{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T16:51:12Z","timestamp":1791132672204,"version":"4.1.0"},"reference-count":105,"publisher":"The Company of Biologists","issue":"2","license":[{"start":{"date-parts":[[2019,7,15]],"date-time":"2019-07-15T00:00:00Z","timestamp":1563148800000},"content-version":"vor","delay-in-days":181,"URL":"http:\/\/www.biologists.com\/user-licence-1-1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,1,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Mammals maintain a constant warm body temperature, facilitating a wide variety of metabolic reactions. Mammals that hibernate have the ability to slow their metabolism, which in turn reduces their body temperature and leads to a state of hypothermic torpor. For this metabolic rate reduction to occur on a whole-body scale, molecular interactions that change the physiology of cells, tissues and organs are required, resulting in a major departure from normal mammalian homeostasis. The aim of this Review is to cover recent advances in the molecular biology of mammalian hibernation, including the role of small molecules, seasonal changes in gene expression, cold-inducible RNA-binding proteins, the somatosensory system and emerging information on hibernating primates. To underscore the importance of differential gene expression across the hibernation cycle, mRNA levels for 14,261 ground squirrel genes during periods of activity and torpor are made available for several tissues via an interactive transcriptome browser. This Review also addresses recent findings on molecular interactions responsible for multi-day survival of near-freezing body temperatures, single-digit heart rates and a slowed metabolism that greatly reduces oxygen consumption. A better understanding of how natural hibernators survive these physiological extremes is beginning to lead to innovations in human medicine.<\/jats:p>","DOI":"10.1242\/jeb.160606","type":"journal-article","created":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T14:49:19Z","timestamp":1548427759000},"source":"Crossref","is-referenced-by-count":107,"title":["Molecular interactions underpinning the phenotype of hibernation in mammals"],"prefix":"10.1242","volume":"222","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6444-3383","authenticated-orcid":false,"given":"Matthew T.","family":"Andrews","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR 97331, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2019,1,25]]},"reference":[{"key":"2021042500401609900_JEB160606C1","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1021\/acs.jproteome.5b01138","article-title":"Proteogenomic analysis of a hibernating mammal indicates contribution of skeletal muscle physiology to the hibernation phenotype","volume":"15","author":"Anderson","year":"2016","journal-title":"J. Proteome Res."},{"key":"2021042500401609900_JEB160606C2","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1002\/bies.20560","article-title":"Advances in molecular biology of hibernation in mammals","volume":"29","author":"Andrews","year":"2007","journal-title":"BioEssays"},{"key":"2021042500401609900_JEB160606C3","doi-asserted-by":"publisher","first-page":"8392","DOI":"10.1073\/pnas.95.14.8392","article-title":"Low-temperature carbon utilization is regulated by novel gene activity in the heart of a hibernating mammal","volume":"95","author":"Andrews","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042500401609900_JEB160606C4","doi-asserted-by":"publisher","first-page":"R383","DOI":"10.1152\/ajpregu.90795.2008","article-title":"Adaptive mechanisms regulate preferred utilization of ketones in the heart and brain of a hibernating mammal during arousal from torpor","volume":"296","author":"Andrews","year":"2009","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"2021042500401609900_JEB160606C5","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1038\/nrm.2015.27","article-title":"Pluripotent stem cells in disease modelling and drug discovery","volume":"17","author":"Avior","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2021042500401609900_JEB160606C6","doi-asserted-by":"publisher","first-page":"162586","DOI":"10.1242\/jeb.162586","article-title":"Nature's fat-burning machine: brown adipose tissue in a hibernating mammal","volume":"221","author":"Ballinger","year":"2018","journal-title":"J. Exp. Biol."