{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T22:40:02Z","timestamp":1791067202392,"version":"4.1.0"},"reference-count":69,"publisher":"The Company of Biologists","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,7,1]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                  <jats:p>Appetite suppression is a common response to hypoxia in fish that confers significant energy savings. Yet little is known about the endocrine signals involved in the regulation of food intake during chronic hypoxia. Thus, we assessed the impact of chronic hypoxia on food intake, the expression of the potent anorexigenic signal leptin and its receptor (lepr), the mRNA levels of key hypothalamic appetite-regulating genes, and the activity of the hypothalamic\u2013pituitary\u2013interrenal (HPI) axis in common carp, Cyprinus carpio. Fish exposed to 10% O2 saturation for 8 days were chronically anorexic and consumed on average 79% less food than normoxic controls. Hypoxia also elicited gradual and parallel increases in the expression of liver leptin-a-I, leptin-a-II, lepr and erythropoietin, a known hypoxia-responsive gene. In contrast, the liver mRNA levels of all four genes remained unchanged in normoxic fish pair-fed to the hypoxia treatment. In the hypothalamus, expression of the appetite-regulating genes were consistent with an inhibition and stimulation of hunger in the hypoxic and pair-fed fish, respectively, and reduced feed intake led to a decrease in lepr. Although both treatments elicited similar delayed increases in plasma cortisol, they were characterized by distinct HPI axis effector transcript levels and a marked differential increase in pituitary lepr expression. Together, these results show that a reduction in O2 availability, and not feed intake, stimulates liver leptin-a expression in common carp and suggest that this pleiotropic cytokine is involved in the regulation of appetite and the endocrine stress response during chronic hypoxia.<\/jats:p>","DOI":"10.1242\/jeb.066183","type":"journal-article","created":{"date-parts":[[2012,6,6]],"date-time":"2012-06-06T13:10:19Z","timestamp":1338988219000},"page":"2273-2282","source":"Crossref","is-referenced-by-count":85,"title":["Differential effects of chronic hypoxia and feed restriction on the expression of leptin and its receptor, food intake regulation and the endocrine stress response in common carp"],"prefix":"10.1242","volume":"215","author":[{"given":"Nicholas J.","family":"Bernier","sequence":"first","affiliation":[{"name":"Department of Integrative Biology, University of Guelph, Guelph, Ontario, N1G 2W1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marnix","family":"Gorissen","sequence":"additional","affiliation":[{"name":"Department of Animal Physiology, Institute for Water and Wetland Research, Faculty of Science, Radboud University Nijmegen, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gert","family":"Flik","sequence":"additional","affiliation":[{"name":"Department of Animal Physiology, Institute for Water and Wetland Research, Faculty of Science, Radboud University Nijmegen, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042507375171600_R1","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.peptides.2010.02.026","article-title":"Central leptin treatment modulates brain glucosensing function and peripheral energy metabolism of rainbow trout","volume":"31","author":"Aguilar","year":"2010","journal-title":"Peptides"},{"key":"2021042507375171600_R2","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.ecl.2008.08.005","article-title":"Brain regulation of appetite and satiety","volume":"37","author":"Ahima","year":"2008","journal-title":"Endocrinol. Metab. Clin. North Am."},{"key":"2021042507375171600_R3","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1146\/annurev.physiol.62.1.413","volume":"62","author":"Ahima","year":"2000","journal-title":"Leptin. Annu. Rev. Physiol."},{"key":"2021042507375171600_R4","doi-asserted-by":"crossref","first-page":"34601","DOI":"10.1074\/jbc.M205172200","article-title":"Transcriptional activation of the human leptin gene in response to hypoxia. Involvement of hypoxia-inducible factor 1","volume":"277","author":"Ambrosini","year":"2002","journal-title":"J. Biol. Chem."},{"key":"2021042507375171600_R5","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.cyto.2008.03.009","article-title":"Human leptin induces angiogenesis in vivo","volume":"42","author":"Anagnostoulis","year":"2008","journal-title":"Cytokine"},{"key":"2021042507375171600_R6","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1111\/j.1463-1326.2008.00852.x","article-title":"Leptin and its metabolic interactions: an update","volume":"10","author":"Anubhuti","year":"2008","journal-title":"Diabetes Obes. Metab."