{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T12:11:16Z","timestamp":1784981476602,"version":"3.55.0"},"reference-count":33,"publisher":"The Company of Biologists","issue":"1","license":[{"start":{"date-parts":[[1984,9,1]],"date-time":"1984-09-01T00:00:00Z","timestamp":462844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1984,9,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>We discuss ideas emerging from our studies on selective axonal fasciculation in the grasshopper embryo that have implications for the organization of the adult neuropile in insects and perhaps other animals. While one of our laboratories has been studying the embryonic development of the G neurone (in the mesothoracic segment) and its lineal homologues (in other segments), the other has been studying the morphology and physiology of this same neurone and its segmental homologues in the adult nervous system. Our embryonic studies show that the growth cone of the G neurone selectively fasciculates with the A\/P fascicle in preference to all other longitudinal axon fascicles as it turns anteriorly. The homologues of G in other thoracic and abdominal segments fasciculate in this same bundle. However, early in their morphological differentiation, they reveal interesting segmental differences. Our studies on the adult nervous system show that the segmental homologues of the G neurone share many properties in common (e.g. axons in the LDT : lateral dorsal tract) while other features are quite different. The notion emerging from these studies is that a basic segmentally-repeated pattern arises during embryogenesis: a stereotyped axonal scaffold upon which growth cones faithfully fasciculate. Evolutionary plasticity allows the specialization of lineally equivalent neurones in different segments within the context of the neuropilar neighbourhood that they find themselves in as a consequence of their selective fasciculation.<\/jats:p>","DOI":"10.1242\/jeb.112.1.45","type":"journal-article","created":{"date-parts":[[2021,4,25]],"date-time":"2021-04-25T01:38:18Z","timestamp":1619314698000},"page":"45-64","source":"Crossref","is-referenced-by-count":37,"title":["From Embryonic Fascicles to Adult Tracts: Organization of Neuropile From a Developmental Perspective"],"prefix":"10.1242","volume":"112","author":[{"given":"Michael","family":"Bastiani","sequence":"first","affiliation":[{"name":"Stanford University * Department of Biological Sciences , , Stanford, CA 94305, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keir G.","family":"Pearson","sequence":"additional","affiliation":[{"name":"University of Alberta \u2020 Department of Physiology , , Edmonton, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corey S.","family":"Goodman","sequence":"additional","affiliation":[{"name":"Stanford University * Department of Biological Sciences , , Stanford, CA 94305, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[1984,9,1]]},"reference":[{"key":"2023051712424066500_JEXBIO_112_1_45C1","article-title":"The first growth cones in insect embryos: a model system for studying selective fasciculation","volume-title":"In Model Neural Networks and Behavior","author":"Bastiani","year":"1984"},{"key":"2023051712424066500_JEXBIO_112_1_45C2","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4613-2717-2_4","article-title":"The first growth cones in the central nervous system of the grasshopper embryo","volume-title":"In Cellular and Molecular Approaches to Neuronal Development","author":"Bastiani","year":"1984"},{"key":"2023051712424066500_JEXBIO_112_1_45C3","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.81.6.1849","article-title":"Neuronal growth cones: specific interactions mediated by filopodial insertion and induction of coated vesicles","volume-title":"Proc. natn. Acad. Set. U.S A. (in press)","author":"Bastiani","year":"1984"},{"key":"2023051712424066500_JEXBIO_112_1_45C4","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.04-09-02311.1984","article-title":"Pathfinding by neuronal growth cones in grasshopper embryos. III. Selective affinity of the G growth cone for the P cells within the A\/P fascicle","volume-title":"J. Neurosa, (in press)","author":"Bastiani","year":"1984"},{"key":"2023051712424066500_JEXBIO_112_1_45C5","first-page":"107","article-title":"Embryogenesis of an insect nervous system. I. A map of the thoracic and abdominal neuroblasts in Locusta migratoria","volume":"35","author":"Bate","year":"1976","journal-title":"J. Embryol. exp. Morph"},{"issue":"6","key":"2023051712424066500_JEXBIO_112_1_45C6","first-page":"838","article-title":"Pioneer neurons