{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T06:46:38Z","timestamp":1791096398245,"version":"4.1.0"},"reference-count":117,"publisher":"The Company of Biologists","issue":"1","license":[{"start":{"date-parts":[[1992,11,1]],"date-time":"1992-11-01T00:00:00Z","timestamp":720576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1992,11,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>The frog skin in vivo is capable of active transepithelial H+ secretion (JH) which is matched by Na+ absorption (JNA). Studies in vitro demonstrate that JH is generated by an H+-ATPase pump localized in apical membranes of mitochondria-rich (MR) cells, whereas JNa occurs through an amiloride-sensitive pathway in principal (P) cells. The H+ pump is sensitive to inhibitors of carbonic anhydrase (e.g. acetazolamide) and to specific inhibitors of mitochondrial F1F0 H+-ATPase (oligomycin) and vacuolar (V)-type H+-ATPase (N-ethylmaleimide) and to inhibitors of both these types of H+-ATPases (dicyclohexylcarbodiimide, DCCD). JH is independent of external K+, which differentiates it from gastric H+\/K+-ATPase and is strictly dependent on aerobic metabolism. The proton pump is primarily implicated in whole-body acid\u2013base regulation. Acute stimulation of JH in response (seconds\u2013minutes) to an acid load involves insertion of H+ pumps (exocytosis) from a cytosolic pool into the apical membrane. The chronic response (days) to metabolic acid load involves morphological changes (increased apical membrane surface area and number of MR cells). Whole-cell patch-clamp recordings of membrane capacitance and current fluctuations from MR cells demonstrate that a respiratory acid load and aldosterone produce rapid exocytotic insertion of DCCD-sensitive conductive membrane.<\/jats:p>\n               <jats:p>A secondary role of the H+ pump is to energize sodium absorption (JNa ) via principal cells from dilute solutions in the absence of a permeant anion under open-circuit conditions. The apparent 1:1 stoichiometry between JH and JNa is a result of transepithelial electrical coupling between these electrogenic fluxes. The H+ pump in MR cells generates a transepithelial current (serosa to apical) which acts as a physiological voltage-clamp to hyperpolarize the apical membrane of P cells. This hyperpolarization can facilitate passive Na+ entry across the apical membrane against a threefold chemical gradient. Since both JH and JNa are sensitive to membrane potential, inhibition or activation of one will produce similar effects on the transport of the other ion. For example, inhibition of JH by ethoxzolamide will reduce JNa. Conversely, blocking JNa with amiloride also inhibits JH. These effects can be avoided or reversed if variations in membrane potential are prevented by voltage-clamping the epithelium. A paradoxical activation of JNa is observed when JH is stimulated by an acid load (CO2), despite inhibition of Na+ channel activity by H+ in P cells. Patch-clamp studies reveal the presence of Na+ channels in MR cells which may provide a route for Na+ absorption energized by the H+ pump when Na+ channels in P cells are closed by an acid load.<\/jats:p>","DOI":"10.1242\/jeb.172.1.289","type":"journal-article","created":{"date-parts":[[2021,4,25]],"date-time":"2021-04-25T03:33:45Z","timestamp":1619321625000},"page":"289-309","source":"Crossref","is-referenced-by-count":99,"title":["Energization of sodium absorption by the H+-ATPase pump in mitochondria-rich cells of frog skin"],"prefix":"10.1242","volume":"172","author":[{"given":"Brian J.","family":"Harvey","sequence":"first","affiliation":[{"name":"Commissariat \u00e0 l\u2019Energie Atomique D\u00e9partement de Biologie Cellulaire et Mol\u00e9culaire , , Laboratoire Jean Maetz BP 68, F-06230 Villefranche-sur-mer, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[1992,11,1]]},"reference":[{"key":"2023051203252352900_JEXBIO_172_1_289C1","first-page":"69","article-title":"Marginal effect of changes in acid-base status in vitro on rheogenic H+ and HCOa\u2212 secretion in turtle urinary bladder","volume":"10","author":"Adrogu\u00e9","year":"1987","journal-title":"Renal Physiol"},{"key":"2023051203252352900_JEXBIO_172_1_289C2","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1146\/annurev.cb.02.110186.001143","article-title":"Proton-translocating ATPases. A","volume":"2","author":"Al-Awqati","year":"1986","journal-title":"Rev. Cell Biol"},{"key":"2023051203252352900_JEXBIO_172_1_289C3","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1242\/jeb.106.1.135","article-title":"Regulation of proton transport in urinary epithelia","volume":"106","author":"Al-Awqati","year":"1983","journal-title":"J. exp. Biol"},{"key":"2023051203252352900_JEXBIO_172_1_289C4","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1172\/JCI108479","article-title":"Characteristics of stimulation of H+ transport by aldosterone