{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T05:38:00Z","timestamp":1757309880115,"version":"3.41.2"},"reference-count":39,"publisher":"The Company of Biologists","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["IBN IOS-0845741"],"award-info":[{"award-number":["IBN IOS-0845741"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"name":"EliteForsk"},{"DOI":"10.13039\/100008394","name":"Natur og Univers, Det Frie Forskningsr\u00e5d","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008394","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Ventricular filling may occur directly from the venous circulation during early diastole or via atrial contraction in late diastole. The contribution of atrial contraction to ventricular filling is typically small in mammals (10-40%), but has been suggested to predominate in reptiles. We investigated the importance of atrial contraction in filling of the ventricle in American alligators (Alligator mississippiensis) by bypassing both atria (with the use of ligatures to prevent atrial filling) and measuring the resultant effects on cardiac output in anesthetized animals. Atrial ligation had no significant effects on total systemic blood flow before or after adrenaline injection. Unexpectedly, pulmonary flow was increased following atrial ligation prior to adrenaline, but was unaffected after it. These findings suggest that the atria are non-essential (i.e. redundant) for ventricular filling in alligators, at least under anesthesia, but may serve as important volume reservoirs.<\/jats:p>","DOI":"10.1242\/jeb.178194","type":"journal-article","created":{"date-parts":[[2018,4,3]],"date-time":"2018-04-03T13:55:59Z","timestamp":1522763759000},"source":"Crossref","is-referenced-by-count":5,"title":["Contribution of active atrial contraction to cardiac output in anesthetized American alligators (<i>Alligator mississippiensis<\/i>)"],"prefix":"10.1242","author":[{"given":"William","family":"Joyce","sequence":"first","affiliation":[{"name":"Department of Zoophysiology, Aarhus University, 8000 Aarhus C, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janna","family":"Crossley","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Developmental Integrative Biology Cluster, University of North Texas, Denton, TX 76203-5017, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth M.","family":"Elsey","sequence":"additional","affiliation":[{"name":"Louisiana Department of Wildlife and Fisheries, Rockefeller Wildlife Refuge, Grand Chenier, LA70643, USA&#x2028;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Zoophysiology, Aarhus University, 8000 Aarhus C, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"II","given":"Dane A.","family":"Crossley","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Developmental Integrative Biology Cluster, University of North Texas, Denton, TX 76203-5017, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2018,1,1]]},"reference":[{"key":"2021042422513344000_JEB178194C1","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1242\/jeb.00742","article-title":"Intrinsic autoregulation of cardiac output in rainbow trout (Oncorhynchus mykiss) at different heart rates","volume":"207","author":"Altimiras","year":"2004","journal-title":"J. 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