{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T13:38:16Z","timestamp":1770557896619,"version":"3.49.0"},"reference-count":40,"publisher":"The Company of Biologists","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Summary<\/jats:title><jats:p>Physiological cardiac hypertrophy is characterized by reversible enlargement of cardiomyocytes and changes in chamber architecture, which increase stroke volume and VO2 max via augmented convective oxygen transport. Cardiac hypertrophy is known to occur in response to repeated elevations of O2 demand and\/or reduced O2 supply in several species of vertebrate ectotherms, including postprandial Burmese pythons (Python molurus). Recent data suggest postprandial cardiac hypertrophy in P. molurus is a facultative rather than obligatory response to digestion, though the triggers of this response are unknown. Here we hypothesize that an O2 supply-demand mismatch stimulates postprandial cardiac enlargement in Burmese pythons. To test this hypothesis, we rendered animals anemic prior to feeding, essentially halving blood oxygen content during the postprandial period. Fed anemic animals had heart rates 126% higher than fasted controls, which, coupled with a 71% increase in mean arterial pressure suggests fed anemic animals were experiencing significantly elevated cardiac work. We found significant cardiac hypertrophy in fed anemic animals, which exhibited ventricles 39% larger than fasted controls and 28% larger than fed controls. These findings support our hypothesis that those animals with a greater magnitude of O2 supply-demand mismatch exhibit the largest hearts. The \"low O2 signal\" stimulating postprandial cardiac hypertrophy is likely mediated by elevated ventricular wall stress associated with postprandial hemodynamics.<\/jats:p>","DOI":"10.1242\/jeb.092841","type":"journal-article","created":{"date-parts":[[2013,12,6]],"date-time":"2013-12-06T03:33:41Z","timestamp":1386300821000},"source":"Crossref","is-referenced-by-count":15,"title":["Reduction of blood oxygen levels enhances postprandial cardiac hypertrophy in Burmese python (<i>Python molurus<\/i>)"],"prefix":"10.1242","author":[{"given":"Chris","family":"Slay","sequence":"first","affiliation":[{"name":"University of California Irvine, USA;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanne","family":"Enok","sequence":"additional","affiliation":[{"name":"Aarhus University, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Hicks","sequence":"additional","affiliation":[{"name":"University of California Irvine, USA;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Wang","sequence":"additional","affiliation":[{"name":"Aarhus University, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2013,1,1]]},"reference":[{"key":"2021042508532742500_R1","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0300-9629(96)00402-1","article-title":"Cholinergic and adrenergic tones in the control of heart rate in teleosts. 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