in turtle urinary bladder","volume":"58","author":"Al-Awqati","year":"1976","journal-title":"J. clin. Invest"},{"key":"2023051203252352900_JEXBIO_172_1_289C5","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1146\/annurev.ph.52.030190.003135","article-title":"Exocytosis","volume":"52","author":"Almers","year":"1990","journal-title":"A. Rev. Physiol"},{"key":"2023051203252352900_JEXBIO_172_1_289C6","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1085\/jgp.86.2.215","article-title":"Intrinsic characteristics of the proton pump in the luminal membrane of a tight urinary epithelium. The relation between transport rate and electrochemical potential difference of the proton","volume":"86","author":"Andersen","year":"1985","journal-title":"J. gen. Physiol"},{"key":"2023051203252352900_JEXBIO_172_1_289C7","first-page":"R222","article-title":"Stimulation of H+ secretion by CO? in turtle bladder: role of intracellular pH, exocytosis and calcium","volume":"258","author":"Arruda","year":"1990","journal-title":"Am. J. Physiol"},{"key":"2023051203252352900_JEXBIO_172_1_289C8","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1038\/ki.1981.210","article-title":"Vanadate inhibits urinary acidification by the turtle Pseudemys scripta bladder","volume":"20","author":"Arruda","year":"1981","journal-title":"Kidney Int"},{"key":"2023051203252352900_JEXBIO_172_1_289C9","first-page":"273","article-title":"Effect of agents that alter cell calcium and microfilaments on CO2 stimulated H+ secretion in the turtle bladder","volume":"293","author":"Arruda","year":"1988","journal-title":"Archs int. Pharm. Therapie"},{"key":"2023051203252352900_JEXBIO_172_1_289C10","first-page":"1","article-title":"Ion fluxes in the gills of fresh water and seawater salmonid fish","volume-title":"In Animal Nutrition and Transport Processes, Comparative Physiology","author":"Avella","year":"1990"},{"key":"2023051203252352900_JEXBIO_172_1_289C11","first-page":"1","article-title":"Electrophysiological identification of cell types in cortical collecting duct monolayers","volume":"14","author":"Bello-Reuss","year":"1991","journal-title":"Renal Physiol. Biochem"},{"key":"2023051203252352900_JEXBIO_172_1_289C12","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1083\/jcb.105.4.1637","article-title":"Structure of the novel membrane-coating material in proton secreting epithelial cells and identification as an H+-ATPase","volume":"105","author":"Brown","year":"1987","journal-title":"J. Cell Biol"},{"key":"2023051203252352900_JEXBIO_172_1_289C13","first-page":"2114","article-title":"Localization of a proton-pumping ATPase in rat kidney","volume":"82","author":"Brown","year":"1988","journal-title":"J. din. Invest"},{"key":"2023051203252352900_JEXBIO_172_1_289C14","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1038\/331622a0","article-title":"An H+-ATPase in opposite plasma membranes domains in kidney epithelial sub-populations","volume":"331","author":"Brown","year":"1988","journal-title":"Nature"},{"key":"2023051203252352900_JEXBIO_172_1_289C15","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/ar.1091920207","article-title":"Rod-shaped particles in the plasma membrane of the mitochondria-rich cell of amphibian epidermis","volume":"192","author":"Brown","year":"1987","journal-title":"Anat. Rec"},{"key":"2023051203252352900_JEXBIO_172_1_289C16","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/314443a0","article-title":"Carbon-dioxide-induced exocytotic insertion of H+ pumps in turtle bladder luminal membrane: role of cell pH and calcium","volume":"314","author":"Cannon","year":"1985","journal-title":"Nature"},{"key":"2023051203252352900_JEXBIO_172_1_289C17","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/BF01869011","article-title":"Membrane electrical parameters in turtle bladder measured using impedance-analysis techniques","volume":"92","author":"Clausen","year":"1986","journal-title":"J. Membr. Biol"},{"key":"2023051203252352900_JEXBIO_172_1_289C18","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1085\/jgp.76.3.381","article-title":"Control of active proton transport in turtle urinary bladder by cell pH","volume":"76","author":"Cohen","year":"1980","journal-title":"J. gen. Physiol"},{"key":"2023051203252352900_JEXBIO_172_1_289C19","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/BF00372954","article-title":"Effects of environmental conditions on mitochondria-rich cell density and chloride transport in toad skin","volume":"417","author":"Devuyst","year":"1991","journal-title":"Pfl\u00fcgers Arch"},{"key":"2023051203252352900_JEXBIO_172_1_289C20","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/BF01875352","article-title":"Constitutive and transport-related endocytotic pathways in turtle bladder epithelium","volume":"102","author":"Dixon","year":"1988","journal-title":"J. Membr. Biol"},{"key":"2023051203252352900_JEXBIO_172_1_289C21","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/BF01869719","article-title":"Proton