},{"key":"2021042507375171600_R7","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1152\/physiolgenomics.00075.2009","article-title":"Gene expression of the liver in response to chronic hypoxia","volume":"41","author":"Baze","year":"2010","journal-title":"Physiol. Genom."},{"key":"2021042507375171600_R8","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/S0960-9822(02)70684-2","article-title":"A role for leptin and its cognate receptor in hematopoiesis","volume":"6","author":"Bennett","year":"1996","journal-title":"Curr. Biol."},{"key":"2021042507375171600_R9","volume-title":"Methods for Enzymatic Analysis","author":"Bergmeyer","year":"1985"},{"key":"2021042507375171600_R10","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ygcen.2005.11.016","article-title":"The corticotropin-releasing factor system as a mediator of the appetite-suppressing effects of stress in fish","volume":"146","author":"Bernier","year":"2006","journal-title":"Gen. Comp. Endocrinol."},{"key":"2021042507375171600_R11","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1079\/9781845935535.0238","article-title":"Food intake regulation and disorders","volume-title":"Fish Diseases and Disorders, Vol. 2, Non-Infectious Disorders","author":"Bernier","year":"2010","edition":"2nd edn"},{"key":"2021042507375171600_R12","doi-asserted-by":"crossref","first-page":"R982","DOI":"10.1152\/ajpregu.00668.2004","article-title":"CRF-related peptides contribute to stress response and regulation of appetite in hypoxic rainbow trout","volume":"289","author":"Bernier","year":"2005","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"2021042507375171600_R13","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1159\/000054642","article-title":"Appetite-suppressing effects of urotensin I and corticotropin-releasing hormone in goldfish (Carassius auratus)","volume":"73","author":"Bernier","year":"2001","journal-title":"Neuroendocrinol."},{"key":"2021042507375171600_R14","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1677\/JOE-07-0568","article-title":"Heads or tails? Stressor-specific expression of corticotropin-releasing factor and urotensin I in the preoptic area and caudal neurosecretory system of rainbow trout","volume":"196","author":"Bernier","year":"2008","journal-title":"J. Endocrinol."},{"key":"2021042507375171600_R15","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S1546-5098(09)28006-X","article-title":"Regulation and contribution of the corticotropic, melanotropic and thyrotropic axes to the stress response in fishes","volume-title":"Fish Neuroendocrinology, Fish Physiology","author":"Bernier","year":"2009"},{"key":"2021042507375171600_R16","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0034-5687(88)90116-8","article-title":"Acute exposure to graded levels of hypoxia in rainbow trout (Salmo gairdneri): metabolic and respiratory adaptations","volume":"71","author":"Boutilier","year":"1988","journal-title":"Respir. Physiol."},{"key":"2021042507375171600_R17","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0044-8486(99)00274-4","article-title":"Effects of water temperature and dissolved oxygen on daily feed consumption, feed utilization and growth of channel catfish (Ictalurus punctatus)","volume":"182","author":"Buentello","year":"2000","journal-title":"Aquaculture"},{"key":"2021042507375171600_R18","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.domaniend.2011.04.002","article-title":"The detection of 3 leptin receptor isoforms in crucian carp gill and the influence of fasting and hypoxia in their expression","volume":"41","author":"Cao","year":"2011","journal-title":"Dom. Anim. Endocrinol."},{"key":"2021042507375171600_R19","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1111\/j.1095-8649.1999.tb00693.x","article-title":"Reduced growth of Atlantic cod in non-lethal hypoxic conditions","volume":"55","author":"Chabot","year":"1999","journal-title":"J. Fish Biol."},{"key":"2021042507375171600_R20","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.mce.2010.01.018","article-title":"Leptin: clue to poor appetite in oxygen-starved fish","volume":"319","author":"Chu","year":"2010","journal-title":"Mol. Cell. Endocrinol."},{"key":"2021042507375171600_R21","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3389\/fphys.2011.00026","article-title":"Leptin in teleost fishes: an argument for comparative study","volume":"2","author":"Copeland","year":"2011","journal-title":"Front. Physiol."},{"key":"2021042507375171600_R22","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.aquatox.2010.04.015","article-title":"Effects of cadmium on hypoxia-induced expression of hemoglobin and erythropoietin in larval sheepshead minnow, Cyprinodon variegatus","volume":"99","author":"Dangre","year":"2010","journal-title":"Aquat. Toxicol."},{"key":"2021042507375171600_R23","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1677\/joe.1.06349","article-title":"Acute and chronic leptin reduces food intake and body weight in goldfish (Carassius auratus)","volume":"188","author":"De Pedro","year":"2006","journal-title":"J. Endocrinol."