},{"key":"2021042500401609900_JEB160606C7","doi-asserted-by":"publisher","first-page":"R325","DOI":"10.1152\/ajpregu.00463.2015","article-title":"Seasonal changes in brown adipose tissue mitochondria in a mammalian hibernator: from gene expression to function","volume":"311","author":"Ballinger","year":"2016","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"2021042500401609900_JEB160606C8","doi-asserted-by":"publisher","first-page":"R301","DOI":"10.1152\/ajpregu.00314.2016","article-title":"Enhanced oxidative capacity of ground squirrel brain mitochondria during hibernation","volume":"312","author":"Ballinger","year":"2017","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"2021042500401609900_JEB160606C9","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1126\/science.2740905","article-title":"Freeze avoidance in a mammal: body temperatures below 0 degree C in an Arctic hibernator","volume":"244","author":"Barnes","year":"1989","journal-title":"Science"},{"key":"2021042500401609900_JEB160606C10","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1126\/science.1108581","article-title":"H2S induces a suspended animation-like state in mice","volume":"308","author":"Blackstone","year":"2005","journal-title":"Science"},{"key":"2021042500401609900_JEB160606C11","doi-asserted-by":"publisher","first-page":"1768","DOI":"10.1038\/srep01768","article-title":"Underground hibernation in a primate","volume":"3","author":"Blanco","year":"2013","journal-title":"Sci. Rep."},{"key":"2021042500401609900_JEB160606C12","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1002\/evan.21588","article-title":"Tropical heterothermy is \u201ccool\u201d: the expression of daily torpor and hibernation in primates","volume":"27","author":"Blanco","year":"2018","journal-title":"Evol. Anthropol."},{"key":"2021042500401609900_JEB160606C13","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1002\/jcp.22850","article-title":"Induction of torpor: mimicking natural metabolic suppression for biomedical applications","volume":"227","author":"Bouma","year":"2012","journal-title":"J. Cell. Physiol."},{"key":"2021042500401609900_JEB160606C14","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1152\/physiolgenomics.00076.2001","article-title":"Coordinate expression of the PDK4 gene: a means of regulating fuel selection in a hibernating mammal","volume":"8","author":"Buck","year":"2002","journal-title":"Physiol. Genomics"},{"key":"2021042500401609900_JEB160606C15","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1152\/physiolgenomics.00120.2015","article-title":"Effects of hibernation on bone marrow transcriptome in thirteen-lined ground squirrels","volume":"48","author":"Cooper","year":"2016","journal-title":"Physiol. Genomics"},{"key":"2021042500401609900_JEB160606C16","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1021\/acs.jproteome.6b00884","article-title":"Comfortably numb and back: plasma metabolomics reveals biochemical adaptations in the hibernating 13-lined ground squirrel","volume":"16","author":"D'Alessandro","year":"2017","journal-title":"J. Proteome Res."},{"key":"2021042500401609900_JEB160606C17","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1038\/429825a","article-title":"Physiology: hibernation in a tropical primate","volume":"429","author":"Dausmann","year":"2004","journal-title":"Nature"},{"key":"2021042500401609900_JEB160606C18","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1007\/s00360-004-0470-0","article-title":"Hibernation in the tropics: lessons from a primate","volume":"175","author":"Dausmann","year":"2005","journal-title":"J. Comp. Physiol. B"},{"key":"2021042500401609900_JEB160606C19","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.1073\/pnas.0409764102","article-title":"Cold stress-induced protein Rbm3 binds 60S ribosomal subunits, alters microRNA levels, and enhances global protein synthesis","volume":"102","author":"Dresios","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042500401609900_JEB160606C20","doi-asserted-by":"publisher","first-page":"e0136113","DOI":"10.1371\/journal.pone.0136113","article-title":"Induction of a torpor-like state by 5\u2032-AMP does not depend on H2S production","volume":"10","author":"Dugbartey","year":"2015","journal-title":"PLoS ONE"},{"key":"2021042500401609900_JEB160606C21","doi-asserted-by":"publisher","first-page":"R1263","DOI":"10.1152\/ajpregu.90455.2008","article-title":"Identification of cold-shock protein RBM3 as a possible regulator of skeletal muscle size through expression profiling","volume":"295","author":"Dupont-Versteegden","year":"2008","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"2021042500401609900_JEB160606C22","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1152\/physiolgenomics.00028.2011","article-title":"Metabolic cycles in a circannual hibernator","volume":"43","author":"Epperson","year":"2011","journal-title":"Physiol. Genomics"},{"key":"2021042500401609900_JEB160606C23","doi-asserted-by":"publisher","first-page":"2413","DOI":"10.1093\/gbe\/evw163","article-title":"Gene expression profiling in the hibernating primate, Cheirogaleus medius","volume":"8","author":"Faherty","year":"2016","journal-title":"Genome Biol. Evol."