transport and membrane shuttling in turtle bladder epithelium","volume":"94","author":"Dixon","year":"1986","journal-title":"J. Membr. Biol"},{"key":"2023051203252352900_JEXBIO_172_1_289C22","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.1073\/pnas.76.7.3135","article-title":"Urinary acidification in turtle bladder is due to a reversible proton translocating ATPase","volume":"76","author":"Dixon","year":"1979","journal-title":"Proc. natn. Acad. Sci. U.S.A"},{"key":"2023051203252352900_JEXBIO_172_1_289C23","doi-asserted-by":"crossref","first-page":"3237","DOI":"10.1016\/S0021-9258(19)85683-1","article-title":"H+\/ATP stoichiometry of the proton pump of turtle urinary bladder","volume":"255","author":"Dixon","year":"1980","journal-title":"J. biol. Chem"},{"key":"2023051203252352900_JEXBIO_172_1_289C24","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/978-3-642-74477-8_17","article-title":"Characterization of electrolyte transport mechanisms and compartments by the use of markers Rb and Br","volume-title":"In Electron Probe Microanalysis: Applications in Biology and Medicine","author":"Dorge","year":"1989"},{"key":"2023051203252352900_JEXBIO_172_1_289C25","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/BF00582513","article-title":"Uptake of Br in mitochondria-rich and principal cells of toad skin epithelium","volume":"412","author":"D\u00f6rge","year":"1988","journal-title":"Pfl\u00fcgers Arch"},{"key":"2023051203252352900_JEXBIO_172_1_289C26","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1113\/jphysiol.1986.sp016214","article-title":"Acid secretion through Rana escalenta skin: involvement of an anion exchange mechanism at the basolateral membrane","volume":"378","author":"Duranti","year":"1986","journal-title":"J. Physiol.. Lond"},{"key":"2023051203252352900_JEXBIO_172_1_289C27","doi-asserted-by":"crossref","first-page":"C609","DOI":"10.1152\/ajpcell.1986.250.4.C609","article-title":"Evidence for separate cellular origins of sodium and acid-base transport in turtle bladder","volume":"250","author":"Durham","year":"1986","journal-title":"Am. J. Physiol"},{"key":"2023051203252352900_JEXBIO_172_1_289C28","first-page":"F46","article-title":"Active hydrogen excretion and sodium absorption through isolated frog skin","volume":"233","author":"Ehrenfeld","year":"1977","journal-title":"Am. J. Physiol"},{"key":"2023051203252352900_JEXBIO_172_1_289C29","first-page":"F33","article-title":"Coupling between chloride absorption and base excretion in isolated skin of Rana escalenta","volume":"235","author":"Ehrenfeld","year":"1978","journal-title":"Am. J. Physiol"},{"key":"2023051203252352900_JEXBIO_172_1_289C30","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1113\/jphysiol.1985.sp015588","article-title":"Electrogenic active proton pump in Rana escalenta skin and its role in sodium ion transport","volume":"359","author":"Ehrenfeld","year":"1985","journal-title":"J. Physiol., Lond"},{"key":"2023051203252352900_JEXBIO_172_1_289C31","first-page":"152","article-title":"Interdependence of Na+ and H+ transport in frog skin","volume-title":"In Animal Nutrition and Transport Processes, Comparative Physiology","author":"Ehrenfeld","year":"1990"},{"key":"2023051203252352900_JEXBIO_172_1_289C32","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/BF00585627","article-title":"The key role of the mitochondria-rich cell in Na+ and H+ transport across frog skin epithelium","volume":"414","author":"Ehrenfeld","year":"1989","journal-title":"Pfl\u00fcgers Arch"},{"key":"2023051203252352900_JEXBIO_172_1_289C33","doi-asserted-by":"crossref","first-page":"C201","DOI":"10.1152\/ajpcell.1981.240.5.C201","article-title":"Effects of inhibitors of FO-F| proton translocating ATPase on urinary acidification","volume":"240","author":"Fanestil","year":"1981","journal-title":"Am. J. Physiol"},{"key":"2023051203252352900_JEXBIO_172_1_289C34","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1073\/pnas.51.4.569","article-title":"Functional organization of amphibian skin","volume":"51","author":"Farquhar","year":"1964","journal-title":"Proc. natn. Acad. Sei. U.S.A"},{"key":"2023051203252352900_JEXBIO_172_1_289C35","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1152\/physrev.1989.69.3.765","article-title":"Structure and function of vacuolar class of ATP driven proton pumps","volume":"69","author":"Forgac","year":"1989","journal-title":"Physiol. Rev"},{"key":"2023051203252352900_JEXBIO_172_1_289C36","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/BF01871147","article-title":"Cellular changes in the toad urinary bladder in response to metabolic acidosis","volume":"40","author":"Frazier","year":"1978","journal-title":"J. Membr. Biol"},{"key":"2023051203252352900_JEXBIO_172_1_289C37","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/0005-2736(71)90299-9","article-title":"Excretion