{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T13:48:58Z","timestamp":1760708938188,"version":"3.41.2"},"reference-count":74,"publisher":"The Company of Biologists","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,1,1]]},"abstract":"<jats:p>The mechanisms of rhythmic motor pattern generation have been studied in detail in vitro, but the long-term stability and sources of variability in vivo are often not well described. The crab stomatogastric ganglion contains the well-characterized gastric mill (chewing) and pyloric (filtering of food) central pattern generators. In vitro, the pyloric rhythm is stereotyped with little variation, but inter-circuit interactions and neuromodulation can alter both rhythm cycle frequency and structure. The range of variation of activity in vivo is, with few exceptions, unknown. Curiously, although the pattern generating circuits in vivo are constantly exposed to hormonal and neural modulation, the majority of published data show only the unperturbed canonical motor patterns typically observed in vitro.<\/jats:p><jats:p>Using long-term extracellular recordings (N=27 animals), we identified the range and sources of variability of the pyloric and gastric mill rhythms recorded continuously over 4 days in freely behaving Jonah crabs (Cancer borealis). Although there was no evidence of innate daily rhythmicity, a 12-hour light-driven cycle did manifest. Both rhythms' frequencies increased modestly albeit consistently during the 3 hours prior to and 3 hours after the lights changed. This cycle was occluded by sensory stimulation (feeding), which significantly influenced both pyloric cycle frequency and structure. This was the only instance where the structure of the rhythm changed. In unfed animals the structure remained stable, even when the frequency varied substantially. So, although central pattern generating circuits are capable of producing many patterns, in vivo outputs typically remain stable in the absence of sensory stimulation<\/jats:p>","DOI":"10.1242\/jeb.126581","type":"journal-article","created":{"date-parts":[[2015,10,31]],"date-time":"2015-10-31T01:48:34Z","timestamp":1446256114000},"source":"Crossref","is-referenced-by-count":10,"title":["Sources and range of long-term variability of rhythmic motor patterns<i>in vivo<\/i>."],"prefix":"10.1242","author":[{"given":"Alexandra M.","family":"Yarger","sequence":"first","affiliation":[{"name":"School of Biological Sciences, Illinois State University, Normal IL 61761-4120, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Stein","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, Illinois State University, Normal IL 61761-4120, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","reference":[{"key":"2021042509065320900_JEB126581C1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/978-4-431-55261-1_4","volume-title":"Circatidal and Circadian Rhythms in Crustacean Swimming Behavior. Annual, Lunar, and Tidal Clocks","author":"Akiyama","year":"2014"},{"key":"2021042509065320900_JEB126581C2","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1523\/JNEUROSCI.17-07-02247.1997","article-title":"Intercircuit control of motor pattern modulation by presynaptic inhibition","volume":"17","author":"Bartos","year":"1997","journal-title":"J. Neurosci."},{"key":"2021042509065320900_JEB126581C3","doi-asserted-by":"crossref","first-page":"6650","DOI":"10.1523\/JNEUROSCI.19-15-06650.1999","article-title":"Coordination of fast and slow rhythmic neuronal circuits","volume":"19","author":"Bartos","year":"1999","journal-title":"J. Neurosci."},{"key":"2021042509065320900_JEB126581C4","doi-asserted-by":"publisher","first-page":"6741","DOI":"10.1523\/jneurosci.1682-04.2004","article-title":"Mechanosensory activation of a motor circuit by coactivation of two projection neurons","volume":"24","author":"Beenhakker","year":"2004","journal-title":"J. Neurosci."},{"key":"2021042509065320900_JEB126581C5","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1152\/jn.00741.2003","article-title":"Long-lasting activation of rhythmic neuronal activity by a novel mechanosensory system in the crustacean stomatogastric nervous system","volume":"91","author":"Beenhakker","year":"2004","journal-title":"J. Neurophysiol."},{"key":"2021042509065320900_JEB126581C6","doi-asserted-by":"publisher","first-page":"6949","DOI":"10.1021\/ac800798h","article-title":"Combining microdialysis, nanoLC-MS, and MALDI-TOF\/TOF to detect neuropeptides secreted in the crab, Cancer borealis","volume":"80","author":"Behrens","year":"2008","journal-title":"Anal. Chem."