{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T18:40:06Z","timestamp":1785177606338,"version":"3.55.0"},"reference-count":23,"publisher":"The Company of Biologists","issue":"1","license":[{"start":{"date-parts":[[1992,4,1]],"date-time":"1992-04-01T00:00:00Z","timestamp":702086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1992,4,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Salivary gland homogenates and oil-induced saliva of the mosquito Aedes aegypti dilate the rabbit aortic ring and contract the guinea pig ileum. The vasodilatory activity is endothelium-dependent, heat-stable, sensitive to both trypsin and chymotrypsin treatments, and both smooth muscle activities cross-desensitize to the tachykinin peptide substance P. Both bioactivities co-elute when salivary gland homogenates are fractionated by reversed-phase HPLC. Molecular sieving chromatography indicates a relative molecular mass of 1400. A monoclonal antibody specific to the carboxy terminal region of tachykinins reacts with material in the posterior part of the central lobe of paraformaldehyde-fixed salivary glands. The presence of a vasodilatory peptide of the tachykinin family in the salivary glands of A. aegypti is proposed and its role in blood feeding is discussed.<\/jats:p>","DOI":"10.1242\/jeb.165.1.61","type":"journal-article","created":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T23:23:02Z","timestamp":1619220182000},"page":"61-71","source":"Crossref","is-referenced-by-count":80,"title":["Characterization of a Vasodilator from the Salivary Glands of the Yellow Fever Mosquito <i>Aedes Aegypti<\/i>"],"prefix":"10.1242","volume":"165","author":[{"given":"Jos\u00e9 M. C.","family":"Ribeiro","sequence":"first","affiliation":[{"name":"University of Arizona Department of Entomology, Center for Insect Science , , Forbes Building, Room 410, Tucson, AZ 85721, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[1992,4,1]]},"reference":[{"key":"2023020210581063100_JEXBIO_165_1_61C1","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1038\/icb.1976.48","article-title":"Prostaglandin in the saliva of the cattle tick Boophilus microplus","volume":"54","author":"Dickinson","year":"1976","journal-title":"Aust. J. exp. Biol. med. Sci"},{"key":"2023020210581063100_JEXBIO_165_1_61C2","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1159\/000234229","article-title":"Substance P and calcitonin-gene related peptide: Effects on mast cells and in human skin","volume":"82","author":"Foreman","year":"1987","journal-title":"Int. Arch. Allergy appl. 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