{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T08:38:08Z","timestamp":1790411888356,"version":"4.1.0"},"reference-count":69,"publisher":"The Company of Biologists","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In the present study, we assess the responses of the vasotocinergic and isotocinergic systems to chronic stress induced by cortisol administration in the gilthead sea bream (Sparus aurata). Pituitary and plasma arginine vasotocin (AVT) and isotocin (IT) levels, as well as hypothalamic pro-vasotocin (pro-VT) and pro-isotocin (pro-IT) mRNA expression levels, were analysed. In addition, the mRNA levels of three receptors, AVTR type V1a2, AVTR type V2 and ITR, were analysed in several target organs associated with the following physiological processes: i) integration and control (hypothalamus), ii) metabolism and its control (liver and hypothalamus), iii) osmoregulation (gills), and iv) stress response (head kidney). Specimens were injected intraperitoneally with slow-release implants (5 \u00b5L\u00b7g-1 body weight) containing coconut oil alone (control group) or with cortisol (50 \u00b5g\u00b7g-1 body weight; cortisol group). Both AVT and IT synthesis and release were correlated with plasma cortisol values, suggesting a potential interaction between both hormonal systems and cortisol administration. Our results suggest that the activation of hepatic metabolism, as well as the hypothalamic control of metabolic processes, provide the energy necessary to overcome stress, which could be partly mediated by AVTRs and ITR. Up-regulation of branchial AVT and IT receptor expression following cortisol treatment suggests an involvement of the vasotocinergic and isotocinergic systems in the regulation of ion channels\/transporters during stressful situations. Finally, changes in AVT and IT receptor mRNA expression in the head kidney suggest these nonapeptides participate in feedback mechanisms that regulate the synthesis\/release of cortisol. Our results indicate a relationship between cortisol and both the vasotocinergic and isotocinergic systems during simulated chronic stress in Sparus aurata.<\/jats:p>","DOI":"10.1242\/jeb.113944","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T11:12:24Z","timestamp":1418987544000},"source":"Crossref","is-referenced-by-count":17,"title":["Cortisol modulates vasotocinergic and isotocinergic pathways in the gilthead sea bream (<i>Sparus aurata<\/i>, Linnaeus 1758)"],"prefix":"10.1242","author":[{"given":"Laura","family":"C\u00e1diz","sequence":"first","affiliation":[{"name":"University of C\u00e1diz; Instituto de Ciencias Marinas de Andaluc\u00eda, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Rom\u00e1n-Padilla","sequence":"additional","affiliation":[{"name":"Faculty of Marine and Environmental Sciences, University of C\u00e1diz, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Gozdowska","sequence":"additional","affiliation":[{"name":"Institute of Oceanology of Polish Academy of Sciences, Poland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Kulczykowska","sequence":"additional","affiliation":[{"name":"Institute of Oceanology of Polish Academy of Sciences, Poland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"Mart\u00ednez-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Instituto de Ciencias Marinas de Andaluc\u00eda (ICMAN-CSIC), Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Miguel","family":"Mancera","sequence":"additional","affiliation":[{"name":"Faculty of Marine and Environmental Sciences, University of C\u00e1diz, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Antonio","family":"Martos-Sitcha","sequence":"additional","affiliation":[{"name":"University of C\u00e1diz; Instituto de Ciencias Marinas de Andaluc\u00eda, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2014,1,1]]},"reference":[{"key":"2021042509053414800_R1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0167-0115(93)90174-7","article-title":"Neurohypophysial peptide systems: processing machinery, hydroosmotic regulation, adaptation and evolution","volume":"45","author":"Acher","year":"1993","journal-title":"Regul. 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