},{"key":"2021042509065320900_JEB126581C7","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1016\/j.conb.2011.05.019","article-title":"Neural circuit flexibility in a small sensorimotor system","volume":"21","author":"Blitz","year":"2011","journal-title":"Curr. Opin. Neurobiol."},{"key":"2021042509065320900_JEB126581C8","doi-asserted-by":"publisher","first-page":"9182","DOI":"10.1523\/JNEUROSCI.1461-12.2012","article-title":"Modulation of circuit feedback specifies motor circuit output","volume":"32","author":"Blitz","year":"2012","journal-title":"J. Neurosci."},{"key":"2021042509065320900_JEB126581C9","doi-asserted-by":"publisher","first-page":"11381","DOI":"10.1523\/JNEUROSCI.3219-04.2004","article-title":"Different sensory systems share projection neurons but elicit distinct motor patterns","volume":"24","author":"Blitz","year":"2004","journal-title":"J. Neurosci."},{"key":"2021042509065320900_JEB126581C10","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1242\/jeb.015222","article-title":"A newly identified extrinsic input triggers a distinct gastric mill rhythm via activation of modulatory projection neurons","volume":"211","author":"Blitz","year":"2008","journal-title":"J. Exp. Biol."},{"key":"2021042509065320900_JEB126581C11","doi-asserted-by":"publisher","first-page":"1611","DOI":"10.1523\/JNEUROSCI.3679-04.2005","article-title":"Animal-to-animal variability in motor pattern production in adults and during growth","volume":"25","author":"Bucher","year":"2005","journal-title":"J. Neurosci."},{"key":"2021042509065320900_JEB126581C12","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1016\/j.jasms.2008.12.007","article-title":"Measurement of neuropeptides in crustacean hemolymph via MALDI mass spectrometry","volume":"20","author":"Chen","year":"2009","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"2021042509065320900_JEB126581C13","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1152\/physrev.00010.2003","article-title":"Regulation and modulation of pH in the brain","volume":"83","author":"Chesler","year":"2003","journal-title":"Physiol. Rev."},{"key":"2021042509065320900_JEB126581C15","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1242\/jeb.198.12.2431","article-title":"Matrix of neuromodulators in neurosecretory structures of the crab Cancer borealis","volume":"198","author":"Christie","year":"1995","journal-title":"J. Exp. Biol."},{"key":"2021042509065320900_JEB126581C16","doi-asserted-by":"crossref","first-page":"2788","DOI":"10.1523\/JNEUROSCI.18-07-02788.1998","article-title":"In vivo modulation of interacting central pattern generators in lobster stomatogastric ganglion: influence of feeding and partial pressure of oxygen","volume":"18","author":"Clemens","year":"1998","journal-title":"J. Neurosci."},{"key":"2021042509065320900_JEB126581C17","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1152\/jn.1998.79.3.1396","article-title":"Long-term expression of two interacting motor pattern-generating networks in the stomatogastric system of freely behaving lobster","volume":"79","author":"Clemens","year":"1998","journal-title":"J. Neurophysiol."},{"key":"2021042509065320900_JEB126581C18","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1016\/0166-2236(92)90006-T","article-title":"Modelling of intersegmental coordination in the lamprey central pattern generator for locomotion","volume":"15","author":"Cohen","year":"1992","journal-title":"Trends Neurosci."},{"key":"2021042509065320900_JEB126581C19","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1038\/378502a0","article-title":"A switch between two modes of synaptic transmission mediated by presynaptic inhibition","volume":"378","author":"Coleman","year":"1995","journal-title":"Nature"},{"key":"2021042509065320900_JEB126581C21","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1159\/000076159","article-title":"Feeding neural networks in the mollusc Aplysia","volume":"13","author":"Cropper","year":"2004","journal-title":"Neurosignals"},{"key":"2021042509065320900_JEB126581C22","first-page":"35","article-title":"Observation botanique","author":"De Mairan","year":"1729","journal-title":"Histoire de l'Academie Royale des Sciences"},{"key":"2021042509065320900_JEB126581C23","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1016\/0959-4388(95)80108-1","article-title":"Interactions among neural networks for behavior","volume":"5","author":"Dickinson","year":"1995","journal-title":"Curr. Opin. Neurobiol."