and axonal pathways. In Neuronal Development: Cellular Approaches in Invertebrates","volume":"20","author":"Bate","year":"1983","journal-title":"Neurosa. Res. Prog. Bull"},{"key":"2023051712424066500_JEXBIO_112_1_45C7","first-page":"317","article-title":"Embryogenesis of an insect nervous system. II. A second class of precursor cells and the origin of the intersegmental connectives","volume":"61","author":"Bate","year":"1981","journal-title":"J. Embryol. exp. Morph"},{"key":"2023051712424066500_JEXBIO_112_1_45C8","article-title":"Filopodial contraction and growth cone guidance","volume-title":"In Cell Behavior","author":"Bray","year":"1982"},{"key":"2023051712424066500_JEXBIO_112_1_45C9","article-title":"Cell recognition during neuronal development in grasshopper and Drosophila","volume-title":"In Molecular Bases of Neuronal Development","author":"Goodman","year":"1984"},{"key":"2023051712424066500_JEXBIO_112_1_45C10","first-page":"163","article-title":"Neuronal development in the grasshopper","volume":"4","author":"Goodman","year":"1981","journal-title":"TrendsNeurosd"},{"key":"2023051712424066500_JEXBIO_112_1_45C11","first-page":"275","article-title":"Pathfinding by neuronal growth cones in grasshopper embryos. In Developmental Order: Its Origins and Regulation","volume":"40","author":"Goodman","year":"1982","journal-title":"Symp. Soc. devl Biol"},{"key":"2023051712424066500_JEXBIO_112_1_45C12","doi-asserted-by":"crossref","DOI":"10.1038\/311151a0","article-title":"Transient expression of a surface antigen on a small subset of neurones during embryonic development","volume-title":"Nature,Lond, (in press)","author":"Kotrla","year":"1984"},{"key":"2023051712424066500_JEXBIO_112_1_45C13","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4684-1131-7_6","article-title":"Nerve fiber growth and its regulation by extrinsic factors","volume-title":"In Neuronal Development","author":"Letourneau","year":"1982"},{"key":"2023051712424066500_JEXBIO_112_1_45C14","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1152\/jn.1980.43.2.257","article-title":"Triggering of locust jump by multimodal inhibitory interneurons","volume":"43","author":"Pearson","year":"1980","journal-title":"J. Neurophysiol"},{"key":"2023051712424066500_JEXBIO_112_1_45C15","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1007\/BF00612571","article-title":"Interneurons coactivating hindleg flexor and extensor motoneurons in the locust: their role in the jump","volume":"144","author":"Pearson","year":"1981","journal-title":"J. comp. Physiol"},{"key":"2023051712424066500_JEXBIO_112_1_45C16","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1126\/science.176.4033.412","article-title":"Branching of central neurons: intracellular cobalt injection for light and electron microscopy","volume":"176","author":"Pitman","year":"1972","journal-title":"Science,N.Y"},{"key":"2023051712424066500_JEXBIO_112_1_45C17","first-page":"860","article-title":"Pathfinding by identified growth cones in the central nervous system of the grasshopper embryo","volume-title":"In Neuronal Development: Cellular Approaches in Invertebrates","author":"Raper","year":"1982"},{"key":"2023051712424066500_JEXBIO_112_1_45C18","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1523\/JNEUROSCI.03-01-00020.1983","article-title":"Pathfinding by neuronal growth cones in grasshopper embryos. I. Divergent choices made by the growth cones of sibling neurons","volume":"3","author":"Raper","year":"1983","journal-title":"J. Neurosci"},{"key":"2023051712424066500_JEXBIO_112_1_45C19","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1523\/JNEUROSCI.03-01-00031.1983","article-title":"Pathfinding by neuronal growth cones in grasshopper embryos. II. Selective fasciculation onto specific axonal pathways","volume":"3","author":"Raper","year":"1983","journal-title":"J. Neurosci"},{"key":"2023051712424066500_JEXBIO_112_1_45C20","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1101\/SQB.1983.048.01.063","article-title":"Guidance of neuronal growth cones: selective fasciculation in the grasshopper embryo","volume":"48","author":"Raper","year":"1983","journal-title":"Cold Spring Harb. Symp. quant. Biol.,Molecular Neurobiology"},{"key":"2023051712424066500_JEXBIO_112_1_45C21","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.04-09-02329.1984","article-title":"Pathfinding by neuronal growth cones in grasshopper embryos. IV. The effects of ablating the A and P axons upon the behavior of the G growth cone","volume-title":"J. Neurosci. (in