of H+ and NH4+ by the urinary bladder of the acidotic toad and the effect of short-circuit current on the excretion","volume":"241","author":"Frazier","year":"1971","journal-title":"Biochim. biophys. Acta"},{"key":"2023051203252352900_JEXBIO_172_1_289C38","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/0300-9629(88)90687-1","article-title":"Mechanisms and regulation of ion transport in the renal collecting duct","volume":"90","author":"Fromter","year":"1988","journal-title":"Comp. Biochem. Physiol. A"},{"key":"2023051203252352900_JEXBIO_172_1_289C39","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1146\/annurev.bi.58.070189.000551","article-title":"ATP synthase (H+-ATPase): Results by combined biochemical and molecular biological approaches. A","volume":"58","author":"Futai","year":"1989","journal-title":"Rev. Biochem"},{"key":"2023051203252352900_JEXBIO_172_1_289C40","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1085\/jgp.53.6.816","article-title":"The nature of the in vivo sodium and chloride uptake mechanisms through the epithelium of the Chilean frog Calyptocephalella gayi (Dum. et Bibr., 1841). Exchanges of hydrogen against sodium and bicarbonate against chloride","volume":"53","author":"Garcia-Romeu","year":"1969","journal-title":"J. gen. Physiol"},{"key":"2023051203252352900_JEXBIO_172_1_289C41","first-page":"F71","article-title":"Proton-translocating ATPase from bovine kidney medulla: partial purification and reconstitution","volume":"254","author":"Gluck","year":"1988","journal-title":"Am. J. Physiol"},{"key":"2023051203252352900_JEXBIO_172_1_289C42","doi-asserted-by":"crossref","first-page":"4327","DOI":"10.1073\/pnas.79.14.4327","article-title":"Exocytosis regulates urinary acidification by rapid insertion of H+ pumps into the luminal membrane","volume":"79","author":"Gluck","year":"1982","journal-title":"Proc. natn. Acad. Sci. U.S.A"},{"key":"2023051203252352900_JEXBIO_172_1_289C43","first-page":"F366","article-title":"High proton flux through membranes containing antidiuretic hormone water channels","volume":"259","author":"Harris","year":"1991","journal-title":"Am. J. Physiol"},{"key":"2023051203252352900_JEXBIO_172_1_289C44","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1007\/BF00590937","article-title":"Regulation of intracellular sodium and pH by the electrogenic H+ pump in frog skin","volume":"406","author":"Harvey","year":"1986","journal-title":"Pfl\u00fcgers Arch"},{"key":"2023051203252352900_JEXBIO_172_1_289C45","first-page":"139","article-title":"Epithelial pH and ion transport regulation by proton pumps and exchangers. Ciba Foundation Symposium 139","volume-title":"Proton Passage Across Cell Membranes","author":"Harvey","year":"1988"},{"issue":"Suppl. 1","key":"2023051203252352900_JEXBIO_172_1_289C46","first-page":"R66","article-title":"Dual role for intracellular protons in the control of sodium transport in frog skin epithelium","volume":"411","author":"Harvey","year":"1988","journal-title":"Pfl\u00fcgers Arch"},{"key":"2023051203252352900_JEXBIO_172_1_289C47","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1113\/jphysiol.1984.sp015170","article-title":"Intracellular ionic activities in relation to external sodium and the effects of amiloride and\/or ouabain","volume":"349","author":"Harvey","year":"1984","journal-title":"J. Physiol., Lond"},{"key":"2023051203252352900_JEXBIO_172_1_289C48","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1085\/jgp.97.4.749","article-title":"Common channels for water and protons at apical and basolateral cell membranes of frog skin and urinary bladder epithelia. Effects of oxytocin, heavy metals and inhibitors of H+-adenosine triphosphatase","volume":"97","author":"Harvey","year":"1991","journal-title":"J. gen. Physiol"},{"key":"2023051203252352900_JEXBIO_172_1_289C49","article-title":"Sodium and chloride currents in single mitochondria-rich cells of amphibian skin. Proc, physiol. Soc. Oxford Meeting July","volume-title":"J. Physiol., Lond. (in press)","author":"Harvey","year":"1992"},{"key":"2023051203252352900_JEXBIO_172_1_289C50","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1085\/jgp.92.6.767","article-title":"Intracellular pH controls membrane Na+ and K+ conductances and transport in frog skin epithelium","volume":"92","author":"Harvey","year":"1988","journal-title":"J. gen. Physiol"},{"key":"2023051203252352900_JEXBIO_172_1_289C51","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1085\/jgp.92.2.145","article-title":"Muscarinic activation of ionic currents measured by a new whole-cell recording method","volume":"92","author":"Horn","year":"1988","journal-title":"J. gen. Physiol"},{"key":"2023051203252352900_JEXBIO_172_1_289C52","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/ki.1981.47","article-title":"Surface characteristics of carbonic