},{"key":"2021042500401609900_JEB160606C24","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1007\/s00360-016-1045-6","article-title":"The effect of body mass and diet composition on torpor patterns in a Malagasy primate (Microcebus murinus)","volume":"187","author":"Faherty","year":"2017","journal-title":"J. Comp. Physiol. B"},{"key":"2021042500401609900_JEB160606C25","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1111\/mec.14483","article-title":"Transcriptomics in the wild: hibernation physiology in free-ranging dwarf lemurs","volume":"27","author":"Faherty","year":"2018","journal-title":"Mol. Ecol."},{"key":"2021042500401609900_JEB160606C26","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1186\/1471-2164-12-171","article-title":"Modulation of gene expression in heart and liver of hibernating black bears (Ursus americanus)","volume":"12","author":"Fedorov","year":"2011","journal-title":"BMC Genomics"},{"key":"2021042500401609900_JEB160606C27","first-page":"R1062","article-title":"Plasma melatonin concentrations in hibernating marmots: absence of a plasma melatonin rhythm","volume":"247","author":"Florant","year":"1984","journal-title":"Am. J. Physiol."},{"key":"2021042500401609900_JEB160606C28","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/978-3-7091-6391-7_9","article-title":"Neuroprotective strategies in nature\u2013novel clues for the treatment of stroke and trauma","volume":"73","author":"Frerichs","year":"1999","journal-title":"Acta Neurochir. Suppl."},{"key":"2021042500401609900_JEB160606C29","doi-asserted-by":"publisher","first-page":"2295","DOI":"10.1038\/s41598-017-02473-x","article-title":"TRPV4-dependent induction of a novel mammalian cold-inducible protein SRSF5 as well as CIRP and RBM3","volume":"7","author":"Fujita","year":"2017","journal-title":"Sci. Rep."},{"key":"2021042500401609900_JEB160606C30","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1016\/j.bbrc.2017.11.136","article-title":"Involvement of TRPV3 and TRPM8 ion channel proteins in induction of mammalian cold-inducible proteins","volume":"495","author":"Fujita","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2021042500401609900_JEB160606C31","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1159\/000095391","article-title":"Lemuriform origins as viewed from the fossil record","volume":"77","author":"Godinot","year":"2006","journal-title":"Folia Primatol."},{"key":"2021042500401609900_JEB160606C32","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1152\/physiolgenomics.00125.2011","article-title":"Multistate proteomics analysis reveals novel strategies used by a hibernator to precondition the heart and conserve ATP for winter heterothermy","volume":"43","author":"Grabek","year":"2011","journal-title":"Physiol. Genomics"},{"key":"2021042500401609900_JEB160606C33","doi-asserted-by":"publisher","DOI":"10.1101\/222307","article-title":"Genetic architecture drives seasonal onset of hibernation in the 13-lined ground squirrel","author":"Grabek","year":"2017","journal-title":"bioRxiv"},{"key":"2021042500401609900_JEB160606C34","doi-asserted-by":"publisher","first-page":"e27021","DOI":"10.1371\/journal.pone.0027021","article-title":"Deep sequencing the transcriptome reveals seasonal adaptive mechanisms in a hibernating mammal","volume":"6","author":"Hampton","year":"2011","journal-title":"PLoS ONE"},{"key":"2021042500401609900_JEB160606C35","doi-asserted-by":"publisher","first-page":"e85157","DOI":"10.1371\/journal.pone.0085157","article-title":"Transcriptomic analysis of brown adipose tissue across the physiological extremes of natural hibernation","volume":"8","author":"Hampton","year":"2013","journal-title":"PLoS ONE"},{"key":"2021042500401609900_JEB160606C36","doi-asserted-by":"publisher","first-page":"R368","DOI":"10.1152\/ajpregu.00365.2014","article-title":"Myocardial performance and adaptive energy pathways in a torpid mammalian hibernator","volume":"309","author":"Heinis","year":"2015","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"2021042500401609900_JEB160606C37","doi-asserted-by":"publisher","first-page":"3855","DOI":"10.1038\/s41598-018-21729-8","article-title":"Exogenous hydrogen sulfide gas does not induce hypothermia in normoxic mice","volume":"8","author":"Hemelrijk","year":"2018","journal-title":"Sci. Rep."