},{"key":"2021042509065320900_JEB126581C24","doi-asserted-by":"publisher","first-page":"2905","DOI":"10.1242\/jeb.124818","article-title":"Distinct or shared actions of peptide family isoforms: II. Multiple pyrokinins exert similar effects in the lobster stomatogastric nervous system","volume":"218","author":"Dickinson","year":"2015","journal-title":"J. Exp. Biol."},{"key":"2021042509065320900_JEB126581C25","doi-asserted-by":"publisher","first-page":"12013","DOI":"10.1523\/JNEUROSCI.1060-13.2013","article-title":"Motor circuit-specific burst patterns drive different muscle and behavior patterns","volume":"33","author":"Diehl","year":"2013","journal-title":"J. Neurosci."},{"key":"2021042509065320900_JEB126581C26","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1016\/S1388-2457(03)00120-2","article-title":"Spinal cord pattern generators for locomotion","volume":"114","author":"Dietz","year":"2003","journal-title":"Clin. Neurophysiol."},{"key":"2021042509065320900_JEB126581C27","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1651\/08-3061.1","article-title":"Predation risk, prey abundance, and the vertical distribution of three brachyuran crabs on Gulf of Maine shores","volume":"29","author":"Donahue","year":"2009","journal-title":"J. Crustacean Biol."},{"key":"2021042509065320900_JEB126581C28","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1007\/BF00609938","article-title":"The effect of eyestalk hormones on the gastric mill in the intact lobster, Panulirus interruptus","volume":"141","author":"Fleischer","year":"1981","journal-title":"J. Comp. Physiol."},{"key":"2021042509065320900_JEB126581C29","doi-asserted-by":"publisher","first-page":"e103459","DOI":"10.1371\/journal.pone.0103459","article-title":"Optical imaging of neuronal activity and visualization of fine neural structures in non-desheathed nervous systems","volume":"9","author":"Goldsmith","year":"2014","journal-title":"PLoS ONE"},{"key":"2021042509065320900_JEB126581C30","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/0022-0981(92)90167-9","article-title":"Experimental assessment of gull predation on the Jonah crab Cancer borealis (Stimpson) in New England rocky intertidal and shallow subtidal zones","volume":"157","author":"Good","year":"1992","journal-title":"J. Exp. Mar. Biol. Ecol."},{"key":"2021042509065320900_JEB126581C31","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/j.conb.2011.05.011","article-title":"Neuromodulation and flexibility in central pattern generator networks","volume":"21","author":"Harris-Warrick","year":"2011","journal-title":"Curr. Opin. Neurobiol."},{"key":"2021042509065320900_JEB126581C32","doi-asserted-by":"publisher","first-page":"2866","DOI":"10.1152\/jn.00618.2009","article-title":"Differential activation of projection neurons by two sensory pathways contributes to motor pattern selection","volume":"102","author":"Hedrich","year":"2009","journal-title":"J. Neurophysiol."},{"key":"2021042509065320900_JEB126581C33","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.1152\/jn.01105.2010","article-title":"Gastric and pyloric motor pattern control by a modulatory projection neuron in the intact crab Cancer pagurus","volume":"105","author":"Hedrich","year":"2011","journal-title":"J. Neurophysiol."},{"key":"2021042509065320900_JEB126581C79","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1152\/jn.1988.59.2.551","article-title":"Gastric mill activity in the lobster. II. Proctolin and octopamine initiate and modulate chewing","volume":"59","author":"Heinzel","year":"1988","journal-title":"J. Neurophysiol."},{"key":"2021042509065320900_JEB126581C35","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1523\/JNEUROSCI.13-04-01793.1993","article-title":"The behavioral repertoire of the gastric mill in the crab, Cancer pagurus: an in situ endoscopic and electrophysiological examination","volume":"13","author":"Heinzel","year":"1993","journal-title":"J. Neurosci."},{"key":"2021042509065320900_JEB126581C36","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1023\/A:1008822218061","article-title":"Phase maintenance in the pyloric pattern of the lobster (Panulirus interruptus) stomatogastric ganglion","volume":"4","author":"Hooper","year":"1997","journal-title":"J. Comput. Neurosci."