{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T02:00:32Z","timestamp":1775786432705,"version":"3.50.1"},"reference-count":26,"publisher":"The Company of Biologists","issue":"1","license":[{"start":{"date-parts":[[1989,5,1]],"date-time":"1989-05-01T00:00:00Z","timestamp":609984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1989,5,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Parachlorophenylalanine (p-CPA) was used for chemical pinealectomy in a study of tail regeneration in the gekkonid lizard, Hemidactylus flaviviridis. Two doses of p-CPA (200 or 400 \u03bcg kg\u22121body mass) were injected into two groups of lizards (5 days prior to and 30 days after caudal autotomy) exposed to continuous light of 2500lx intensity during the summer season (March-May). Our observations show that the initiation of regeneration, the daily growth rate, the total length of new growth (regenerate) produced, and the total percentage replacement of the lost (autotomized) tails 30 days after autotomy were all significantly less with 400 \u03bcg kg\u22121 and insignificantly less with 200 \u03bcg kg\u22121 of p-CPA than in the control group of animals. The results may indicate that the effect of the drug p-CPA, an agent employed for chemical pinealectomy, on tail regeneration in H. flaviviridis is dose-dependent and that p-CPA at the high dose of 400 \u03bcg kg\u22121 has a similar retardation effect to that of complete pineal ablation. The role of the pineal in photoperiodic photoreception, and the effect of p-CPA on serotonin melatonin biosynthesis and the consequent effects on tail regeneration, are discussed.<\/jats:p>","DOI":"10.1242\/jeb.143.1.235","type":"journal-article","created":{"date-parts":[[2021,4,25]],"date-time":"2021-04-25T03:01:59Z","timestamp":1619319719000},"page":"235-243","source":"Crossref","is-referenced-by-count":6,"title":["Parachlorophenylalanine Retards Tail Regeneration in the Gekkonid Lizard <i>Hemidactylus Flaviviridis<\/i> Exposed to Continuous Light"],"prefix":"10.1242","volume":"143","author":[{"given":"A. V.","family":"Ramachandran","sequence":"first","affiliation":[{"name":"Division of Developmental Physiology and Endocrinology, Department of Zoology, MS University of Baroda, Baroda 390 002, Gujarat State, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick I.","family":"Ndukuba","sequence":"additional","affiliation":[{"name":"Division of Developmental Physiology and Endocrinology, Department of Zoology, MS University of Baroda, Baroda 390 002, Gujarat State, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[1989,5,1]]},"reference":[{"key":"2023012313072211000_JEXBIO_143_1_235C1","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1210\/endo-96-1-10","article-title":"Effects of biogenic amines and TRH on release of prolactin and TSH in the rat","volume":"96","author":"Chen","year":"1975","journal-title":"Endrocrinology"},{"key":"2023012313072211000_JEXBIO_143_1_235C2","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1210\/endo-100-3-692","article-title":"Further evidence that serotonin is a neurotransmitter involved in the control of prolactin secretion","volume":"100","author":"Clemens","year":"1977","journal-title":"Endrocrinology"},{"key":"2023012313072211000_JEXBIO_143_1_235C3","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1111\/j.1749-6632.1962.tb50107.x","article-title":"On current status of serotonin as a brain neurohormone and in action of reserpine-like drugs","volume":"96","author":"Costa","year":"1962","journal-title":"Ann. 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