},{"key":"2021042500401609900_JEB160606C38","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1111\/j.1471-4159.2007.04514.x","article-title":"Brain energy metabolism and neurotransmission at near-freezing temperatures: in vivo 1H MRS study of a hibernating mammal","volume":"101","author":"Henry","year":"2007","journal-title":"J. Neurochem."},{"key":"2021042500401609900_JEB160606C39","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.15252\/embr.201540749","article-title":"The H1 linker histones: multifunctional proteins beyond the nucleosomal core particle","volume":"16","author":"Hergeth","year":"2015","journal-title":"EMBO Rep."},{"key":"2021042500401609900_JEB160606C40","doi-asserted-by":"publisher","first-page":"e71627","DOI":"10.1371\/journal.pone.0071627","article-title":"Cytoskeletal regulation dominates temperature-sensitive proteomic changes of hibernation in forebrain of 13-lined ground squirrels","volume":"8","author":"Hindle","year":"2013","journal-title":"PLoS ONE"},{"key":"2021042500401609900_JEB160606C41","doi-asserted-by":"publisher","first-page":"E284","DOI":"10.1152\/ajpendo.00431.2013","article-title":"Intrinsic circannual regulation of brown adipose tissue form and function in tune with hibernation","volume":"306","author":"Hindle","year":"2014","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"2021042500401609900_JEB160606C42","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1152\/physiolgenomics.00190.2013","article-title":"Metabolic changes associated with the long winter fast dominate the liver proteome in 13-lined ground squirrels","volume":"46","author":"Hindle","year":"2014","journal-title":"Physiol. Genomics"},{"key":"2021042500401609900_JEB160606C43","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1007\/s00424-018-2120-5","article-title":"TRPs et al.: a molecular toolkit for thermosensory adaptations","volume":"470","author":"Hoffstaetter","year":"2018","journal-title":"Pflugers Arch."},{"key":"2021042500401609900_JEB160606C44","doi-asserted-by":"publisher","first-page":"2998","DOI":"10.1016\/j.cub.2018.07.020","article-title":"Somatosensory neurons enter a state of altered excitability during hibernation","volume":"28","author":"Hoffstaetter","year":"2018","journal-title":"Curr. Biol."},{"key":"2021042500401609900_JEB160606C45","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1152\/physiolgenomics.00010.2012","article-title":"Kidney proteome changes provide evidence for a dynamic metabolism and regional redistribution of plasma proteins during torpor-arousal cycles of hibernation","volume":"44","author":"Jani","year":"2012","journal-title":"Physiol. Genomics"},{"key":"2021042500401609900_JEB160606C46","doi-asserted-by":"publisher","first-page":"188","DOI":"10.4093\/dmj.2015.39.3.188","article-title":"Pyruvate dehydrogenase kinases: therapeutic targets for diabetes and cancers","volume":"39","author":"Jeoung","year":"2015","journal-title":"Diabetes Metab. J."},{"key":"2021042500401609900_JEB160606C47","doi-asserted-by":"publisher","first-page":"10752","DOI":"10.1523\/JNEUROSCI.1240-11.2011","article-title":"Season primes the brain in an arctic hibernator to facilitate entrance into torpor mediated by adenosine A(1) receptors","volume":"31","author":"Jinka","year":"2011","journal-title":"J. Neurosci."},{"key":"2021042500401609900_JEB160606C48","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1097\/SHK.0b013e3181e15063","article-title":"Small-volume d-beta-hydroxybutyrate solution infusion increases survivability of lethal hemorrhagic shock in rats","volume":"34","author":"Klein","year":"2010","journal-title":"Shock"},{"key":"2021042500401609900_JEB160606C49","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1007\/s00114-009-0580-3","article-title":"Hibernation in Malagasy mouse lemurs as a strategy to counter environmental challenge","volume":"96","author":"Kobbe","year":"2009","journal-title":"Naturwissenschaften"},{"key":"2021042500401609900_JEB160606C50","first-page":"R462","article-title":"Ketone body metabolism in a ground squirrel during hibernation and fasting","volume":"249","author":"Krilowicz","year":"1985","journal-title":"Am. J. Physiol."