},{"key":"2021042509065320900_JEB126581C37","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/0022-0981(92)90187-F","article-title":"Endogenous rhythms of circatidal swimming activity in the estuarine copepod Eurytemora affinis (Poppe)","volume":"161","author":"Hough","year":"1992","journal-title":"J. Exp. Mar. Biol. Ecol."},{"key":"2021042509065320900_JEB126581C38","article-title":"Overview of the stomatogastric nervous system","volume-title":"Dynamic Biological Networks: The Stomatogastric Nervous System","author":"Johnson","year":"1992"},{"key":"2021042509065320900_JEB126581C39","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.pneurobio.2005.09.004","article-title":"Neuronal control of leech behavior","volume":"76","author":"Kristan","year":"2005","journal-title":"Prog. Neurobiol."},{"key":"2021042509065320900_JEB126581C40","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1002\/cne.10139","article-title":"Orcokinin peptides in developing and adult crustacean stomatogastric nervous systems and pericardial organs","volume":"444","author":"Li","year":"2002","journal-title":"J. Comp. Neurol."},{"key":"2021042509065320900_JEB126581C41","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1046\/j.1471-4159.2003.02031.x","article-title":"Mass spectrometric investigation of the neuropeptide complement and release in the pericardial organs of the crab, Cancer borealis","volume":"87","author":"Li","year":"2003","journal-title":"J. Neurochem."},{"key":"2021042509065320900_JEB126581C42","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1163\/156854007780162442","article-title":"Circatidal rhythm of free-roaming sub-tidal green crabs, Carcinus maenas, revealed by radio-acoustic positional telemetry","volume":"80","author":"Lynch","year":"2007","journal-title":"Crustaceana"},{"key":"2021042509065320900_JEB126581C43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neuron.2012.09.010","article-title":"Neuromodulation of neuronal circuits: back to the future","volume":"76","author":"Marder","year":"2012","journal-title":"Neuron"},{"key":"2021042509065320900_JEB126581C44","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1146\/annurev.physiol.69.031905.161516","article-title":"Understanding circuit dynamics using the stomatogastric nervous system of lobsters and crabs","volume":"69","author":"Marder","year":"2007","journal-title":"Annu. Rev. Physiol."},{"key":"2021042509065320900_JEB126581C45","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1152\/physrev.1996.76.3.687","article-title":"Principles of rhythmic motor pattern generation","volume":"76","author":"Marder","year":"1996","journal-title":"Physiol. Rev."},{"key":"2021042509065320900_JEB126581C46","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1152\/jn.1984.51.6.1345","article-title":"Transmitter identification of pyloric neurons: electrically coupled neurons use different transmitters","volume":"1","author":"Marder","year":"1984","journal-title":"J. Neurophysiol."},{"key":"2021042509065320900_JEB126581C47","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/S0893-6080(02)00043-6","article-title":"Cellular, synaptic and network effects of neuromodulation","volume":"15","author":"Marder","year":"2002","journal-title":"Neural Netw."},{"key":"2021042509065320900_JEB126581C48","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/B978-0-08-041986-2.50006-0","article-title":"Modulatory control of multiple task processing in the stomatogastric nervous system","volume-title":"Neurobiology of Motor Progamme Selection","author":"Marder","year":"1992"},{"key":"2021042509065320900_JEB126581C49","doi-asserted-by":"publisher","first-page":"R685","DOI":"10.1016\/j.cub.2005.08.022","article-title":"Invertebrate central pattern generation moves along","volume":"15","author":"Marder","year":"2005","journal-title":"Curr. Biol."},{"key":"2021042509065320900_JEB126581C50","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1146\/annurev-neuro-071013-013958","article-title":"Neuromodulation of circuits with variable parameters: single neurons and small circuits reveal principles of state-dependent and robust neuromodulation","volume":"37","author":"Marder","year":"2014","journal-title":"Annu. Rev. Neurosci."