anhydrase-rich cells in turtle urinary bladder","volume":"19","author":"Husted","year":"1981","journal-title":"Kidney Inti"},{"key":"2023051203252352900_JEXBIO_172_1_289C53","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/ar.1091960205","article-title":"Modification of mitochondria-rich cells in different ionic conditions: Changes in cell morphology and cell number in the skin of Xenopus laevis","volume":"196","author":"Ilic","year":"1980","journal-title":"Anat. Rec"},{"key":"2023051203252352900_JEXBIO_172_1_289C54","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1007\/978-3-662-00989-5_24","article-title":"The role of the amphibian epidermis in osmoregulation and its adaptive response to changing environment","volume":"2","author":"Katz","year":"1986","journal-title":"In Biology of the Integument"},{"key":"2023051203252352900_JEXBIO_172_1_289C55","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/BF00215851","article-title":"Mitochondria-rich cells and carbonic anhydrase content of toad skin epithelium","volume":"251","author":"Katz","year":"1988","journal-title":"Cell Tissue Res"},{"key":"2023051203252352900_JEXBIO_172_1_289C56","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/0005-2736(86)90457-8","article-title":"The voltage-dependent chloride current conductance of toad skin is localized to mitochondria-rich cells","volume":"861","author":"Katz","year":"1986","journal-title":"Biochim. biophys. Acta"},{"key":"2023051203252352900_JEXBIO_172_1_289C57","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1768-322X.1985.tb00433.x","article-title":"The role of mitochondria-rich cells in the chloride current conductance across toad skin","volume":"55","author":"Katz","year":"1985","journal-title":"Biol. Cell"},{"key":"2023051203252352900_JEXBIO_172_1_289C58","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/BF01870240","article-title":"Metabolic pathways coupled to hydrogen ion transport in turtle pseudemys scripta urinary bladder","volume":"54","author":"Kelly","year":"1980","journal-title":"J. Membr. Biol"},{"key":"2023051203252352900_JEXBIO_172_1_289C59","first-page":"F177","article-title":"Short-term effect of aldosterone on NEM-sensitive ATPase in rat collecting tubule","volume":"257","author":"Khadouri","year":"1989","journal-title":"Am. J. Physiol"},{"key":"2023051203252352900_JEXBIO_172_1_289C60","first-page":"199","article-title":"NaCl transport in intact frogs and isolated frog skins: a reconciliation","volume-title":"In Functional Regulation at the Cellular and Molecular Levels","author":"Kirschner","year":"1982"},{"key":"2023051203252352900_JEXBIO_172_1_289C61","first-page":"R984","article-title":"Basis for apparent saturation kinetics of Na+ influx in fresh water hyperregulators","volume":"254","author":"Kirschner","year":"1988","journal-title":"Am. J. Physiol"},{"key":"2023051203252352900_JEXBIO_172_1_289C62","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1111\/j.1748-1716.1958.tb01563.x","article-title":"The nature of the frog skin potential","volume":"42","author":"Koefoed-Johnsen","year":"1958","journal-title":"Acta physiol, scand"},{"key":"2023051203252352900_JEXBIO_172_1_289C63","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1007\/BF00584761","article-title":"Electrophysiological identification of principal and intercalated cells in the rabbit outer medulary collecting duct","volume":"409","author":"Koeppen","year":"1987","journal-title":"Pfl\u00fcgers Arch"},{"key":"2023051203252352900_JEXBIO_172_1_289C64","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/BF00692682","article-title":"Effects of ion substitution on the transepithelial potential difference of the gills of the fiddler crab Uca-tangeri: Evidence for a proton pump in the apical membrane","volume":"159","author":"Krippeit-Drews","year":"1989","journal-title":"J. comp. Physiol B"},{"key":"2023051203252352900_JEXBIO_172_1_289C65","first-page":"173","article-title":"Epithelial organization","volume-title":"In The Kidney: Physiology and Pathophysiology","author":"Kristensen","year":"1985"},{"key":"2023051203252352900_JEXBIO_172_1_289C66","volume-title":"Osmotic Regulation in Aquatic Animals","author":"Krogh","year":"1939"},{"key":"2023051203252352900_JEXBIO_172_1_289C67","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1152\/physrev.1991.71.1.235","article-title":"Chloride transport by high-resistance heterocellular epithelia","volume":"71","author":"Larsen","year":"1991","journal-title":"Physiol. Rev"},{"key":"2023051203252352900_JEXBIO_172_1_289C68","first-page":"A1237","article-title":"Chloride currents of single mitochondria-rich cells","volume":"6","author":"Larsen","year":"1992","journal-title":"FASEB J"},{"key":"2023051203252352900_JEXBIO_172_1_289C69","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1098\/rstb.1982.0141","article-title":"Chloride channels in toad