},{"key":"2021042507375171600_R24","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1159\/000328435","article-title":"Evolution of leptin structure and function","volume":"94","author":"Denver","year":"2011","journal-title":"Neurodocrinol."},{"key":"2021042507375171600_R25","first-page":"1","article-title":"The hypoxic environment","volume-title":"Hypoxia, Fish Physiology","author":"Diaz","year":"2009"},{"key":"2021042507375171600_R26","first-page":"185","article-title":"Hematocrit and blood oxygen-carrying capacity","volume-title":"Fish Respiration, Fish Physiology","author":"Gallaugher","year":"1998"},{"key":"2021042507375171600_R27","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s00360-009-0419-4","article-title":"Effects of nutritional status on metabolic rate, exercise and recovery in a freshwater fish","volume":"180","author":"Gingerich","year":"2010","journal-title":"J. Comp. Physiol. B"},{"key":"2021042507375171600_R28","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1677\/JOE-09-0034","article-title":"Two divergent leptin paralogues in zebrafish (Danio rerio) that originate early in teleostean evolution","volume":"201","author":"Gorissen","year":"2009","journal-title":"J. Endocrinol."},{"key":"2021042507375171600_R29","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1163\/157075606778967829","article-title":"Peptides and proteins regulating food intake: a comparative view","volume":"56","author":"Gorissen","year":"2006","journal-title":"Anim. Biol."},{"key":"2021042507375171600_R30","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ygcen.2012.04.004","article-title":"Recombinant human leptin attenuates stress axis activity in common carp (Cyprinus carpio L.)","volume":"178","author":"Gorissen","year":"2012","journal-title":"Gen. Comp. Endocrinol."},{"key":"2021042507375171600_R31","doi-asserted-by":"crossref","first-page":"42953","DOI":"10.1074\/jbc.M206775200","article-title":"Hypoxia-inducible factor 1 transactivates the human leptin gene promoter","volume":"277","author":"Grosfeld","year":"2002","journal-title":"J. Biol. Chem."},{"key":"2021042507375171600_R32","doi-asserted-by":"crossref","first-page":"3987","DOI":"10.1210\/en.2007-0261","article-title":"Disruption of peripheral leptin signaling in mice results in hyperleptinemia without associated metabolic abnormalities","volume":"148","author":"Guo","year":"2007","journal-title":"Endocrinol."},{"key":"2021042507375171600_R33","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1146\/annurev-physiol-012110-142155","article-title":"Effects of oxygen on growth and size: synthesis of molecular, organismal, and evolutionary studies with Drosophila melanogaster","volume":"73","author":"Harrison","year":"2010","journal-title":"Annu. Rev. Physiol."},{"key":"2021042507375171600_R34","doi-asserted-by":"crossref","first-page":"5786","DOI":"10.1210\/en.2006-0824","article-title":"Increased leptin expression in common carp (Cyprinus carpio) after food intake but not after fasting or feeding to satiation","volume":"147","author":"Huising","year":"2006","journal-title":"Endocrinology"},{"key":"2021042507375171600_R35","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.mrfmmm.2008.01.001","article-title":"Hypoxia induces a novel signature of chromatin modifications and global repression of transcription","volume":"640","author":"Johnson","year":"2008","journal-title":"Mutat. Res."},{"key":"2021042507375171600_R36","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S1096-4959(01)00314-1","article-title":"Serum insulin-like growth factor binding proteins (IGFBPs) as markers for anabolic\/catabolic condition in fishes","volume":"129B","author":"Kelley","year":"2001","journal-title":"Comp. Biochem. Physiol."},{"key":"2021042507375171600_R37","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.ygcen.2009.04.003","article-title":"A homologous salmonid leptin radioimmunoassay indicates elevated plasma leptin levels during fasting of rainbow trout","volume":"162","author":"Kling","year":"2009","journal-title":"Gen. Comp. Endocrinol."},{"key":"2021042507375171600_R38","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.peptides.2004.12.017","article-title":"Identification of cDNA coding for a homologue to mammalian leptin from pufferfish, Takifugu rubripes","volume":"26","author":"Kurokawa","year":"2005","journal-title":"Peptides"},{"key":"2021042507375171600_R39","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.1242\/jeb.02279","article-title":"Effects of moderate and substantial hypoxia on erythropoietin levels in rainbow trout kidney and spleen","volume":"209","author":"Lai","year":"2006","journal-title":"J. Exp. Biol."},{"key":"2021042507375171600_R40","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.ygcen.2009.10.009","article-title":"Gene structure, recombinant expression and functional characterization of grass carp leptin","volume":"166","author":"Li","year":"2010","journal-title":"Gen. Comp. Endocrinol."