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Plasma levels of noradrenaline rose to a plateau of approximately 50 nmol l\u22121 with infusion. In the group infused with noradrenaline alone, noradrenaline levels were maintained for 1 h. Supplementation with 3-OHB induced a decrease in plasma noradrenaline level that was inversely correlated with 3-OHB level. Aortic and interscapular brown adipose tissue temperatures increased with noradrenaline infusion, but the rise was arrested by 3-OHB; replacing 3-OHB with glucose had no effect. Infusion of saline, glucose or 3-OHB in the absence of noradrenaline did not induce a rise in temperature in either tissue. Blood 3-OHB concentration increased to 1.2 mmol l\u22121 during 3-OHB infusion, decreasing rapidly at the end of infusion. Blood glucose levels increased with noradrenaline infusion; the presence of high 3-OHB levels decreased glucose concentration. The effects observed were transient and dependent on 3-OHB concentration; these effects may help explain most of the other effects of noradrenaline described here. The role of 3-OHB as a regulator of adrenergic responses seems to be part of a complex fail-safe mechanism which prevents wasting.<\/jats:p>","DOI":"10.1242\/jeb.200.20.2641","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T00:04:37Z","timestamp":1619395477000},"page":"2641-2646","source":"Crossref","is-referenced-by-count":2,"title":["3-Hydroxybutyrate Co-Infused With Noradrenaline Decreases Resulting Plasma Levels Of Noradrenaline In Wistar Rats"],"prefix":"10.1242","volume":"200","author":[{"given":"X.","family":"Ca\u00f1as","sequence":"first","affiliation":[{"name":"Universitat de Barcelona 1 Departament de Bioqu\u00edmica i Biologia Molecular , Facultat de Biologia , , Avinguda Diagonal 645, 08028 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Sanchis","sequence":"additional","affiliation":[{"name":"Universitat de Barcelona 1 Departament de Bioqu\u00edmica i Biologia Molecular , Facultat de Biologia , , Avinguda Diagonal 645, 08028 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"G\u00f3mez","sequence":"additional","affiliation":[{"name":"Universitat de Barcelona 1 Departament de Bioqu\u00edmica i Biologia Molecular , Facultat de Biologia , , Avinguda Diagonal 645, 08028 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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