{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T21:52:21Z","timestamp":1781128341874,"version":"3.54.1"},"reference-count":26,"publisher":"The Company of Biologists","issue":"16","license":[{"start":{"date-parts":[[2000,8,15]],"date-time":"2000-08-15T00:00:00Z","timestamp":966297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,8,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>The principal function of the cardiopulmonary systemis the precise matching of O2 and CO2 transport to the metabolic requirements of different tissues. In som e ecothermic vertebrates (amphibians and reptiles), increases dramatically following feeding. Factorial increments in range from 1.7 to 44 times above resting rates, and in some cases approaches or even exceeds values measured during physical activity. There is virtually no information on the cardiopulmonary response during the postprandial period in these animals or how the pattern of cardiopulmonary support compares with that during activity. In our experiments, pulmonary ventilation , heart rate (fH), systemic blood flow (Q\u0307sys), rate of oxygen consu mption and rate of carbon dioxide production were measured at 35 \u00b0C in the lizard Varanus exanthematicus for 24 h prior to the ingestion of meals of various sizes and measured continuously for up to 72 h during the postprandial period. The results of this study were compared with previously published values for treadmill exercise in the same experimental animals. The change in fH and stroke volume (VS) for a given increment in did not differ during exercise and digestion. In contrast, the ventilatory response was very dependent on the nature of the elevated metabolic state. During digestion, an increase in resulted in a relative hypoventilation in comparison with resting values, whereas hyperventilation characterized the response during activity. During exercise, breathing frequency (f) increased 10-to 40-fold above resting values accompanied by large reductions in tidalvolume (VT). In contrast, postprandial increases in resulted in relatively minor changes in f and VT almost doubled. These results indicate that, in these lizards, the cardiac response to elevated is stereotyped, the response being predictable irrespective of the source of the metabolic increment. In contrast, the ventilatory response is flexible and state-dependent, not only in pattern but also in its frequency and volume components.<\/jats:p>","DOI":"10.1242\/jeb.203.16.2437","type":"journal-article","created":{"date-parts":[[2021,4,25]],"date-time":"2021-04-25T04:33:24Z","timestamp":1619325204000},"page":"2437-2445","source":"Crossref","is-referenced-by-count":69,"title":["Patterns of Cardiovascular and Ventilatory Response to Elevated Metabolic States in the Lizard <i>Varanus Exanthematicus<\/i>"],"prefix":"10.1242","volume":"203","author":[{"given":"James W.","family":"Hicks","sequence":"first","affiliation":[{"name":"University of California at Irvine 1 Department of Ecology and Evolutionary Biology , , Irvine, CA 92697, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Wang","sequence":"additional","affiliation":[{"name":"University of Birmingham 2 School of Biological Sciences , , Birmingham B15 2TT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert F.","family":"Bennett","sequence":"additional","affiliation":[{"name":"University of California at Irvine 1 Department of Ecology and Evolutionary Biology , , Irvine, CA 92697, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2000,8,15]]},"reference":[{"key":"2024121805080944500_JEXBIO_203_16_2437C1","first-page":"485","article-title":"Meal size and specific dynamic action in the rattlesnake Crotalus durissus (Serpentes: Viperidae)","volume":"53","author":"Andrade","year":"1997","journal-title":"Herpetologica"},{"key":"2024121805080944500_JEXBIO_203_16_2437C2","volume-title":"The Physiology of Large Reptiles with Special Reference to the Heat Production of Snakes, Tortoises, Lizards and Alligators","author":"Benedict","year":"1932"},{"key":"2024121805080944500_JEXBIO_203_16_2437C3","first-page":"113","volume-title":"Adaptations, vol. 38B","author":"Bennett","year":"1994"},{"key":"2024121805080944500_JEXBIO_203_16_2437C4","volume-title":"Bioenergetics and Growth","author":"Brody","year":"1945"},{"key":"2024121805080944500_JEXBIO_203_16_2437C5","first-page":"R185","article-title":"The effects of feeding on blood gases, acid\u2013base parameters and selected metabolites in the bullfrog Rana catesbeiana","volume":"278","author":"Busk","year":"2000","journal-title":"Am. 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