},{"key":"2021042507375171600_R41","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S0016-6480(02)00510-5","article-title":"Murine leptin injections increase intracellular fatty acid-binding protein in green sunfish (Lepomis cyanellus)","volume":"129","author":"Londraville","year":"2002","journal-title":"Gen. Comp. Endocrinol."},{"key":"2021042507375171600_R42","first-page":"241","article-title":"Recent advances in the regulation of feeding behavior by neuropeptides in fish","volume":"1163","author":"Matsuda","year":"2009","journal-title":"Trends Comp. Endocrinol. Neurobiol."},{"key":"2021042507375171600_R43","doi-asserted-by":"crossref","first-page":"R814","DOI":"10.1152\/ajpregu.00826.2004","article-title":"ACTH, alpha-MSH, and control of cortisol release: cloning, sequencing, and functional expression of the melanocortin-2 and melanocortin-5 receptor in Cyprinus carpio","volume":"289","author":"Metz","year":"2005","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"2021042507375171600_R44","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.cbpb.2008.04.007","article-title":"Production of recombinant leptin and its effects on food intake in rainbow trout (Oncorhynchus mykiss)","volume":"150B","author":"Murashita","year":"2008","journal-title":"Comp. Biochem. Physiol."},{"key":"2021042507375171600_R45","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.cbpa.2010.09.001","article-title":"Leptin reduces Atlantic salmon growth through the central pro-opiomelanocortin pathway","volume":"158A","author":"Murashita","year":"2011","journal-title":"Comp. Biochem. Physiol."},{"key":"2021042507375171600_R46","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1146\/annurev.physiol.70.113006.100707","article-title":"Mechanisms of leptin action and leptin resistance","volume":"70","author":"Myers","year":"2008","journal-title":"Annu. Rev. Physiol."},{"key":"2021042507375171600_R47","doi-asserted-by":"crossref","first-page":"R1079","DOI":"10.1152\/ajpregu.00626.2004","article-title":"Oxygen-dependent gene expression in fishes","volume":"288","author":"Nikinmaa","year":"2005","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"2021042507375171600_R48","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/0044-8486(87)90171-2","article-title":"Energy budgets for juvenile rainbow trout at various oxygen concentrations","volume":"62","author":"Pedersen","year":"1987","journal-title":"Aquaculture"},{"key":"2021042507375171600_R49","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.domaniend.2003.10.005","article-title":"Effects of fasting on circulating IGF-binding proteins, glucose, and cortisol in channel catfish (Ictalurus punctatus)","volume":"26","author":"Peterson","year":"2004","journal-title":"Dom. Anim. Endocrinol."},{"key":"2021042507375171600_R50","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1111\/j.1095-8649.2001.tb00158.x","article-title":"Comparative effects of long-term hypoxia on growth, feeding and oxygen consumption in juvenile turbot and European sea bass","volume":"59","author":"Pichavant","year":"2001","journal-title":"J. Fish Biol."},{"key":"2021042507375171600_R51","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.mehy.2009.10.022","article-title":"Impact of oxygen availability on body weight management","volume":"74","author":"Quintero","year":"2010","journal-title":"Med. Hypotheses"},{"key":"2021042507375171600_R52","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S1095-6433(00)00159-8","article-title":"Leptin: an essential regulator of lipid metabolism","volume":"125A","author":"Reidy","year":"2000","journal-title":"Comp. Biochem. Physiol."},{"key":"2021042507375171600_R53","first-page":"443","article-title":"Metabolic and molecular responses of fish to hypoxia","volume-title":"Hypoxia, Fish Physiology","author":"Richards","year":"2009"},{"key":"2021042507375171600_R54","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.marenvres.2006.10.003","article-title":"Influence of estuarine hypoxia on feeding and sound production by two sympatric pipefish species (Syngnathidae)","volume":"63","author":"Ripley","year":"2007","journal-title":"Mar. Environ. Res."},{"key":"2021042507375171600_R55","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ygcen.2010.04.010","article-title":"Leptin and leptin receptor genes in Atlantic salmon: cloning, phylogeny, tissue distribution and expression correlated to long-term feeding status","volume":"168","author":"R\u00f8nnestad","year":"2010","journal-title":"Gen. Comp. Endocrinol."},{"key":"2021042507375171600_R56","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1677\/joe.0.1750089","article-title":"Corticotropin-releasing hormone-binding protein: biochemistry and function from fishes to mammals","volume":"175","author":"Seasholtz","year":"2002","journal-title":"J. Endocrinol."