},{"key":"2021042509065320900_JEB126581C51","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1007\/s00359-014-0975-2","article-title":"How can motor systems retain performance over a wide temperature range? Lessons from the crustacean stomatogastric nervous system","volume":"201","author":"Marder","year":"2015","journal-title":"J. Comp. Physiol. A Neurothol. Sens. Neural. Behav. Physiol."},{"key":"2021042509065320900_JEB126581C52","doi-asserted-by":"crossref","first-page":"3950","DOI":"10.1523\/JNEUROSCI.16-12-03950.1996","article-title":"Modulation of a neural network by physiological levels of oxygen in lobster stomatogastric ganglion","volume":"16","author":"Massabuau","year":"1996","journal-title":"J. Neurosci."},{"key":"2021042509065320900_JEB126581C54","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1152\/japplphysiol.00523.2002","article-title":"Invited Review: Neuroplasticity in respiratory motor control","volume":"94","author":"Mitchell","year":"2003","journal-title":"J. Appl. Physiol"},{"key":"2021042509065320900_JEB126581C56","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.pneurobio.2010.11.001","article-title":"Neuronal control of swimming behavior: comparison of vertebrate and invertebrate model systems","volume":"93","author":"Mullins","year":"2011","journal-title":"Prog. Neurobiol."},{"key":"2021042509065320900_JEB126581C57","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1152\/jn.1996.75.1.97","article-title":"Pyloric motor pattern modification by a newly identified projection neuron in the crab stomatogastric nervous system","volume":"75","author":"Norris","year":"1996","journal-title":"J. Neurophysiol."},{"key":"2021042509065320900_JEB126581C58","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1163\/1568540041717975","article-title":"Diurnal activity in a group of Gulf of Maine decapods","volume":"77","author":"Novak","year":"2004","journal-title":"Crustaceana"},{"key":"2021042509065320900_JEB126581C59","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1038\/417343a","article-title":"A small-systems approach to motor pattern generation","volume":"417","author":"Nusbaum","year":"2002","journal-title":"Nature"},{"key":"2021042509065320900_JEB126581C60","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/0022-0981(91)90114-C","article-title":"Feeding ecology of benthic mobile predators: experimental analyses of their influence in rocky subtidal communities of the Gulf of Maine","volume":"149","author":"Ojeda","year":"1991","journal-title":"J. Exp. Mar. Biol. Ecol."},{"key":"2021042509065320900_JEB126581C61","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1002\/cne.10331","article-title":"Neuromodulatory complement of the pericardial organs in the embryonic lobster, Homarus americanus","volume":"451","author":"Pulver","year":"2002","journal-title":"J. Comp. Neurol."},{"key":"2021042509065320900_JEB126581C62","first-page":"454","article-title":"Rhythmicity under constant conditions in the rock crab","volume":"36","author":"Rebach","year":"1985","journal-title":"Cancer irroratus. Bull. Mar. Sci."},{"key":"2021042509065320900_JEB126581C63","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/BF00610338","article-title":"Expression of the crustacean pyloric pattern generator in the intact animal","volume":"153","author":"Rezer","year":"1983","journal-title":"J. Comp. Physiol. A"},{"key":"2021042509065320900_JEB126581C64","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/0022-0981(92)90245-6","article-title":"Habitat selection and predator avoidance: ontogenetic shifts in habitat use by the Jonah crab Cancer borealis (Stimpson)","volume":"156","author":"Richards","year":"1992","journal-title":"J. Exp. Mar. Biol. Ecol."},{"key":"2021042509065320900_JEB126581C65","doi-asserted-by":"publisher","first-page":"6664","DOI":"10.1523\/JNEUROSCI.0315-07.2007","article-title":"Convergent motor patterns from divergent circuits","volume":"27","author":"Saideman","year":"2007","journal-title":"J. Neurosci."},{"key":"2021042509065320900_JEB126581C66","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1021\/ac302403e","article-title":"Mass spectrometric detection of neuropeptides using affinity-enhanced microdialysis with antibody-coated magnetic nanoparticles","volume":"85","author":"Schmerberg","year":"2013","journal-title":"Anal. Chem."},{"key":"2021042509065320900_JEB126581C67","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/S0920-1211(98)00058-8","article-title":"Osmolarity, ionic flux, and changes in brain excitability","volume":"32","author":"Schwartzkroin","year":"1998","journal-title":"Epilepsy Res."