press)","author":"Raper","year":"1984"},{"key":"2023051712424066500_JEXBIO_112_1_45C22","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1007\/BF00659142","article-title":"Auditory neurons in the ventral cord of the locust: morphological and functional properties","volume":"110","author":"Rehbein","year":"1976","journal-title":"J. comp. Physiol"},{"key":"2023051712424066500_JEXBIO_112_1_45C23","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1016\/0092-8674(78)90256-8","article-title":"Functional connections between cells revealed by dye-coupling with highly fluorescent naphthalamide tracer","volume":"14","author":"Stewart","year":"1978","journal-title":"Cell"},{"key":"2023051712424066500_JEXBIO_112_1_45C24","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1126\/science.162.3849.132","article-title":"Neuronal geometry: determination with a technique of intracellular dye injection","volume":"162","author":"Stretton","year":"1968","journal-title":"Science,N.Y"},{"key":"2023051712424066500_JEXBIO_112_1_45C25","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/978-3-642-87123-8_2","article-title":"Intracellular dye injection: the selection of procion yellow and its application in preliminary studies of neuronal geometry in the lobster nervous system","volume-title":"In Intracellular Staining in Neurobiology","author":"Stretton","year":"1973"},{"key":"2023051712424066500_JEXBIO_112_1_45C26","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1523\/JNEUROSCI.04-04-00989.1984","article-title":"Cell determination and differentiation of identified serotonin-containing neurons in the grasshopper embryo","volume":"4","author":"Taghert","year":"1984","journal-title":"J. Neurosci"},{"key":"2023051712424066500_JEXBIO_112_1_45C27","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/0012-1606(82)90356-6","article-title":"Guidance of pioneer growth con, filopodial contacts and coupling revealed with an antibody to Lucifer Yellow","volume":"94","author":"Taghert","year":"1982","journal-title":"Devi Biol"},{"key":"2023051712424066500_JEXBIO_112_1_45C28","doi-asserted-by":"crossref","DOI":"10.1038\/310203a0","article-title":"From grasshopper to Drosophila: a common plan for neuronal development","volume-title":"Nature,Lond, (in press)","author":"Thomas","year":"1984"},{"key":"2023051712424066500_JEXBIO_112_1_45C29","first-page":"91","article-title":"A guide to the neuroanatomy of locust suboesophageal and thoracic ganglia","volume":"297","author":"Tyrer","year":"1982","journal-title":"Phil. Trans. R. Soc. Ser. B"},{"key":"2023051712424066500_JEXBIO_112_1_45C30","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1101\/SQB.1983.048.01.067","article-title":"Factors that determine connectivity in the nervous system of Caenorhabditis elegans","volume":"48","author":"White","year":"1983","journal-title":"Cold Spring Harb. Symp. quant. Biol"},{"key":"2023051712424066500_JEXBIO_112_1_45C31","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1002\/cne.901100306","article-title":"On the functional connections of single units in the central nervous system of the crayfish, Procambarus clarkii, Girard","volume":"110","author":"Wiersma","year":"1958","journal-title":"J. comp. Neurol"},{"key":"2023051712424066500_JEXBIO_112_1_45C32","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1002\/cne.901160209","article-title":"On the functional anatomy of neuronal units in the abdominal cord of the crayfish, Procambarus clarkii (Girard)","volume":"116","author":"Wiersma","year":"1961","journal-title":"J. comp. Neurol"},{"key":"2023051712424066500_JEXBIO_112_1_45C33","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/0010-406X(64)90153-7","article-title":"Interneurons commanding swimmeret movements in the crayfish Procambarus clarkii (Girard)","volume":"12","author":"Wiersma","year":"1964","journal-title":"Comp. Biochem. Physiol"}],"container-title":["Journal of Experimental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/jeb\/article-pdf\/112\/1\/45\/2863209\/jexbio_112_1_45.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/jeb\/article-pdf\/112\/1\/45\/2863209\/jexbio_112_1_45.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T12:43:36Z","timestamp":1684327416000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/jeb\/article\/112\/1\/45\/4132\/From-Embryonic-Fascicles-to-Adult-Tracts"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,9,1]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1984,9,1]]}},"URL":"https:\/\/doi.org\/10.1242\/jeb.112.1.45","relation":{},"ISSN":["0022-0949","1477-9145"],"issn-type":[{"value":"0022-0949","type":"print"},{"value":"1477-9145","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,9,1]]}}}