skin","volume":"299","author":"Larsen","year":"1982","journal-title":"Phil. Trans. R. Soc. Lond. B"},{"key":"2023051203252352900_JEXBIO_172_1_289C70","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/BF01870619","article-title":"Ion transport by mitochondria-rich cells in toad skin","volume":"99","author":"Larsen","year":"1987","journal-title":"J. Membr. Biol"},{"key":"2023051203252352900_JEXBIO_172_1_289C71","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1113\/jphysiol.1992.sp019124","article-title":"Role of proton pump of mitochondria-rich cells for active transport of chloride ions in toad skin epithelium","volume":"450","author":"Larsen","year":"1992","journal-title":"J. Physiol., Lond"},{"key":"2023051203252352900_JEXBIO_172_1_289C72","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/BF00582306","article-title":"Patch-clamp techniques for time-resolved capacitance measurements in single cells","volume":"411","author":"Lindau","year":"1988","journal-title":"Pfl\u00fcgers Arch"},{"key":"2023051203252352900_JEXBIO_172_1_289C73","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1152\/ajplegacy.1972.223.6.1338","article-title":"Acidification of urine by the isolated urinary bladder of the toad","volume":"223","author":"Ludens","year":"1972","journal-title":"Am. J. Physiol"},{"key":"2023051203252352900_JEXBIO_172_1_289C74","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1152\/ajplegacy.1974.226.6.1321","article-title":"Aldosterone stimulation of acidification of urine by the isolated urinary bladder of the Columbian toad","volume":"226","author":"Ludens","year":"1974","journal-title":"Am. J. Physiol"},{"key":"2023051203252352900_JEXBIO_172_1_289C75","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/0005-2736(75)90047-4","article-title":"Some features of hydrogen (ion) secretion by the frog skin","volume":"406","author":"Machen","year":"1975","journal-title":"Biochim. biophys. Acta"},{"key":"2023051203252352900_JEXBIO_172_1_289C76","first-page":"268","article-title":"Response of intercalated cells of rat outer medullary collecting duct to chronic metabolic acidosis","volume":"51","author":"Madsen","year":"1984","journal-title":"Lab. Invest"},{"key":"2023051203252352900_JEXBIO_172_1_289C77","first-page":"2704","article-title":"Structure-function relationships in H+-secreting epithelia","volume":"44","author":"Madsen","year":"1985","journal-title":"Fedn Proc. Fedn Am. Socs exp. Biol"},{"key":"2023051203252352900_JEXBIO_172_1_289C78","first-page":"34","article-title":"Effects of aldosterone on rat collecting tubule N-ethylmaleimide-sensitive adenosine triphosphatase","volume":"109","author":"Muj\u00e1is","year":"1987","journal-title":"J. Lab. clin. Med"},{"key":"2023051203252352900_JEXBIO_172_1_289C79","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1007\/BF00370569","article-title":"Chloride-related current fluctuation in amphibian skin","volume":"418","author":"Nagel","year":"1991","journal-title":"Pfl\u00fcgers Arch"},{"key":"2023051203252352900_JEXBIO_172_1_289C80","doi-asserted-by":"crossref","first-page":"416","DOI":"10.3181\/00379727-184-42495","article-title":"Morphological changes in the skin of Rana pipiens in response to metabolic acidosis","volume":"184","author":"Page","year":"1987","journal-title":"Proc. Soc. exp. Biol. Med"},{"key":"2023051203252352900_JEXBIO_172_1_289C81","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1073\/pnas.83.8.2767","article-title":"Amiloride-sensiti ve Na+ channels from the apical membrane of rat cortical collecting tubule","volume":"83","author":"Palmer","year":"1986","journal-title":"Proc. natn. Acad. Sci. U.S.A"},{"key":"2023051203252352900_JEXBIO_172_1_289C82","first-page":"F65","article-title":"Aldosterone induces apical vesicles in rat distal colon","volume":"259","author":"Perrone","year":"1990","journal-title":"Am. J. Physiol"},{"key":"2023051203252352900_JEXBIO_172_1_289C83","doi-asserted-by":"crossref","first-page":"94","DOI":"10.3181\/00379727-170-41404","article-title":"Membrane potentials, resistances and conductances of toad Bufo marinus bladder during sodium and hydrogen ion transport","volume":"170","author":"Ramsay","year":"1982","journal-title":"Proc. Soc. exp. Biol. Med"},{"key":"2023051203252352900_JEXBIO_172_1_289C84","first-page":"237","article-title":"Role of endocytosis in H+ transport regulation by turtle bladder","volume":"23","author":"Reeves","year":"1983","journal-title":"Kidney Int"},{"key":"2023051203252352900_JEXBIO_172_1_289C85","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/BF01870073","article-title":"Changes in membrane conductances and areas associated with bicarbonate secretion in turtle bladder","volume":"113","author":"Rich","year":"1990","journal-title":"J. Membr. Biol"},{"key":"2023051203252352900_JEXBIO_172_1_289C86","article-title":"Different types of mitochondria-rich cells in the frog skin epithelium","volume-title":"J. Membr. Biol. (in