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Trichoplax displays a repertoire of different feeding behaviors despite the apparent absence of a true nervous system with electrical or chemical synapses. It glides along surfaces to find food, propelled by beating cilia on cells at its ventral surface, and pauses during feeding by arresting ciliary beating. We found that when endomorphin-like peptides are applied to an animal, ciliary beating is arrested, mimicking natural feeding pauses. Antibodies against these neuropeptides label cells that express the neurosecretory proteins and voltage-gated calcium channels implicated in regulated secretion. These cells are embedded in the ventral epithelium, where they comprise only 4% of the total, and are concentrated around the edge of the animal. Each bears a cilium likely to be chemosensory and used to detect algae. Trichoplax pausing during feeding or spontaneously in the absence of food often induce their neighbors to pause as well, even neighbors not in direct contact. Pausing behavior propagates from animal to animal across distances much greater than the signal that diffuses from just one animal, so we presume that the peptides secreted from one animal elicit secretion from nearby animals. Signal amplification by peptide-induced peptide secretion explains how a small number of sensory secretory cells lacking processes and synapses can evoke a wave of peptide secretion across the entire animal to globally arrest ciliary beating and allow pausing during feeding.<\/jats:p>","DOI":"10.1242\/jeb.162396","type":"journal-article","created":{"date-parts":[[2017,9,20]],"date-time":"2017-09-20T21:25:19Z","timestamp":1505942719000},"page":"3381-3390","source":"Crossref","is-referenced-by-count":124,"title":["Neuropeptidergic integration of behavior in <i>Trichoplax adhaerens<\/i>, an animal without synapses"],"prefix":"10.1242","volume":"220","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5180-1180","authenticated-orcid":false,"given":"Adriano","family":"Senatore","sequence":"first","affiliation":[{"name":"University of Toronto Mississauga, Mississauga, ON, Canada L5L 1C6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1081-1670","authenticated-orcid":false,"given":"Thomas S.","family":"Reese","sequence":"additional","affiliation":[{"name":"NINDS, NIH, Bethesda, MD 20892, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6603-0753","authenticated-orcid":false,"given":"Carolyn L.","family":"Smith","sequence":"additional","affiliation":[{"name":"NINDS, NIH, Bethesda, MD 20892, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042512552894800_JEB162396C1","doi-asserted-by":"publisher","first-page":"E6048","DOI":"10.1073\/pnas.1513771112","article-title":"Glycine activated ion channel subunits encoded by ctenophore glutamate receptor genes","volume":"112","author":"Alberstein","year":"2015","journal-title":"Proc. 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