},{"key":"2021042509065320900_JEB126581C68","doi-asserted-by":"publisher","first-page":"9351","DOI":"10.1523\/JNEUROSCI.1744-09.2009","article-title":"Coordination of rhythmic motor activity by gradients of synaptic strength in a neural circuit that couples modular neural oscillators","volume":"29","author":"Smarandache","year":"2009","journal-title":"J. Neurosci."},{"key":"2021042509065320900_JEB126581C69","doi-asserted-by":"publisher","first-page":"2603","DOI":"10.1152\/jn.00906.2013","article-title":"Phase maintenance in a rhythmic motor pattern during temperature changes in vivo","volume":"111","author":"Soofi","year":"2014","journal-title":"J. Neurophysiol."},{"key":"2021042509065320900_JEB126581C70","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1007\/s00359-009-0483-y","article-title":"Modulation of stomatogastric rhythms","volume":"195","author":"Stein","year":"2009","journal-title":"J. Comp. Physiol. A Neuroethol. Sens. Neural. Behav. Physiol."},{"key":"2021042509065320900_JEB126581C71","article-title":"Stability and flexibility: evolutionary aspects of motor pattern generation in the crustacean stomatogastric nervous system","volume-title":"Structure and Evolution of Invertebrate Nervous Systems","author":"Stein","year":"2016"},{"key":"2021042509065320900_JEB126581C72","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/nrn1668","article-title":"Neuronal variability: noise or part of the signal?","volume":"6","author":"Stein","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"2021042509065320900_JEB126581C73","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1111\/j.1460-9568.2007.05744.x","article-title":"Divergent co-transmitter actions underlie motor pattern activation by a modulatory projection neuron","volume":"26","author":"Stein","year":"2007","journal-title":"Eur. J. Neurosci."},{"key":"2021042509065320900_JEB126581C74","doi-asserted-by":"publisher","first-page":"10075","DOI":"10.1523\/JNEUROSCI.1443-12.2012","article-title":"Robustness of a rhythmic circuit to short- and long-term temperature changes","volume":"32","author":"Tang","year":"2012","journal-title":"J. Neurosci."},{"key":"2021042509065320900_JEB126581C75","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1016\/S0960-9822(00)00199-8","article-title":"Switching neurons are integral members of multiple oscillatory networks","volume":"4","author":"Weimann","year":"1994","journal-title":"Curr. Biol."},{"key":"2021042509065320900_JEB126581C76","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1152\/jn.1991.65.1.111","article-title":"Neurons that form multiple pattern generators: identification and multiple activity patterns of gastric\/pyloric neurons in the crab stomatogastric system","volume":"65","author":"Weimann","year":"1991","journal-title":"J. Neurophsiol."},{"key":"2021042509065320900_JEB126581C77","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1242\/jeb.47.2.229","article-title":"Spontaneously induced rhythm of tidal periodicity in laboratory-reared Carcinus","volume":"47","author":"Williams","year":"1967","journal-title":"J. Exp. Biol."},{"key":"2021042509065320900_JEB126581C78","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fnbeh.2010.00021","article-title":"Pacemaker neuron and network oscillations depend on a neuromodulator-regulated linear current","volume":"4","author":"Zhao","year":"2010","journal-title":"Front. Behav. Neurosci."}],"container-title":["Journal of Experimental Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.biologists.com\/jeb\/article-pdf\/218\/24\/3950\/1890234\/jeb126581.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/jeb\/article-pdf\/doi\/10.1242\/jeb.126581\/2038514\/jeb_126581v1.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/jeb\/article-pdf\/doi\/10.1242\/jeb.126581\/2038514\/jeb_126581v1.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T22:26:35Z","timestamp":1653431195000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/jeb\/article\/doi\/10.1242\/jeb.126581\/262033\/Sources-and-range-of-long-term-variability-of"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,1]]},"references-count":74,"URL":"https:\/\/doi.org\/10.1242\/jeb.126581","relation":{},"ISSN":["1477-9145","0022-0949"],"issn-type":[{"type":"electronic","value":"1477-9145"},{"type":"print","value":"0022-0949"}],"subject":[],"published":{"date-parts":[[2015,1,1]]},"article-number":"jeb.126581"}}