press)","author":"Rick","year":"1992"},{"key":"2023051203252352900_JEXBIO_172_1_289C87","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/BF01869897","article-title":"Electron microprobe analysis of frog skin epithelium: Evidence for a syncytial sodium transport compartment","volume":"39","author":"Rick","year":"1978","journal-title":"J. Membr. Biol"},{"key":"2023051203252352900_JEXBIO_172_1_289C88","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00310114","article-title":"Carbonic anhydrase activity in Rana pipiens skin: Biochemical and histochemical analysis","volume":"36","author":"Rosen","year":"1973","journal-title":"Histochimie"},{"key":"2023051203252352900_JEXBIO_172_1_289C89","first-page":"F817","article-title":"Characteristics of the proton pump in rat renal cortical endocytotic vesicles","volume":"250","author":"Sabolic","year":"1986","journal-title":"Am. J. Physiol"},{"key":"2023051203252352900_JEXBIO_172_1_289C90","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/257241a0","article-title":"Binding of aldosterone by mitochondria-rich cells of the toad urinary bladder","volume":"257","author":"Sapirstein","year":"1975","journal-title":"Nature"},{"key":"2023051203252352900_JEXBIO_172_1_289C91","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1007\/BF00370227","article-title":"Sodium entry routes in principal and intercalated cells of the isoalted perfused cortical collecting duct","volume":"416","author":"Sauer","year":"1990","journal-title":"Pfl\u00fcgers Arch"},{"key":"2023051203252352900_JEXBIO_172_1_289C92","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/BF01998081","article-title":"Molecular and cellular mechanisms involved in transepithelial transport","volume":"123","author":"Schaerer","year":"1991","journal-title":"J. Membr. Biol"},{"key":"2023051203252352900_JEXBIO_172_1_289C93","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1172\/JCI111871","article-title":"Carbon dioxide causes exocytosis of vesicles containing hydrogen ion pumps in isolated perfused proximal and collecting tubules","volume":"75","author":"Schwartz","year":"1985","journal-title":"J. clin. Invest"},{"key":"2023051203252352900_JEXBIO_172_1_289C94","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1146\/annurev.ph.48.030186.001101","article-title":"Regulation of transepithelial H+ transport by exocytosis and endocytosis. A","volume":"48","author":"Schwartz","year":"1986","journal-title":"Rev. Physiol"},{"key":"2023051203252352900_JEXBIO_172_1_289C95","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/318368a0","article-title":"Plasticity of functional epithelial polarity","volume":"318","author":"Schwartz","year":"1985","journal-title":"Nature"},{"key":"2023051203252352900_JEXBIO_172_1_289C96","first-page":"F627","article-title":"Specialized function of carbonic anhydrase-rich and granular cells in turtle bladder","volume":"242","author":"Schwartz","year":"1982","journal-title":"Am. J. Physiol"},{"key":"2023051203252352900_JEXBIO_172_1_289C97","first-page":"F145","article-title":"Metabolism, energy and pCCh as determinants of H+ secretion in turtle urinary bladder","volume":"233","author":"Schwartz","year":"1977","journal-title":"Am. J. Physiol"},{"key":"2023051203252352900_JEXBIO_172_1_289C98","first-page":"2051","article-title":"CO2 requirements for H+ secretion by the isolated bladder. Am","volume":"220","author":"Schwartz","year":"1971","journal-title":"J. Physiol"},{"key":"2023051203252352900_JEXBIO_172_1_289C99","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1749-6632.1982.tb25730.x","article-title":"Structure and genetics of the H+ conducting Fo portion of the ATP synthase","volume":"402","author":"Sebald","year":"1982","journal-title":"Ann. N. Y. Acad. Sci"},{"key":"2023051203252352900_JEXBIO_172_1_289C100","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/BF01870434","article-title":"The proton ATPase of bacteria and mitochondria","volume":"73","author":"Senior","year":"1983","journal-title":"J. Membr. Biol"},{"key":"2023051203252352900_JEXBIO_172_1_289C101","first-page":"309","article-title":"Dicyclohexylcarbodiimide as a probe for proton translocation enzymes","volume-title":"Trends biol. Sci","author":"Solioz","year":"1984"},{"key":"2023051203252352900_JEXBIO_172_1_289C102","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/BF01869012","article-title":"The volume of mitochondria-rich cells of frog skin epithelium","volume":"92","author":"Spring","year":"1986","journal-title":"J. Membr. Biol"},{"key":"2023051203252352900_JEXBIO_172_1_289C103","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1152\/physrev.1974.54.4.890","article-title":"Cellular mechanism of urinary acidification","volume":"54","author":"Steinmetz","year":"1974","journal-title":"Physiol. Rev"},{"key":"2023051203252352900_JEXBIO_172_1_289C104","first-page":"F173","article-title":"Cellular