOI":"10.1111\/j.1742-4658.2008.06508.x","article-title":"Globins and hypoxia adaptation in the goldfish, Carassius auratus","volume":"275","author":"Roesner","year":"2008","journal-title":"FEBS J."},{"key":"2021042505550359900_R77","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1161\/01.CIR.83.3.1076","article-title":"Myocardial perfusion\u2013contraction matching. 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Physiol."},{"key":"2021042505550359900_R81","first-page":"H838","article-title":"Endogenous nitric oxide enhances coupling between O2 consumption and ATP synthesis in guinea pig hearts","volume":"281","author":"Shen","year":"2001","journal-title":"Am. J. Physiol."},{"key":"2021042505550359900_R82","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1161\/01.RES.0000260171.52224.6b","article-title":"Deoxymyoglobin is a nitrite reductase that generates nitric oxide and regulates mitochondrial respiration","volume":"100","author":"Shiva","year":"2007","journal-title":"Circ. Res."},{"key":"2021042505550359900_R83","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1084\/jem.20070198","article-title":"Nitrite augments tolerance to ischemia\/reperfusion injury via the modulation of mitochondrial electron transfer","volume":"204","author":"Shiva","year":"2007","journal-title":"J. Exp. Med."},{"key":"2021042505550359900_R84","doi-asserted-by":"crossref","first-page":"7448","DOI":"10.1158\/0008-5472.CAN-08-0565","article-title":"Cytoglobin, the newest member of the globin family, functions as a tumor suppressor gene","volume":"68","author":"Shivapurkar","year":"2008","journal-title":"Cancer Res."},{"key":"2021042505550359900_R85","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1242\/jeb.02091","article-title":"When bad things happen to good fish: the loss of hemoglobin and myoglobin expression in Antarctic icefishes","volume":"209","author":"Sidell","year":"2006","journal-title":"J. Exp. Biol."},{"key":"2021042505550359900_R86","doi-asserted-by":"crossref","first-page":"e2039","DOI":"10.1371\/journal.pone.0002039","article-title":"NO dioxygenase activity in hemoglobins is ubiquitous in vitro, but limited by reduction in vivo","volume":"3","author":"Smagghe","year":"2008","journal-title":"PLoS ONE"},{"key":"2021042505550359900_R87","doi-asserted-by":"crossref","first-page":"36562","DOI":"10.1074\/jbc.M005347200","article-title":"Reaction of S-nitrosoglutathione with the heme group of deoxyhemoglobin","volume":"275","author":"Spencer","year":"2000","journal-title":"J. Biol. Chem."},{"key":"2021042505550359900_R88","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1126\/science.276.5321.2034","article-title":"Blood flow regulation by S-nitrosohemoglobin in the physiological oxygen gradient","volume":"276","author":"Stamler","year":"1997","journal-title":"Science"},{"key":"2021042505550359900_R89","doi-asserted-by":"crossref","first-page":"3497","DOI":"10.1073\/pnas.0637726100","article-title":"Neuroglobin protects the brain from experimental stroke in vivo","volume":"100","author":"Sun","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042505550359900_R90","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.cbpb.2005.04.019","article-title":"NO modulation of myocardial performance in fish hearts","volume":"142","author":"Tota","year":"2005","journal-title":"Comp. Biochem. Physiol. A Physiol."},{"key":"2021042505550359900_R91","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1152\/japplphysiol.00887.2001","article-title":"A comparison of voluntary and electrically induced contractions by interleaved 1H- and 31P-NMRS in humans","volume":"94","author":"Vanderthommen","year":"2003","journal-title":"J. Appl. Physiol."},{"key":"2021042505550359900_R92","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1007\/s00018-006-6374-2","article-title":"Nitric oxide synthase reduces nitrite to NO under anoxia","volume":"64","author":"Vanin","year":"2007","journal-title":"Cell. Mol. Life Sci."},{"key":"2021042505550359900_R93","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s007750100284","article-title":"Nitrite binding to metmyoglobin and methemoglobin in comparison to nitric oxide binding","volume":"7","author":"Wanat","year":"2002","journal-title":"J. Biol. Inorg. Chem."},{"key":"2021042505550359900_R94","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1152\/physrev.1970.50.4.559","article-title":"Myoglobin-facilitated oxygen diffusion: role of myoglobin in oxygen entry into muscle","volume":"50","author":"Wittenberg","year":"1970","journal-title":"Physiol. Rev."},{"key":"2021042505550359900_R95","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1161\/01.RES.0000079026.70629.E5","article-title":"Acute inhibition of myoglobin impairs contractility and energy state of iNOS-overexpressing hearts","volume":"92","author":"Wunderlich","year":"2003","journal-title":"Circ. Res."},{"key":"2021042505550359900_R96","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1073\/pnas.96.2.657","article-title":"Nitric oxide synthase in cardiac sarcoplasmic reticulum","volume":"96","author":"Xu","year":"1999","journal-title":"Proc. Natl. Acad. Sci. 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