{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:59:22Z","timestamp":1791219562964,"version":"4.1.0"},"reference-count":55,"publisher":"The Company of Biologists","issue":"1","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,1,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Microvesicles in endocrine cells are the morphological and functional equivalent of neuronal synaptic vesicles. Microvesicles accumulate various neurotransmitters through a transmitter-specific vesicular transporter energized by vacuolar H+ -ATPase. We found that mammalian pinealocytes, endocrine cells that synthesize and secrete melatonin, accumulate L-glutamate in their microvesicles and secrete it through exocytosis. Pinealocytes use L-glutamate as either a paracrine- or autocrine-like chemical transmitter in a receptor-mediated manner, resulting in inhibition of melatonin synthesis. In this article, we briefly describe the overall features of the microvesicle-mediated signal-transduction mechanism in the pineal gland and discuss the important role of acidic organelles in a novel regulatory mechanism for hormonal synthesis and secretion.<\/jats:p>","DOI":"10.1242\/jeb.203.1.117","type":"journal-article","created":{"date-parts":[[2021,4,25]],"date-time":"2021-04-25T05:32:46Z","timestamp":1619328766000},"page":"117-125","source":"Crossref","is-referenced-by-count":48,"title":["Synaptic-Like Microvesicles, Synaptic Vesicle Counterparts in Endocrine Cells, are Involved in a Novel Regulatory Mechanism for the Synthesis and Secretion of Hormones"],"prefix":"10.1242","volume":"203","author":[{"given":"Yoshinori","family":"Moriyama","sequence":"first","affiliation":[{"name":"Okayama University 1 Department of Biochemistry , Faculty of Pharmaceutical Sciences , , Okayama 700-8530, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuko","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Okayama University 1 Department of Biochemistry , Faculty of Pharmaceutical Sciences , , Okayama 700-8530, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Yamada","sequence":"additional","affiliation":[{"name":"Okayama University 1 Department of Biochemistry , Faculty of Pharmaceutical Sciences , , Okayama 700-8530, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouki","family":"Yatsushiro","sequence":"additional","affiliation":[{"name":"Okayama University 1 Department of Biochemistry , Faculty of Pharmaceutical Sciences , , Okayama 700-8530, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shougo","family":"Ishio","sequence":"additional","affiliation":[{"name":"Okayama University 1 Department of Biochemistry , Faculty of Pharmaceutical Sciences , , Okayama 700-8530, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akitsugu","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Kansai Medical University 2 Department of Physiology , , Moriguchi, Osaka 570-8506, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2000,1,1]]},"reference":[{"key":"2024121803524790500_JEXBIO_203_1_117C1","doi-asserted-by":"publisher","first-page":"1595","DOI":"10.1053\/gast.1996.v110.pm8613067","article-title":"\u03b3-Aminobutyric acid secretion from pancreatic neuroendocrine cells","volume":"110","author":"Ahnert-Hilger","year":"1996","journal-title":"Gastroenterol"},{"key":"2024121803524790500_JEXBIO_203_1_117C2","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/0014-5793(92)81457-W","article-title":"The amphicrine pancreatic cell line, AR42J, secretes GABA and amylase by separate regulated pathways","volume":"314","author":"Ahnert-Hilger","year":"1992","journal-title":"FEBS Lett"},{"key":"2024121803524790500_JEXBIO_203_1_117C3","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1159\/000124990","article-title":"Alpha-adrenergic control of serotonin release from rat pineal glands","volume":"48","author":"Aloyo","year":"1988","journal-title":"Neuroendocr"},{"key":"2024121803524790500_JEXBIO_203_1_117C4","doi-asserted-by":"publisher","first-page":"4838","DOI":"10.1073\/pnas.81.15.4838","article-title":"Visualization of acidic organelles in intact cells by electron microscopy","volume":"81","author":"Anderson","year":"1984","journal-title":"Proc. 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