},{"key":"2021042500401609900_JEB160606C51","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/0300-9629(88)91109-7","article-title":"The intestinal epithelial cells of ground squirrel (Citellus undulatus) accumulate at G2 phase of the cell cycle throughout a bout of hibernation","volume":"90","author":"Kruman","year":"1988","journal-title":"Comp. Biochem. Physiol. A Comp. Physiol."},{"key":"2021042500401609900_JEB160606C52","doi-asserted-by":"publisher","first-page":"e0123509","DOI":"10.1371\/journal.pone.0123509","article-title":"Opposing activity changes in AMP deaminase and AMP-activated protein kinase in the hibernating ground squirrel","volume":"10","author":"Lanaspa","year":"2015","journal-title":"PLoS ONE"},{"key":"2021042500401609900_JEB160606C53","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1086\/375436","article-title":"Melatonin production accompanies arousal from daily torpor in Siberian hamsters","volume":"76","author":"Larkin","year":"2003","journal-title":"Physiol. Biochem. Zool."},{"key":"2021042500401609900_JEB160606C54","doi-asserted-by":"publisher","first-page":"11342","DOI":"10.1073\/pnas.1604269113","article-title":"Low-cost functional plasticity of TRPV1 supports heat tolerance in squirrels and camels","volume":"113","author":"Laursen","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042500401609900_JEB160606C55","doi-asserted-by":"publisher","first-page":"18775","DOI":"10.1073\/pnas.0608785103","article-title":"Rapid and reversible changes in intrahippocampal connectivity during the course of hibernation in European hamsters","volume":"103","author":"Magarinos","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042500401609900_JEB160606C56","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1111\/jpi.12267","article-title":"Melatonin: an ancient molecule that makes oxygen metabolically tolerable","volume":"59","author":"Manchester","year":"2015","journal-title":"J. Pineal Res."},{"key":"2021042500401609900_JEB160606C57","doi-asserted-by":"publisher","first-page":"3329","DOI":"10.1016\/j.celrep.2017.11.083","article-title":"Molecular prerequisites for diminished cold sensitivity in ground squirrels and hamsters","volume":"21","author":"Matos-Cruz","year":"2017","journal-title":"Cell Rep."},{"key":"2021042500401609900_JEB160606C58","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/j.tem.2009.09.005","article-title":"Torpor induction in mammals: recent discoveries fueling new ideas","volume":"20","author":"Melvin","year":"2009","journal-title":"Trends Endocrinol. Metab."},{"key":"2021042500401609900_JEB160606C59","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.resuscitation.2011.08.003","article-title":"Treatment with beta-hydroxybutyrate and melatonin is associated with improved survival in a porcine model of hemorrhagic shock","volume":"83","author":"Mulier","year":"2012","journal-title":"Resuscitation"},{"key":"2021042500401609900_JEB160606C60","doi-asserted-by":"publisher","first-page":"2193","DOI":"10.1016\/j.celrep.2017.05.053","article-title":"Linker histone H1.2 directs genome-wide chromatin association of the retinoblastoma tumor suppressor protein and facilitates its function","volume":"19","author":"Munro","year":"2017","journal-title":"Cell Rep."},{"key":"2021042500401609900_JEB160606C61","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.cbd.2010.07.002","article-title":"Global analysis of circulating metabolites in hibernating ground squirrels","volume":"5","author":"Nelson","year":"2010","journal-title":"Comp. Biochem. Physiol. Part D Genomics Proteomics"},{"key":"2021042500401609900_JEB160606C62","doi-asserted-by":"publisher","first-page":"e53574","DOI":"10.1371\/journal.pone.0053574","article-title":"Metabolic hormone FGF21 is induced in ground squirrels during hibernation but its overexpression is not sufficient to cause torpor","volume":"8","author":"Nelson","year":"2013","journal-title":"PLoS ONE"},{"key":"2021042500401609900_JEB160606C63","doi-asserted-by":"publisher","first-page":"e10797","DOI":"10.1371\/journal.pone.0010797","article-title":"Torpor on demand: heterothermy in the non-lemur primate Galago moholi","volume":"5","author":"Nowack","year":"2010","journal-title":"PLoS ONE"},{"key":"2021042500401609900_JEB160606C64","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1177\/0748730413490667","article-title":"Circannual rhythm in body temperature, torpor, and sensitivity to A(1) adenosine receptor agonist in arctic ground squirrels","volume":"28","author":"Olson","year":"2013","journal-title":"J. Biol. Rhythms"},{"key":"2021042500401609900_JEB160606C65","doi-asserted-by":"publisher","first-page":"1888","DOI":"10.1111\/j.1471-4159.2008.05543.x","article-title":"Mammalian cerebral metabolism and amino acid neurotransmission during hibernation","volume":"106","author":"Osborne","year":"2008","journal-title":"J. Neurochem."