},{"key":"2021042507375171600_R57","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1111\/j.1440-1681.2006.04474.x","article-title":"Hypoxia-induced erythropoietin production: a paradigm for oxygen-regulated gene expression","volume":"33","author":"Stockmann","year":"2006","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"2021042507375171600_R58","first-page":"301","article-title":"Human and recombinant erythropoietin stimulate erythropoiesis in the goldfish Carassius auratus","volume":"41","author":"Taglialatela","year":"1997","journal-title":"Eur. J. Histochem."},{"key":"2021042507375171600_R59","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/0014-5793(95)00719-P","article-title":"Effects of fasting and refeeding on ob gene expression in white adipose tissue of lean and obese (ob\/ob) mice","volume":"368","author":"Trayhurn","year":"1995","journal-title":"FEBS Lett."},{"key":"2021042507375171600_R60","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1111\/j.1469-185X.1989.tb00683.x","article-title":"Ecology and physiology of hibernation and overwintering among freshwater fishes, turtles, and snakes","volume":"64","author":"Ultsch","year":"1989","journal-title":"Biol. Rev."},{"key":"2021042507375171600_R61","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/BF02337889","article-title":"Substrate mobilization and hormonal changes in rainbow trout (Oncorhynchus mykiss, L.) and common carp (Cyprinus carpio, L.) during deep hypoxia and subsequent recovery","volume":"166","author":"VanRaaij","year":"1996","journal-title":"J. Comp. Physiol. B"},{"key":"2021042507375171600_R62","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/S0006-8993(03)02507-1","article-title":"Role of leptin in the control of feeding of goldfish Carassius auratus: interactions with cholecystokinin, neuropeptide Y and orexin A, and modulation by fasting","volume":"972","author":"Volkoff","year":"2003","journal-title":"Brain Res."},{"key":"2021042507375171600_R63","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S1546-5098(09)28009-5","article-title":"The endocrine regulation of food intake","volume-title":"Fish Neuroendocrinology, Fish Physiology","author":"Volkoff","year":"2009"},{"key":"2021042507375171600_R64","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1146\/annurev.physiol.68.040104.105739","article-title":"The comparative physiology of food deprivation: from feast to famine","volume":"68","author":"Wang","year":"2006","journal-title":"Annu. Rev. Physiol."},{"key":"2021042507375171600_R65","first-page":"361","article-title":"The effects of hypoxia on growth and digestion","volume-title":"Hypoxia, Fish Physiology","author":"Wang","year":"2009"},{"key":"2021042507375171600_R66","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.marpolbul.2007.01.025","article-title":"Characterization of a hypoxia-responsive leptin receptor (omLepR(L)) cDNA from the marine medaka (Oryzias melastigma)","volume":"54","author":"Wong","year":"2007","journal-title":"Mar. Pollut. Bull."},{"key":"2021042507375171600_R67","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.cbpa.2009.06.024","article-title":"Ontogenetic development of erythropoiesis can be studied non-invasively in GATA-1:DsRed transgenic zebrafish","volume":"154","author":"Yaqoob","year":"2009","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"2021042507375171600_R68","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1111\/j.1095-8649.2000.tb00478.x","article-title":"Metabolic adjustments in the common carp during prolonged hypoxia","volume":"57","author":"Zhou","year":"2000","journal-title":"J. Fish Biol."},{"key":"2021042507375171600_R69","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s003600000149","article-title":"Bioenergetics and RNA\/DNA ratios in the common carp (Cyprinus carpio) under hypoxia","volume":"171","author":"Zhou","year":"2001","journal-title":"J. Comp. Physiol. B"}],"container-title":["Journal of Experimental Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.biologists.com\/jeb\/article-pdf\/215\/13\/2273\/1280486\/2273.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/jeb\/article-pdf\/215\/13\/2273\/1280486\/2273.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,25]],"date-time":"2021-04-25T05:03:22Z","timestamp":1619327002000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/jeb\/article\/215\/13\/2273\/10903\/Differential-effects-of-chronic-hypoxia-and-feed"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,1]]},"references-count":69,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2012,7,1]]}},"URL":"https:\/\/doi.org\/10.1242\/jeb.066183","relation":{},"ISSN":["1477-9145","0022-0949"],"issn-type":[{"value":"1477-9145","type":"electronic"},{"value":"0022-0949","type":"print"}],"subject":[],"published":{"date-parts":[[2012,7,1]]}}}