{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T22:23:08Z","timestamp":1759962188085,"version":"3.41.2"},"reference-count":33,"publisher":"The Company of Biologists","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Unilateral naris occlusion, a standard method for causing odor deprivation, also alters airflow on both sides of the nasal cavity. We reasoned that manipulating airflow by occlusion could affect nasal turbinate development given the ubiquitous role of environmental stimuli in ontogenesis. To test this hypothesis, newborn mice received unilateral occlusion or sham surgery and were allowed to reach adulthood. Morphological measurements were then made of paraffin sections sampled throughout the nasal cavity. Occlusion significant affected the size, shape, and position of turbinates. In particular, the nasoturbinate, the focus of our quantitative analysis, had a more delicate appearance on the occluded side relative to the open side. Occlusion also caused an increase in the width of the dorsal meatus within the non-occluded and occluded nasal fossae, compared to controls, and the position of most turbinates was altered. These results suggest that a mechanical stimulus from respiratory airflow is necessary for the normal morphological development of turbinates. To explore this idea, we estimated the mechanical forces on turbinates due to airflow during normal respiration that would be abrogated by occlusion. MRI scans were used to construct a 3D model of the mouse nasal cavity that provided the input for a computational fluid dynamics simulation of nasal airflow. The simulation revealed maximum shear stress values for the walls of turbinates in the 1 Pa range, a magnitude that causes remodeling in other biological tissues. These observations raise the intriguing possibility that nasal turbinates develop partly under the control of respiratory mechanical forces.<\/jats:p>","DOI":"10.1242\/jeb.092940","type":"journal-article","created":{"date-parts":[[2013,12,6]],"date-time":"2013-12-06T03:33:41Z","timestamp":1386300821000},"source":"Crossref","is-referenced-by-count":26,"title":["The effects of naris occlusion on mouse nasal turbinate development"],"prefix":"10.1242","author":[{"given":"David","family":"Coppola","sequence":"first","affiliation":[{"name":"Randolph Macon College, USA;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brent","family":"Craven","sequence":"additional","affiliation":[{"name":"Pennsylvania State University, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2013,1,1]]},"reference":[{"key":"2021042507241328900_R1","first-page":"135","article-title":"On a revision of the ethmoid bone in the Mammalia, with special reference to the description of this bone and of the sense of smelling in the Cheiroptera","volume":"10","author":"Allen","year":"1882","journal-title":"Bull. 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