organization of urinary acidification","volume":"251","author":"Steinmetz","year":"1986","journal-title":"Am. J. Physiol"},{"key":"2023051203252352900_JEXBIO_172_1_289C105","first-page":"122","article-title":"Electrogenic proton transport by intercalated cells of tight urinary epithelia. Ciba Foundation Symposium 139","volume-title":"Proton Passage Across Cell Membranes","author":"Steinmetz","year":"1988"},{"key":"2023051203252352900_JEXBIO_172_1_289C106","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/BF01869960","article-title":"Electrogenic proton transport in epithelial membranes","volume":"65","author":"Steinmetz","year":"1982","journal-title":"J. Membr. Biol"},{"key":"2023051203252352900_JEXBIO_172_1_289C107","first-page":"67","article-title":"Cellular organization of active proton transport in urinary epithelia","volume-title":"In Contemporary Issues in Nephrology. Modern Techniques of Ion Transport","author":"Steinmetz","year":"1987"},{"key":"2023051203252352900_JEXBIO_172_1_289C108","first-page":"R973","article-title":"Turtle urinary bladder regulation of ion transport by dynamic changes in plasma membrane area","volume":"257","author":"Stetson","year":"1989","journal-title":"Am. J. Physiol"},{"key":"2023051203252352900_JEXBIO_172_1_289C109","doi-asserted-by":"crossref","first-page":"C113","DOI":"10.1152\/ajpcell.1983.245.1.C113","article-title":"Role of membrane fusion in CO2 stimulation of proton secretion by turtle bladder","volume":"245","author":"Stetson","year":"1983","journal-title":"Am. J. Physiol"},{"key":"2023051203252352900_JEXBIO_172_1_289C110","first-page":"F553","article-title":"\u03b1 and \u03b2 types of carbonic anhydrase-rich cells in the turtle bladder","volume":"249","author":"Stetson","year":"1985","journal-title":"Am. J. Physiol"},{"key":"2023051203252352900_JEXBIO_172_1_289C111","doi-asserted-by":"crossref","first-page":"S80","DOI":"10.1007\/BF00584934","article-title":"Correlation between apical intramembrane particles and H+ secretion during CO2 stimulation in turtle bladder","volume":"407","author":"Stetson","year":"1986","journal-title":"Pfl\u00fcgers Arch"},{"key":"2023051203252352900_JEXBIO_172_1_289C112","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/ki.1988.65","article-title":"Proton translocating ATPases","volume":"33","author":"Stone","year":"1988","journal-title":"Kidney Int"},{"key":"2023051203252352900_JEXBIO_172_1_289C113","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/j.1432-1033.1988.tb14279.x","article-title":"Diethylstilbestrol. Interactions with membranes and proteins and the different effects upon Ca2+- and Mg2+-dependent activities of the Fi-ATPase from Rhodospirillum rubrum","volume":"176","author":"Strid","year":"1988","journal-title":"Eur. J. Biochem"},{"key":"2023051203252352900_JEXBIO_172_1_289C114","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1083\/jcb.102.5.1638","article-title":"Regulation of cell pH by Ca2+-mediated exocytotic insertion of H+-ATPases","volume":"102","author":"van Adelsberg","year":"1986","journal-title":"J. Cell Biol"},{"key":"2023051203252352900_JEXBIO_172_1_289C115","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1152\/physrev.1985.65.4.833","article-title":"Ionic channels in epithelial cell membranes","volume":"65","author":"van Driessche","year":"1985","journal-title":"Physiol. Rev"},{"key":"2023051203252352900_JEXBIO_172_1_289C116","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0022-4731(72)90046-5","article-title":"Aldosterone induced morphological changes in amphibian epithelia in vivo","volume":"3","author":"Vo\u00fbte","year":"1972","journal-title":"J. Steroid Biochem"},{"key":"2023051203252352900_JEXBIO_172_1_289C117","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/BF01871197","article-title":"Membrane potentials and intracellular CD activity of toad skin epithelium in relation to activation and deactivation of the transepithelial CD conductance","volume":"94","author":"Willumsen","year":"1986","journal-title":"J. Membr. Biol"}],"container-title":["Journal of Experimental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/jeb\/article-pdf\/172\/1\/289\/2848799\/jexbio_172_1_289.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/jeb\/article-pdf\/172\/1\/289\/2848799\/jexbio_172_1_289.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T03:29:51Z","timestamp":1683862191000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/jeb\/article\/172\/1\/289\/6567\/Energization-of-sodium-absorption-by-the-H-ATPase"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,11,1]]},"references-count":117,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1992,11,1]]}},"URL":"https:\/\/doi.org\/10.1242\/jeb.172.1.289","relation":{},"ISSN":["0022-0949","1477-9145"],"issn-type":[{"value":"0022-0949","type":"print"},{"value":"1477-9145","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,11,1]]}}}