},{"key":"2021042500401609900_JEB160606C66","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1016\/j.cell.2018.03.010","article-title":"iPSCs from a hibernator provide a platform for studying cold adaptation and its potential medical applications","volume":"173","author":"Ou","year":"2018","journal-title":"Cell"},{"key":"2021042500401609900_JEB160606C67","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1038\/nature14142","article-title":"RBM3 mediates structural plasticity and protective effects of cooling in neurodegeneration","volume":"518","author":"Peretti","year":"2015","journal-title":"Nature"},{"key":"2021042500401609900_JEB160606C68","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1007\/s00360-017-1076-7","article-title":"Hibernation-based blood loss therapy increases survivability of lethal hemorrhagic shock in rats","volume":"187","author":"Perez de Lara Rodriguez","year":"2017","journal-title":"J. Comp. Physiol. B"},{"key":"2021042500401609900_JEB160606C69","doi-asserted-by":"publisher","first-page":"867525","DOI":"10.1155\/2011\/867525","article-title":"Suspension of mitotic activity in dentate gyrus of the hibernating ground squirrel","volume":"2011","author":"Popov","year":"2011","journal-title":"Neural Plast."},{"key":"2021042500401609900_JEB160606C70","doi-asserted-by":"publisher","first-page":"R1054","DOI":"10.1152\/ajpregu.00562.2001","article-title":"Periodic arousal from hibernation is necessary for initiation of immune responses in ground squirrels","volume":"282","author":"Prendergast","year":"2002","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"2021042500401609900_JEB160606C71","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1139\/z81-108","article-title":"Ketone bodies: a source of energy during hibernation","volume":"59","author":"Rauch","year":"1981","journal-title":"Can. J. Zool."},{"key":"2021042500401609900_JEB160606C72","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1152\/physiol.00011.2014","article-title":"Melatonin: exceeding expectations","volume":"29","author":"Reiter","year":"2014","journal-title":"Physiology"},{"key":"2021042500401609900_JEB160606C73","doi-asserted-by":"publisher","first-page":"3863","DOI":"10.1007\/s00018-017-2609-7","article-title":"Melatonin as a mitochondria-targeted antioxidant: one of evolution's best ideas","volume":"74","author":"Reiter","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"key":"2021042500401609900_JEB160606C74","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1261\/rna.066522.118","article-title":"Dynamic temperature-sensitive A-to-I RNA editing in the brain of a heterothermic mammal during hibernation","volume":"24","author":"Riemondy","year":"2018","journal-title":"RNA"},{"key":"2021042500401609900_JEB160606C75","doi-asserted-by":"publisher","first-page":"3198","DOI":"10.1093\/nar\/gkx1317","article-title":"Cold-inducible RNA-binding protein (CIRP) induces translation of the cell-cycle inhibitor p27Kip1","volume":"46","author":"Roilo","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"2021042500401609900_JEB160606C76","doi-asserted-by":"publisher","first-page":"17392","DOI":"10.1038\/srep17392","article-title":"Hibernation in the pygmy slow loris (Nycticebus pygmaeus): multiday torpor in primates is not restricted to Madagascar","volume":"5","author":"Ruf","year":"2015","journal-title":"Sci. Rep."},{"key":"2021042500401609900_JEB160606C77","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1007\/s00360-010-0484-8","article-title":"Extensive use of torpor in 13-lined ground squirrels in the fall prior to cold exposure","volume":"180","author":"Russell","year":"2010","journal-title":"J. Comp. Physiol. B"},{"key":"2021042500401609900_JEB160606C78","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1021\/pr050306a","article-title":"Identification of proteins from non-model organisms using mass spectrometry: application to a hibernating mammal","volume":"5","author":"Russeth","year":"2006","journal-title":"J. Proteome Res."},{"key":"2021042500401609900_JEB160606C79","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/B978-0-12-396968-2.00009-9","article-title":"Circannual transitions in gene expression: lessons from seasonal adaptations","volume":"105","author":"Schwartz","year":"2013","journal-title":"Curr. Top. Dev. Biol."