{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T18:04:15Z","timestamp":1771265055808,"version":"3.50.1"},"reference-count":39,"publisher":"The Company of Biologists","issue":"22","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,11,15]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Insects, including cockroaches, self-select a balanced diet when faced with different nutrient choices. For self-selection to be carried out effectively, insects possess neuroregulatory systems to control their food intake. In the present study, we examined the role of the neurotransmitter dopamine (DA) in the feeding regulation of the Madeira cockroach (Rhyparobia maderae). When R. maderae nymphs were injected with 20 \u03bcl of 100 mmol l\u20131 DA, they showed an 83.3% reduction in sucrose intake and a 78.9% reduction in total intake compared with saline-injected controls. The DA agonist, 2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene (6,7-ADTN) (100 mmol l\u20131 in 1 \u03bcl), caused a significant reduction in sucrose feeding, reducing feeding by 47.3% compared with saline-injected controls. Protein feeding was also significantly reduced by 6,7-ADTN to 62%. Rhyparobia maderae nymphs injected with the DA antagonist chlorpromazine (100 mmol l\u20131 in 1 \u03bcl) did not differ significantly from control nymphs in their feeding behavior. Interestingly, R. maderae nymphs injected with 2 \u03bcl or 5 \u03bcl chlorpromazine (100 mmol l\u20131) showed significantly increased mortality rates of 47.5% or 66.7%, respectively. The DA antagonist, spiperone (100 mmol l\u20131 in 1 \u03bcl), caused a significant feeding response, showing an increase in feeding in both sucrose (310.6%) and total intake (236.3%). Casein feeding in R. maderae nymphs was also elevated (70.8%) but this was not statistically significant. The experiments with DA, the DA agonist 6,7-ADTN and the DA antagonist spiperone strongly suggest that the neurotransmitter DA is involved in regulating feeding in the cockroach R. maderae.<\/jats:p>","DOI":"10.1242\/jeb.062430","type":"journal-article","created":{"date-parts":[[2011,10,26]],"date-time":"2011-10-26T17:16:59Z","timestamp":1319649419000},"page":"3843-3849","source":"Crossref","is-referenced-by-count":8,"title":["Dopamine as an anorectic neuromodulator in the cockroach<i>Rhyparobia maderae<\/i>"],"prefix":"10.1242","volume":"214","author":[{"given":"Jaclyn M.","family":"Allen","sequence":"first","affiliation":[{"name":"Department of Biology, California State University, Northridge, CA 91330-8303, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brooke H.","family":"Van Kummer","sequence":"additional","affiliation":[{"name":"Department of Biology, California State University, Northridge, CA 91330-8303, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randy W.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Biology, California State University, Northridge, CA 91330-8303, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","reference":[{"key":"2021042506243270500_R1","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.ibmb.2005.03.005","article-title":"Characterization of a D2-like dopamine receptor (AmDOP3) in honeybee, Apis mellifera","volume":"35","author":"Beggs","year":"2005","journal-title":"Insect Biochem. 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