},{"key":"2021042500401609900_JEB160606C80","doi-asserted-by":"publisher","first-page":"e58427","DOI":"10.1371\/journal.pone.0058427","article-title":"Seasonal and regional differences in gene expression in the brain of a hibernating mammal","volume":"8","author":"Schwartz","year":"2013","journal-title":"PLoS ONE"},{"key":"2021042500401609900_JEB160606C81","doi-asserted-by":"publisher","first-page":"R1292","DOI":"10.1152\/ajpregu.00292.2015","article-title":"Melatonin receptor signaling contributes to neuroprotection upon arousal from torpor in thirteen-lined ground squirrels","volume":"309","author":"Schwartz","year":"2015","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"2021042500401609900_JEB160606C82","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1111\/gbb.12199","article-title":"Hypothalamic gene expression underlying pre-hibernation satiety","volume":"14","author":"Schwartz","year":"2015","journal-title":"Genes Brain Behav."},{"key":"2021042500401609900_JEB160606C83","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1152\/physiolgenomics.00168.2002","article-title":"Pancreatic triacylglycerol lipase in a hibernating mammal. II. Cold-adapted function and differential expression","volume":"16","author":"Squire","year":"2003","journal-title":"Physiol. Genomics"},{"key":"2021042500401609900_JEB160606C84","doi-asserted-by":"publisher","DOI":"10.1093\/dnares\/dsy036","article-title":"Genome assembly and gene expression in the American black bear provides new insights into the renal response to hibernation","author":"Srivastava","year":"2018","journal-title":"DNA Res."},{"key":"2021042500401609900_JEB160606C85","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1002\/jez.1402390212","article-title":"Pineal melatonin: circadian rhythm and variations during the hibernation cycle in the ground squirrel, Spermophilus lateralis","volume":"239","author":"Stanton","year":"1986","journal-title":"J. Exp. Zool."},{"key":"2021042500401609900_JEB160606C86","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1385\/ENDO:27:2:149","article-title":"Physiological ischemia\/reperfusion phenomena and their relation to endogenous melatonin production: a hypothesis","volume":"27","author":"Tan","year":"2005","journal-title":"Endocrine"},{"key":"2021042500401609900_JEB160606C106","doi-asserted-by":"publisher","first-page":"598","DOI":"10.3390\/genes9120598","article-title":"The genome of the North American brown bear or grizzly: Ursus arctos ssp. horribilis","volume":"9","author":"Taylor","year":"2018","journal-title":"Genes"},{"key":"2021042500401609900_JEB160606C87","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.cryobiol.2017.02.008","article-title":"The role of global histone post-translational modifications during mammalian hibernation","volume":"75","author":"Tessier","year":"2017","journal-title":"Cryobiology"},{"key":"2021042500401609900_JEB160606C88","doi-asserted-by":"publisher","first-page":"jeb185900","DOI":"10.1242\/jeb.185900","article-title":"Extreme physiological plasticity in a hibernating basoendothermic mammal, Tenrec ecaudatus","volume":"221","author":"Treat","year":"2018","journal-title":"J. Exp. Biol."},{"key":"2021042500401609900_JEB160606C89","doi-asserted-by":"publisher","first-page":"R1374","DOI":"10.1152\/ajpregu.2001.281.5.R1374","article-title":"Translational initiation is uncoupled from elongation at 18 degrees C during mammalian hibernation","volume":"281","author":"van Breukelen","year":"2001","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"2021042500401609900_JEB160606C90","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1007\/s00360-002-0256-1","article-title":"Reversible depression of transcription during hibernation","volume":"172","author":"van Breukelen","year":"2002","journal-title":"J. Comp. Physiol. B"},{"key":"2021042500401609900_JEB160606C91","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1152\/physiolgenomics.00108.2014","article-title":"Gene expression changes controlling distinct adaptations in the heart and skeletal muscle of a hibernating mammal","volume":"47","author":"Vermillion","year":"2015","journal-title":"Physiol. Genomics"},{"key":"2021042500401609900_JEB160606C92","doi-asserted-by":"publisher","first-page":"4792","DOI":"10.1021\/acs.jproteome.5b00575","article-title":"Characterizing cardiac molecular mechanisms of mammalian hibernation via quantitative proteogenomics","volume":"14","author":"Vermillion","year":"2015","journal-title":"J. Proteome Res."},{"key":"2021042500401609900_JEB160606C93","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1093\/icb\/icu048","article-title":"Comparative genomics of mammalian hibernators using gene networks","volume":"54","author":"Villanueva-Canas","year":"2014","journal-title":"Integr. Comp. Biol."},{"key":"2021042500401609900_JEB160606C94","doi-asserted-by":"publisher","first-page":"10590","DOI":"10.1523\/JNEUROSCI.2874-06.2006","article-title":"Ubiquitous and temperature-dependent neural plasticity in hibernators","volume":"26","author":"von der Ohe","year":"2006","journal-title":"J. Neurosci."},{"key":"2021042500401609900_JEB160606C95","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1523\/JNEUROSCI.4385-06.2007","article-title":"Synaptic protein dynamics in hibernation","volume":"27","author":"von der Ohe","year":"2007","journal-title":"J. Neurosci."},{"key":"2021042500401609900_JEB160606C96","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1038\/nrn3784","article-title":"Peripheral thermosensation in mammals","volume":"15","author":"Vriens","year":"2014","journal-title":"Nat. Rev. Neurosci."},{"key":"2021042500401609900_JEB160606C97","first-page":"R213","article-title":"Sleep and hibernation in ground squirrels (Citellus spp.): electrophysiological observations","volume":"233","author":"Walker","year":"1977","journal-title":"Am. J. Physiol."},{"key":"2021042500401609900_JEB160606C98","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.cbpb.2018.06.001","article-title":"Torpor-arousal cycles in Syrian hamster heart are associated with transient activation of the protein quality control system","volume":"223","author":"Wiersma","year":"2018","journal-title":"Comp. Biochem. Physiol. B Biochem. Mol. Biol."},{"key":"2021042500401609900_JEB160606C99","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1152\/physiolgenomics.00301.2004","article-title":"Seasonally hibernating phenotype assessed through transcript screening","volume":"24","author":"Williams","year":"2005","journal-title":"Physiol. Genomics"},{"key":"2021042500401609900_JEB160606C100","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1097\/SHK.0000000000001094","article-title":"Hibernation-based approaches in the treatment of hemorrhagic shock","volume":"50","author":"Wolf","year":"2017","journal-title":"Shock"},{"key":"2021042500401609900_JEB160606C101","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1186\/s13104-017-2975-0","article-title":"D-beta-Hydroxybutyrate and melatonin for treatment of porcine hemorrhagic shock and injury: a melatonin dose-ranging study","volume":"10","author":"Wolf","year":"2017","journal-title":"BMC Res. Notes"},{"key":"2021042500401609900_JEB160606C102","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.ijpharm.2018.06.046","article-title":"Evaluation of novel formulations of d-beta-hydroxybutyrate and melatonin in a rat model of hemorrhagic shock","volume":"548","author":"Wolf","year":"2018","journal-title":"Int. J. Pharm."},{"key":"2021042500401609900_JEB160606C103","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/1743-7075-11-10","article-title":"The pivotal role of pyruvate dehydrogenase kinases in metabolic flexibility","volume":"11","author":"Zhang","year":"2014","journal-title":"Nutr. Metab. (Lond)"},{"key":"2021042500401609900_JEB160606C104","doi-asserted-by":"publisher","first-page":"4229","DOI":"10.1096\/fj.201701516R","article-title":"Antioxidant defense and protection against cardiac arrhythmias: lessons from a mammalian hibernator (the woodchuck)","volume":"32","author":"Zhao","year":"2018","journal-title":"FASEB J."}],"container-title":["Journal of Experimental Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.biologists.com\/jeb\/article-pdf\/doi\/10.1242\/jeb.160606\/1919899\/jeb160606.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/jeb\/article-pdf\/doi\/10.1242\/jeb.160606\/1919899\/jeb160606.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,25]],"date-time":"2021-04-25T00:40:33Z","timestamp":1619311233000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/jeb\/article\/222\/2\/jeb160606\/2889\/Molecular-interactions-underpinning-the-phenotype"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,15]]},"references-count":105,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,1,15]]}},"URL":"https:\/\/doi.org\/10.1242\/jeb.160606","relation":{},"ISSN":["1477-9145","0022-0949"],"issn-type":[{"value":"1477-9145","type":"electronic"},{"value":"0022-0949","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1,15]]},"article-number":"jeb160606"}}